CS252992B1 - Method of real chamomile's water-alkoholic extract preparation - Google Patents
Method of real chamomile's water-alkoholic extract preparation Download PDFInfo
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- CS252992B1 CS252992B1 CS86233A CS23386A CS252992B1 CS 252992 B1 CS252992 B1 CS 252992B1 CS 86233 A CS86233 A CS 86233A CS 23386 A CS23386 A CS 23386A CS 252992 B1 CS252992 B1 CS 252992B1
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- camomile
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- propylene glycol
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- 239000000284 extract Substances 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 235000007232 Matricaria chamomilla Nutrition 0.000 title abstract description 9
- 235000007866 Chamaemelum nobile Nutrition 0.000 title abstract description 6
- 240000003538 Chamaemelum nobile Species 0.000 title abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000003814 drug Substances 0.000 claims abstract description 25
- 229940079593 drug Drugs 0.000 claims abstract description 24
- 239000002904 solvent Substances 0.000 claims abstract description 10
- 239000012675 alcoholic extract Substances 0.000 claims abstract description 9
- 238000000926 separation method Methods 0.000 claims abstract description 3
- 239000007790 solid phase Substances 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- -1 fatty acid esters Chemical class 0.000 claims description 9
- 238000001256 steam distillation Methods 0.000 claims description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 16
- 238000004821 distillation Methods 0.000 abstract description 7
- 238000001914 filtration Methods 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 238000004062 sedimentation Methods 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 244000042664 Matricaria chamomilla Species 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 150000004775 coumarins Chemical class 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 229930189957 Bisabolol oxide Natural products 0.000 description 2
- WJHRAVIQWFQMKF-IPYPFGDCSA-N Bisabolol oxide A Chemical compound C1CC(C)=CC[C@H]1[C@@]1(C)OC(C)(C)[C@@H](O)CC1 WJHRAVIQWFQMKF-IPYPFGDCSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 2
- 229940036350 bisabolol Drugs 0.000 description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 229960001231 choline Drugs 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- NJLYCNZOTQCQMC-UHFFFAOYSA-N 2-hexa-2,4-diynyl-1,6-dioxaspiro[4.4]non-3-ene Chemical compound C1=CC(CC#CC#CC)OC11OCCC1 NJLYCNZOTQCQMC-UHFFFAOYSA-N 0.000 description 1
- WJHRAVIQWFQMKF-UHFFFAOYSA-N Bisabolol oxide A Natural products C1CC(C)=CCC1C1(C)OC(C)(C)C(O)CC1 WJHRAVIQWFQMKF-UHFFFAOYSA-N 0.000 description 1
- RKBAYVATPNYHLW-NFAWXSAZSA-N Bisabolol oxide B Natural products OC(C)(C)[C@@H]1O[C@](C)([C@@H]2CC=C(C)CC2)CC1 RKBAYVATPNYHLW-NFAWXSAZSA-N 0.000 description 1
- RKBAYVATPNYHLW-UHFFFAOYSA-N Bisabolol oxide B Chemical compound C1CC(C)=CCC1C1(C)OC(C(C)(C)O)CC1 RKBAYVATPNYHLW-UHFFFAOYSA-N 0.000 description 1
- GXGJIOMUZAGVEH-UHFFFAOYSA-N Chamazulene Chemical compound CCC1=CC=C(C)C2=CC=C(C)C2=C1 GXGJIOMUZAGVEH-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 1
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 1
- 235000008714 apigenin Nutrition 0.000 description 1
- 229940117893 apigenin Drugs 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- PMRJYBALQVLLSJ-UHFFFAOYSA-N chamazulene Natural products CCC1=CC2=C(C)CCC2=CC=C1 PMRJYBALQVLLSJ-UHFFFAOYSA-N 0.000 description 1
- 229910052956 cinnabar Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- OCLXJTCGWSSVOE-UHFFFAOYSA-N ethanol etoh Chemical compound CCO.CCO OCLXJTCGWSSVOE-UHFFFAOYSA-N 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- LIIALPBMIOVAHH-UHFFFAOYSA-N herniarin Chemical compound C1=CC(=O)OC2=CC(OC)=CC=C21 LIIALPBMIOVAHH-UHFFFAOYSA-N 0.000 description 1
- JHGVLAHJJNKSAW-UHFFFAOYSA-N herniarin Natural products C1CC(=O)OC2=CC(OC)=CC=C21 JHGVLAHJJNKSAW-UHFFFAOYSA-N 0.000 description 1
- 239000000399 hydroalcoholic extract Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- QMYDVDBERNLWKB-UHFFFAOYSA-N propane-1,2-diol;hydrate Chemical compound O.CC(O)CO QMYDVDBERNLWKB-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
