CS234079B1 - Desinfecting agent and/or component - Google Patents

Abstract

Disinfectant and / or disinfectant the component is based on phenols or formula C6H5CH / CH3 / CgH40M in which Μ = H, Na, K, NH 4, wherein the position of the arylalkyl group on phenol or phenol is in position 2 or 4. Has a significantly higher disinfectant effect as cresol (cresol) and yet practically does not smell. The active substance may be for example, by arylalkylation of phenol styrene and is used organic intermediate.

Description

TECHNICAL FIELD The present invention relates to a technically relatively effective, yet practically odorless disinfectant or disinfectant component with antibacterial, anti-bacterial, and ticqua Inca action properties suitable for coarse and fine disinfection, as well as for the stabilization and sterilization of products, articles and devices »

It is known that in order to prevent infectious diseases as well as to eradicate infection! It is also important in public and private sanitary facilities, when using textiles, especially based on synthetic fibers, which cannot be sterilized * at high temperatures under pressure or even as cotton fabrics · Disinfection room , where patients with reduced resistance to infections are hospitalized, as well as in cases where the medical staff is increasingly at risk of disinfection! medical equipment and, last but not least, in veterinary medicine and livestock production with mass-scale livestock, where there is a danger of various epidemics.

For these purposes, the benzylphenols and benzylphenollates of alkali (metal alcohols, dibenzylphenols, optionally in admixture with phenol / US Patents 150 889, 152 180 and 183 478) and other phenol derivatives are suitable for this purpose. 5/1972 / $

- 3,234,079

Schmidt B .: Pharm. Ind. 36 »no. 3, 179 (1974)], but a relatively large number of technological steps are required for their manufacture. An effective disinfectant for textiles, leather, wood, paper and paints is pentachlorophenol laurate, o-phenylphenol, methyl p-hydroxybenzoate, cresols, halogenated phenols Jindner K .: Tenside-Textilhilfsmittel Waschrohstoffe, Wissenschaftiche Verlagsgesselschaft 19 published pat. 2,211,266. The disadvantage of many of them is an unpleasant odor or undesirable. side effects. A much more readily obtainable yet efficient and practically odorless and without side-effect is a disinfectant of the present invention.

The disinfectant and / or component based on alkali metal phenols and / or phenolates and / or ammonium phenolates is characterized in that the active ingredient is methylbenzylphenol of the formula C 8 H 9 CHCl 2 CH 3 CH 4 OM wherein '11 is hydrogen, sodium, potassium and NH4. wherein the position of the arylalkyl group on the phenol and / or the phenolate is in the 2 or 4 position or mixtures thereof.

The advantage of the disinfectant or component of the present invention in addition to its high disinfectant efficiency is its technical availability as the compounds of the general formula

C 8 H 9 CHCCH 3 C 8 H 9 OM are an intermediate of the production of known antioxidants, produced for example by arylalkylation of phenol with styrene [przem. Chémiczny 56. 530 - 532/1977 /] · Easy handling and storage.

The compounds of the general formula C8H4CH3CH3CH3CH3O are mainly products of arylalkylation of phenol with styrene, most often under the catalytic action of sulfuric acid. They are usually a mixture of 1-phenyl-1- (4-hydroxyphenyl) ethane.

with 1-phenyl-1- (2-hydroxyphenyl) ethane

CH.

I

C

I

H

OH

4,234,079 is added with the admixtures of [beta] -phenoxy-1-phenylethane

These are liquid at room temperature and can be converted into the corresponding phenolates by alkaline earth hydroxides, usually in the form of powders or solutions, whether aqueous or alcoholic, whether they are mixtures or individual substances · The corresponding ammonium phenolate is mainly obtained by ammonia ·

The disinfectant is applied as such, i.e. in the form of the active substance itself, but it is preferable to apply it in the form of solutions. · In the case of organic solvents the form of the active substance or substances with free hydroxyl groups is more suitable; apply * active ingredients in the form of phenolates * disinfectant can also be applied * by spraying, evaporating, sprinkling and

The disinfectant according to the invention can also be a component of known disinfectants, detergents (soaps, washing powders), emulsion stabilizers, dispersions, paints and the like. It can be applied in a single or multiple manner. Depending on the intended application of the disinfectant, it is most often in the range of 0.01 to 20% by weight. The effectiveness of the disinfectant as well as the application possibilities are apparent from the examples.

