CS270143B1 - KeeralsaBean Compounds and Sustainable Preparation - Google Patents

Abstract

The invention and relates to keriination problems. N-ealicylKén-^-alaniaáte-ti-•cyanate«Be4natanev vSeekecnéh· vzerca M[Cu(TSB)(SCN)J. χ H20 , alek· m2[cú(tsb)(scn)^1 . x h2o, where M stands for cationic alkalckéhe kevu alek· ΝΗΪ, TSB stands for iianiin tr*J4«n*r·- in j Schlff«vej zaeaiy ·4ν·4βηβj ·< Z)-alanine and saliijylaldehyia and x = O, 1, 2 alek· 3} and sp»s»ku leh preparation reactiab! N-eallcyliene-/3-alanine. HgO ale- »i£Cu(TSB)LO. x H20, where L denotes a k*«rdined je4n»4«nír*vý B«lekul»vy ligand, usually H20 and x - O, 1, 2 alek· 3, with thi*cyanatan*B inBe»kgcnéh· vz«rea.MSCN, ▼ kt«r«B M denotes a katlen alkallekéh· k«vu alek»zNH.. The compounds have significant antiBikrakné, especially fungíčíine vlaetneeti.

Description

EN 270 143 B1 1

BACKGROUND OF THE INVENTION The present invention relates to N-8allcylidene- (5-alaninate-thiocyanate-silane-tannin) kerdine compounds in Seekeonehe's M [omega] (TSB) (SCN) D. x H2O, but · M2CCu (TSB) (SCN) 21. x h 2 0 where M represents the alkali alkene alkene, but NH 4, TSB denotes a lane of the base of the base, the diluted edy9-alanine and the salleylaldekyde (O.CgH 2 OCH 2 N, CH 3 CH 3 O 2), and O 2, 1, 2, or 2; 3, as well as the preparation of such compounds.

Compounds of the present invention are preferred compounds of the N-ealioylidene-ε-aaine-alkane-thiocyanate-type (J. Krtttsmár-Šme, Rev. S, V. O. Sevá, S. Varkendaa V, KeneSnyi Se. , HBiI and lid, TSBs, edixed edX-amine, are then regenerated.

Also known are the recombinant compounds of the sclerosis type, N-sidylidene-β-ala-ninate-naphthalic acid, in the echoes of the Cu (TSB) 13, χ HgO, or COugCTSB β1J. Hgo, where TSB and x represent! the same as the compound of the present invention and possessing a dinitrile mucus H20t or a non-functional microspheres of the type pyridine, mein, aleketiemeSeviny.

The known types of keerdine combine copper compounds have, in several instances, simple honeycomb syrups, e.g., metallenzymes, and exhibit anti-cramping properties. Of these, N-alkoxylden-1-ylanicin-based camping complexes, which are mildew-resistant, are practically non-susceptible to ducts, their skins are easy to apply and applications. The N-salicylidene-4-amine alkane-thiocyanate-methanate, which can be resolved in the lead, again exhibits superior activity and a perishable compound in the present invention. In the Czech literature, the deterases of the epithelial moiety are copper and the dianlene of the N-salicyclene-4-alanine type, which by binding to SCN and to the other aniline forms a laminate anion, in the lead soluble salt of M (Cu (TŠB) (SCN)). HgO, alekeM2fCu (TSB) (SCN) 2 ·]. Χ H 2 O.

The description of the preparation of the compounds of the compounds is based on the reaction of the respective starting materials of the type [Cu2 (TSB) 2 ^] or {Cu (TSB) I1 (the abbreviations vSdy mean the same as in the previous text), used in the ferme crystals with MSCN in a mixture of ethanol and science at temperatures of 40 ° C and 70 ° C. Pe out of the realizing crystallization systems! Compounds of the Invention in Decryption of Crockery The ancient, selenium-stained specimens, of the very high grade Sistet.

