CS277380B6 - Surface-active disinfectants based on amino oxides - Google Patents

Abstract

Surface-active disinfectants contain the compositions as an antimicrobially active ingredient, active chlorine and linear or branched alkyldimethylamine oxide, which also serves as a detergent with an antlmicrobial potentiating effect active chlorine activity. Looking at these properties can be used e.g. for disinfection of sanitary facilities, v health, public buildings and facilities, municipal hyglene, in the food industry, v agriculture and pharmaceuticals cosmetics, water treatment.

Description

Field of technology

The invention relates to surfactant disinfectants containing active chlorine, in which the surfactants! the activity, solubilisation and potentiation of the antimicrobial effect is ensured by amine oxide or mixtures of amine oxides of general formula ch ₃

R - ⁺ N - 0 “, 'ch ₃ .

wherein R represents a linear or branched alkyl chain with a number of carbon atoms of 10 to 18, and wherein the content of active chlorine is provided by sodium hypochlorite.

Prior art

Hypochlorite disinfectants, although one of the oldest disinfectants in general, are still widely used because they are germicidally effective on a wide range of microorganisms, have a deodorizing effect in useful concentrations, are not toxic to humans, do not leave toxic residues, are colorless and colorless. , easy to handle, are economically advantageous. On the other hand, they are unstable in low-concentration solutions (the active form of the preparations is perchloric acid, which is unstable and the solutions are stabilized by the addition of NaOH), must not be used for washing wool and silk, must not come into contact with silver and aluminum attacking fabrics are white and, if they do not contain detergent, their penetrating and cleaning ability is relatively low.

In addition to the sodium hypochlorite NaClO solutions themselves, various combinations with detergents are used. Combinations with cationic surfactants have not proved successful, as hypochlorite decomposes at higher concentrations. Recently, combinations of NaClO with amine oxides have also been promoted, and these preparations have, in addition to disinfectant, also a cleaning and bleaching effect. However, with all these agents, with the decrease in the presence of active chlorine, there is also a decrease in the antimicrobial effect, which definitively disappears after complete decomposition of NaClO.

The essence of the invention

The essence of the invention consists in the fact that surfactants, disinfectants consist of an aqueous solution of active chlorine and amine oxide of general formula pr - + n - 0 ", ch ₃ where R represents an alkyl chain with the number of carbon atoms 10 to 18, which can be linear or branched , and whose content in the pros class is 0.1 to 3% by weight and the active chlorine content is 1 to 10% by weight.

The amine oxide surfactants which are the subject of the present invention have the advantage that the amine oxides used solve the above-mentioned disadvantages by providing, as multifunctional compounds, a cleaning and detergent effect, and since the amine oxides themselves and mixtures thereof are antimicrobially active. , even after the disappearance of the active chlorine in solution, these compositions retain their antimicrobial activity (relative to the activity of the fresh composition) to about 85%, while the cleaning and detergent effect of the preparation does not change over time. Compared to other formulations containing active chlorine and currently commercially available, they outperform them several times, especially in stress tests, stability and the retention of high residual antimicrobial activity.

Examples of embodiments of the invention

Example 1

A technically filtered aqueous solution of sodium hypochlorite is mixed with an aqueous solution of amine oxide (e.g. (1-methyldodecyl) -N, N-dimethylamine oxide, abbreviated as ATDNO) so that the resulting solution contains 0.1 to 3% by weight of amine oxide, preferably 1% by weight and 1 to 10% by weight of active chlorine, preferably 3% by weight. The active chlorine content is determined by the Kolthoff method of iodometric titration. The surface tension of the solutions was measured with a K 12 Krus processor tensiometer using the ring method.

Example 2

The procedure and optimal concentrations of the components are the same as in Example 1, except that a mixture of linear alkyldimethylamine oxides (abbreviated as ADANO) containing approximately 90% homologue with 14 carbon atoms in the chain was used to prepare the solution (the amine oxides represented are C ₁₀ , C ₁₂ , ^c ig ^and C ₁₈ ).

The antimicrobial activity of all solutions was tested for microorganisms from Czechoslovakia. state collection of type cultures as well as microorganisms originating from the field (Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Bacillus subtilis, Candida albicans). Only selected concentrations, efficacies and strains are given in the tables for illustration. Minimum inhibitory concentrations (MICs) are given in% of sample solution. The onset of action of the tested solutions is almost immediate, after five minutes of optimally concentrated solutions no microorganisms survive, the presence of small amounts of protein (0.2%) does not affect the activities of ¹ 'solutions having low temperature coefficient and very good disinfectant capacity.

Table 1

Minimum inhibitory activity of a solution containing 0.2% ADANO or ATDNO and 3% active chlorine

Microorganisms active content (ppm) MIC in terms of chlorine amine oxide content (μg.cm ³ ) S. aureus 1875 125 E. coli 3750 250 S. typhimurium 468 31 P. aeruginosa 468 31 B. subtilis 468 31 C. albicans 1875 125

Table 2

Surface tension and antimicrobial activity of disinfectants containing 1% ATDNO or ADANO and 3% active chlorine (MIC in% of sample solution)

Amine oxide surface tension [mN / m] S. aureus MIC E. coli C. albicans ATDNO 3 2.0 0.09 1.56 0-, 04 ADANO 31.6 0.04 1.56 0.04 ATDNO ^a 32.4 0.39 6.25 0.39 ADANO ^a 31.8 0.02 12.5 0.04 _ b 70.1 1.56 1.56 1.56

^{and a} 1% aqueous solution of amine oxide containing no active chlorine b an aqueous solution containing 3% active chlorine and containing no amine oxide.

Claims (1)

PATENT CLAIMS Surface-active amine oxide disinfectants, characterized in that they consist of an aqueous solution of active chlorine and an amine oxide of the general formula ^C <3 R - ⁺ N - O ", ^Cl 3 where R represents an alkyl chain with a number of carbon atoms of 10 to 18, which may be linear or branched, and whose content in the composition is 0.1 to 3% by weight and the content of active chlorine is 1 to 10% by weight. .