CS234079B1

CS234079B1 - Disinfectant and / or component

Info

Publication number: CS234079B1
Application number: CS917683A
Authority: CS
Inventors: Vendelin Macho; Ludovit Jurecek; Rudolf Kosalko; Jan Masek; Jan Sipos; Ladislav Novak; Ladislav Komora
Original assignee: Vendelin Macho; Ludovit Jurecek; Rudolf Kosalko; Jan Masek; Jan Sipos; Ladislav Novak; Ladislav Komora
Priority date: 1983-12-08
Filing date: 1983-12-08
Publication date: 1985-03-14

Abstract

Dozinfekčný prostriedok a/alebo dezinfekčný komponent je na báze fenolov alebo obecného vzorca C6H5CH/CH3/CgH40M, v ktorom Μ = H, Na, K, NH^, pričom poloha arylalkylskupiny na fenole alebo fenolá.te je v polohe 2 alebo 4. Má výrazné vyšší dezinfokčný účinok ako krezol (krezoláty) a přitom prakticky nezapáchá. Učinnú látku možno připravit například arylalkyláciou fenolu styrénom a je používaným organickým medziproduktom.The disinfectant and/or disinfectant component is based on phenols or the general formula C6H5CH/CH3/CgH40M, in which Μ = H, Na, K, NH^, with the position of the arylalkyl group on the phenol or phenolate being in position 2 or 4. It has a significantly higher disinfectant effect than cresol (cresolates) and is practically odorless. The active substance can be prepared, for example, by arylalkylation of phenol with styrene and is an organic intermediate used.

Description

234 079

BACKGROUND OF THE INVENTION The present invention relates to a technically relatively readily available, effective, yet almost odorless, antibacterial or antimicrobial disinfectant component suitable for coarse disinfection, as well as for the stabilization and sterilization of articles, articles. and equipment ·

It is known that harmless disinfectants are effective in the prevention of infectious diseases as well as in the eradication of outbreaks. Such is important in public and private sanitary facilities, in the use of textiles, especially synthetic fibers, which cannot be sterilized. pressurized and even as cotton fabrics · Salmon for disinfection and non-nontime treatment where patients with reduced infection resistance are hospitalized as well as in cases where medical personnel are at increased risk for disintegration! medical equipment and, last but not least, in veterinary medicine and livestock production with a large number of animal husbandry where there is a risk of rash epidemics ·

For this purpose, benzylphenols and benzylphenates alka- (alkali metal, dibenzylphenols, optionally in addition to the phenomena / patents 150 889, 152 180 and 183 478) and other phenolic derivatives of Spaulding E. J, Hosp · Res, J ?, 5/1972 / $ - 3 - 234,079

Schmidt B .: Pharm. Indian. 36, No. 3, 179 (1974)], but quite a number of technological steps are needed to produce them. An effective disinfectant for textiles, leather, wood, paper and paints is pentachlorophenol laurate, o-phenylphenol, methyl-p-hydroxybenzoate, cresols, halogenated phenols, as follows: Tenside - Textilhilfsmittel Waschrohstoffe, Wissenschaftiche Verlags-gesselschaft MBH - Stuttgart / 1971 / j. 2,111,266. The disadvantage of many of them is unpleasant odor or unwanted. side effects. Much more technically feasible and yet effective and practically odorless and less damaging negative effects are the disinfectant of the present invention.

The alkali metal phenol and / or phenolic phenolate disinfectant and / or anionic phenolate consists in that the active ingredient is a methylbenzylphenol of the formula C 8 H 11 CHCl 2 CH 2 OH, in which M is hydrogen, so- wherein the position of the arylalkyl group of naphenol and / or phenolate is in the 2 or 4 position or a mixture thereof. The advantage of the disinfectant or component of the present invention, in addition to the high disinfection efficiency, is the technical availability, or the compounds of the formula

C8H6CHCCH2C8H4O4 are the intermediates for the preparation of known antioxidants produced, for example, by arylalkylation of phenol with styrene [przema]. Chémiczny 56. 530-532 / 1977 /] · Easy to manipulate and store.

In particular, the compounds of the formula C 8 H 11 CH 2 CH 2 C 6 H 6 OM represent the products of arylalkylation of phenol by styrene, most often under the catalytic effect of sulfuric acid.

with 1-phenyl-1 (2-hydroxyphenyl) ethane CH.

AND

C

AND

H

OH

- 234 079 with 1-phenoxy-1-phenylethane

These are liquid at room temperature, and may be mixed or individually converted to the corresponding phenolates, the alkaline earth metal hydroxides, most often in the form of dusts or solutions, whether aqueous or alcoholic. The particular ammonium phenolate is mainly obtained by the action of ammonia.

