CS251908B1 - Combined sorbent dialyzer - Google Patents

Combined sorbent dialyzer Download PDF

Info

Publication number
CS251908B1
CS251908B1 CS814601A CS460181A CS251908B1 CS 251908 B1 CS251908 B1 CS 251908B1 CS 814601 A CS814601 A CS 814601A CS 460181 A CS460181 A CS 460181A CS 251908 B1 CS251908 B1 CS 251908B1
Authority
CS
Czechoslovakia
Prior art keywords
unit
units
hemoperfusion
hjih
adsorbent
Prior art date
Application number
CS814601A
Other languages
Czech (cs)
Other versions
CS460181A1 (en
Inventor
Horst Klinkmann
Dieter Falkenhagen
Rainer Korf
Petra Horl
Original Assignee
Horst Klinkmann
Dieter Falkenhagen
Rainer Korf
Petra Horl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Horst Klinkmann, Dieter Falkenhagen, Rainer Korf, Petra Horl filed Critical Horst Klinkmann
Publication of CS460181A1 publication Critical patent/CS460181A1/en
Publication of CS251908B1 publication Critical patent/CS251908B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

A combination sorbent dialyser comprises a series connection of one or more haemodialysis units 1 with one or more haemoperfusion units 2. The haemoperfusion units may be arranged on one or both sides of the haemodialysis units. Each haemoperfusion unit may comprise one or more adsorption units with the same or different adsorbent substances or ion exchangers 7. Filters 11 may also be provided. <IMAGE>

Description

KOMBHHHPOBAHHHň COPBEHTHBlK AHAJIH3AT0PKOMBHHHPOBAHHHH COPBEHTHBlK AHAJIH3AT0P

OriHcaHHe HHTepHauHOManbHaH πβτβΗτκβΗ KJiaccHcfcMKauHH: A 61 M - 1/03 OCnacTb^ npHMeHeHH» HaoCpeTeHHflž B KJiMHH^ecKoň πρβκτΗκβ Bce Matné Ha6n»naeTca xapTHHa ocTpoft h xpoHHnecKoňnoneMHoft HeflocTaTOMHocTH. Kax Η3βθοτηο, φγΗκιρπο πομκη qejioBexa Μοχβτ nepe-HHMaTb BKčTpaKopnopajibHaji CHCTeMa. 3Ta cHCTewa: "«cKyccTBeHHaH ποΗκβ”, βκπιο-naer annaparypy h oCMeHHbiřt MexaHHSM. HacToamee naoCpeTeHHe xacaeTca annapa-Ta απη HoBoro o6MeHHoro MexaHHSMa, τβκ HasMBaeMoro κομ6ηηηροββηηογο cop6eHT-Horo BHaJwaaTopa.OriHcaHHe HHTepHauHOManbHaH πβτβΗτκβΗ KJiaccHcfcMKauHH: A 61 M - 1/03 OCnacTb ^ npHMeHeHH »HaoCpeTeHHflz B KJiMHH ^ ecKoň πρβκτΗκβ Bce Matt Ha6n» naeTca xapTHHa ocTpoft h xpoHHnecKonenoneMHoft HeflocTaTOMHocTH. Kax Η3βθοτηο, φγΗκιρπο πομκη qejioBexa Μοχβτ nepe-HHMaTb BKcTpaKopnopajibHaji CHCTeMa. 3Ta cHCTewa: "cKyccTBeHHaH ποΗκβ", βκπιο-naer annaparypy h oCMeHHbiMtMHaHHSM.

XapaKTepHCTHKa HSBecTHbix TexHmecKHx pemeHHňXapaKTepHCTHKa HSBecTHbix TexHmecKHx pemeHHn

OcHOBHOfl φορΜΟϋ ΠβΗβΗΗΗ ΧρΟΗΗΊβΟΚΟϋ ΠΟΜβΜΗοΑ HeflOCTaTOMHOCTH ílO-npeJKHeMyHBJíaeTCH reMOfluarwa. Πρκ stom hcxo^ht na τογο, mto reMOflKaraia yxe 6onee20 JieŤ ΟΊβΗΒ xopomo aapeKOMeHfloBan ce6a β κπηηηίθοκομ πρΗΜβΗβΗΗΗ h nepeHO-cmmoctí» ero mowho ο6ο3Η8μητβ kbk xopomaa. YcHJieHHoe tipuMeHetme κρβτκοΒρβΜβΗ-.Horo flHannsa βηοββ οτηβητ Ha nepeflHHň nnaH npo6neMy 6bicTpoň h HanpaejieHHoftajiHMHHaiíHH ypeMHHecKH flteftcTByiomHx eemecTB. IlpoSneMa, κοτορβΗ, κοΗβηκο, ΗΜβ-βτ pemaromee sHaneHtie oco6eHHO npH MHHHaTiopHaaipiH artnapaTOB h oGMeHHbix chc-τβΜ, KaK 3το, HanpHMep, ΗΜββτ Μβοτο πρκ nepeHocHoíi HcxyccTBeHHoft ποηκβ.OcHOBHOfl φορΜΟϋ ΠβΗβΗΗΗ ΧρΟΗΗΊβΟΚΟϋ ΠΟΜβΜΗοΑ HeflOCTaTOMHOCTH ílO-npeJKHeMyHBJíaeTCH reMOfluarwa. Πρκ stom hcxo ^ ht na τογο, mto reMOflKaraia yxe 6onee20 ie ΗΒ ΗΒ ΗΒ op op op op op nep nep nep nep nep nep nep nep ο ο ο YcHJieHHoe tipuMeHetme κρβτκοΒρβΜβΗ-. IlpoSneMa, κοτορβΗ, κοΗβηκο, ΗΜβ-βτ pemaromee sHaneHtie oco6eHHO npH MHHHaTiopHaaipiH artnapaTOB h oGMeHHbix chc-τβΜ, KaK 3το, HanpHMep, ββτ Μβοτο πρκ nepeHocHoíi HcxyccTBeHHoft ποηκβ.

