CS246594B1 - Mechanically machinable bioactive glassy crystalline material - Google Patents

Abstract

The solution relates to a mechanically machinable bioactive glassy crystalline material, which can be used, for example, for prosthetics. The aim of the solution is to produce a biologically active material with excellent mechanical properties, in particular good mechanical machinability. This is achieved by subjecting a material with a mass composition of SiO 19 to 52%, Al 2 O 3 12 to 23%, MgO 5 to 15%, R 2 O 3 to 10%, CaO 9 to 30%, P 2 O 5 4 to 24% and P 0.5 to 7%, provided that R 2 O is the sum of 0 to 8%, Na 2 O and 0 to 8% K 2 O, to melting and heat treatment. The basic crystalline phases of crystalline glass are mica and apatite. -

Description

(54) Mechanically machinable bioactive glassy crystalline material The solution relates to a mechanically machinable bioactive glassy crystalline material, which can be used, for example, for prosthetics. The aim of the solution is to produce a biologically active material with excellent mechanical properties, in particular good mechanical machinability,

This is achieved by using a material with a SiO2 mass composition of 19 to 52%,

Al2O3 12 to 23%, MgO 5 to 15%, R2O 3 to 10%, CaO 9 to 30%, P2O5 4 to 24% and P- 0.5 to 7%, provided that RgO is the sum of 0 to 8%, Na2 0 and 0 to 8% K2O, are subjected to melting and heat treatment. The basic crystalline phases of crystalline glass are mica and apatite. 246 594

Ha3BaHHe_H3o6£ereHHH

MexáHHuecxH o6pa6aTbiBaeMt>tá ©ηοβκτηβηη CTeKJioxpHCTajuiHuecKHň MaTepnaji OŠnaCTh ΠρΗΜβΗβΗΗΗ Η3θ6ρβΤβΗΗΗ

H3o6peTeHne othochtch κ H3roTOBjieHHio MexaHHuecxH o6pa6aTbiBaeMoro CHoaxTHBHoro CTexjioKpHCTajiJiHuecxoro MaTepnajia.

npeflJiaraeMbiň cTexjioxpHCTanjiHuecKHň MaTepnaji MoaceT npuMeHHTbCH, β uacTHocτη, flJiH npoTesHpoBaHHH.

XapaxTepHCTHKa n3BecTHbix TexHHuecxHx pemeHnň

Kax H3BeCTHo, rHflpoxcHji-anaTHT u φτορβπβτκτ Caj./(P0 ₄ ) _á OH,F/ hbjihiotch rjiaBHbíMH KPHCTaJunreecxHMH (JiaaaMH b kocthx KHBOTHbix h uejioBeKa. C yyeTOM 3Toro HapHfly c ©SíocřexjiaMH h KepaMHuecKHMH MaTepnajiaMH 6μπη cosflaHbí CTexjioxpncTaJijnmecKne MaTepnajibi, κοτορωβ Sjíaroflapa cboìíctbhm. MoryT 6ητβ πρΗΜβΗβκω xax 3aMeHHiomHe kocth MaTepnaJibi. IlpoHcxoflHT · npnMoe coeflHHeHHe Meatfly kocthmh HMruiaHTupyeMbiM MaTepnajioM. KpucTajinbi anaTHTa hbjihiotch 3TOM. HcxoflHbíM nyHKTOM flJiH pereHepaflHH KOCTH.