The disinfectant is applied as such, i.e. in the form of the active substance itself, but it is more convenient to apply it as a solution. In the case of the use of organic solvents, the more active form or substances with free hydroxyl groups is more suitable, in the case of application in the form of aqueous ones. it is preferable to apply the active ingredients in the form of phenolates * The disinfectant can also be applied by spraying, evaporating, scattering, and the like.

The disinfectant of the present invention may also be a component of known disinfectants, saliva / soaps, laundry powders / stabilizers, emulsions, dispersions, coatings, and can be applied in a single or multi-dose manner. depending on the anticipated application of the disinfectant, it is most commonly in the range of 0.01 to 20% by weight. The efficacy of the disinfectant as well as the application possibilities are apparent from the examples. EXAMPLE 1 A product consisting of 12% rel-1-phenyl-1- (2) is isolated as a disinfection agent or component from the product of arylalkylation of phenol by sphyrene at 80 ° C and the catalytic action of sulfuric acid after washing off the sulfuric acid residues. -Hydroxyphenyl / ethane with a pH of 135 ° C / 2 · 7 Pa, 86% of rel. Phenoxy-1-phenylethane of 115 ° C / 2/7 Pa Pa. The appropriate sodium phenolates in the form of an aqueous solution of - 5 - 234,079 15% by weight of the active ingredient are prepared. , 2.5 and 5%, and for comparison tricreol / cresol detergent / and sodium cumylphenolate · The potency is expressed by the minimum inhibitory concentration / MIC / v of the active ingredient per ml of medium. modifying the method by which the inoculum is added to the prepared warm (42 ° C) agar organisms and certain concentration of the substance. This is poured onto an agar layer on a Petri dish. After 24 and 48 hours of culture, the sample is evaluated for the effect that the cells do not grow valid. The last agar plate sterile in the dilution series is the last concentration with inhibitory effect. The MIC values for the three disinfectant pre / v. g / ml / per 15 stem are in Table 1 · /

The results in the table show that the bacteriostatic and func- tional effects of cresol are relatively insignificant, but the disinfectant effects of the 1-phenyl-1/4-hydroxyphenyl / ethane-1-phenyl-1-hydroxyphenyl / ethane mixture as well as the cutaneous lphenol are relatively high · The most appropriate concentration of the lphenol kunty and said mixture are 2-5-5 -

Table 1

MIC values of three disinfectants (in µg / ml) 234,079

Cine Disinfectant cresol · 1-Phenyl-4-hydroxy-phenyl-1-phenyl-1 (2-hydroxyphenyl) ethane cumylphenol bacterium Pseudomonas aeruginosa 320 100 100 Proteus mirabilis 500 250 250 Proteus vulgaris 500 300 250 Escherichia coli 320 62 62 Staphylococcus epidemic> 500 500 500 Bacillus subtilis 135 32 32 Bacillus cereus 500 150 500 Staphylococus aureus 320 125 125 Sarcina lutea> 500 200 175 Yeast and mold Candida albicans> 500 125 150 Sacaromyces cerevisiae 500 125 75 Candida crusei 320 20 75 Candida pseudotropicalis 320 20 50 Trichophyto rubrum 500 50 50 Trichophyton mentagrophytes 320 40 40 J.

The primary effect of the three disinfectants studied, characterized in Example 1 in the model evaluation of growth curves of a sensitive strain of Candidaalbicans, is monitored. Experimentally proven fungicidal efficacy, expressed in MIC (vycg / ml), against the candidate strain Candida albicans 234 079-7 is such! cresol and 2500; 1-phenyl-1-2-hydroxyphenyl / ethane 1-phenyl-1-4-hydroxyphenyl / ethane 125 and cumylphenol 150.

Cultivation of this isolate / control and experimentation is carried out under sub-standard conditions on a reciprocating shaker / 100 oscillations / milliseconds at 28 ° C in culture flasks containing 100 ml of this compound: glucose = 10g; "Yeast" extract = 2 , 0 g; water = 1000 ml. Thereafter, 100 ml of medium is inoculated with 2 ml of an aqueous suspension of the strain, diluted to OD = 0.1 / spectrophotometer, s = 560 [mu] m. After 8 hours of submerged culture in a growing culture into individual culture flasks, 100, 150, 200, 500 and 1000 7 g / ml media are added disinfectively. 6

Experiments in the model system confirm that cumyl phenol and 1-phenyl-1-U-hydrophenyl / ethane with 1-phenyl-1-2-hydroxyphenyl / ethane are more potent than cresol and the mixture is more effective than cumylphenol / also a mixture of 2-ethylphenol 2-cumylphenol / ·

Claims

Disinfectant and / or component based on phenols and / or phenolates of alkali metals and / or ammonium phenolates, characterized in that the active ingredient is methylbenzylphenol of the general formula Cgft ^ CHCCH2JCgH2 OM, in which M is hydrogen, sodium, potassium and a group wherein the position of the arylalkyl group on the phenol and / or the phenolate is in the 2 or 4 position or a mixture thereof.

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