CneflyeT 3aMeTHTb, hto reMoflHanH3 cBasaH c οτηοοητ&amp;πβηο bwcokhmh TexHHHec-ΚΗΜΗ 3βΤρβΤβΜΗ. OcHOBHblM ero ΗββΟΟΤβΤΚΟΜ ΗΒΠΗβΤΟΗ ΟΓΡ&amp;ΗΗΗβΗΗΒΗ BOSMOJKHOCTbyflaneHHH cenexTHBHbix BemecTB. 3φφβκτΗΒΗοετΒ οτΗοοπτβΠΒΗο onpeneneHHbix Be-mecTB - sto β ochobhom Bonpoc MoneKynapHoro seca nonne»amHx ynaneHHio Be-mecTB. flanbHeňmHM ΜβτοηοΜ neneHHa, oco6eHHo npH ocTpoft noueiHoň ΗβηοοτβτοΗ-HOCTH, ΗΒΠΗβΤΟΗ ΓβΜΟΠβρφγ3ΗΗ. Β ΠΡΟΤΗΒΟΠΟΠΟΧΗΟΟΤΒ Κ reMOflHaJIH3y 3HaHHTeJIb-Hoe npeHMymecTBÓ ΓβΜοηβρφγ3ΗΗ saKJHoBaeTCH b HeáHaBHTejibHbix TexHnaecKHx 3βτ-paTBX Ha ΠρΟΒβΑβΗΗβ ΠβΗβΗΗΗ. ΚρΟΜβ ΤΟΓΟ, ΗΜββΤΟΗ ΠΡΗΗΐχΗΠΗβΠΒΗβΗ BO3MO*HOCTb .npoH3BOAHTb ceneKTHBHyjo aacopSipno, to ecTb HáMeHHTb ee b tom HanpaBJíeHHH, 251908 2 mto6m amcop6npoBaJincb τοηπκο onpefleneHHbie ΗεφΗ3ΗσποΓΗΗεοκΗε BemecTBa. EcnnMeTOtf ΓβΜΟΠβρφγ3ΗΚ IipHMGimKTCH XUIH HeMeHHH XpOHHHeCKOň noyenHoft HeftOCTaTOM-HOCTH, ·ΤΟ OH npe«OCTaBHHeT OMeHb XOpOniHe BO3MO3KHOCTH, ΗβΠρΗΜβρ, ΠρΗ ΠΟΜΟΠρίΘΚΤΗΒΗ3Ηρ0Β3ΗΗΟΓΟ yrjIH, ypaneHHH Τ3ΚΗΧ Β&amp;ΚΗΜΧ ΑΠΗ ΟΗΜΓΙΤΟΜβΤΗΚΗ ypeříHH Ββ-mecTB, κβκ, HanpHMep, KpeaTHHHH, MoneBan KHcnoTa, opraHHqecxHe BemecTBa,HanpHMep, φβΗοπΗ, coepHHeHHH ryaHunuHa h BemecTBa cpepHero MoneKynnpHoro Be-ca, ορΗβκο, ΗεροοτβτκΗ ero oneBHflHbi. Tax, hcxoas na h3B6cthi>jx b HacronmeeBpeMH apcopSeHToB, He HMeeTCH bo3mo>khočth ηπη tojibko He3HaqHTejibHan bo3Mojk-HOCTb SJlHMHHailHH ΜΟΗβΒΗΗΜ, BOflbl, SneKTpOPHTOB H HOHOB BOflOpOfla.CneflyeT 3aMeTHTb, hto reMoflHanH3 cBasaH c οτηοοητ &amp; πβηο bwcokhmh TexHHHec-ΚΗΜΗ 3βΤρβΤβΜΗ. OcHOBHblM ero ΗββΟΟΤβΤΚΟΜ ΗΒΠΗβΤΟΗ ΟΓΡ &;βΗΗΒΗ BOSMOJKHOCTbyflaneHHH cenexTHBHbix BemecTB. 3φφβκτΗΒΗοετΒ οτΗοοπτβΠΒΗο onpeneneHHbix Be-mecTB - one hundred bp Bonpoc MoneKynapHoro seca nonne »amHx ynaneHHio Be-mecTB. flanbHenmHM ΜβτοηοΜ neneHHa, oco6eHHo npH ocTpoft noueiHoň ΗβηοοτβτοΗ-HOCTH, ΗΒΠΗβΤΟΗ ΓβΜΟΠβρφγ3ΗΗ. M ΠΡΟΤΗΒΟΠΟΠΟΧΗΟΟΤΒ Κ reMOflHaJIH3y 3HaHHTeJIb-Hoe npeHMymecTBÓ ΓβΜοηβρφγ3ΗΗ saKJHoBaeTCH b HeáHaBHTejibHbix TexHnaecKHx 3βτ-paTBX Ha ΠρΟΒβΑβΗΗβ ΠβΗβΗΗΗ. 3ρΟΜβ ΤΟΓΟ, ΗΜββΤΟΗΠΗβΠΒΗβΗ BO3MO * HOCTb .npoH3BOAHTb ceneKTHBHyjo aacopSipno, to ecTb HáMeHHTb ee b tom HanpaBJíeHHH, 251908 2 mto6m amcop6npoBaJincb τοηπκο onpefleneHHbie ΗεφΗ3ΗσποΓΗΗεοκΗε BemecTBa. EcnnMeTOtf ΓβΜΟΠβρφγ3ΗΚ IipHMGimKTCH XUIH HeMeHHH XpOHHHeCKOň noyenHoft HeftOCTaTOM-HOCTH · ΤΟ OH NPE «OCTaBHHeT OMeHb XOpOniHe BO3MO3KHOCTH, ΗβΠρΗΜβρ, ΠρΗ ΠΟΜΟΠρίΘΚΤΗΒΗ3Ηρ0Β3ΗΗΟΓΟ yrjIH, ypaneHHH Τ3ΚΗΧ Β &amp; ΚΗΜΧ ΑΠΗ ΟΗΜΓΙΤΟΜβΤΗΚΗ ypeříHH Ββ-mecTB, κβκ, HanpHMep, KpeaTHHHH, MoneBan KHcnoTa, opraHHqecxHe BemecTBa , HanpHMep, φβΗοπΗ, coepHHeHHH ryaHunuHa h BemecTBa cpepHero MoneKynnpHoro Be-ca, ορΗβκο, ΗεροοτβτκΗ ero oneBHflHbi. Tax, hcxoas on h3B6cthi> jx b HacronmeeBpeMH apcopSeHToB, He HMeeTCH bo3mo> khočth tojibko He3HaqHTejibHan bo3Mojk-HOCTb SJlHMHHailHH ΜΟΗβΒΗΗΜ, BOflbl, SneKTpOPHTOB H HOHOB BOflOpOfla.

OcofíeHHO npo6j7eMaTHHHbiM ocTaeTCH yjjajreHne BOfíbí πρκ ΓεΜοηερφν3ΗΗ. flaxce,ecjin c tohkh apeHHB nepcneKTHBHbix paspaóoTOK πρεηοτβΒΠΗετεΗ bo3moxhmm ypa-jieme BOflw nocpeflCTBOM ancop6npyioinHx Bopy renoB, b HacTOHmee BpeMH ocTaeTcaHeoOxOflHMOCTb ΟΟββΗΗβΗΗΗ ΓeMOΠepφy3HOHHOň KanCyjlb! C yJ^bTpaφHJlbTpOM ΗΠΗ flHa-jiH3aTopoM. 3to coeflHHeHHe nyTeM nocnepoBaTenbiioro πορκηιοΜεΗΗΗ flnanH3aTopah reMonei^y3HOHHoň Kancynbi b KanecTBe pa3penbHbix οΒμβηηι,ιχ ηπη apcop6HpyronmxMexaHH3M0B cooTBeTCTByeT πρκ κομ6ηηηροβ3ηηομ npHM6HeHHn npw Teparom ypoBH»τεχΗΗΚΗ. flo chx nop 6bina H3BecTHa κομ6ηηηηηβ ΓεΜθπερφν3ΗΗ h ,ananH3a τοπβκοb φορΜε Tax Ha3biBaeMoro copĎeHTHoro pnanH3aTopa, ocHameHHoro copSeHTHbíMHMeM6paHaMH. CornacHo DD - AP 135 565 H3BecTHa HCKyccTBeHHan noMKa, coctoh-man H3 oÓpaaoBaHHoro flnajiH3npyionieň MGMSpanoň nonoro npocrpaHCTBa, πο κοτορο-My προτεκβετ KpoBb, h HaxonnmerocH no npyryio cTopoHy flHanH3Hpywmeň MGMBpaHbíHnajiHaaTHoro npocTpancTBa, πρΗΗεΜ οτΗοπιεΗΗε oSbeMa OMbieaeMoro KpoBbio nonoronpocTpaHCTBa κ pHanH3aTHOMy npocTpaHCTBy cocTaBnaeT 1:100. AncopÓHpyiomiHeBemecTBa HCKyccTBOHHaB nonka copepacHT bhg OMHBaeMoro kpobbjo nonoro npocTpaH-cTBa. 3to pocTHraeTCH mra τεΜ, ητο b pnanHaHpyiomeň MeMOpane ΗΜβετεΗ,'ποMGHbmaň Μερε, οχριπ copepxanpiň apcopfíeHTbi cnoň mra τεΜ, mto apcop6.eHTbi copep-jícaTcn b flnanH3aTe. flanee, no DE-PS 2 627 858 n3BecTHt. pHanH3HpyK>man MeMfípa-Ha B φορΜβ BByKOMnOHGHTHblX nOJIblX HHTGH H3 ρεΓΒΗερΗρΟΒβΗΗΟίί ηεηηΐ0ΠΟ3Η, ΠΟΠΜεηητη κοτοροη o6pa3OBaHbi H3 peyx npoMHO cpenneHHbix cnoeB. Opím cnoň coctohtH3 pereHepHpoBaHHoň ηεηηιοηο3Η h, npn HeoSxopHMoeTH, pepHBaTa penmonosbi. flpy-roň cnoň o6pa3OBaH pereHepHpoBaHHoň pennrono3oň c 1-96 bgc.Z BKmoneHHbix b ηβθh paBHOMapHO pacnpepeneHHbix nacTHn apcopSHpyioinHX BemecTB co cpepHeň BenHHH—Hoň nacTHp po 40 mm. ΤΗΠ KOM6HHam-W reM0flHanH3/ΓεΜΟΠερφν3ΗΠ B φ0ΡΜβ COpSeHTHOň MeMÓpaHbl HeoneHb 3φφεκτΗΒεΗ. Oh He ΗΜεετ npeHMymecTB hh npn neneHHH ocTpbix 3K3oreHHbixHHTOKCHKannň, hh npH xpoHHnecKoň nonenHoň nn6o neneHOMHoň HepocTaTOMHocTHno cpaBHeHHio c ο6μηημμ pnanHaaTopoM.OcofíeHHO npo6j7eMaTHHHbiM ocTaeTCH yjjajreHne BOfíbí πρκ ΓεΜοηερφν3ΗΗ. flaxce, ecjin c tohkh apeHHB nepcneKTHBHbix paspaóoTOK πρεηοτβΒΠΗετεΗ bo3moxhmm ypa-jieme BOflw nocpeflCTBOM ancop6npyioinHx Bobs renoB, b HacTOHmee BpeMH ocTaeTcaHeoOxOflHMOCTb ΟΟββΗΗβΗΗΗ ΓeMOΠepφy3HOHHOň KanCyjlb! C yJ ^ bTpaφHJlbTpOM ΗΠΗ flHa-jiH3aTopoM. 3to coeflHHeHHe rivet nocnepoBaTenbiioro πορκηιοΜεΗΗΗ flnanH3aTopah reMonei ^ y3HOHHoň Kancynbi b KanecTBe pa3penbHbix οΒμβηηι, ιχ ηπη apcop6HpyronmxMexaHH3M0B cooTBeTCTByeT πρκ κομ6ηηηροβ3ηηομ npHM6HeHHn NPW Teparom ypoBH »τεχΗΗΚΗ. flo chx nop 6bina H3BecTHa κομ6ηηηηηβ ΓεΜθπερφν3 ΗΗ h, ananH3a τοπβκοb φορΜε Tax Ha3biBaeMoro copĎeHTHoro pnanH3aTopa, ocHameHHoro copSeHTHbíMHMeM6paHaMH. CornacHo DD - AP 135565 H3BecTHa HCKyccTBeHHan noMKa, coctoh-man H3 oÓpaaoBaHHoro flnajiH3npyionieň MGMSpanoň nonoro npocrpaHCTBa, πο κοτορο-My προτεκβετ KpoBb h HaxonnmerocH well npyryio cTopoHy flHanH3Hpywmeň MGMBpaHbíHnajiHaaTHoro npocTpancTBa, πρΗΗεΜ οτΗοπιεΗΗε oSbeMa OMbieaeMoro KpoBbio nonoronpocTpaHCTBa κ pHanH3aTHOMy npocTpaHCTBy cocTaBnaeT 1: 100. AncopÓHpyiomiHeBemecTBa HCKyccTBOHHaB nonka copepacHT bhg OMHBaeMoro kpobbjo nonoro npocTpaH-cTBa. 3ToReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReReBeReBeTe. flanee, no DE-PS 2 627 858 n3BecTHt. pHanH3HpyK> man MeMfIpa-Ha B φορΜβ BByKOMnOHGHTHblX nOJIblX HHTGH H3 ρεΓΒΗερΗρΟΒβΗΗΟίί ηεηηΐ0ΠΟ3Η, ΠΟΠΜεηητη κοτοροη o6pa3OBaHbi H3 peyx npoMHO cpenneHHbix cnoeB. Again, coctohtH3 pereHepHpoBaHHo ηεηηιοηο3Η h, npn HeoSxopHMoeTH, pepHBaTa penmonosbi. flpy-year-old o6pa3OBaH pereHepHpoBaHoPoNoPoNoNo 1-96 bgc.Z BKmoneHHbix b ηβθh paBHOMapHO pacnpepeneHHbix nacTHn apcopSHpyioinHX BemecTB what about 40mm. 6Π KOM6HHam-W reM0flHanH3 / ΓεΜΟΠερφν3ΗΠ B φ0ΡΜβ COpSeHTHO MeMÓpaHbl HeoneHb 3φφεκτΗΒεΗ. Oh He ΗΜεετ npeHMymecTB hh npn neneHHH ocTpbix 3K3oreHHbixHHTOKCHKannn, hh npH xpoHHnecKon nonenHon nn6o not HOMHoHomHocTHno cpaBHeHHio c ο6μηημμ pnanHaaTopoM.