B DT-OS 2818 630 h US-PS 4 103 002 onHcaHbí SHoJiornuecxH aKTHBHbie CTexjia h cTeKJioxpHCTaJiJiHflecKHe MaTepnaJibi, κοτορωβ MoacHo nojiyuHTh cncTeMbi Si0 ₄ B ₄ 0 ₃ -Na _a 0-Ca0-P ₄ 0 _s -F“. Πτοδω αο6ητβοη Bbicoxoň npouHoCTH Ha Η3Γη6 HMHJiaHTara, sth crexjia h cTexnoxpHCTaJinHuecxHe MaTepnaJibi πρΗΜβΗΗΐοτ β xauecTBe fijia MeTaJuiHnecxHX ciuiaBOB npoflyxTopoB. Cepbe3HbiM HeflocTaTKOM HBJíneTCH, OflHaKO KOHfleHTpaflHH OKCHflOB meJIOBHblX MeTaJIJIOB Β 3THX 0HoaXTHBHbIX CTexxiax h cTexjioxpHCTajuiHuecKHx MaTepnajiax. Ccbinancb na noflofíHbie cTexnoxpHCTajuiHHecxHe MaTepnajiH, aBTopu DT-AS 2 326 100 nojiaraioT, uto· cjihiukom BblCOKHe KOHIieHTpaflHH OKCHflOB mejIOUHblX MeTaJIJIOB B HMIUiaHTaTe H HBJIHKHUHeCH pe3yjibTaT0M 3τογο peaxflHH ηοηηογο oSMeHa μογυτ oxa3aTb oTpHpaTeJiBHoe fleft CTBHe Ha φγΗκιρίΗ HepBOB m Mbímfl b opraHH3Me uejioBexa h acHBOTHbix. C yueTOM npopeccoB ηοηηογο oSMeHa Meacfly 6HocTeKjioxpHCTajijiHuecxHMH MaTepnajiaMH h kocthmh ©buiH H3roTOBJieHbi β DT-AS 236 100 H3 SiO ₁ -MgO-Na ₁ OK _l O-CaO-P ₁ O _T -F CTexjloxpHCTaJUiHuecxHe MarepnaJiM #jih προτβ3ΗροΒ3ΗΗΗ, Coflepacanne okchaob mejiouHbix MeTajuioB 3βμθτηο yMeHbmeHO no cpaBHeHHw c hx coflepacaHneM β οπηcaHHbix b DT-OS 2818 630 MaTepnaJiax. Tax xax b ochobhoě xpHCTaJiJiHuecxoft φ33β ΒΟ3ΗΗΚΗΙ0Τ TOJIbKO anaTHTbl, HyaCHO OTMeTHTb, MTO STH HMnjiaTaUHOHHbie Ma* ArteryJibi oSjíaflawT iuioxhmh MexaHHMecxHMH CBoňcTBaMH, thkhmh, xax o6pa6aTWeaeMOCTb h npouHOCTb Ha η3γη6.

Οτ 3ΤΗΧ HenocTaTKOB ne yflanocb noJiHOCTbio H3ÓaBHTbCH h b DT-AS 2 349 859, KOTopwň HBJlHeTCH flonojiHeHHeM κ DT-AS 2 326 100. B coflepxamHx Φπογοπητ MexaHmecKH oópaóaTbiBaeMbix cTeKJioKpHCTajuiHnecKHX MaTepnaJiax, m, HanpMHep, Tex, κοτορωθ MoryT ÓbiTb nonyqeHbí, cornacno DT-AS 2133 652, DE-PS 113 885, DE-PS 132 332,DE-PS 153 108 HeBO3Mo»HO oflHOBpeMeHHoe BbiflejieHHe KpHCTajuioB anaTHTa h cjnoflHHbix ia3.

D,ejib H3o6peTeHHH

Uejib H3o6peTeHHH coctoht b tom, ητο6η npeononeTb oTCTaBaHHe b ypoBHe TexHHKH, yjiyHlUHB MexaHHHeCKHe CBOftCTBa ÓHOJIOrHHeCKH aKTHBHbIX CTeKJlOKpHCTaJUIH' necKHx MaTepnajioB.

H3JIO«eHHe CymHOCTH Η3θ6ρβΤβΗΗΗ

3aflana H30ópeTeHHH coctoht b tom, htoóh C03flaBaTb óHOJtorHnecKH aKTHBHbiň CTeKJioKpHCTajuiHnecKHH MaTepnaJi, κοτορωκ OTJiHnaeTCH oaeHb xopouihmh MexaHHnecKHMH CBoňcTBaMH, b qacTHocTH, oneHb xopoiueň MexaHHnecKoň oópaóaTbiBaeMOCTbKl.

