CS243598B1 - Bile acid adsorption agent - Google Patents

Bile acid adsorption agent Download PDF

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CS243598B1
CS243598B1 CS852358A CS235885A CS243598B1 CS 243598 B1 CS243598 B1 CS 243598B1 CS 852358 A CS852358 A CS 852358A CS 235885 A CS235885 A CS 235885A CS 243598 B1 CS243598 B1 CS 243598B1
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Czechoslovakia
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bile acid
adsorption agent
acid adsorption
water
lignin
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CS852358A
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Czech (cs)
Slovak (sk)
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CS235885A1 (en
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Dusan Joniak
Bozena Kosikova
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Dusan Joniak
Bozena Kosikova
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Priority to CS852358A priority Critical patent/CS243598B1/en
Publication of CS235885A1 publication Critical patent/CS235885A1/en
Publication of CS243598B1 publication Critical patent/CS243598B1/en

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Abstract

Vynález sa týká prostriedku na adsorpciu žlčových kyselin. Podstata vynálezu spočívá v použití vodonerozpustných kationoidných lignínových amínov ako prostriedku na adsorpciu žlčových kyselin. Vynález má použitie v medicíně.The invention relates to a bile acid adsorption agent. The essence of the invention lies in the use of water-insoluble cationic lignin amines as a bile acid adsorption agent. The invention has application in medicine.

Description

Vynález sa týká prostriedku na adsorpciu žlčových kyselin.The present invention relates to a bile acid adsorption composition.

Podstata vynálezu spočívá v použití vodonerozpustných kationoidných lignínových amínov ako prostriedku na adsorpciu žlčových kyselin. Vynález má použitie v medicíně. 243598 4 ÍT) tiThe invention is based on the use of water-insoluble cationic lignin amines as a bile acid adsorption agent. The invention has utility in medicine. 243598 4 IT) ti

Vynález sa týká prostriedku na adsorpcip žlčových kyselin. 5 > ’’The invention relates to a composition for the adsorption of bile acids. 5> ’’

Pri liečení hypercholesterolémie sa doteraz používajú dva druhy hypolipidemických liečiv subklasiíikované ako absorbovatelné a neabsorbovatelné v gastrointestinálnom trakte. Medzi neabsorbovatelné patria hlavně syntetické živice, ako například kopolymér styrénu a dlvinylbenzénu obsahujúci trimetylbenzylamóniové skupiny (cholestyramín) alebo kopolymér dietylpentamínu a epichlórhydrínu (colestipolj, ktoré sú specificky předurčené na viazanie žlčových kyselin v hrubom čreve. Účinok týchto látok sa prejavuje znižovaním hladiny cholesterolu v krvnom sére 1'udského organizmu urýchfovaním fekálnej exkrécie žlčových kyselin.To date, two types of hypolipidemic drugs have been used to treat hypercholesterolemia subclassified as absorbable and non-absorbable in the gastrointestinal tract. Non-absorbable mainly include synthetic resins, such as styrene copolymers and dvinylbenzene containing trimethylbenzylammonium groups (cholestyramine) or diethylpentamine-epichlorohydrin copolymers (colestipolj, which are specifically designed for bile acid binding in the colon). Human organism by accelerating the faecal excretion of bile acids.

Podstata vynálezu spočívá v použití vodonerozpustných kationoidných lignínových amínov ako prostriedku na adsorpciu žlčových kyselin. Výhodou připraveného nového adsorbenta žlčových kyselin je, že má dobrú adsorpcnú kapacitu na žlčové kyseliny pri pH 5,4 a pH 8,0 ako je pH tráviaceho traktu, jeho příprava je vel'mi jednoduchá, nenáročná na zariadenie a chemikálie a využívá odpadnú zložku drevnej hmoty. Výhodou je tiež, že rieši otázku likvidácie odpadu vznikajúceho pri hydrolýze dřeva alebo tiež pri hydrolýze jednoročných llgnifikovaných rastlín. Příklad 1The invention is based on the use of water-insoluble cationic lignin amines as a bile acid adsorption agent. The advantage of the prepared new bile acid adsorbent is that it has a good bile acid adsorption capacity at pH 5.4 and pH 8.0 such as the pH of the digestive tract, its preparation is very simple, low in equipment and chemicals and uses the wood waste component. mass. The advantage is also that it solves the problem of waste disposal resulting from the hydrolysis of wood or also in the hydrolysis of one-year-old lysed plants. Example 1