Uenb Η3θ6ρετεΗΗη:Uenb Η3θ6ρετεΗΗη:

Uenb Η3θόρετεΗΗ« 3aKnjonaeTcn b o6T>epHHeHHH npeHMýmecTB reMopHanH3a h re-MOΠepφy3HH ΠρΗ OMHmeHHH KpOBH B BKCTpaKOpnopanbHOM KOHType C yenbio ΠΟΒΜΠε-hhh 3φφεκτΗΒΗοετΗ npH nenemra xpororaecKoň h ocTpoň ποηθμηοη HepocTaTonnocTH. H3noyeHHe cymHOCTH Η3ο6ρετεκΗΗ 3apaneň Η3θ6ρετεΗΗΗ ΗΒηηετεη paapaÓoTKa cocTOHinero H3 pHanH3Hpyioiueň efíu-HHUbi h ΓeMOπepφy3HOHHoň epHHHpM copĎeHTHoro pHanH3aTopa, no3Bonjnoinero o6be-flHHHTb Μετόχι reMopHanH3a h ΓeMoπepφy3HH b ophom oĎMeHHOM MexaHH3Me, 6esI ΒΟ3ΗΗΚΗΟΒβΗΗΗ ΠρΗ 3TOM BblCOKOň Harpy3KH^ ΠΟ KpOBH Ha reMOflHanH3e. 3anana pemaeTCH τεΜ, mto ΓεΜοηερφγ3ΗθΗΗ3Η effHHHpa, eocTOjnuan H3 fleyx HnHHecKonbKHx a,ncop6nHOHHbrx e«HHHH c oflHoň ηπη c οΘεκχ ctopoh coefpiHeHa Henoc- 251908 3 peflCTBeHHO c reMOflHaJiH3Hpyiomeň e/wiiHiieň, npn otom ι·βΜθπβρφγ3ΗθΗΗβΒ ejiHHHiiahjih aflcop6u(HOHHMe e/xHHHUbi ΗΜβκιτ nponycKHoe oTBepcTHe, cooTBeTCTByiomee ce*ie-hhjo reMO0HanH3HpyK)ineň θαηηηιιμ.Uenb Η3θόρετεΗΗ «3aKnjonaeTcn o6T b> epHHeHHH npeHMýmecTB reMopHanH3a h re-MOΠepφy3HH ΠρΗ OMHmeHHH KpOBH B BKCTpaKOpnopanbHOM KOHType C yenbio ΠΟΒΜΠε-hhh 3φφεκτΗΒΗοετΗ NPH nenemra xpororaecKoň h ocTpoň ποηθμηοη HepocTaTonnocTH. H3noyeHHe cymHOCTH Η3ο6ρετεκΗΗ 3apaneň Η3θ6ρετεΗΗΗ ΗΒηηετεη paapaÓoTKa cocTOHinero H3 pHanH3Hpyioiueň efíu-HHUbi h ΓeMOπepφy3HOHHoň epHHHpM copĎeHTHoro pHanH3aTopa, no3Bonjnoinero o6be-flHHHTb Μετόχι reMopHanH3a h ΓeMoπepφy3HH b ophom oĎMeHHOM MexaHH3Me, 6esI ΒΟ3ΗΗΚΗΟΒβΗΗΗ ΠρΗ 3TOM BblCOKOň Harpy3KH ^ ΠΟ KpOBH reMOflHanH3e Ha. 3anana pemaeTCH τεΜ MTO ΓεΜοηερφγ3ΗθΗΗ3Η effHHHpa, eocTOjnuan fleyx HnHHecKonbKHx and H3, ncop6nHOHHbrx e «c HHHH oflHoň ηπη c οΘεκχ ctopoh coefpiHeHa Henoc- peflCTBeHHO 251 908 3 c e reMOflHaJiH3Hpyiomeň / wiiHiieň, NPN Otom ι · βΜθπβρφγ3ΗθΗΗβΒ ejiHHHiiahjih aflcop6u (e HOHH / xHHHUbi ΗΜβκιτ nponycKHoe oTBepcTHe, cooTBeTCTByiomee ce * ie-hhjo reMO0HanH3HpyK) ineno θαηηηιιμ.

Bo BpeMB neqenHB naijHenTa AHajraaoM nojineHcamaH oumneHHio KpoBb HanpaBnaeT-ca nocneflOBaTenbHO nepea reMOHHaJiH3HpyiomHe ennHHnbi h reMonep$y3HOHHbie enHHH-Ubl ÍUIB SJtHMHHaiIHH H3 KpOBH C OflHOň CTOpOHbl ΜΟΗβΒΗΗΜ, BOflbl, 3ΠβΚΤρθΠΗΤΟΒ Hhohob BOflopofla, a c flpyroň - KpeaTHHHHa, Moueeoň khcjiotm, opraHHuecKHx ee-mepTB, tskhx m φβΗθ/η>>, coeflHHeHHH ryaHHflHfla h cpeflHeMoneKynHpHbtx BeqecTB.Bo BpeMB neqenHB naijHenTa AHajraaoM nojineHcamaH oumneHHio KpoBb HanpaBnaeT-ca nocneflOBaTenbHO NEP reMOHHaJiH3HpyiomHe ennHHnbi h reMonep $ y3HOHHbie enHHH-Ubl ÍUIB SJtHMHHaiIHH H3 KpOBH C OflHOň CTOpOHbl ΜΟΗβΒΗΗΜ, BOflbl, 3ΠβΚΤρθΠΗΤΟΒ Hhohob BOflopofla, ac flpyroň - KpeaTHHHHa, Moueeoň khcjiotm, opraHHuecKHx ee-mepTB, tskhx m φβΗθ / η >>, coeflHHeHHH ryaHHflHfla h cpeflHeMoneKynHpHbtx BeqecTB.