Riešenie sa týká spósobu přípravy vodno- alkoholického extraktu rumančeka pravého s obsahom účinných látok pozostávajúcich z lipofilnej a] hydrofilnej zložky. Postup spočívá v tom, že rumančeková droga po oddělení časti lipofilnej zložky destiláciou s vodnou parou sa extrahuje e- tano om pri teplote 20 až 50 °C po dobu 1 až 8 hodin, tuhá fáza sa oddělí a k roztoku po sedimentácii a filtrácii sa přidá 0,5 až 10 hmot. % propylén glykolového extraktu čerstvého kvetu rumančeka pravého a 0,2 až 5 hmot. % solubilizátora. Extrakt má po- užitie vo farmaceutických a kozmetických prípravkoch.The present invention relates to a process for the preparation of an aqueous alcoholic extract of chamomile containing active ingredients consisting of a lipophilic and hydrophilic component. The process consists in extracting the chamomile drug after separation of the lipophilic component by distillation with water vapor at a temperature of 20 to 50 ° C for 1 to 8 hours, separating the solid phase and adding 0 to the solution after sedimentation and filtration. 5 to 10 wt. % propylene glycol extract of fresh flower of chamomile and 0.2 to 5 wt. % solubilizer. The extract is used in pharmaceuticals and cosmetics.
Description
Vynález sa týká spósobu přípravy vodnoalkoholického extraktu z drogy rumančeka pravého po oddělení časti lipofilnej zložky.The invention relates to a process for the preparation of a water alcoholic extract from the drug of camomile after separation of a portion of the lipophilic component.
Mnohostranný liečivý účinok rumančeka pravého je daný prítomnosťou niekolkých skupin látok. Farmakodynamický účinok vykazujú lipofilné zložky drogy (bisabolol, bisabololoxidy, chamazulén, en-in-dicykloétery) majúce prevažne antiflogistický a mierne antiseptický účinok a tiež hydrofilné zložky (flavonoidy apigenin, luteolin a kumarínové deriváty umbeliferon a herniarin) so spasmolytickým účinkom (Felklová M., Čes. farm. 27, [8], 359 [1978]). Najpriaznivejší liečivý účinok obsahových látok rumančeka pravého vykazuje komplex obsahujúci ich lipofilnú aj hydrofilnú časť (O. Isaac: Deutsch. Apoth. Zeit. 114, 7, 225 [1974]).The multifaceted healing effect of chamomile is due to the presence of several groups of substances. The lipodynamic components of the drug (bisabolol, bisabololoxides, chamazulene, en-in-dicycloethers) having a predominantly antiphlogistic and mild antiseptic effect, as well as hydrophilic components (flavonoids apigenin, luteolin and coumarin derivatives umbeliferone and herniarin) with a pharmacodynamic effect Czech Pharm. 27, [8], 359 [1978]). A complex containing both lipophilic and hydrophilic moieties has the most beneficial healing effect of camomile ingredients (O. Isaac: Deutsch. Apoth. Zeit. 114, 7, 225 [1974]).
Pre získanie účinných látok z drogy rumančeka pravého je vypracovaných mnoho postupov. Například podlá pat. spisu NSR 1296 305 sa droga rumančeka pravého melie v gulovom mlýne s dexylolsátom 6 hodin a extrakt sa získá lisováním a centrifugovaním. Podlá pat. spisu EP 583 365 a DE 2 709 033 sa droga rumančeka pravého extrahuje pomocou nadkritických plynov například kysličníkom uhličitým. Ďalšie postupy využívajú k získavaniu účinných látok z drogy rumančeka pravého samotné organické rozpúštadlo, alebo jeho kombináciu s vodou pat. spis NSR 1 093 951, NSR 2 165 633, NSR 2 249 433, NSR 2 227 292, NSR 2 316 363, NSR 2 548 820, švajč. pat. spis 430 947. V uvedených postupoch sa účinné látky izolujú priamo z neuptravenej drogy rumančeka pravého. Iné postupy využívajú kombináciu izo'ačných metod napr. podlá mad. pat. spisu Hung. Feljes 14 432 sa z drogy rumančeka pravého časť lipofilnej zložky vydestiluje s vodnou parou, vodný zvyšok sa skoncentruje na obsah sušiny 48 % a rozpustí v 80 % etanole, získaný extrakt sa kombinuje s dichlórmetánovým extraktom čerstvej drogy, ktorý bol po zahuštění rozpuštěný v 96 % etanole, spojené extrakty sa upravia etanolom na koncentráciu 70 % etanolu a přidá sa vysušená lipofilná zložka získaná destiláciou s vodnou parou. Další kombinovaný postup podlá mad. pat. spisu 15 020 po izolácii časti lipofilnej zložky dešti’áciou s vodnou parou, popisuje extrakciu zvyškov vodou, zahustenie