CS247337B1 - Bile acids adsorption agent - Google Patents
Bile acids adsorption agent Download PDFInfo
- Publication number
- CS247337B1 CS247337B1 CS235585A CS235585A CS247337B1 CS 247337 B1 CS247337 B1 CS 247337B1 CS 235585 A CS235585 A CS 235585A CS 235585 A CS235585 A CS 235585A CS 247337 B1 CS247337 B1 CS 247337B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- bile acids
- adsorption agent
- adsorption
- hydrothermally treated
- bile acid
- Prior art date
Links
- 238000001179 sorption measurement Methods 0.000 title claims abstract description 15
- 239000003613 bile acid Substances 0.000 title claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 title claims description 6
- 239000012978 lignocellulosic material Substances 0.000 claims abstract description 8
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 7
- 239000003814 drug Substances 0.000 abstract description 3
- 241000218657 Picea Species 0.000 description 6
- 241001070947 Fagus Species 0.000 description 3
- 235000010099 Fagus sylvatica Nutrition 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 229920001268 Cholestyramine Polymers 0.000 description 1
- 229920002911 Colestipol Polymers 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000003524 antilipemic agent Substances 0.000 description 1
- YOUGRGFIHBUKRS-UHFFFAOYSA-N benzyl(trimethyl)azanium Chemical group C[N+](C)(C)CC1=CC=CC=C1 YOUGRGFIHBUKRS-UHFFFAOYSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- GMRWGQCZJGVHKL-UHFFFAOYSA-N colestipol Chemical compound ClCC1CO1.NCCNCCNCCNCCN GMRWGQCZJGVHKL-UHFFFAOYSA-N 0.000 description 1
- 229960002604 colestipol Drugs 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical class O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Riešenie sa týká prostriedku na adsorpciu žlčových kyselin. Jeho podstata spočívá v použití mechanicky a hydrotermicky upra veného lignocelulózového materiálu ako prostriedku na adsorpciu žlčových kyselin. Vynález má použitie v medicíně.solution the relates to means on the adsorption bile acids. his nature is in application mechanically and hydrothermally Upra Venet lignocellulosic material than means on the adsorption bile acids. invention my the use in medicine.
Description
(54) Prostriedok na adsorpciu žlčových kyselin ,(54) Bile acid adsorption agent,
22
Riešenie sa týká prostriedku na adsorpciu žlčových kyselin. Jeho podstata spočívá v použití mechanicky a hydrotermicky upraveného lignocelulózového materiálu ako prostriedku na adsorpciu žlčových kyselin.The invention relates to a bile acid adsorption agent. It is based on the use of a mechanically and hydrothermally treated lignocellulosic material as a bile acid adsorption agent.
Vynález má použitie v medlcíne.The invention has utility in medication.
Vynález sa týká prostriedku na adsorpciu židových kyselin.The invention relates to a composition for adsorption of Jewish acids.
Pri liečení hypercholesterolémie sa doteraz používajú dva druhy hypolipidemických liečiv subklasifikované ako absorbovateíné a neabsorbovatelné v gastrointestinálnom trakte. Medzi neabsorbovatelné patria hlavně syntetické živice, ako například kopolymér styrénu a divinylbenzénu obsahujúci trimetylbenzylamóniové skupiny (cholestyramín] alebo kopolyhiér dietylpentamínu a epichlórhy dřínu (colestipolj, ktoré sú Specificky předurčené na viazanie žlčových kyselin v hrubom čreye. Účinok týchto látok sa prejavuje znižovaním hladiny cholesterolu v krvnom sere 1'udského organizmu urýchfovaním fekálnej exkrécie žlčových kyselin.To date, two types of hypolipidemic drugs, subclassified as absorbable and non-absorbable in the gastrointestinal tract, have been used in the treatment of hypercholesterolemia. Nonabsorbable mainly include synthetic resins, such as a copolymer of styrene and divinylbenzene containing trimethylbenzylammonium groups (cholestyramine) or a copolytherium of diethylpentamine and epichlorothyrin (colestipol), which are specifically destined to bind bile acids in the bloodstream of the cholesterol. sera of the human organism by accelerating the faecal excretion of bile acids.
Podstata vynálezu spočívá v použití mechanicky a hydrotermicky upraveného lignocelulózového materiálu ako prostriedku na adsorpciu žlčových kyselin.The present invention is based on the use of a mechanically and hydrothermally treated lignocellulosic material as a bile acid adsorption agent.