Henecoo6pa3Ho ΓβΜΟπερφγβκοΗΗγιο eflHHHyy ηπη ee BHemHHe aacop6flHOHHhie epft-HHflbl BbinOJIHHTb B BHfle ΠρΗΤΟΚβ RpOBH HJIH OTTOKa KpOBH HJIH ΠΡΗ flByXCTOpOHHeMpacnojio«enHH ΓβΜθπερφγ3ΗθΗΗΜΧ eflHHHti hx hjih hx BHemHHe aflcop6ixHoHHbie eaHHH-flbl BbinoJIHHTb B BHfle npHTOKa KPOBH H OTTOKa ΚρΟΒΗ. ΚρΟΜβ ΤΟΓΟ, ΓβΜΟΠβρφγ3ΗΟΗ-Han eflHHHija ηπη eflHHHflbí hjih hx aacopSflHOHHbie eflHHHflbí MoryT 6μτβ uacTHMH κρο-BenpOBOflHoft cucTeMbi. HeJiecoo6pa3HbiM o6pa3OM b ΓβΜοηβρφγ3ΗθΗΗοή eflHHHfle pac-nOJIOHteHbl OflHa HJIH HeCKOJlbKO aflCOpSHpyiomHX eflHHHfl C OflHHaKOBblMH HJIH paSJIHH“HbiMH aflCOpfíeHTaMH HJIH HOHOOĎMeHHHKaMH. TaKHM 06pa30M, npH ΠβΗβΗΗΗ OCTPHXHHTOKCHKaiJHň HMeeTCH BO3MOWHOCTb nOCJieflOBaTeJlbHOrO COeflHHeHHS HeCKOJIbKHXnoflxoflBtnHx a,ncop6HpyioinHx eflHHHfl απη npnflenbHoro yflaneHHH H3 kpobh nofljiexamHXSJIHMHHaflHH BenjeCTB, B OCOSeHHOCTH IipH CMemaHHbIX HHTOKCHKaHHHX.Henecoo6pa3Ho ΓβΜΟπερφγβκοΗΗγιο eflHHHyy ηπη ee BHemHHe aacop6flHOHHhie epft-HHflbl BbinOJIHHTb B BHfle ΠρΗΤΟΚβ RpOBH HJIH OTTOKa KpOBH HJIH ΠΡΗ flByXCTOpOHHeMpacnojio «enHH ΓβΜθπερφγ3ΗθΗΗΜΧ eflHHHti hjih HX HX BHemHHe aflcop6ixHoHHbie eaHHH-flbl BbinoJIHHTb B BHfle npHTOKa KPOBH H OTTOKa ΚρΟΒΗ. HanρΟΜβ ΤΟΓΟ, ΓβΜΟΠβρφγ3ΗΟΗ-Han eflHHHija ηπη eflHHHflb hjih hx aacopSflHOHHbie eflHHHflb MoryT 6μτβ uacTHMH κρο-BenpOBOflHoft cucTeMbi. HeJiecoo6pa3HbiM o6pa3OM b ΓβΜοηβρφγ3ΗθΗΗοή eflHHHfle pac-nOJIOHHbl OflHa HJIH HeCKOJlbKO aflCOpSHpyiomHX eflHHHfl C OfHHaKOBblMH HJIH paSJIHH “HbiMH aflCOpHHTHMH HJIH HOHOOHMeHHHKaMH. Takhte 06pa30M, NPH ΠβΗβΗΗΗ OCTPHXHHTOKCHKaiJHň HMeeTCH BO3MOWHOCTb nOCJieflOBaTeJlbHOrO COeflHHeHHS HeCKOJIbKHXnoflxoflBtnHx and, ncop6HpyioinHx eflHHHfl απη npnflenbHoro yflaneHHH H3 kpobh nofljiexamHXSJIHMHHaflHH BenjeCTB B OCOSeHHOCTH IipH CMemaHHbIX HHTOKCHKaHHHX.

KpoMe Toro, uenecoo6pa3Ho, hto6m Mexay reMOflHanH3Hpyraineň eflHHHfleň ηπηeflHHHqaMH, ΓβΜοπερφγ3ΗθΗΗοή eflHHHfleň ηπη eflHHHflaMH η aflCop6flHOHHbiMH eflHHHfla-MH fíbUIH pacnOnOKeHbl CHCTeMbl φΗΠΒΤρόΒ. IIpHMep qcymecTBJíeHHH H3o6peTeHHa; , Η3θ6ρβτβΗΗβ oóbHCHaeTCH Ha cneflyramHx npHMepax noapoSHee. Ha cooTBeTCTByio—mHx pHcyHKax npeflCTaBneno: Φηγ.1: KoMSHHHpoBaHHbift copSeHTHbiň BHanH3aTop c ΓεΜθπβρφγ3ΗθΗΗΜΜΗ epjnmu,a-MH, npeflBKHIOHeHHblMH HJIH ΑΟΠΟΠΗΗΤβΠΒΗΟ nOflKHIOfleHHblMH K ΓβΜΟβΗ3ΠΗ3Η“pywmeň eflHHHfle ΦΗΓ.2: K0M6HHHP0BaHHblň COpGeHTHblň flHanH33T0p C ΓβΜΟΠβρφΥ3ΗΟΗΗθή eflHHHfleň,flononHHTenbHo πο«κπκ>ΗβΗΗοή κ reMOflHanH3Hpyromeň eflHHHfle.KpoMe Toro, uenecoo6pa3Ho, hto6m Mexay reMoHlHanH3Hpyraineň eflHHHfleň ηπηeflHHHqaMH η aflCop6flHOHHbiMH eflHHHfla-MH fIbUIH pacnOnOKeHbl CHCTeMbl φΗΠΒΤρόΒ. IIpHMep qcymecTBJiHHH H3o6peTeHHa; , Θ3θ6ρβτβΗΗβ oóbHCHaeTCH Ha cneflyramHx npHMepax noapoSHee. Ha-cooTBeTCTByio MHX pHcyHKax npeflCTaBneno: Φηγ.1: KoMSHHHpoBaHHbift copSeHTHbiň BHanH3aTop c ΓεΜθπβρφγ3ΗθΗΗΜΜΗ epjnmu and-MH npeflBKHIOHeHHblMH HJIH ΑΟΠΟΠΗΗΤβΠΒΗΟ nOflKHIOfleHHblMH ΓβΜΟβΗ3ΠΗ3Η K "pywmeň eflHHHfle ΦΗΓ.2: K0M6HHHP0BaHHblň COpGeHTHblň flHanH33T0p C ΓβΜΟΠβρφΥ3ΗΟΗΗθή eflHHHfleň, flononHHTenbHo πο« κπκ> ΗβΗΗοή κ reMOflHanH3Hpyromeň eflHHHfle.