extraktu na 50 % sušiny, filtráciu a sprayové sušenie produktu. Na vysušený produkt, ktorý sa kombinuje s hydrouhličitanom sodným, vitamínom C a polyvinylpyrolidónom sa nanesie izolovaná lipofilná zložka a zmes sa vysuší.Numerous processes have been developed for obtaining active substances from the drug camomile. For example, according to Pat. U.S. Pat. No. 1296,305, the drug of camomile is milled in a dexyl oleate ball mill for 6 hours and the extract is obtained by compression and centrifugation. According to pat. EP 583 365 and DE 2 709 033 the drug of camomile is extracted with supercritical gases such as carbon dioxide. Other processes utilize organic solvent alone, or a combination thereof with water pat. U.S. Pat. No. 1,093,951, DE 2 165 633, DE 2 249 433, DE 2 227 292, DE 2 316 363, DE 2 548 820, švajč. U.S. Pat. 430 947. In the above procedures, the active ingredients are isolated directly from the untreated drug of camomile. Other methods employ a combination of isolation methods, e.g. U.S. Pat. file Hung. Feljes 14 432 removes the right portion of the lipophilic constituent from the drug of camomile with water vapor, concentrates the aqueous residue to a dry matter content of 48% and dissolves it in 80% ethanol. ethanol, the combined extracts are treated with ethanol to a concentration of 70% ethanol, and the dried lipophilic component obtained by steam distillation is added. Another combined procedure according to Mad. U.S. Pat. No. 15,020, after isolating a portion of the lipophilic component by water vapor rain, describes extracting the residue with water, concentrating the extract to 50% dry matter, filtering and spray drying the product. The isolated lipophilic component is applied to the dried product, which is combined with sodium bicarbonate, vitamin C and polyvinylpyrrolidone, and dried.
Nevýhodou vyššie uvedených postupov pri použití organického rozpúšťadlá k izolácii účinných látok je získanie prevažne lipofilnej zložky v extrakte a vypadávanie polymérnych látok po jeho zmiešaní s vodou. U kombinovaných postupov nevýhoda spočívá v izolácii len časti lipofilnej zložky destiláciou s vodnou parou (Glasl. H., Wagner H. Deutsch. Apoth. Zeit. 116, 3, 45 [1976]], a časť zostáva vo vydestilovanom zvyšku drogy, nevyužitá, Například bisabololoxid a spiroéter sa izoluje len v minimálnom množstve pri destilácii s vodnou parou nielen z dóvodov nestability za daných podmienok, ale aj kvóli svoji špecifickým fyzikálno-chémickým vlastnostiam. V tabulke je uvedené, kvantitativné GC stanovenie zložiek éterického oleja destilovaného s vodnou parou pri různých hodnotách pH v porovnaní s extrakciou drogy dichlórmetánom.A disadvantage of the above-mentioned processes when using an organic solvent to isolate the active ingredients is to obtain a predominantly lipophilic component in the extract and to precipitate polymeric substances when mixed with water. In combination processes, the disadvantage lies in the isolation of only a portion of the lipophilic component by steam distillation (Glasl, H., Wagner, H. Deutsch. Apoth. Zeit. 116, 3, 45 [1976]), and some remains in the distilled remainder of the drug, unused, For example, bisabololoxide and spiroether are isolated only in minimal amounts in water vapor distillation not only for reasons of instability under the given conditions, but also for their specific physico-chemical properties. pH values compared to extraction of the drug with dichloromethane.
485,1485.1
Najrozšírenejšou metodou izolácie éterického oleja z rumančeka pravého je destilácia drogy s vodnou parou. Týmto postupom sa z drogy kvantitativné neizolujú účinné látky komplexně. Droga po destilácii s vodnou parou, ktorá obsahuje flavonoidy, kumarínové deriváty, cholín, slizovité látky a časť z!ožiek éterického oleja, zostáva pri tomto spósobe spracovania nevyužitým odpadom.The most widespread method of isolation of essential oil from camomile is by distilling the drug with water vapor. This procedure does not completely isolate the active compounds from the drug quantitatively. Drug after distillation with water vapor containing flavonoids, coumarin derivatives, choline, mucilaginous substances and part of ! In this method of treatment, waste remains unused.
