CS230874B1 - Pharmaceutical or cosmetic agent containing antibacterium component - Google Patents

Abstract

Pharmaceutical or cosmetic preparation containing an antibacterial component, a carrier and excipients are characterized in that as an antibacterial component it contains 10 "5 up to 10-1 wt. % amocomplex compounds hydroboric acid and its derivatives in aqueous or a water-ethanolic solution it contains 0.01 to 40 wt. % alkyl diols or alkyltrioles and 0.01 to 5 wt. % of low molecular weight carboxylic acids. Antibacterial component present with alkyl diols and alkyltrioles form hydrated complexes, thereby stabilizing amo-complexity silver acid compounds hydroborate and its derivatives. In the pH range from 5-8.5 which is achieved by carboxyl acids, adhesion increases pharmaceutical and cosmetic products on the skin and mucosa and is further increased their diffuse efficacy into tissue and hence their preventive and healing effects.

Description

The invention relates to a pharmaceutical or cosmetic composition comprising an antibacterial component for the prevention and treatment of inflammatory processes of the skin and mucosa.

At present, a variety of preventive and therapeutic agents for mucosal and skin inflammations are used in pharmacy, dentistry and cosmetics, but not with satisfactorily expected results. E.g. different types of varnishes are used to prevent tooth decay. sealing teeth. The disadvantage of this method is the great laboriousness. Among the most widespread preventive agents and methods currently used against tooth decay are various ways of fluoridating drinking water, table salt, milk, and the like. A wide range of toothpastes containing fluorine compounds is also produced.

The current state of treatment of inflammation of the skin and mucous membranes is made using amocomplex silver compounds of hydroboric acid and its derivatives (Cs AO No. 209 390 and Cs AO No. 212 431), various disinfectants - propolis (L. Adamčík et al., Preparations, which contain plant tanning agents (allantoin, azulene, etc.), E-vitamin concentrate, etc. However, the vast majority of disinfectants have contaminating mucosal and short-term effects.

The above drawbacks are overcome according to the invention by using the synergism of tri-boron tri-borate or di-boron tri-borate in combination with alkyldiols, respectively. alkyltriolmi. The synergistic enhancement diffuses efficacy into the tissue. They show improved effects in the treatment of skin and mucosal (vaginal) diseases. They have an increased bacterioagglutination ability, the ability to kill bacteria, therefore products containing them have improved effects in the treatment of skin and mucosal diseases.

Said efficacy of the antibacterial component is dependent on a pH of 5 to 8.5. This area is achieved by the addition of low molecular weight carboxylic acids. Examples of use:

1. Preparations for prevention, hygiene and treatment of the oral cavity (toothpastes, mouthwashes, etc.)

Mouthwash with antibacterial component: fine refined alcohol 96.4% 57.540% diammonium quartrate borate 5% ethanolic solution 0.060 glycerine according to ČSN 20.000 lactic acid 0.010 saccharin 0.040 aromatic and flavor composition 6,500 menthol 0.030 distilled water 15.820

2. Suppositories, ointments, poultices, solutions and the like.

Trisodium trisulphate 0.060% propylene glycol 28,000 propionic acid 0.010 suppository base (or butter base ad

100,000 (coating for tiles and solutions 30% refined fine alcohol)

3. Lotions, pre-shave and after-shave spirits refined fine 96,4% 68,640% alcoholic diammonium borohydride solution 0,060 glycerin 18,000 fragrant composition 2,200 distilled water 11,090 lactic acid 0,010

100,000%

4. Face creams, emulsions, hand creams, face masks - etc.

cocoa butter 10,000% beeswax 4,000 sunflower oil 20,000 petrolatum white 25,640 eucerine 10,000 lanolin 3,000% solution of tri-silver trihydrate alcohol 0.060 glycerin pharmaceutical 3,000 lactic acid 0.020 fragrance composition 0.250 preservative 0.100 water distilled 32.930

100,000%

5. Body deodorants and the like.

% alcoholic solution of diammonium tetrachloride 0.060% propylene glycol 0.250 propionic acid 0.010 fragrance composition 0.250 alcohol dehydrated 99.430

100.0001% body deodorants can be practically applied with a mechanical sprayer, or filled as an aerosol (with freons) in a ratio of body deodorant (solution) 50% freon 12 50%

100%

100,000%

In the manufacturing process of cosmetic and pharmaceutical emulsion formulations, the components of the fat base need to be homogenized with the aqueous components after heating to about 80 ° C, which preferably allows the presence of alkyldiols and alkyltriols. These form hydrated complexes, thereby stabilizing! the effectiveness of the antibacterial component. The synergism of the antibacterial component is manifested by an increase in the adhesion of these preparations to the mucosa and skin.

The antibacterial effect was tested on a wide range of anaerobic and aerobic bacterial plaques, with the death of bacteria occurring in 20 seconds. There was no contamination of oral tissue.

Bactericidal effect on a wide range of anaerobic and aerobic plaque bacteria by application of 10 ^-4 -10 10% ² % trisodium silver trihydrate solution alone in 15-40% alcohol, according to AO no. 209,390 and Cs. AO 212 431, occurred in 30 seconds.

The use of this bactericidal component is not limited to the examples herein, but has a wider application in pharmaceutical products in the treatment of skin and mucosal inflammations (acne, etc.) where it can be applied directly to the affected areas, optionally after addition to the liquid, ointment supplementary ingredients. , suspension, powder or tablet. Thus, the use of the invention is important in terms of hygiene and prevention.

Claims (3)

SUBJECT 1. A pharmaceutical or cosmetic composition comprising the antibacterial ingredient, carriers and adjuvants, characterized in that the antibacterial ingredient a 10 ^-5 to 10 wt ^_1. 0.01 to 40 wt. % alkylldiols or alkyltriols having a carbon number of 2 to 5 and 0.01 to 5 wt. % of weak carboxylic acids based on the weight of the preparation. We claim: 2. A pharmaceutical or cosmetic composition according to claim 1, wherein the alkyldiol or alkyltriol is propylene glycol or glycerin. 3. A pharmaceutical or cosmetic composition according to claim 1, wherein the weak carboxylic acid is preferably propionic acid, lactic acid or citric acid.