Ha Φηγ. 1 npeflCTaBneHo nocnefloBaTenhHoe coeflHHeHHe reMOflHanH3Hpywnieň eflH-HHflbl (1) C paCnonÓXeHHblMH ΠΟ ΟββΗΜ CTOpOHaM ee ΓεΜΟΠβρφγ3ΗΟΗΗΜΜΗ eflHHHflaMH (2). flHanH3Hpyioinaa eflHHHfla (1) coctoht H3 aaflenaHHbix b cooTBeTCTByromHň Μβτβ-pnan nonbix βοποκοη (3)» nepe3 nojibie npocTpaHCTsa (4) κοτορκχ προτβκβετ nofl-neacamaa OMHmeHHio kpobb, η ceKflHH προμηβοηηογο pacTBopa (5), o6ecnenHBaiomanHeOÓXOflHMblň· ΠΟΤΟΚ ΠρΟΜΗΒΟΠΗΟΓΟ paCTBOpa. Γ6ΜΟΠβρφγ3ΗΟΗΗ8Η eflHHHfla (2) o6pa-3OBaHa οδοποΗκοή (6), aanonHeHHoň aflcopSeHTOM (7) hjih CMecbio aflcopčeHTOB. C o6enx ctopoh, το ecTb, b Mectax coeflHHeHHH c αρυγημη eflHHHflaMH hjih πρητο- 'Ka kpobh (8) η οττοκβ kpobh (9) κ KpoBenpoBoflHmeň CHCTeMe (10), οδοποπκβ (6) orpaHHHeHa CHCTeMoň Φηπβτροβ (11). reM0flHanH3Hpyroniaa eflHHHfla 1 η ΓβΜθπβρφγ3ΗθΗΗ3π eflHHHfla 2 ημθιοτ τβκγιο φορ-My h BenHHHHy, HTo6bi AHaMeTpw hx cefleHHň b MecTax nepexofla 6buiH οαηηβκοβμμη· H3o6pa»eHHbift Ha Φηγ.2 κοΜβήΗΗροΒβΗΗωή copSeHTHbiň ananHaaTop coctoht hs’reM0fíHanH3Hpyromeň eflHHHflbí (1), κ κοτοροή c oflHoň cTopoHbí noflKnioMeHa reMonep-φγ3ΗΟΗΗΗΗ eflHHHfla (2) . ΓβΜ0ΠβρφΥ3Η0ΗΗ3Η eflHHHfla (2) COflepjKHT flBe aflcopĎH-pywmne eflHHHflbí (12), BKnmflaioiuHe pa3JiHUHbie aflcopSeHTbi (7) ηπη CMecn aflcopčen-TOB ΠΗ6Ο ΗΟΗΟΟδΜβΗΗΗΚΗ. AflCOp6Hpy»IHHe eflHHHflbí (12) OrpaHHHeHbl c o6eHX CTO-POH CHCTeMaMH φΗΠΒΤρΟΒ (11). flaHHan φορΜβ HCnonHeHHH nOSBOJineT ΠΟΛΚΠΚΜβΗΗε K OflHoň ΓβΜ0Πβρφγ3ΗΟΗΗ0ήeflHHHiie (2) flByx hjih τβισκβ "HecKojibKHx a/icopČHpyioinHX enHHHti (12) c pa3JiHMHbi- 251908 μη aflcopSeHTaMH (7), mto6m ypanaTb caMwe pa3nMMHt>ie BpenHbie BeiuecTBa H3 κρο-BH B 3aBHCHMOCTH OT nOTpeĎHOCTH H HGOGXOJIHMOCTH .Ha Φηγ. 1 npeflCTaBneHo nocnefloBaTenhHoe coeflHHeHHe reMOflHanH3Hpywnieň eflH-HHflbl (1) C paCnonÓXeHHblMH ΠΟ ΟββΗΜ CTOpOHaM ee ΓεΜΟΠβρφγ3ΗΟΗΗΜΜΗ eflHHHflaMH (2). flHanH3Hpyioinaa eflHHHfla (1) coctoht H3 aaflenaHHbix b cooTBeTCTByromHň Μβτβ-pnan nonbix βοποκοη (3) »nepe3 nojibie npocTpaHCTsa (4) κοτορκχ προτβκβετ nOFL-neacamaa OMHmeHHio kpobb, η ceKflHH προμηβοηηογο pacTBopa (5) · o6ecnenHBaiomanHeOÓXOflHMblň ΠΟΤΟΚ ΠρΟΜΗΒΟΠΗΟΓΟ paCTBOpa. Γ6 ,Πβρφγ3ΗΟΗΗ8Η eflHHHfla (2) o6pa-3OBaHa οδοποΗκοή (6), aanonHeHHoň aflcopSeHTOM (7) hjih CMecbio aflcopčeHTOB. C o6enx ctopoh, b Mectax coeflHHeHHH c eflHHHflaMH hjih πρητο- 'Ka kpobh (8) ηττοκβ kpobh (9) κ KpoBenpoBoflHme CHCTeMe (10), οδοποπκβ (6) orpaHHHeHa CHCTeMoň Φηπβτροβ (11). reM0flHanH3Hpyroniaa eflHHHfla 1 2 η ΓβΜθπβρφγ3ΗθΗΗ3π eflHHHfla ημθιοτ τβκγιο φορ We-h BenHHHHy, HTo6bi AHaMeTpw hx cefleHHň b MecTax nepexofla 6buiH οαηηβκοβμμη · H3o6pa »eHHbift Ha Φηγ.2 κοΜβήΗΗροΒβΗΗωή copSeHTHbiň ananHaaTop coctoht hs'reM0fíHanH3Hpyromeň eflHHHflbí (1), c κ κοτοροή oflHoň cTopoHbí noflKnioMeHa reMonep-φγ3ΗΟΗΗΗΗ eflHHHfla (2). FβΜ0ΠβρφΥ3Η0ΗΗ3l eflHHHfla (2) COflepjKHT flBe aflcopHH-pywmne eflHHHlb (12), BKnmflaioiuHe pa3JiHUHbie aflcopSeHTbi (7) ηπη CMecn aflcopčen-TOB ΠΗ6Ο ΗΟΗΟΟδΜβΗΗΗΚΗ. <RTIgt; AflCOp6Hpy </RTI> <RTIgt; IHH </RTI> efHHHflb (12) OrpaHHHeHbl c o6eHX CTO-POH CHCTeMaMH φΗΠΒΤρΟΒ (11). flaHHan φορΜβ HCnonHeHHH nOSBOJineT ΠΟΛΚΠΚΜβΗΗε K OflHoň ΓβΜ0Πβρφγ3ΗΟΗΗ0ήeflHHHiie (2) flByx hjih τβισκβ "HecKojibKHx and / icopČHpyioinHX enHHHti (12) c 251 908 pa3JiHMHbi- μη aflcopSeHTaMH (7) mto6m ypanaTb caMwe pa3nMMHt> ie BpenHbie BeiuecTBa κρο H3 BH-B 3aBHCHMOCTH OT nOTpeĎHOCTH H HGOGXOJIHMOCTH.

AacopGuHOHHHe eflHHHuw 12 HMeroT uponycKHoe otbgpcthg, cooTBeTCTBywmee ce-qeHHio reMO£(HajiH3HpyiomeH eflHHHUbi 1. IIpeHMymeCTBO 3aKJWMaGTCB B TOM, Mrč ΤβΚθΛ KOMnaKTHblň 6jlOK HM88T TOJIbKOBXOfl H BblXOP KPOBH C KaMepaMH“C6opHHKaMH ΚρΟΒΗ Η BTO KpOBb MO7KGT. HOCTynaTbH9 o/jhoji εβΗΗΗϋΜ b ppyryio e^HHHuy HGnocpepcTBeHHo h no Bceň njiomajjH ceneHHHreMOflHajinaHpyiomHx hjih reMonepýyaHOHHbix ghhhhii, Tskhm o6pa3OM, οβεοπεηΗΒβετ-ca SecnpenHTCTBeHHbiH tok κροΒΗ, a narpy3Ka no κροβη hg GoJibme, mgm npH reMO-OHaJiH3e. flHajiH3HpyiomHe GflHHHiibi (1) h reMonep(by3HOHHbie epHHHiibi (2) μοχηο κοΜπηεκτο-BaTb B COOTBeTCTBHH C MeflHUHHCKHMH ΠΟΤρβδΗΟΟΤΒΜΗ HeCTepHJlbHO B ΠρΟΜΜΠΒίεΗΗΟΜnopapKe, bto6h npenocTaBHTb hx b pacnopaxceHHe-noTpeGHTeJia nocne npoH3BepeH-Hoň CTepHnH3aUHH B BHfle CTepHJIbHOrO KOMGHHHpOBaHHOrO COpGeHTHOrO OTannaaTO-pa. OflHako, KOM6HHHpoBaHHbiň copGenTHbiň flHanH3aTop mojkho KOMnneKTOBaTb TajoxeB KJIHHHneCKHX yCJlOBHHX COOTBeTCTBeHHO MeflHflHHCKHM nOTpeGKOCTHM, ΠρΗΒβΜ npo-H3BOflHTCH coenHHeHHe CTepHnbHbix flnann3npyioMHx (1) h reMonep<}}y3HOHHbix eflHHHu;(2) jih6o ancopSHpyromHx eflHHHy c coGjnofleHHeM CTepnjihHocTH.AacopGuHOHHHe eflHHHuw 12 HMeroT uponycKHoe otbgpcthg, cooTBeTCTBywmee cetyl qeHHio Remote £ (HajiH3HpyiomeH eflHHHUbi first IIpeHMymeCTBO 3aKJWMaGTCB B TOM MRC ΤβΚθΛ KOMnaKTHblň 6jlOK HM88T TOJIbKOBXOfl H BblXOP KPOBH C KaMepaMH "C6opHHKaMH ΚρΟΒΗ Η BTO KpOBb MO7KGT. HOCTynaTbH9 a / b jhoji εβΗΗΗϋΜ ppyryio e ^ HHHuy HGnocpepcTBeHHo h no Bceň njiomajjH ceneHHHreMOflHajinaHpyiomHx hjih reMonepýyaHOHHbix ghhhhii, Tskhm o6pa3OM, οβεοπεηΗΒβετ-ca SecnpenHTCTBeHHbiH flow κροΒΗ and narpy3Ka well κροβη Hg GoJibme MGM NPH remote-OHaJiH3e. flHajiH3HpyiomHe GflHHHiibi (1) h reMonep (by3HOHHbie epHHHiibi (2) μοχηο κοΜπηεκτο -BaTb COOTBeTCTBHH b C b MeflHUHHCKHMH ΠΟΤρβδΗΟΟΤΒΜΗ HeCTepHJlbHO ΠρΟΜΜΠΒίεΗΗΟΜnopapKe, bto6h npenocTaBHTb hx-b pacnopaxceHHe noTpeGHTeJia nocne npoH3BepeH-hon CTepHnH3aUHH b BHfle CTepHJIbHOrO KOMGHHHpOBaHHOrO COpGeHTHOrO OTannaaTO-PA. OflHako, KOM6HHHpoBaHHbiň copGenTHbiň flHanH3aTop mojkho KOMnneKTOBaTb Tajo xeB KJIHHHneCKHX yCJlOBHHX COOTBeTCTBeHHO MeflHflHHCKHM nOTpeGKOCTHM, ΠρΗΒβΜ NPO-H3BOflHTCH coenHHeHHe CTepHnbHbix flnann3npyioMHx (1) h reMonep <}} y3HOHHbix eflHHHu; (2) jih6o ancopSHpyromHx eflHHHy c coGjnofleHHeM CTepnjihHocTH.