CorjiacHO Η3ο6ρέτβΗΗΐο, 3το flocTHraeTCH τθμ, mto HcxoflHoe CTexjio cocTaBa (b Bec.Z)

_Si02 : 19-52 CaO: 9-30

A1 ₂ 0j: 12-23 Ρ _ζ 0 _? : 4-24

MgO: 5-15 F 0.5-7

RjO : 2-10 ,ΡΗ ycjiOBHH, mto RjO - cyMMa 0-8 Bec.%, Na ₂ 0 h 0 - 8 sec.ZK _z 0 noflBepraeTCH nocjie njiaBJíeHHH TepMHnecKoň oÓpaóoTKe.

CorjiacHO H3o6peTeHHio, HcxoflHoe cTeKjio njiaBHTCH b TeMnepaTypHOM HHTepBajie 1370°C - 1550°C h 3aTeM oxjiaxflaeTcn HHxe TeMnepaTypbi CTeKjioBaHHH hjih nóflBepraeTCH perympyeMoň KpHCTajuiHaaiiHH HenocpeflCTBeHHo H3 pacnjiaBa. Τορμοβ3ηηθ nepefl peryjiHpyeMoň KpHCTajuiHaaiiHeň μοχθτ ocymecTBJíHTbCH jih6o 3ajiHBKoň b φορΜγ (MoccoBbiH MaTepnaji), jihSo HaHeceHHeM b BHfle cjioh Ha 3aflanHoe Tejio (cjiohcthh MaTepnaji) . PeryjiHpyeMan KpHCTajuiH3aflHH ocymecTBJíneTCH πγτβΜ TepMHnecKoň oÓpaóoTKH HexoflHoro CTexjia oflHo- hjih MHorocTyneHqaTO b HHTepBane TeMnepaTyp ót 610°C flo 1050 C hjih oxjiaxfleHHeM pacnnaBa b HHTep— BaJie TeMnepaTyp 1000-500.

B pe3yjibTaTe TepMooópaóoTKH Henonb3yeMoro b H3o6peTeHHe HexoflHoro CTeKJia HeoxHflaHHo 6bmo HaňfleHo c noMombio ρθΗΤΓβΗΟΑΗφφρβκιΐΗΟΗΗΟΓο MeTOfla, a TaKxe c noMombio 3JieKTpoHHoň ΜΗκροοκοπΗΗ, mto HapHfly c KpHCTajuiaMH anaTHTa fly BbI3BaTb BblfleJieHHe KpHCTaJIJIHHeCKHX φ33 CJHOflbl.

B 33BHCHM0CTH OT COCTaBa B TepMOOÓpaÓOTKH, a Taxxe B 3aBHCHMOCTH OT yCJIOBHň njiaBJíeHHH HexoflHoro cTexjia b cTpyKType cTeKJiOKpHCTajuiHnecKoro MaTepnana Μοχετ flOMHHHpoBaTb anaTHT hjih cjiiofla (φτοφηοΓοηκτ KajiHH—h3tphh) . KpHCTaJiJiw MoryT cocTaBJíHTb flo 90% ot oómero oÓteMa, npn 3tom bo3Moxho, mto HapHfly co cjiioflOH h anaTHTOM βο3ηηκηκ)τ h flpyrHe KpHCTaJiJiHwecKHe φβ3Η, HanpHMep, aHopTHT.