Výhodou připraveného nového adsorbenta žlčových kyselin je, že má dobrú adsorpčnú kapacitu na žlčové kyseliny pri pH 5,4 a pH 8,0, ako je pH tráviaceho traktu, jeho příprava je vel'mi jednoduchá, nenáročná na zariadenia, nepoužívajú sa chemikálie á využívá odpadnú časť drevnej hmoty·The advantage of the prepared new bile acid adsorbent is that it has a good bile acid adsorption capacity at pH 5.4 and pH 8.0, such as the pH of the gastrointestinal tract; waste wood part ·
Příklad 1Example 1
Adsorpčná kapacita hydrotermicky upravených smrekových pilin (smrekový lignocelulózový materiál) (50 mg) sa stanoví „in vitro“ po pretrepaní počas 18 hod. s 5 ml 10 %-ného hmot. roztoku sodnej soli kyseliny cholovej v puýri s pH 5,4 (připraveného zmiešaním 3,1 ml 0,2 mol roztoku hydrogénfosforečnanu dvojsodného s 96,9 ml 0,1 mol roztoku dihydrogénfosforečnanu sodného) spektrofotomericky po přidaní 4 ml 72 % hmot. kyseliny sírovej k 1 ml filtrátu. Adsorpčná kapacita pri pH 5,4 bola 79,8 %. Ďalej sa stanoví adsorpčná kapacita s použitím pufru s pH 8,0 (připraveného zmiešaním 94,5 ml 0,2 mol roztoku hydrogénfosforečnanu dvojsodného a 5,5 ml 0,1 mol roztoku dihydrogénfosforečnanu sodného), ktorá bola 76 % [I. Mosbach, K. Smid: Arch. Biochem. Biophys. 51, 402 (1954)].The adsorption capacity of hydrothermally treated spruce sawdust (spruce lignocellulosic material) (50 mg) is determined 'in vitro' after shaking for 18 hours. with 5 ml of 10 wt. of a solution of sodium cholic acid in a pH 5.4 buffer (prepared by mixing 3.1 ml of a 0.2 mol solution of disodium hydrogen phosphate with 96.9 ml of a 0.1 mol sodium dihydrogen phosphate solution) spectrophotomerically after the addition of 4 ml of 72 wt. sulfuric acid to 1 ml of filtrate. The adsorption capacity at pH 5.4 was 79.8%. The adsorption capacity is then determined using a buffer of pH 8.0 (prepared by mixing 94.5 ml of a 0.2 mol disodium hydrogen phosphate solution and 5.5 ml of a 0.1 mol sodium dihydrogen phosphate solution) which was 76% [I. Mosbach, K. Smid: Arch. Biochem. Biophys. 51, 402 (1954)].
P r i k 1 a d 2Example 1 and d 2
Postupuje sa ako v příklade 1 s tým rozdielom, že sa použijú hydrotermicky upravené smrekové štiepky (smrekový lignocelulózový materiál). Adsorpčná kapacita pri pH 5,4 bola 70,0 % a pri pH 8,0 bola 50,3 proč.The procedure is as in Example 1 except that hydrothermally treated spruce chips (spruce lignocellulosic material) are used. The adsorption capacity at pH 5.4 was 70.0% and at pH 8.0 was 50.3 why.
Příklad 3Example 3
Postupuje sa ako v příklade 1 s tým rozdielom, že sa použijú hydrotermicky upravené bukové piliny (bukový lignocelulózový materiál). Adsorpčná kapacita pri pH 5,4 bola 81 % a pri pH 8,0 bola 65 %.The procedure is as in Example 1 except that hydrothermally treated beech sawdust (beech lignocellulosic material) is used. The adsorption capacity at pH 5.4 was 81% and at pH 8.0 was 65%.
Použité mechanicky a hydrotermicky upravené lignocelulózové materiály v príkladoch 1, 2 a 3 dostaneme nasledujúcimi známými sposotami [B. Košíková, D. Joniak, M. Tomáš, M. Košík: Dřev. výskům 23, 157 (1977); I. Melcer: Cell. Chem. Technol. 6, 405, (1972);The mechanically and hydrothermally treated lignocellulosic materials used in Examples 1, 2 and 3 are obtained by the following known spots [B. Kosikova, D. Joniak, M. Tomas, M. Kosik: Dre. Res. 23, 157 (1977); I. Melcer: Cell. Chem. Technol. 6, 405 (1972);
H. Nimž: Holzforschung 20, 105 (1966); R. L. Casebier, J. K. Hamilton, H. L. Hergert: Tappi 52, 2 369 (1969); R. L. Casebier, J. K. Hamilton, H. L. Hergert: Tappi 56, 135 (1973); R. Leask: Pulp. Pap. Mag. Can. 76, 10, 52 (1975)].H. N., Holzforschung 20, 105 (1966); Casebier R. L., Hamilton Hamilton, K. Hergert, H. L. Tappi 52, 2369 (1969); Casebier R. L., Hamilton Hamilton, J. Hergert, H. L. Tappi 56, 135 (1973); R. Leask: Pulp. Pap. Mag. Can. 76, 10, 52 (1975)].