MeflHUHHCKHe npeHMyiuecTBa, κοτορωε npeflocTaBJíaeT Η3θϋ'ρετεΗΗωή komGhhhpo-BaHHbiň copSeiiTHbiň flnajiH3aTop, 3aKjnonaioTCH b tom, hto npeHMymecTBa reMOflHajiH-3Hpyi01UHX eflHHHfl, K3K , ΗΗΠρΗΜβρ, flOnOJIHHTeJIbHaH BO3MO3KHOCTh φΗΠΒΤρβηΗΗ, Ť8M~περΗροΒθΗΗε κροβη η yflajieHHe flecopSHpyiomHX BemecTB, flonojiHaioT npnHííHnuajib-Hbrfí cnoco6 r8M0n8p(J>y3HH. OTHOCHTeJIbHO ΟΠθρΗφΗΜεΟΚΟΓΟ npHM8H8HHH ΜΟ3ΚΗΟ TajOK8ΠΡΗΒεεΤΗ HeCKOJIbKO npOHMyniBCTB: - npHfleJibHaa 3JiHMHHaflHa ΒεπιεοτΒ, κοτορωε nyTeM reMOflHajiH3a βηβοαητοηTOJibKO b HBflOCTaTonHoň οτεπεΗΗ, HanpHMep, HeopraHHaecKHťi φοεφετ npHKpaTKOBpOMOHHOM flHaJTH3e HJ1H CpeflHeMOJieKyJIHpHbie bemeCTBa. TaKHM θ6ρ33ΟΜΓeMoπεpφy3HK) mojkho paccMaTpHBaTb κβκ flonojiHeHHe κ repanHH ppasiusoM πρκjieaeHHH xpoHHpecKoň nouenHoň HeflocTaTOHHocŤH. - ΥκοροηεΗΗε ΒρεωεΗΗ flHanH3a κεκ cjieflCTBHe noBbímeHHH βΦΦβκτηβηοοτη πρπ ,JieHeHHH XpOHHHeCKOH ΠΟΗεΗΗΟΗ HeflOCTaTOHHOCTH. - ΠθΒ6ΠΠεΗΗ8 3φφβΚΤΗΒΗΟΟΤΗ ΠΡΗ JieaeHHH OCTPbIX HHTOKCHKaflHII , Β OCOÓ8HHOCTHβ pa3yjibTaT8 pacnmpoHHH cneKTpa 3JiHMHHHpyeMbix BamecTB npn CMemaHHbixHHTOKCHKapHHX C H8H3B8CTHblM Π3ΤΟΓ8ΗΗΜΜ φθΚΤΟρΟΜ. - B cnynae JieaeHHa neneHOUHoft HeflocTaTonHocTH - 3φφεκτΗΒΗ3Η 3JiHMHHaflHHHH3K0- H Cp8flH8MOJ18KyJIHpHbIX BBIUOCTB. - OnTHMaJIbH08 JI8H8HH8 3K30r8HHblX OTpaBJíeHHň 1, CopGeHTHbiň flHaflH3aTop flJia reM0flHaflH3a η Γ8Μθπερφγ3ΗΗ, coflepjKamnň reMO-flMajiH3Hpyiomyio epnHHpy h ΓεMOΠ8pφy3HOHHyιo eflflHHfly, coeflHHeHHbie nocjiapoBaTeJTb-ho, oTjmnaKHUHHca τεω, hto cocToamaa H3 flByx hjih HecKouhKHX apcopGpHOHHbixeflHHHfl.(12) ΓεΜΟΠερφγ3ΗΟΗΗΗΗ eflHHHfla (2) C OflHOH HJIH C OČ8HX CTOPOH coeflHHe-Ha HenOCpepCTBeHHO C reMOflHajIH3HpyiOmeň eflHHHfleň ( 1 ) , npH 3TOJ>1 Γ8ΜΟΠερφγ3ΗΟΗ-Haa eflHHHfla (2) hjih aflcopGflHOHHbie eflHHHflbí (12) hmoiot nponycKHoe οτΒεροτπε,cooTB8TCTByiomee cevonm reMOflHaJiHSHpywineŘ eflHHHflbí (1). 2. CopGeHTHblH flHajIH3aTOp ΠΟ Π.1, OTJIHHaJOmHJÍCa T8M, HTO ΓεΜΟΠερφγ3ΜΟΗΗ3ΒeflHHHfla (2) HJIH ββ ΒΗ8ΠΙΗΗ8 aflCOpGflHOHHbie eflHHHflH (12) BbinOJIHBHbí Β BHfle npH“ 251908 5 TOKa KpOBH (8) HJIH OTTOKa ΚΡΟΕΗ (9) UJÍM ΠρΗ flByeropOHHeM pacnOJlOWeHHM reMO-Πβρφγ3ΜΟΗΗΜΧ eflHHHH (2) OHM UJÍM HX ΒΗβΠΗΗβ aflČOpGUHOHHbie eflHHHUbl (12) BMnOJl“HeHbl B BHfle ΠρΗΤΟΚΘ KpOBH (8) H OTTOKa KPOBH (9). 3. Cop6eHTHbiň nnajiHaaTop no n.l, oTjmMaronmňcB τβΜ, hto reMonep$y3HOHHafleflHHHfla HJIH aflHHHflbl (12) HJIH HX anCop6UHOHHbie eflHHHUbl (12) «BJWMTCfl MaCTHMtitKpOBenpOBOflHoň CHCTeMbl (10). ^4. Cop6eHTHblň flMaJIH3aTOP no n.l, OTJIHM8IOIHHftCH ΤβΜ, HTO B ΓβΜΟΠβρφγβΗΟΗΗΜΧenHmmax (2) MJiH b mx ancopCnMOHMbix eflHHHuax (12) pacnoJioxeHM ΟΗΗΗβκοΒΜβ hjihpa3J!HHHbie aflCOp6eHTbl (7) MJIH ΗΟΗοοβΜβΗΗΗΚΗ. 5. CopeeHTHbrfi ΑΗβπΗ3βτορ no nn. 1-4, OTJiHvaiomHňcH τβΜ, hto Mexny .reMOflHa-JlH3HpyíOIHeň eflHHHflefl HJIH eflHHHflaMH ( 1 ) , ΓβΜΟΠβρφγ3Η:θΗΗθίΙ eflHHHflefl MJIH eflHHHfla-MH H aflCOpGflHOHHfalMH eflHHHflaMH (12) pacnojIOSteHM CHCTeMbl ΦΗΠΒΤΡΟΒ (11). AHHOTatJHfl Η3θ6ρβτβΗΜβ KacaeTca κοΜδΗΗΗροΒβΗΗΟΓΟ copGeHTHoro AHaJiHsaTopa nn« Jiene-HHH OCTpoň H XpOHHqeCKOň nOHeHHOň HeflOCTaTOHHOCTH. IJejib H3o6peTeHHH samnoHaeTca b oCbeflHHeHHH npeHMymecTB reMOflHajiHaa H re-Monep4»y3HH npH oHHmettHH κροβη b sKCTpaKOprtopajibHOM ROHType. 3aflaqeň Η3θ6ρετεΗΗΗ «BJiHeTCH paspaSoTKa κομ6ηηηροΒ8ΗΗογο copGeHTHoro flHa-jmoaTopa, nosBOJiaroqero ofíbeflHnerHe MeTofloB reMOflHaJiHaa η ΓβΜοπβρφγβΗΗ b oprhom ο6μθηηομ MexannaMe. 