CS242023B1 - Anilide of 3-benzylsalicylic acid - Google Patents
Anilide of 3-benzylsalicylic acid Download PDFInfo
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- CS242023B1 CS242023B1 CS847796A CS779684A CS242023B1 CS 242023 B1 CS242023 B1 CS 242023B1 CS 847796 A CS847796 A CS 847796A CS 779684 A CS779684 A CS 779684A CS 242023 B1 CS242023 B1 CS 242023B1
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Abstract
Anilid kyseliny 3-benzylsalicylové vzorce I Způsob jeho přípravy spočívá v reakci kyseliny 3-benzylsalicylové s anilinem v xylenu za přítomnosti fosfortrichloridu za zvýšené teploty. Tato nová, dosud nepopsaná látka vykazuje anthelmintickou účinnost proti modelovému helmintu Aspiculuris tetraptera.3-Benzylsalicylic acid anilide AND The method of its preparation lies in the reaction 3-benzylsalicylic acid with aniline v xylene in the presence of phosphorothrichloride elevated temperature. This new, not yet described substance shows anthelmintic activity against model helmint Aspiculuris tetraptera.
Description
(54 J Anilid kyseliny 3-benzylsalicylové(54 J 3-Benzylsalicylic acid anilide
22
Anilid kyseliny 3-benzylsalicylové vzorce I3-Benzylsalicylic anilide of formula I
Způsob jeho přípravy spočívá v reakci kyseliny 3-benzylsalicylové s anilinem v xylenu za přítomnosti fosfortrichloridu za zvýšené teploty.A process for its preparation consists in reacting 3-benzylsalicylic acid with aniline in xylene in the presence of phosphoricrichloride at elevated temperature.
Tato nová, dosud nepopsaná látka vykazuje anthelmintickou účinnost proti modelovému helmintu Aspiculuris tetraptera.This novel, yet undescribed substance exhibits anthelmintic activity against a model helminth of Aspiculuris tetraptera.
Vynález se týká anilidu kyseliny 3-benzylsalicylové vzorce IThe invention relates to a 3-benzylsalicylic acid anilide of the formula I
OHOH
Tato nová, dosud nepopsaná, sloučenina vykazuje použitelnou anthelmintickou účinnost, zejména proti modelovému helmintu Aspiculuris tetraptera.This novel, yet undescribed, compound exhibits useful anthelmintic activity, particularly against the Aspiculuris tetraptera model helminth.
Sloučeninu vzorce I lze podle vynálezu připravit reakcí o sobě známé kyseliny 3-benzylsalicylové (US pat. č. 2 042 343) s anilinem v přítomnosti fosfortrichloridu v prostředí inertního rozpouštědla za zvýšené teploty, výhodně s 0,35 molárním množstvím fosfortrichloridu v xylenu při teplotě 130 až 140 °C.The compound of formula (I) according to the invention can be prepared by reacting the known 3-benzylsalicylic acid (US Pat. No. 2,042,343) with aniline in the presence of phosphfortrichloride in an inert solvent at elevated temperature, preferably with 0.35 molar amount of phosphfortrichloride in xylene at 130-140 ° C.
Hodnocení antheímintické účinnosti proti modelovému helmintu Aspiculuris tetrapteraEvaluation of antheímintic efficacy against Aspiculuris tetraptera model helminth
Pokusy byly provedeny na myších samcích kmene SPF/Velaz s hmotností 18 až 20 gramů ve skupinách po 3 kusech. Myši by-The experiments were performed on male SPF / Velaz mice weighing 18-20 grams in groups of 3 pieces each. Mice were-
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS847796A CS242023B1 (en) | 1984-10-12 | 1984-10-12 | Anilide of 3-benzylsalicylic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CS847796A CS242023B1 (en) | 1984-10-12 | 1984-10-12 | Anilide of 3-benzylsalicylic acid |
Publications (2)
Publication Number | Publication Date |
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CS779684A1 CS779684A1 (en) | 1985-08-15 |
CS242023B1 true CS242023B1 (en) | 1986-04-17 |
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Application Number | Title | Priority Date | Filing Date |
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CS847796A CS242023B1 (en) | 1984-10-12 | 1984-10-12 | Anilide of 3-benzylsalicylic acid |
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CS (1) | CS242023B1 (en) |
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1984
- 1984-10-12 CS CS847796A patent/CS242023B1/en unknown
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CS779684A1 (en) | 1985-08-15 |
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