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Využitie hmoty po destilácii rumančekovej drogy s vodnou parou rieši postup pódia vynálezu tak, že sa droga rumančeka pravého zbavená časti lipofilnej zložky destiláciou s vodnou parou, po úpravě na obsah sušiny 10 až 35 % hmot., extrahuje etanolom pri teplote 10 až 50 °C po dobu 1 až 8 hodin, tuhá fáza sa oddělí a k roztoku po sedimentácii a filtrácii sa přidá 0,5 až 10 % hmot. propylénglykolového extraktu připraveného extrakciou čerstvých kvetov runiančeka pravého propylénglykolom v pomere 1 : 4 až 1 : 5 a ďalej sa přidá 0,2 až 5 % hmot. solubilizátora, typu esterov, mastných kyselin s polyoxietylén glycerínmi, polyoxyetylén sorbitanmi, alebo polyoxyetylénmi a polyetylénglykolmi. Droga po destilácii s vodnou parou obsahuje 10 až 20 % hmot. sušiny a odstředěním časti vodného extraktu sa obsah sušiny upraví na 20 až 35 % hmot. Takto upravená droga, ktorá obsahuje najma flavonoidy, kumarínové deriváty, slizovité látky, cholín, cukry a neizolovaný éterický olej v procese destilácie s vodnou parou, sa extrahuje takým množstvom etanolu aby jeho výsledná koncentrácia v extrakte bola 35 až 60 % hmot. Přidávaný propylénglykolový extrakt obsahuje najma zložky éterického oleja rozpuštěné v zmesi propylénglykol — voda 4 : 1. Prídavok tohto propylénglykolového extraktu výrazné zlepšuje organoleptické vlastnosti připraveného vodnoalkoholického extraktu. Připravený vodnoalkalický extrakt s prídavkom propylénglykolového extraktu čerstvého kvetu rumančeka sa stabilizuje prídavkom solubilizátoru typu esterov mastných kyselin s polyoxyetylénglycerínmi alebo s polyoxyetylénsorbitanmi alebo polyoxyetylénmi. Prídavok solubilizátoru sposobuje, že extrakt sa mieša s vodou v akomkoivek pomere bez vytvorenia zákalu. Použitie tohto typu solubilizátora nie je známe týmto postupom. Známe je použitie solubilizátora tohto typu pri priamej extrakcii drogy a pri príprave roztokov éterických olejov. Extrakt připravený postupom podl'a vynálezu má velmi dobré organoleptické vlastnosti, s vodou sa mieša bez tvorby zákalu a vyznačuje sa vyššou stabilitou. Postupom pódia vynálezu sa připraví extrakt s ohsahom komplexu účinných látok lipofilnej aj hydrofilnej povahy a dosiahne sa vyššie zhodnotenie rumančekovej drogy.The use of the water vapor-distillation mass of the water vapor is solved by the process of the invention by extracting the camomile drug deprived of a portion of the lipophilic component by water vapor distillation, after treatment to a dry matter content of 10-35 wt. for 1 to 8 hours, the solid phase is separated and 0.5-10% by weight is added to the solution after sedimentation and filtration. % of propylene glycol extract prepared by extracting fresh flowers of rhodium propylene glycol in a ratio of 1: 4 to 1: 5 and further adding 0.2 to 5 wt. a solubilizer, ester type, fatty acids with polyoxyethylene glycerines, polyoxyethylene sorbitans, or polyoxyethylenes and polyethylene glycols. The drug after steam distillation contains 10 to 20 wt. The solids content is adjusted to 20-35 wt.% by centrifugation of a portion of the aqueous extract. The treated drug, which contains in particular flavonoids, coumarin derivatives, mucilaginous substances, choline, sugars and unisolated essential oil in a steam-distillation process, is extracted with an amount of ethanol so that its final concentration in the extract is 35 to 60% by weight. The propylene glycol extract added contains, in particular, the essential oil components dissolved in the propylene glycol-water 4: 1 mixture. The addition of this propylene glycol extract greatly improves the organoleptic properties of the prepared hydroalcoholic extract. The prepared aqueous alkali extract with the addition of propylene glycol extract of fresh camomile flower is stabilized by addition of a fatty acid ester type solubilizer with polyoxyethylene glycerines or with polyoxyethylene sorbitans or polyoxyethylenes. The addition of the solubilizer causes the extract to be mixed with water in any proportion without clouding. The use of this type of solubilizer is not known by this procedure. It is known to use a solubilizer of this type in direct drug extraction and in the preparation of essential oil solutions. The extract prepared by the process according to the invention has very good organoleptic properties, is mixed with water without haze formation and is characterized by higher stability. According to the process according to the invention, an extract is obtained comprising a complex of active substances of both lipophilic and hydrophilic nature and a higher appreciation of the camomile drug is achieved.