3afla’ia pemaeTCH nyTeM nocjieflonaTejibHpro coeflHneHHH oflHoft hjih HecKOjibKHxreM0ňHajIH3HpyWIHHX eflHHHfl C OflHOft MJIH HeCKOJlbKHMH ΓεΜΟΠερφν3ΗΟΗΗΜΜΗ eflHHHfla-MH. ΓeMoπepφy^HOHHbIe eflHHHflbí MoryT 6wTb ,pa3MemeHM č oflHoft hjih c oGenx cto-Poh reMOffMajiH3Hpyiomeřt eflHHHflbí. FéMonep4iy3HoHHaa eflHHHfla Μσχετ cofcToaTb hsOflHoft MJIH HeCKOJlbKHX aflCÓp6HpyiOIHHX eflHHHfl C OflHH8ROBbIMH HJIH pa3 JIHHHblMH aprcopCeHTaMH jih6o ηοηοο6μ6ΗΗΗκ3μη . ΠρΜ3ΗβΗΟ Η3θ6ρεΤβΗΗβΜ ΠΟ peayjIbTaTflM 3KCnepTH3KI, OCymeCTBJWHHOft BeflOMCTBOMno aejiaM Η3ο6ρετεΗΗή η πθτθητοβ TUP. 1 περτεχ 251908MeflHUHHCKHe npeHMyiuecTBa, κοτορωε npeflocTaBJíaeT Η3θϋ'ρετεΗΗωή komGhhhpo-BaHHbiň copSeiiTHbiň flnajiH3aTop, b 3aKjnonaioTCH that HTO npeHMymecTBa reMOflHajiH-3Hpyi01UHX eflHHHfl, K3K, ΗΗΠρΗΜβρ, flOnOJIHHTeJIbHaH BO3MO3KHOCTh φΗΠΒΤρβηΗΗ, T8M ~ περΗροΒθΗΗε κροβη η yflajieHHe flecopSHpyiomHX BemecTB, flonojiHaioT npnHííHnuajib-HBrFOs cnoco6 r8M0n8p (J > y3HH. OTHOCHTeJIbHO ΟΠθρΗφΗΜεΟΚΟΓΟ npHM8H8HHH ΜΟ3ΚΗΟ TajOK8ΠΡΗΒεεΤΗ HeCKOJIbKO npOHMyniBCTB - npHfleJibHaa 3JiHMHHaflHa ΒεπιεοτΒ, κοτορωε rivet reMOflHajiH3a βηβοαητοηTOJibKO b HBflOCTaTonHoň οτεπεΗΗ, HanpHMep, HeopraHHaecKHťi φοεφετ npHKpaTKOBpOMOHHOM flHaJTH3e HJ1H CpeflHeMOJieKyJIHpHbie bemeCTBa. Takhte θ6ρ33ΟΜΓeMoπεpφy3HK) mojkho paccMaTpHBaTb κβκ flonojiHeHHe κ repanHH ppasiusoM πρκjieaeHHH xpoHHpecKoň nouenHoň HeflocTaTOHHocŤH. - HκοροηεΗΗε ΒρεωεΗΗ flHanH3a κεκ cjieflCTBHe noBbímeHHH βΦΦβκτηβηοοτη πρπ, JieHeHHH XpOHHHeCKOH ΠΟΗεΗΗΟΗ HeflOCTaTOHHOCTH. Ea Β ea ea ea ea ea ea ea ea ea ea ea ea ea ea ea ea ea CO CO CO CO CO CO CO CO CO CO CO CO CO ema ema ema ema ema ema ema ema. - B cnynae JieaeHHa neneHOUHoft HeflocTaTonHocTH - 3φ 3κ 3JiHMHHaflHHHH3K0- H Cp8flH8MOJ18KyJIHpHbIX BBIUOCTB. - OnTHMaJIbH08 JI8H8HH8 3K30r8HHblX OTpaBJíeHHň 1 CopGeHTHbiň flHaflH3aTop flJia reM0flHaflH3a η Γ8Μθπερφγ3ΗΗ, coflepjKamnň remote-flMajiH3Hpyiomyio epnHHpy h ΓεMOΠ8pφy3HOHHyιo eflflHHfly, coeflHHeHHbie nocjiapoBaTeJTb-ho, oTjmnaKHUHHca τεω, HTO cocToamaa H3 flByx hjih HecKouhKHX apcopGpHOHHbixeflHHHfl (12). ΓεΜΟΠερφγ3ΗΟΗΗΗΗ eflHHHfla (2) C OflHOH HJIH C OČ8HX CTOPOH coeflHHe-Ha HenOCpepCTBeHHO reMOflHajIH3HpyiOmeň eflHHHfleň C (1), NPH 3TOJ> 1-Haa Γ8ΜΟΠερφγ3ΗΟΗ eflHHHfla (2) hjih aflcopGflHOHHbie eflHHHflbí (12) hmoiot nponycKHoe οτΒεροτπε, cooTB8TCTByiomee Čevona reMOflHaJiHSHpywineŘ eflHHHflbí (1). Second CopGeHTHblH flHajIH3aTOp ΠΟ Π.1, OTJIHHaJOmHJÍCa T8M, HTO ΓεΜΟΠερφγ3ΜΟΗΗ3ΒeflHHHfla (2) HJIH ββ ΒΗ8ΠΙΗΗ8 aflCOpGflHOHHbie eflHHHflH (12) BbinOJIHBHbí Β BHfle NPH "Tokai KpOBH 5 251 908 (8) HJIH OTTOKa ΚΡΟΕΗ (9) assuming ΠρΗ flByeropOHHeM pacnOJlOWeHHM remote-Πβρφγ3ΜΟΗΗΜΧ eflHHHH (2) OHM LEARN HX ΒΗβΠΗΗβ aflČOpGUHOHHbie eflHHHUbl (12) BMnOJl “HeHbl B BHfle ΠρΗΤΟΚΘ KpOBH (8) H OTTOKa KPOBH (9). 3. HHHflHlHlHlHlHHlHlHlHlHlHlHlHHlHlHIHHlHHHflbl (12) HHlHHX anCop6UHOHHbIlHHHUbl (12) BJWMTCfl MaCTHMtitKpOBenpOBOflHOn CHCTeMbl (10). ^ 4. 6 HT OP OP Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ Μ H H H H H H H H H H H H H H H H H H H H. 5. CopeeHTHbrfi ΑΗβπΗ3βτορ no nn. 1-4, OTJiHvaiomHňcH τβΜ, HTO Mexny .reMOflHa-JlH3HpyíOIHeň eflHHHflefl HJIH eflHHHflaMH (1) ΓβΜΟΠβρφγ3Η: θΗΗθίΙ eflHHHflefl MJIH eflHHHflaMH H aflCOpGflHOHHfalMH eflHHHflaMH (12) pacnojIOSteHM CHCTeMbl ΦΗΠΒΤΡΟΒ (11). AHHOTatJHfl θ3θ6ρβτβΗΜβ KacaeTca κοΜδΗΗΗροΒβΗΗΟΓΟ copGeHTHoro AHaJiHsaTopa nn Jiene-HHH OCT at least HppOHHqeCoCnnHeflOCTaTOHHOCTH. IJejib H3o6peTeHHH samnoHaeTca b oCbeflHHeHHH npeHMymecTB reMOflHajiHaa H re-Monep4 »y3HH npHHHmettHH κροβη b sKCTpaKOprtopajibHOM ROHType. 3aflaqen Η3θ6ρετεΗΗΗ «BJiHeTCH paspaSoTKa κομ6ηηηροΒ8ΗΗογο copGeHTHoro flHa-jmoaTopa, nosBOJiaroqero ofíbeflHnerHe MeTofloB reMOflHaJiHaa η ΓβΜοπβρφγβΗΗ b oprhom ο6μθηηομ MexannaMe. 3afla'ia pemaeTCH nyTeM nocjieflonaTejibHpro coeflHneHHH oflHoft hjih HecKOjibKHxreM0nHajIH3HpyWIHHX eflHHHfl C OflHOft MJIH HeCKOJlbKHMH ΓεΜΟΠερφν3ΗΟΗΗΜΜΗ eflHHHfla-MH. ΦeMoπepy ^ HOHHbIe eflHHHflbí MoryT 6wTb, pa3MemeHM č oflHoft hjih c oGenx cto-Poh reMOffMajiH3Hpyiomeřt eflHHHflbí. FéMonep4iy3HoHHaa eflHHHfla ofσχετ cofcToaTb hsOflHoft MJIH HeCKOJlbKHX lCCÓp6HpyiOIHHX eflHHHfl C OflHH8ROBbIMH HJIH pa3 JIHHHblMH aprcopCeHTaMH jih6o ηοηοο6μ6ΗΗΗκ3μη. Πρθ3ΗβΗΟ θ3θ6ρεΤβΗΗβΜ ΠΟ peayjIbTaTflM 3KCnepTH3KI, OCymeCTBJWHHOft BeflOMCTBOMno aejiaM Η3ο6ρετεΗΗή η πθτθητοβ TUP. 1 περτεχ 251908