Example 1

From the product by arylalkylation of phenol with phenylene at 80 ° C and with the catalytic effect of sulfuric acid, after washing the sulfuric acid residues, a mixture consisting of 12% rel · 1-phenyl-1- (2-hydroxyphenyl) ethane of tl is isolated as a disinfectant or component. · 135 ° C / 2.7 Pa, 86% rel · 1-phenyl-1- (4-hydroxyphenyl) ethane of 150 ° C / 267 Pa and 1.5% rel · 1-phenoxy-1-phenylethane 115 ° C / 2.7 Pa, The appropriate sodium phenolates are prepared in the form of an aqueous solution at a concentration

- 5 234 079% by weight of active substance. Aqueous solutions of concentrations of 1, 2.5 and 5% are used for the experiments and, for comparison, tricresol (cresolum detergents) and sodium cumylphenolate · Efficiency is expressed as the value of minimum inhibitory concentration (MIC) in the active substance per ml of medium. have a strong basic character, a modified method is used to add the inoculum of organisms and a certain concentration of the substance to the prepared warm (42 ° C) agar. This is poured onto an agar layer on a Petri dish * After 24 and 48 hours of cultivation, the experiment is evaluated · The effect is that the cells do not grow and remain sterile · The last agar plate, which is sterile in a series of dilutions, is the last concentration with inhibitory effect . The MIC values of three disinfectants (in µg / ml) per 15 strains are shown in Table 1.

/ '

J

The results in the table show that the bacteriostatic and fungiostatic effects of cresol are relatively insignificant, but the disinfectant effects of the mixture of 1-phenyl-1/4-hydroxyphenyl / ethane with 1-phenyl-1/2-hydroxyphenyl / ethane high. The most suitable concentrations of lumen phenol and said mixture are 2 to 5

- 6 Table 1

MIC values of three disinfectants. (In ug / ml)

234 079

Kinen Disinfectant cresol · 1-phenyl- - (4-hydroxyphenyl) ethane with 1-phenyl-1- (2-hydroxyphenyl) ethane kumyl- fenůl bacteria Pseudomonas aeruginosa 320 100 100 Proteus mirabilis 500 250 250 Proteus vulgaris 500 300 250 Escherichia ooli 320 62 62 Staphylococus epidemic > 500 500 500 Bacillus subtilis 135 32 32 Bacillus cereus 500 150 500 Staphylococus aureus 320. 125 175 Sarcina lutea > 500 200 175 Yeast and mold Candida albicans > 500 125 150 Sacaromyces cerevisiae 500 125 75 Candida crusei 320 20 75 Candida pseudotropicalis 320 20 50 Trichophyto rubrum 500 50 50 Trichophyton mentagrophytes 320 40 40 J

.Example 2

The primary effect of the three investigated disinfectants described in Example 1 in a model trial for the evaluation of growth curves of a susceptible Candida albicans strain is monitored. Experimentally demonstrated fungicidal activity, expressed in MIC (cg / ml) against Candida albicans strain tested

234 079 is like this! cresol and 2500; a mixture of 1-phenyl-1 (2-hydroxyphenyl) ethane with 1-phenyl-1 (4-hydroxyphenyl) ethane 125 and cumylphenol 150.

The culture of this isolate (control and experiment) is carried out under submerged conditions on a reciprocating shaker (100 oscillations.mm ”) at a temperature of 28 ° C in culture flasks containing 100 ml of the following composition: glucose = 10 g; Yeast extract = 2.0 g ; dest. water = 1000 ml. Then 100 ml of the medium is inoculated with 2 ml of an aqueous suspension of the strain, diluted to an OD value of 0.1 (spectrophotometer sintered, γ = 560 nm). After 8 hours of submerged culture, 100, 150, 200, 500 disinfectants are added to the growing culture in each culture flask.

1000 7 g / ml medium.

Experiments in the model system confirm that the preparations of cumylphenol and a mixture of 1-phenyl-1 (U-hydrophenyl) ethane with 1-phenyl-1 (2-hydroxyphenyl) ethane are significantly more effective than cresol, and said mixture is considerably more effective than cumylphenol (also mixture of 4-cumylphenol with 2-cumylphenol

Claims (1)

Disinfectant and / or component based on phenols and / or phenolates of alkali metals and / or ammonium phenolates, characterized in that the active ingredient is methylbenzylphenol of the general formula Cgft ^ CHCCH2JCgH2 OM, in which M is hydrogen, sodium, potassium and a group wherein the position of the arylalkyl group on the phenol and / or the phenolate is in the 2 or 4 position or a mixture thereof. Printed by Moravian Printing Works, Price: CZK 2,40 with operation 12, Leninova 21, Olomouc