CS274704B2 - Method of 4-alkoxy-3-pyrroline-2-on-1-yl acetic acid's alkyl esters production - Google Patents
Method of 4-alkoxy-3-pyrroline-2-on-1-yl acetic acid's alkyl esters productionInfo
- Publication number
- CS274704B2 CS274704B2 CS76790A CS76790A CS274704B2 CS 274704 B2 CS274704 B2 CS 274704B2 CS 76790 A CS76790 A CS 76790A CS 76790 A CS76790 A CS 76790A CS 274704 B2 CS274704 B2 CS 274704B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- alkoxy
- carbon atoms
- pyrroline
- alkyl ester
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The method of production of alkylesters of 4-alkoxy-3-pyrroline-2-one-1-ylacetic acid, which contain from 1 to 4 carbon atoms in alkyl part of alkyl ester and 1 or 2 carbon atoms in alkoxyl part of the acid, consists in the fact that the alkyl ester of 4-halogen-3-alkoxy-2-E-butenic acid, in which the alkyl part of the alkyl ester contains 1 or 2 carbon atoms, is introduced into a reaction with glycine alkyl ester, in which the alkyl part contains from 1 to 4 carbon atoms, in presence of weak inorganic base or tertiary aliphatic amine in presence of polar protic or aprotic solvent at a temperature of 60 to 120 degrees C. These products are valuable as intermediary products for production of cerebrally effective 4-hydroxy-2-oxopyrrolidine-1-ylacetamide.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1958/86A CH668066A5 (en) | 1986-05-14 | 1986-05-14 | New alkyl 4-alkoxy-2-oxo-3 -pyrroline-1-acetate cpds. |
CS600986A CS274660B2 (en) | 1985-09-24 | 1986-08-14 | Method of 4-alkoxy-3-pyrroline-2-on-1-yl-acetic acid's alkyl esters production |
Publications (2)
Publication Number | Publication Date |
---|---|
CS76790A2 CS76790A2 (en) | 1990-11-14 |
CS274704B2 true CS274704B2 (en) | 1991-09-15 |
Family
ID=4222573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS76790A CS274704B2 (en) | 1986-05-14 | 1986-08-14 | Method of 4-alkoxy-3-pyrroline-2-on-1-yl acetic acid's alkyl esters production |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH668066A5 (en) |
CS (1) | CS274704B2 (en) |
SU (1) | SU1486057A3 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH680293A5 (en) * | 1990-06-26 | 1992-07-31 | Lonza Ag |
-
1986
- 1986-05-14 CH CH1958/86A patent/CH668066A5/en not_active IP Right Cessation
- 1986-08-14 CS CS76790A patent/CS274704B2/en unknown
-
1987
- 1987-10-12 SU SU874203443A patent/SU1486057A3/en active
Also Published As
Publication number | Publication date |
---|---|
CS76790A2 (en) | 1990-11-14 |
CH668066A5 (en) | 1988-11-30 |
SU1486057A3 (en) | 1989-06-07 |
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