Adsorpčná kapacita vodonerozpustného kationoidného lignínového aminu, t. j. 0- (trimetylamónio-2-hydroxypr opyl) -lignínovej bázy (50 mg) připraveného zo smrekového dřeva sa stanoví „in vitro“ po pretrepaní počas 18 h s 5 ml 10 % hmot. roztoku sodnej soli kyseliny cholovej v pufri s pH 5,4 (připraveného zmiešaním 2,1 ml 0,2 mól roztoku hydrogénfosforečnanu dvojsodného s 96,9 ml 0,1 mól roztoku dihydrogénfosforečnanu sodného) spektrofotometricky po přidaní 4 ml 72 % hmot. kyseliny sírovej k 1 ml filtrátu. Adsorpčná kapacita pri pH 5,4 bola 89 %. Ďalej sa stanoví adsorpčná kapacita s po- užitím pufru s pH 8,0 (připraveného zmiešaním 94,5 ml 0,2 mól roztoku hydrogénfosforečnanu dvojsodného a 5,5 ml 0,1 mól roztoku dihydrogénfosforečnanu sodného], ktorá bola 81,0 % (I. Mosbach, K. Smid: Arch. Biochem. Biophys. 51, 402 /1954/}. Příklad 2The adsorption capacity of the water-insoluble cationic lignin amine, i.e. O- (trimethylammonium-2-hydroxypropyl) lignin base (50 mg) prepared from spruce wood is determined "in vitro" after shaking for 18 h with 5 ml 10% w / w. a solution of the sodium salt of cholic acid in a pH 5.4 buffer (prepared by mixing 2.1 ml of a 0.2 molar solution of disodium hydrogen phosphate with 96.9 ml of a 0.1 molar solution of sodium dihydrogen phosphate) spectrophotometrically after adding 4 ml of 72 wt. sulfuric acid to 1 ml of filtrate. The adsorption capacity at pH 5.4 was 89%. Further, the adsorption capacity was determined using a pH 8.0 buffer (prepared by mixing 94.5 ml of a 0.2 mol solution of disodium hydrogen phosphate and 5.5 ml of a 0.1 mol solution of sodium dihydrogen phosphate) which was 81.0% ( I. Mosbach, K. Smid: Arch. Biochem., Biophys., 51, 402 (1954)

Postupuje sa ako v příklade 1 s tým rozdielom, že sa použije vodonerozpustný katlonoidný lignínový amin, t. j. O-(trimetylamónio-2-hydroxypr opyl) -lignínová báza připravená zo slamy. Adsorpčná kapacita pri pH 5,4 bola 96 % a pri pH 8,0 bola 81 °/o.The procedure is as in Example 1 except that a water-insoluble lignin lignin amine, i.e. O- (trimethylammonium-2-hydroxypropyl) lignin base prepared from straw, is used. The adsorption capacity at pH 5.4 was 96% and at pH 8.0 it was 81%.

Použité vodonerozpustné kationoidné lignínové aminy, t. j. O-(trimetylamónio-2-hydroxypropylj-lignínové bázy v príkladoch 1 a 2 dostaneme nasledujúcim známým sposobom (I. A. Pearl: Tappi 52, 594 /1969/). Příklad 3 10 g vysokokondenzovaného ligninu připraveného hydrolýzou smrekového dřeva sa aktivuje počas 30 min pri teplote 20 °C s 20 ml 20 % hmot. roztoku hydroxidu sodného. Po přidaní 20 ml 50 % hmot. roztoku 2-hydroxy-3-chlórpropyltrimetylamónium chloridu vo vodě sa reakčná zmes zahrieva pri teplote 60 °C počas 4 h.The water-insoluble cationic lignin amines used, ie the O- (trimethylammonium-2-hydroxypropyl-lignin bases in Examples 1 and 2, are obtained by the following known method (IA Pearl: Tappi 52, 594 (1969)). with 20 ml of 20% by weight sodium hydroxide solution at 20 DEG C. After addition of 20 ml of a 50% by weight solution of 2-hydroxy-3-chloropropyltrimethylammonium chloride in water, the reaction mixture is heated at 60 DEG C. for 20 minutes. 4 h.

Zo vzniknutého reakčného produktu sa po zriedení s 500 ml vodou, odfiltruje nerozpustný podiel, ktorý sa premyje vodou až má premývacia voda pH 7,0. Po vysušení na vzduchu sa získalo 6,8 g vodonerozpustného kationoidného lignínového aminu, t. j. O- (trimetylamónio-2-hydroxypropyl) -lignínovej bázy. Příklad 4The resulting reaction product is diluted with 500 ml of water, filtered to remove insoluble matter, which is washed with water until the wash water has a pH of 7.0. After air-drying, 6.8 g of a water-insoluble cationic lignin amine, i.e. O- (trimethylammonium-2-hydroxypropyl) lignin base was obtained. Example 4

Postupuje sa ako v příklade 3 s tým rozdielom, že sa použije lignin připravený zo slamy. Získá sa 9 g vodonerozpustného kationoidného lignínového aminového derivátu, t. j. O-(trimetylamónio-2-hydroxypropylj-lignínovej bázy.The procedure is as in Example 3 except that lignin prepared from straw is used. 9 g of a water-insoluble cationic lignin amine derivative are obtained, i.e. O- (trimethylammonium-2-hydroxypropyl) lignin base.

Vynález može nájsť široké použitie v medicíně.The invention can be widely used in medicine.

Claims (1)

PREDMET VYNÁLEZUOBJECT OF THE INVENTION Použitie vodonerozpustných kationoidných lignínových amínov ako prostriedku na adsorpciu žlčových kyselin.Use of water-insoluble cationic lignin amines as a bile acid adsorption agent.
CS852358A 1985-04-01 1985-04-01 Bile acid adsorption agent CS243598B1 (en)

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CS243598B1 true CS243598B1 (en) 1986-06-12

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