CS267192B1 - Antimycotic agent for treatment of dermatomycoses of farm animals - Google Patents

Abstract

The solution relates to a composition for the treatment of dermatomycoses in cattle and horses, which does not have toxic effects even with frequent use. The essence of the solution is that the composition contains 2.9 to 3.1 wt. % dehydrochloramphenicol dissolved in a mixture of glycerol and 60 wt. % aqueous ethanol in a weight ratio of 0.9 to 1.1:1.

Description

2 EN 267 192 B1

The present invention relates to an antimycotic agent for the treatment of dermatomycoses of commercial animals. The composition is used for the treatment of bovine dermatomycoses caused by zoophilic species.

Trichophyton verrucosum and T. mentagrophytes and for the treatment of equine dermatomycosis caused by infection with Tripchophyton equinum. These species are the most common in the CSSR in animal infection. In the field of the treatment of dermatomycoses of bovine and equine animals, hexachlorophene in 5% w / w is still used for local treatment. concentration, acid undecylization in 15% w / w. concentration, 2-aminotridecan-2-chlorohexachlorophene in 7.5% by weight. 2-amino-tridecane-2-chloro-4-nitrophenolate in 3% by weight; concentration. Said formulations in the form of a spray give good results but their disadvantage is that they can be applied most to one-third of the body, otherwise they are toxic. After contact with the mucous membrane of the eye, they cause severe conjunctivitis. In equine trichophytiasis, natamycin has been used with success. It may be exposed to sunlight for this treatment.

These drawbacks are eliminated by the antimycotic agent of the invention, which is that it consists of 2.9 to 3.1% by weight. % dehydrochloramphenicol dissolved in a mixture of glycerol and 60 wt. aqueous ethanol in a weight ratio of 0.9 to 1.1: 1. The antimycotic composition of the invention is prepared by heating a mixture of glycerol, ethanol and dehydrochloramphenicol to 75 to 90 ° C and gently stirring for 10 to 20 minutes. In terms of efficacy, the use of dehydrochloramphenicol in the treatment of dermatomycosis is equal to the known composition and, moreover, is not toxic and does not damage the epithelium of the cornea of the eyes. Example

The composition according to the invention was prepared from dehydrochloramphenicol, which is a waste material for the production of chloramphenicol, 3 g of dehydrochloramphenicol are mixed with 95 g of a glycerol mixture and 60% by weight. ethanol in water in a weight ratio of 11a is heated to 80 ° C.

The composition has been tested in the treatment of dermatomycosis of 327 bovine animals and 12 horses of total cure after two applications.

The harmlessness tests were only indirectly investigated, i.e., nurses who, in the course of their work duties, such as feeding, animal cleaning, had been treated with a good effect treatment - healing of primary foci with the dermatophytes Trichofyton verrucosum, Trichophyte mentagrophytes and Mikrosporum verrucosum and T. gypseum.

After application of the preparation in vivo, it will be cured after a single or repeated administration. After curing, samples were taken and the properties of the growth ability of dermatophytes on Cychloheximide antibiotic agar were investigated. The culture results were evaluated for 24 days. Of the 73 samples, dermatophyte growth was found in 3 cases, i.e. 4.1%. Disclosed herein, the diseased animals may infest the environment in each case, i.e., 100% and treated in 4.1%. In animals where vaccination and revaccination were performed, the protection was maximally 80%, the animals vaccinated or revaccinated, where untreated changes remained after 28 days were treated. Of the total number of treated animals after vaccination and revaccine, 135 animals. Of this number, 108 animals, i.e. 80%, were cured after a single administration of the preparation. Two sites of new infection were detected in 27 animals after the second drug application in only 1 animal. New sites at the time of treatment were in the latent stage of infection and Trichofyton verrucosum, thus not treated. This is a local infection and therefore a treatment. Repeated treatment was successful in 25 animals, i.e. 96%. The success rate of treatment in the third year decreased and in the fourth year the efficacy of the treatment after a single drug administration decreased to 53% and after the two-stroke application to 76%.

Claims (1)

An antifungal agent for the treatment of dermatomycoses in livestock, characterized in that it contains 2.9 to 3.1% by weight of dehydrochloramphenicol dissolved in a mixture of glycerol and 60% by weight of aqueous ethanol in a weight ratio of 0.9 to 1.1: 1.