V ďalšom je predmei vynálezu objasněný na troch príkladoch bez toho, že by ho obmedzova'i.In the following, the subject matter of the invention is illustrated by three examples without limiting it.
Příklad 1 kg sušenej drogy rumančeka pravého (Matricaria chamomilla) sa 5 hodin destiluje s vodnou parou. Rozvařená hmota sa od středí. K 20 kg odstredenej hmoty s obsahem 23,6 % sušiny sa za miešania přidává 13 kg etanolu po častiach. Celá zmes sa mieša 5 hodin a potom sa odstředí a přefiltruje. Získá sa 12 kg vodno alkoholického extraktu s ohsahom 3,9 % sušiny, ku kterému sa přidá 0,06 k j propylénglykolc.vého extraktu z čerstvého kvetu a extrakt sa stabilizuje 60 g stabilizátoru.EXAMPLE 1 kg of dried drug of chamomile (Matricaria chamomilla) is distilled with steam for 5 hours. The cooked mass is centered. To 20 kg of the skimmed mass containing 23.6% dry matter, 13 kg of ethanol are added in portions with stirring. The whole was stirred for 5 hours and then centrifuged and filtered. 12 kg of an aqueous alcoholic extract are obtained having a content of 3.9% of dry matter, to which 0.06 is added to the propylene glycol extract of fresh flower and the extract is stabilized with 60 g of stabilizer.
Příklad 2 kg rozvarenej hmoty, získanej destiláciou suchéj drogy rumančeka pravého (Matricaria chamomilla], s obsahom 26,9 % sušiny sa mieša 3 hodiny a 3.65 kg etanolu. Oddělením tuhej fázy sa připraví 3,93 kg vodnoa koholického extraktu s obsahom 4,49 °/o sušiny a o hustotě 924 kg . m~3, ku ktorému sa přidá 0,2 kg propylénglykolového extraktu z čerstvého kvetu. Extrakt sa stabilizuje prídavkom 19 g solubilizátora (Arlatone 980].EXAMPLE 2 kg of boiled mass obtained by distillation of a dry drug of cinnabar (Matricaria chamomilla), containing 26.9% dry matter, was stirred for 3 hours and 3.65 kg of ethanol. Dry matter and a density of 924 kg / m 3 , to which 0.2 kg of fresh flower propylene glycol extract is added, and the extract is stabilized by adding 19 g of a solubilizer (Arlatone 980).
Příklad 3 kg hmoty rumančeka pravého s obsahom sušiny 24 % hmot, získanej destiláciou čerstvej drogy rumančeka pravého (Matricaria chamomilla) s vodnou parou a odstředěním vodnej fázy sa. mieša 8 hodin s 43,3 kilogramu etanolu. Odstředěním a nasledovnou filtráciou sa připraví 52 kg vodno-alkoholického extraktu s hustotou 928 kg . m~3 a s obsahom sušiny 2,1 %. K extraktu sa přidá 5,2 kg propylénglykolového extraktu čerstvého kvetu rumančeka pravého. Extrakt sa stabilizuje prídavkom 1 kg solubilizátoru (Arlatone 980).EXAMPLE 3 kg of the mass of camomile with a dry matter content of 24% by weight, obtained by distillation of the fresh drug Camomile (Matricaria chamomilla) with water vapor and centrifugation of the aqueous phase sa. was stirred for 8 hours with 43.3 kg of ethanol. By centrifugation and subsequent filtration, 52 kg of an aqueous alcoholic extract having a density of 928 kg are prepared. m ~ 3 and with a dry matter content of 2.1%. 5.2 kg of propylene glycol extract of fresh camomile flower are added to the extract. The extract is stabilized by adding 1 kg of solubilizer (Arlatone 980).
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS86233A CS252992B1 (en) | 1986-01-10 | 1986-01-10 | Method of real chamomile's water-alkoholic extract preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS86233A CS252992B1 (en) | 1986-01-10 | 1986-01-10 | Method of real chamomile's water-alkoholic extract preparation |
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| Publication Number | Publication Date |
|---|---|
| CS23386A1 CS23386A1 (en) | 1987-03-12 |
| CS252992B1 true CS252992B1 (en) | 1987-10-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS86233A CS252992B1 (en) | 1986-01-10 | 1986-01-10 | Method of real chamomile's water-alkoholic extract preparation |
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| Country | Link |
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| CS (1) | CS252992B1 (en) |
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1986
- 1986-01-10 CS CS86233A patent/CS252992B1/en unknown
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| CS23386A1 (en) | 1987-03-12 |
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