CS354391A3 - Antiparasitic avermectin and milbemycin derivatives and process forpreparing thereof - Google Patents

Antiparasitic avermectin and milbemycin derivatives and process forpreparing thereof

Info

Publication number
CS354391A3
CS354391A3 CS913543A CS354391A CS354391A3 CS 354391 A3 CS354391 A3 CS 354391A3 CS 913543 A CS913543 A CS 913543A CS 354391 A CS354391 A CS 354391A CS 354391 A3 CS354391 A3 CS 354391A3
Authority
CS
Czechoslovakia
Prior art keywords
double bond
absent
alpha
avermectin
alkyl
Prior art date
Application number
CS913543A
Other languages
Czech (cs)
Inventor
Stephen Paul Gibson
Kelvin Scott Holdom
Alexander Crossan Goudie
Lock John Desmond Bu
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858518999A external-priority patent/GB8518999D0/en
Priority claimed from GB858520069A external-priority patent/GB8520069D0/en
Priority claimed from GB868610063A external-priority patent/GB8610063D0/en
Priority claimed from GB868610862A external-priority patent/GB8610862D0/en
Priority claimed from EP86305604A external-priority patent/EP0214731B1/en
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of CS354391A3 publication Critical patent/CS354391A3/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

THE INVENTION PROVIDES NOVEL COMPOUNDS HAVING THE FORMULA:(FORMULA 1)WHEREIN THE BROKEN LINE AT THE 22-23 POSITION REPRESENTS AN OPTIONAL DOUBLE BOND AND WHEREIN R1 IS H OR OH AND THE DOUBLE BOND IS ABSENT, OR, THE DOUBLE BOND IS PRESENT AND R1 IS ABSENT; R2 IS AN ALPHA-BRANCHED C3-C8 ALKYL, ALKENYL, ALKYNYL, ALKOXYALKYL OR ALKYLTHIOALKYL GROUP; A C3-C8 CYCLOALKYL, C5-C8 CYCLOALKENYL OR C5-C8 CYCLOALKYLALKYL GROUP, ANY OF WHICH MAY OPTIONALLY BE SUBSTITUTED BY METHYLENE OR ONE OR MORE C1-C4 ALKYL GROUPS OR HALO ATOMS; OR A 3 TO 6 MEMBERED OXYGEN OR SULPHUR CONTAINING HETEROCYCLIC RING WHICH MAY OPTIONALLY BE SUBSTITUTED BY ONE OR MORE C1-C4 ALKYL GROUPS OR HALO ATOMS; R3 IS HYDROGEN OR METHYL; R4 IS H OR 4''-(ALPHA-L-OLEANDROSYL)-ALPHA-L-OLEANDROSYLOXY, WITH THE PROVISO THAT WHEN R2 IS ALKYL IT IS NOT ISOPROPYL OR SEC-BUTYL, AND WHEN R4 IS H, R1 IS OH, AND THE DOUBLE BOND IS ABSENT, R2 IS NOT 2-BUTEN-2-YL,, 2-PENTENE-2-YL OR 4-METHYL-2-PENTENE-2-YL. THE COMPOUNDS ARE BROAD SPECTRUM ANTIPARASITIC AGENTS HAVING UTILITY AS ANTHELMINTICS, ECTOPARASITICIDES, INSECTICIDES AND ACARICIDES. THE INVENTION ALSO PROVIDES A PROCESS FOR PRODUCING THE NOVEL AVERMECTIN AND MILBEMYCIN DERIVATIVES BY ADDING A CARBOXYLIC ACID OR DERIVATIVE THEREOF TO A FERMENTATION OF AN AVERMECTIN OR MILBEMYCIN PRODUCING ORGANISM.
CS913543A 1985-07-27 1991-11-22 Antiparasitic avermectin and milbemycin derivatives and process forpreparing thereof CS354391A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB858518999A GB8518999D0 (en) 1985-07-27 1985-07-27 Antiparasitic agents
GB858520069A GB8520069D0 (en) 1985-08-09 1985-08-09 Anti-parasitic agents
GB868610063A GB8610063D0 (en) 1986-04-24 1986-04-24 Antiparasitic agents
GB868610862A GB8610862D0 (en) 1986-05-02 1986-05-02 Antiparasitic agents
EP86305604A EP0214731B1 (en) 1985-07-27 1986-07-22 Antiparasitic avermectin and milbemycin derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
CS354391A3 true CS354391A3 (en) 1992-08-12

Family

ID=27513440

Family Applications (1)

Application Number Title Priority Date Filing Date
CS913543A CS354391A3 (en) 1985-07-27 1991-11-22 Antiparasitic avermectin and milbemycin derivatives and process forpreparing thereof

Country Status (3)

Country Link
AT (1) ATE59652T1 (en)
CS (1) CS354391A3 (en)
MY (1) MY101771A (en)

Also Published As

Publication number Publication date
ATE59652T1 (en) 1991-01-15
MY101771A (en) 1992-01-17

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic