CS274704B2 - Method of 4-alkoxy-3-pyrroline-2-on-1-yl acetic acid's alkyl esters production - Google Patents

Method of 4-alkoxy-3-pyrroline-2-on-1-yl acetic acid's alkyl esters production

Info

Publication number
CS274704B2
CS274704B2 CS76790A CS76790A CS274704B2 CS 274704 B2 CS274704 B2 CS 274704B2 CS 76790 A CS76790 A CS 76790A CS 76790 A CS76790 A CS 76790A CS 274704 B2 CS274704 B2 CS 274704B2
Authority
CS
Czechoslovakia
Prior art keywords
alkoxy
carbon atoms
pyrroline
alkyl ester
alkyl
Prior art date
Application number
CS76790A
Other languages
Czech (cs)
Other versions
CS76790A2 (en
Inventor
Thomas Dr Meul
Leander Dr Tenud
Laurent Dr Duc
John Dr Mcgarrity
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Priority claimed from CS600986A external-priority patent/CS274660B2/en
Publication of CS76790A2 publication Critical patent/CS76790A2/en
Publication of CS274704B2 publication Critical patent/CS274704B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The method of production of alkylesters of 4-alkoxy-3-pyrroline-2-one-1-ylacetic acid, which contain from 1 to 4 carbon atoms in alkyl part of alkyl ester and 1 or 2 carbon atoms in alkoxyl part of the acid, consists in the fact that the alkyl ester of 4-halogen-3-alkoxy-2-E-butenic acid, in which the alkyl part of the alkyl ester contains 1 or 2 carbon atoms, is introduced into a reaction with glycine alkyl ester, in which the alkyl part contains from 1 to 4 carbon atoms, in presence of weak inorganic base or tertiary aliphatic amine in presence of polar protic or aprotic solvent at a temperature of 60 to 120 degrees C. These products are valuable as intermediary products for production of cerebrally effective 4-hydroxy-2-oxopyrrolidine-1-ylacetamide.
CS76790A 1986-05-14 1986-08-14 Method of 4-alkoxy-3-pyrroline-2-on-1-yl acetic acid's alkyl esters production CS274704B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1958/86A CH668066A5 (en) 1986-05-14 1986-05-14 New alkyl 4-alkoxy-2-oxo-3 -pyrroline-1-acetate cpds.
CS600986A CS274660B2 (en) 1985-09-24 1986-08-14 Method of 4-alkoxy-3-pyrroline-2-on-1-yl-acetic acid's alkyl esters production

Publications (2)

Publication Number Publication Date
CS76790A2 CS76790A2 (en) 1990-11-14
CS274704B2 true CS274704B2 (en) 1991-09-15

Family

ID=4222573

Family Applications (1)

Application Number Title Priority Date Filing Date
CS76790A CS274704B2 (en) 1986-05-14 1986-08-14 Method of 4-alkoxy-3-pyrroline-2-on-1-yl acetic acid's alkyl esters production

Country Status (3)

Country Link
CH (1) CH668066A5 (en)
CS (1) CS274704B2 (en)
SU (1) SU1486057A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH680293A5 (en) * 1990-06-26 1992-07-31 Lonza Ag

Also Published As

Publication number Publication date
CS76790A2 (en) 1990-11-14
CH668066A5 (en) 1988-11-30
SU1486057A3 (en) 1989-06-07

Similar Documents

Publication Publication Date Title
DE69104312D1 (en) Process for the preparation of hydroxyamides.
HUT41386A (en) Process for preparing 1-substituted oxindole-3-carboxamide derivatives
PL272899A1 (en) Method of obtaining oxophtalazinacetic acids
CS274704B2 (en) Method of 4-alkoxy-3-pyrroline-2-on-1-yl acetic acid's alkyl esters production
IL76740A0 (en) Process for the preparation of aromatically substituted l-amino acids
EP0222561A3 (en) Process for enzymatic separation of optical isomers of 2-aminobutanol
DE3379640D1 (en) Semi-synthetic preparation of human insulin
IL73998A0 (en) Preparation of esters
CA1273347C (en)
ES2001573A6 (en) Cyclohexanealkanoic acids.
GB2191490B (en) Process for the recovery of carboxylic acids from fermentation broth
EP0155165A3 (en) Process for introducing phosphinoyl groups into amino groups
JPS57118547A (en) Preparation of glutamic acid and its derivative
BG41030A1 (en) Method for preparing alkyl esters of alpha- aminocarboxylic acids