Příklad 4Example 4
100 g bukových pilin s 80 %-nou vlhkosťou sa zahrieva pri teplote 170 QC a tlaku100 g of beech sawdust with 80% moisture were heated at 170 C and a pressure Q
I, 01 MPa počas 2 hod.; získaný materiál sa suší počas 16 hod. pri teplote 105 °C.1.0 MPa for 2 hours; the material obtained is dried for 16 hours. at 105 ° C.
Příklad 5Example 5
Smrekové štiepky s 53 %-nou vlhkosťou sa zahrievajú počas 5 min. pri teplote 115 ° Celsia, následné sa defibrujú a vysušía na vzduchu.Spruce chips with 53% humidity are heated for 5 min. at 115 ° C, then defibrate and air dry.
Příklad 6Example 6
Smrekové piliny (10 gj sa paria prefukováním tenkej vrstvy nasýtenou vodnou parou pri teplote 160 °C počas 1 hod. Získaný preparát sa suší po dobu 16 hod. pri teplote 105 °C.Spruce sawdust (10 gj) is steamed by flushing with saturated water vapor at 160 ° C for 1 hour. The resulting preparation is dried for 16 hours at 105 ° C.
Vynález može nájsť široké použitie v medicíně.The invention can be widely used in medicine.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS235585A CS247337B1 (en) | 1985-04-01 | 1985-04-01 | Bile acids adsorption agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS235585A CS247337B1 (en) | 1985-04-01 | 1985-04-01 | Bile acids adsorption agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS247337B1 true CS247337B1 (en) | 1986-12-18 |
Family
ID=5360455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS235585A CS247337B1 (en) | 1985-04-01 | 1985-04-01 | Bile acids adsorption agent |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS247337B1 (en) |
-
1985
- 1985-04-01 CS CS235585A patent/CS247337B1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Marafante et al. | The effect of methyltransferase inhibition on the metabolism of [74As] arsenite in mice and rabbits | |
| US6132706A (en) | Methods of medical treatment for excess phosphate using guanidino-containing polymers | |
| AU651332B2 (en) | Cellulose fiber modified with poly(methyl vinyl ether-co-maleate) and polyol | |
| Crowther et al. | Counter‐ion binding to mucus glycoproteins | |
| SIMESEN | Calcium, phosphorus, and magnesium metabolism | |
| US20050011623A1 (en) | Reducing odor in absorbent products | |
| US6176973B1 (en) | Absorbent material, absorbent body of the material, and method for preparation of the same | |
| CS247337B1 (en) | Bile acids adsorption agent | |
| ES546783A0 (en) | PROCEDURE FOR THE PREPARATION OF MEMBRANE POLYSACCHARIDES OF BACTERIAL ORIGIN | |
| CS243597B1 (en) | Bile acids adsorotion agent | |
| CS243598B1 (en) | Bile acids adsorption agent | |
| CA2064243A1 (en) | Gangliotetraosylceramide as an adsorbent for enteric viral pathogens | |
| CA1176173A (en) | Process for obtaining a drug useful in the treatment of arthritis and other diseases of the locomotive system | |
| US5223258A (en) | Antiviral disinfecting composition and method of inactivating the aids virus in vitro | |
| Ghirardi et al. | Changes in intestinal absorption of glucose in rats treated with ethanol | |
| Soundran et al. | Hepatotoxicity of eugenol | |
| CA2021240A1 (en) | Method for recycling sulfur dioxide from sulfite pulping liquors | |
| GB2145626A (en) | Anti-ulcerogenic pharmaceutical compositions | |
| Ravi et al. | Induction of Cd-metallothionein in cadmium exposed monkeys under different nutritional stresses | |
| Smith et al. | The development of a liquid antihistaminic preparation with sustained release properties | |
| KR100373447B1 (en) | Cataplasma using the medicinal charcol | |
| Luner et al. | Equilibrium and kinetic factors influencing bile sequestrant efficacy | |
| Kagawa et al. | Exocytotic excretion of dextran sulfates from liver to bile | |
| GB2229919A (en) | Composition for antiviral medicines comprising lignin derivatives | |
| TSUCHIYA et al. | The effect of carbohydrate sulfate salts on the absorption and excretion of paraquat in rats |