PeryjiHpoBaHHe npoflecca KpHCTajuiH3aflHH HexoflHoro CTexjia c yejibio nojiyqeHHH npeflJiaraeMoro CTeKJioKpHCTaJiJiHqecKoro Marepnajia npeflnonaraeT 3H3HHe npofleccob o6pa3OBaHHH MHKpocTpyxTypbi b cTexjiax. Kax H3BecTHo, jiynine Bcero yflaeTch peryjiHpoBaTb npoiiecc KpHCTaJiJiH3aflHH, OKa3biBaa uejieHanpaBJíeHHoe BJiHHHHe Ha jiHKBaflHio cTeKJia. CoraacHo H3o6peTeHHio, BbmejieHne xpucrajuioB b CTeK— ne npoHexoflHT TaKHM o6pa3OM, mto ohh pacTyT H3 BoraTbix Ca ^l+ -P 0 _? -F" Kanjieoópa3Hbix oójiacTeň jihkbhiihh. . Tax, xaK oSbeMHan aojih, mhcjio h pa3Mep 3THX oÓjiacTeň JiHKBamiH μοχθτ peryjiHpoBaTbcn b 33bhchmocth ot xHMHMecKoro cocTaBa, ycjioBMň nnaBJíBHHH η τθρμηηθοκοη oópaóoTKH, μοχηο peryjiHpoBaTb

H ofíteMHy» flOJHO, ΒβΠΗΗΗΗγ KpHCTaJIJIQB H CTeneHb CUIHBKH anaTHTOBOň φβ3Μ. Hapnfly c KpHCTajiJiHaaipíeň anaTHTa Ηββτ o6pa3OBaHHe KpHCTajuioB φποΓοπκτβ h ΤβΜ CaMblM GO3flaeTCH OCHOBa flJIH HOBblX KOMČHHaflHň CBOŮCTB (ΜβΧβΗΗΜββΚβΗ θ6pafíaTbiBaeMocTb η ΟκοηοΓΗΗβκβΗ aKTHBHocTb).

Bjiaroflapfl npeHMymecTBeHHOMy pacmenjieHH» φποτοπΗΤβ b iijiockocth 001 oGecneMHBaeTCH xopomafl ofípafíaTbiBaeMocTb npefljiaraeMoro βτβκίΐοκρΗβτβπΗΜβεκοΓΟ MaTepHana, a anaTHT HBJIHeTCH npeflnocbinxoň GHonorHMecKofl ηκτιβηοοτη.

ΠρΗΜβρΜ BbinOJIHeHHH

B TaGnHfle Γ npHBOflflTca xHMHuecxHe cocTaBbi (b bbc.7.) npefljiaraeMbix CTeKOJi h cTeKJioKpucTajuiHHecKHx MaTepHanoB.

Ha TaGjiHflbí 2 BHflHa CB»3b Mexfly XHMHMecKHM cocTaBOM, TepMHMecxoň oGpaGoTKoň H KpHCTajIJIHMeCKHMH φβ33ΜΗ. ΤβΜ CaMblM CTaHOBHTCH OMeBHflHhlM peryjIHpOB8HHe MexaHHSMa KpHCTanjiHsaiptH, KpHCTajinbi anaTHTa, κοτορωβ b TaCnnue 2 oGoaHaneHbi xax anaTHTosafl cMemaHHan φ833 coctoht, b ochobhom, hs φτορο- H thapokcm nanaTHTa. KpHCTajuíM cjiroflbí npeflCTaBJíflioT coGoň φτοροφποΓοπκτ ηβτρηη—xajiHfl · MexaHHnecKHe CBoňcTBa 3βμθτηο 3Ββηοητ ot BbiflejiH»mnxcH KpHCTannHnecKHX φβ3. Pe3ynbTaTOM oflHOBpeMeHHoň KpHCTajuiH3aflHH φποΓοπΗΤβ h anaTHTa η, βοοτΒβτcTBeHHo, Φπογοπητ3, anaTHTa h aHopTHTa HBJIHeTCH xopomafl MexaHHqecKaH oGpaČaTbiBaeMocTb. C yMeHbmeHHeM bojih φποΓοπΗΤβ MexaHHMecKaH oGpaGaTbiBaeMocTb yxyflmaeTCH. Ορ,ΗΟΒρβΜβΗΗο noBbímaeTCH nponHocTb Ha Η3ΓΗ6 cTeKJioKpHCTannHMeckογο MaTepHana h flocTHraeT 3Η3Μ6ηηη 220 ΜΠΑ, xax bhaho hs Τ36πηβμ 3.