Claims (5)

PŘEDMĚT VYNÁLEZU 1· Kombinovaný sorbentový dialyzátor pro hemodialýzua hemoperfuzl obsahující hemodialyzující jednotku a hemo-perfuzní jednotku, spojené za sebou. vyznačující se tím,že sestává alespoň ze dvou adsorpčních jednotek (12), he-moperfuzní jednotky (2) z jedné nebo-', z obou stran přímospojené s hemodialyzacní jednotkou (1), přičemž hemoperfuzníjednotka (2), nebo adsorbční jednotky (12) mají propustnostodpovídající průřezu hemodialyzační jednotky (1).OBJECT OF THE INVENTION 1 · Combined sorbent dialyser for hemodialysis and hemoperfusion comprising a hemodialysis unit and a hemo-perfusion unit, connected in series. characterized in that it comprises at least two adsorption units (12), a hemoperfusion unit (2) of one or both, and a hemodialysis unit (1), on either side, wherein the hemoperfusion unit (2) or the adsorbent unit (12) ) have permeability corresponding to the cross-section of the hemodialysis unit (1). 2· Kombinovaný sorbentový dialyzátor podle bodu 1, vyzna-čující se tím, že hemoperfuzní jednotka (2) nebo její vněj-ší adsorbční jednotky (12) jsou provedeny jako přítok ('8) krvenebo odtok (9) krve, nebo při dvoustranném uložení hemoper-fuzních jednotek (2), jsou popřípadě jejich vnější adsorb-ční jednotky (12) provedeny jako přítok (8) krve a odtok(9) krve. ·The combined sorbent dialyser according to claim 1, wherein the hemoperfusion unit (2) or its external adsorbent unit (12) is designed as a blood inlet (8) or a blood outlet (9), the hemoperfusion units (2), optionally their outer adsorbent units (12) are provided as a blood inlet (8) and a blood outlet (9). · 3. Kombinovaný sorbentový dialyzátor podle bodu 2, vyznaču-jící se tím, že hemoperfuzní jednotka nebo jednotky (12)'nebo jejich adsorbční jednotky (12) jsou částmi systému (10)propouštějícího krev.3. The sorbent dialyser according to claim 2, wherein the hemoperfusion unit or units (12) or their adsorbent units (12) are portions of the blood permeable system (10). 4. Kombinovaný sorbentový dialyzátor podle bodu 1, vyzna-čující se tím, že v hemoperfuzních jednotkách (2), nebo vjejích adsobčních jednotkách (12) je uložen alespoň jeden 4 adsorbent (7). nebo měnič iontů.4. The combined sorbent dialyser according to claim 1, wherein at least one 4 adsorbent (7) is disposed in the hemoperfusion units (2) or in said additive units (12). or an ion exchanger. 5· Kombinovaný sorbentový dialyzátor podle bodů 1 až 4,251908 . - vyznačující se tím, Se mezi hemodialyzační jednotkou nebojednotkami (1)« hemoperfuzní jednotkou nebo jednotkami(2) a adsorbčními jednotkami (12) jsou uloženy systémyfiltrů (11)♦ · 2519085 · Combined sorbent dialyser according to items 1 to 4,251908. characterized in that filter systems (11) are deposited between the hemodialysis unit (s) (1) and the hemoperfusion unit (s) (2) and the adsorbent units (12).
CS814601A 1980-09-11 1981-06-18 Combined sorbent dialyzer CS251908B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD80223838A DD159494A3 (en) 1980-09-11 1980-09-11 SORBENTDIALYSATOR

Publications (2)

Publication Number Publication Date
CS460181A1 CS460181A1 (en) 1987-01-15
CS251908B1 true CS251908B1 (en) 1987-08-13

Family

ID=5526240

Family Applications (1)

Application Number Title Priority Date Filing Date
CS814601A CS251908B1 (en) 1980-09-11 1981-06-18 Combined sorbent dialyzer

Country Status (9)

Country Link
JP (1) JPS5759552A (en)
CS (1) CS251908B1 (en)
DD (1) DD159494A3 (en)
DE (1) DE3121606A1 (en)
GB (1) GB2083761B (en)
HU (1) HU188676B (en)
IT (1) IT1167463B (en)
NL (1) NL8103085A (en)
SU (1) SU1291158A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5016584A (en) * 1988-10-11 1991-05-21 Honda Giken Kogyo Kabushiki Kaisha Engine block construction with skeletal frame
FR2721217B1 (en) 1994-06-20 1996-08-02 Hospal Ind Multifunction device for the treatment of blood.
CN101843932B (en) * 2010-05-26 2012-06-27 重庆希尔康血液净化器材研发有限公司 Hemoperfusion cartridge
CN108114333B (en) * 2016-11-28 2023-09-05 健帆生物科技集团股份有限公司 Blood purification device, blood purification system and pre-flushing method thereof
CN108114334B (en) * 2016-11-28 2024-01-12 健帆生物科技集团股份有限公司 Blood purifier, blood purifying system and pre-flushing method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5841066B2 (en) * 1975-07-25 1983-09-09 帝人株式会社 Jinko Zouuki
JPS52130195A (en) * 1976-04-26 1977-11-01 Teijin Ltd Artificial liver

Also Published As

Publication number Publication date
HU188676B (en) 1986-05-28
SU1291158A1 (en) 1987-02-23
NL8103085A (en) 1982-04-01
IT1167463B (en) 1987-05-13
GB2083761B (en) 1984-01-11
DD159494A3 (en) 1983-03-16
CS460181A1 (en) 1987-01-15
IT8122685A0 (en) 1981-07-01
DE3121606A1 (en) 1982-04-08
GB2083761A (en) 1982-03-31
JPS5759552A (en) 1982-04-09

Similar Documents

Publication Publication Date Title
SE8502757D0 (en) DIALYSIS CONTROL SYSTEM
Stegmayr et al. Beyond dialysis: current and emerging blood purification techniques
Schaefer et al. The role of molecular adsorbent recirculating system dialysis for extracorporeal liver support in children
DE69206046D1 (en) Disc-shaped arrangement for connectors with filters.
CS251908B1 (en) Combined sorbent dialyzer
JPS5755150A (en) Dialysate bag assemblage for peritoneum dialysis
ATE27231T1 (en) MEMBRANE MODULE AND ITS USE FOR SEPARATION OF LIQUIDS BY THE PERVAPORATION PROCESS.
US4585552A (en) System for the measurement of the difference between two fluid flows in separate ducts
ES2157017T3 (en) DEVICE FOR FILTERING AND SEPARATION OF FLUIDS.
GB2110112A (en) Method and apparatus for high-efficiency ultrafiltration of complex fluids
RO87917B (en) Dialysis device
ES516966A0 (en) A BALANCE FILTER OF THE FINITE IMPULSE RESPONSE TYPE, INTENDED TO BE USED IN A TELECOMMUNICATION SYSTEM.
Papamichalis et al. Liver replacement therapy with extracorporeal blood purification techniques current knowledge and future directions
IT8121440A0 (en) SYSTEM FOR THE ELIMINATION OF GHOST DRAWINGS IN THE TELEVISION FIELD USING A TRANSVERSAL FILTER WITH WEIGHTED INPUT.
DE69110164D1 (en) System to suppress the spread of errors caused by differential coding.
Kanayama et al. Comparison of free light chain removal by four blood purification methods
GB1109833A (en) Apparatus for degassing liquids
ES2033469T3 (en) EXTRACORPOREAL TREATMENT PROCEDURE OF ASCITIC LIQUID.
SU1011177A2 (en) Hydraulic filter
DE3381006D1 (en) LOW VOLUME, LARGE AREA FILTERS FOR INTRAVENOSE OR BLOOD FILTRATION.
JPH01143614A (en) Multistage filter
EP0097863A3 (en) Mixing fluids by means of semipermeable membranes
IT1212748B (en) IMPROVED DIFFERENTIAL STAGE, IN PARTICULAR FOR ACTIVE FILTERS.
Chapman et al. Uremic middle molecules
JPS6240667Y2 (en)