The exemplified examples illustrate, but do not limit, any method of preparing compounds of the present invention, and characterize their compositions as well as some properties and effects. The extract, the determined exposure of the element (C, H, I?) And the spectral characteristics in the solid state (techniques of the solid suspensions) based on the diaphragm of the dd passageway in the visible spectrum region, is also provided by the ensured antimicrobial αSinneat veSi Eecherlohia oeli, Stap -hyleeeeoue aureus, Candida alkicans, Mieresperum fypseum and Trichophyton terreatre, eharak-terizeyana miimnim inhikiSneu. kencentácie (MIC v / u <.cm- ^) staneveneu dilučneu metedeu.Gold kedet edpevedají erfanizmem v aveden peradím. Example 1 5.45 <((, Ό m1) mole hydrate of aquacis (N-εalylylidene-lan-alaninate) 4-dimethane complex is dissolved in 240 cc 75 75 ethanol at 60 ° C, filtered and mixed with 6.1. c (0.08 mole) thiocyanate amine at 40 os? the Vedas, so how do you react reactive to the calla 45 * C. The pellets were collected on 0% and the discharged selenium effluent crystalline was washed with fritted ethanol and dried at room temperature. The yield of N-salylidene-β-alanine-tartrate-ammonium is 75%.

Analysis. 35.93 / 39.85% 0) 2.96 / 2.80 £ H 7.47 / 7.60 N. Electrospray (VIS) with 16 460 ca-1. MIC »600, 200, 700, 90, 200.

Claims (2)

EXAMPLE 2 Working paste It is the same as in Example 1, with the proviso that thiocyanate and potassium is still present and the potassium thiocyanate is not present. The potassium salt of N-salicylidene-γ-alaninate-thiocyanate-oate is 79%. Analysis. For cnH9N2 ° 3SCuK 'Μρ = 351.9; Caked (found: 37.54 / 37.61% C; 2.58 (2.73% H); 7.96 (8.14%). Electron Spectrum (VIS); MIČ: 7CO, 200, 700, 90, 200. Example 3 In a 64 cn? 5.45 g (0.01 aa) aanahydrate of acacia (N-salicylidene-4-alaninate) mono-pentanaldehyde and 6.48 g (0.08 aa) of thiocyanatanamide are added to the ethanal and 8% by weight of ethanol. The reactive mixture is heated to a temperature of 70 ° C to the solid phase by evaporation. The batch is filtered for the acupuncture and allowed to cool to a lautereal heat. From the filtrate eliminated by the crystals of the tainted color, it is pre-dried on the fried powder and 1 ethanol and ethaned and dried very much in the lacratory heat. The yield of N-salicylidene-4-alaninate-cisacetic acid dihydrate is 85%. For C ^ HHjjN jOjSCCCluN,,, My = 452.9 $ calculated / found: 31.82 / 31.88 # C; H, 2.89; 9.28 / 9.20% N, Electron Spectrum »(VIS): VBax = 15,460 ca-1. MIC => 1000, 200, 800, 1000, 200. PHEDMET OF THE INVENTION 1. KERDINATING COMPOUNDS OF ANCIENT REFERENCE FORMULA [cu (TSB) SCN] J. x H 2 O, m 2 F cu (TSB) (SCN) ^. x HgO where M denotes the alkali alkene alkene or NH 4, TSB denotes the dianiene of the treienervic Schiff base (OCgH 2 OCH 2 CN, CH 3 CH 3 COO) enej -dislanine and salicylaldehyde ax = 0.1, 2 aleke 3. 2. The preparation of compounds in the present invention as described in claim 1, characterized in that the kerdination compound and the like are reacted more readily (cu 2 (TSB) 2 · 13 · h 2 ° or (TSB))). x H20 where L denotes a caarded single-malignant "ligand", usually HgO, TSB, and x is also referred to as "m", with more than one MSCN in which M denotes the same as in 1, in aalavaa paaere 1: 2 to 1: 8, in ethanes: defect in steam 1, 5: 1 to 8: 1 at 45 to 70 ° C.