TaGjiHfla 1

1 2 3 4 5 6 7. 8 Si0 ₄ 37.3 41.5 33.8 36.0 34.8 35.2 19.4 30.3 AljO, 20.8 23.1 18.8 20.0 21.9 19.6 12.2 17.0 MgO 9.0 10.0 8.1 10.9 8.3 8.4 5,’2 15.0 The best 2.5 2.7 2.2 2.3 - 2.3 2.0 2.2 To ₂ 0 4.0 4.5 . 7.7 3.9 7.8 3.8 2.0 6.0 F 2.9 1.8 2.5 4.9 3.2 2.6 6.6 4.5 CaO 12.6 9.3 15.4 12.5 13.8 16.0 29.9 14.3 P _and 0 _S 11.0 7.1 11.5 9.5 10.1 12.0 23.6 10.7 9 10 11 12 13 14 15 Si0 ₄ 36.9 32.9 51.3 31.6 34.7 34.4 34.0 AljOj 20.4 18.3 16.3 19.7 19.5 22.1 19.0 MgO 8.9 7.9 7.4 13.8 8.4 8.4 11.0 Na ₂ O 1.2 2.1 3.2 0.9 2.2 7.8 2.2

ripoflonxeHHe TaOJi.l

1 2 3 4 5 6 7 To ₄ o 1.0 3.5 4.3 6.8 3.7 - 3.6 F 2.7 2.5 1.6 3.2 3.5 3.2 5.0 CaO 16.5 18.7 9.5 13.9 16.0 13.9 13.2 This is 2 12.4 14.1 6.4 10.1 12.0 10.1 12.0 Time IP Ρθχημ t,°c: Temperature T, M KpucTajuiHMecKaH

2 q πρκ 1000°C anaTHTOBan CMemaHHaH <Jja— 3a Φπογοπητ anopTHT 1 q πρκ 1000°C anaTHTOBaa CMemaHHaH φβ- a a Φπογοπητ 5 q npn 6l0*C anaTHTOBaa CMemaHHaH φβ38 1 q npn 1000°C Φπογοπητ 0.5 q npw 1000°C anaTHTOBan CMemaHHaH φΒ33 Φπογοπητ 3ΗθρΤΗΤ 1 q npn 1050°C anaTHTOBan CMemaHHaH φβ3β 5 q npn 680°C anaTHTOBaH CMemaHHaH φβ38 5 m npn 900 ^e C Φπογοπητ KOHTpoJiHpyeMoe oxnaxne- anaTHTOBaH CMemaHHaH φθ3Β Hne b HH-pe τ-ρ Φπογοπητ aHOpTHT 1 q npn 1000°C anaTHTOBaH CMemaHHaH φ83β Φπογοπητ 1 q πρκ 1000 ^e C anaTHTOBaH CMemaHHaH φβ3β Φπογοπητ 1 q npH 850°C anaTHTOBaH CMemaHHaH φβ33 Φπογοπητ 3Η0ρΤΗΤ

TaGnHfla 3

Otek,po, N’

KpHCTajuiHMecKHe <J>a3bi

MexaHHnecKaH o6pa6aTbiBaeMOCTb

IlpOMHOCTb Ha Η3ΓΗ6 MPA

4 anaTHTóBaa 4>asa φηοΓοπΗτ ΗΗΟρΤΗΤ xopoman 5 anaTHTosaa CMemaHHaH 4>a3a φηοΓΟΠΗτ xopomaH 140 8 anaTHTOBafl CMemaHHaH φβ3β φΠΟΓΟΠΗΤ oneHb xopoman 160 11 anaTHTOBaa CMemaHHaH φ333 φΠΟΓΟΠΗΤ xopoman 110 13 anaTHTOBan CMemaHHaH φ33β φΠΟΓΟΠΗΤ aHOpTHT' flOCTaTOMHO xopoman 220 15 anaTHTOBan CMemaHHaH φβ38 φΠΟΓΟΠΗΤ “aHOpTHT xopoman 30

3a«BKa Ha οτκρυτκβ

MexaHHqecKH 06pa6aTbiBaeMan GHoaKTHBHan cTeKJioKepaMHxa xapaKTepHayeTCH τβΜ mto oHa coctoht H3 Marepnana cnenyioinero cocTaBa (b Mace,Z)

Si0 ₂ 19-52 Al,0, 12-23 MgO 5-15 r ₂ o 3-10 CaO 9-3< P ₂ 0, 4-2' F 0.5-7

npH yenoBHH, mto R ₂ 0 HBJíHeTcs cyMMoň H3 0-8 Mace.Z h 0-8 Mace.Z KjO H mto TBepflbiň pacTBop coflepxHT KpHCTannbi H3 anaTHTa h cnioflbí hjih H3 anaTHTa, cnwflbí h aHopTHTa.

Pe3ioMe

KaočpeTeHne othochtch κ Η3Γοτοβπθηηιο MexaHHnecKH o6pa6aTbiBaeMoro 6ηο8κτηβηογο CTeKHOKpHCTajuiHqecKoro MaTepnana, KOTopwň μοχθτ npHMeHHTbcn, b nacTHOCTH, fina ΠρθΤΘΗρθΒ3ΗΗΗ . Renb H306peTeHHH COCTOHT B TOM, HTO6bI nonyqHTb ĎHOnorHMeCKH aKTHBHbM CT6KJlOKpHCTaHJIHqeCKHň Μ3ΤβρΗ3Η C OMeHb XOpOtlIHMH ΜΘxaHHMecKHMH CBoňcTBaMH. 3aflana coctoht b tom, μτο6μ nonynHTb óHonorHqecKH aKTHBHbiň cTeKjioKpHCTaruiHqecKHň MaTepHan c ocoóeHHo xopomeň MexaHHnecKoň o6pa6aTbiBaeMOCTbro. '

3to flocTHraeTCH τβΜ, ητο HexoflHoe CTexno cocTaBa (b eec.X) SiO ₂ 19-52; Al _t Oj 12-23;; MgO 5-15; RjO 2-10; CaO 9-30; P ₂ 0 _? 4-24; F 0.5-7 npH ycno bhh, hto Ø _a 0 npeflCTaBJíHeT coóoň cyMMy 0-8 eec.Z Na ₂ 0 h 0 - 8 Bec.ZK ₄ 0 noflBepraeTCH nocne nnaBneHHH TepMunecHorse oGpaGoTKe. Ochóbhmmh xpHCTannHnec khmh φβ33ΜΗ CTeKnoKpHCTannHnecKoro MaTepHana hbhhiotch cntofla h anaTHT.

ΠρΗ3ΗβΗ0 H3o6peTeHHeM no pe3ynbTaTaM 3KcnepTH3M, ocymecTBneHHoff ÉeflOMCTBOM no nenaM Η3θ6ρετεΗΗΗ η πβτβΗτοβ ΓβΡ.

Claims (1)

OF THE INVENTION A mechanically machinable bioactive glassy crystalline material, characterized in that it consists of: concentration of 19 to 52% Al _n O, "cp V magnesium oxide MgO in sodium and / or potassium R ^ O in calcium oxide CaO in phosphorus pentoxide ^v and fluoride F" in wt. concentration 12 to 25 % wt. concentration 5 to 15 Dec % wt. concentration 5 in az 10 % wt. concentration 9 in az 50 % wt. concentration 4 to 24 % wt. concentration O, , 5 i to < ? % with the proviso that the maximum weight concentration of the individual potassium and sodium oxides Na ₂ O is 8%, wherein the solid solution comprises apatite and mica crystals or apatite, mica and anotite.