CS221403B1 - Method of hygienic faultless stabilization of the polyolefine against thermooxidation and photooxidation degradation - Google Patents
Method of hygienic faultless stabilization of the polyolefine against thermooxidation and photooxidation degradation Download PDFInfo
- Publication number
- CS221403B1 CS221403B1 CS973681A CS973681A CS221403B1 CS 221403 B1 CS221403 B1 CS 221403B1 CS 973681 A CS973681 A CS 973681A CS 973681 A CS973681 A CS 973681A CS 221403 B1 CS221403 B1 CS 221403B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- tocopherol
- parts
- polyolefins
- mixture
- alpha
- Prior art date
Links
- 229920000098 polyolefin Polymers 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 9
- 230000015556 catabolic process Effects 0.000 title claims abstract description 6
- 238000006731 degradation reaction Methods 0.000 title claims abstract description 6
- 230000006641 stabilisation Effects 0.000 title claims abstract 3
- 238000011105 stabilization Methods 0.000 title claims abstract 3
- 238000007539 photo-oxidation reaction Methods 0.000 title claims description 3
- 239000000203 mixture Substances 0.000 claims abstract description 7
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 claims abstract description 6
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 claims abstract description 6
- GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229940066595 beta tocopherol Drugs 0.000 claims abstract description 3
- 235000010389 delta-tocopherol Nutrition 0.000 claims abstract description 3
- 235000010382 gamma-tocopherol Nutrition 0.000 claims abstract description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000011590 β-tocopherol Substances 0.000 claims abstract description 3
- 235000007680 β-tocopherol Nutrition 0.000 claims abstract description 3
- 239000002478 γ-tocopherol Substances 0.000 claims abstract description 3
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 claims abstract description 3
- 239000002446 δ-tocopherol Substances 0.000 claims abstract description 3
- 239000003381 stabilizer Substances 0.000 claims abstract 2
- 239000011732 tocopherol Substances 0.000 claims abstract 2
- 229960001295 tocopherol Drugs 0.000 claims abstract 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 10
- 229940087168 alpha tocopherol Drugs 0.000 claims description 5
- 229960000984 tocofersolan Drugs 0.000 claims description 5
- 239000002076 α-tocopherol Substances 0.000 claims description 5
- 235000004835 α-tocopherol Nutrition 0.000 claims description 5
- 230000000087 stabilizing effect Effects 0.000 claims description 4
- 230000032683 aging Effects 0.000 claims description 3
- 239000007943 implant Substances 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 claims 4
- 239000004033 plastic Substances 0.000 claims 4
- 229920003023 plastic Polymers 0.000 claims 4
- 238000005516 engineering process Methods 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- -1 polyethylene Polymers 0.000 claims 2
- 206010067484 Adverse reaction Diseases 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 230000006838 adverse reaction Effects 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 229920001083 polybutene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920000306 polymethylpentene Polymers 0.000 claims 1
- 239000011116 polymethylpentene Substances 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 description 2
- KEQFTVQCIQJIQW-UHFFFAOYSA-N N-Phenyl-2-naphthylamine Chemical compound C=1C=C2C=CC=CC2=CC=1NC1=CC=CC=C1 KEQFTVQCIQJIQW-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 1
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- Compositions Of Macromolecular Compounds (AREA)
Abstract
Způsob zdravotně nezávadné stabilizace polyolefinů proti ternicoxidační a fotooxi- dační degradaci, při kterém se jako stabilizátoru použije lalfa-tokoferolu, beta-tokofero- lu, gama-tokoferolu, delta-tokoferolu nebo jejich směsi.A process for the safe stabilization of polyolefins against ternoxidative and photooxidative degradation, wherein lapha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol or a mixture thereof is used as a stabilizer.
Description
Vynález se týká způsobu stabilizace polyolefinů, kterým se dosahuje zvýšení odolnosti proti termooxidačnímu a fotooxidačnímu stárnutí, přičemž polyolefiny stabilizované podle vynálezu jsou zdravotně nezávadné.The present invention relates to a process for stabilizing polyolefins by means of which the resistance to thermooxidation and photooxidation aging is increased, the polyolefins stabilized according to the invention being wholesome.
Dosavadní způsob stabilizace polyolefinů proti termooxidační degradaci a proti fotooxidační degradaci se provádí aplikací antioxidamtů, které jsou odvozeny z derivátů fenolů, aromatických aminů, fosfitů. Tyto látky jsou většinou zdravotně závadné a nelze je použít ve styku s potravinami. Polyolefiny stabilizované těmito látkami vyvolávají nežádoucí zánětlivé procesy, jestliže jsou použity jako implantáty ve styku s tkáněmi organismu. U některých z těchto sloučenin byl zjištěn karcinogenní účinek (například u f enyl-beta-naf tylaminu j.The prior art method of stabilizing polyolefins against thermooxidative degradation and photooxidative degradation is accomplished by applying antioxidants derived from phenol derivatives, aromatic amines, phosphites. These substances are mostly harmful to health and cannot be used in contact with food. Polyolefins stabilized by these substances induce unwanted inflammatory processes when used as implants in contact with body tissues. Some of these compounds have been found to be carcinogenic (e.g., phenyl-beta-naphthylamine).
Výše uvedené nedostatky jsou odstraněny stabilizací polyolefinů podle vynálezu, jejíž podstatou je aplikace 0,01 až 5 % alfa-tokoferolu, beta-tokořerolu, gama-tokoferolu, delta-tokoferolu nebo jejich směsi do polyolefinů.The above drawbacks are overcome by stabilizing the polyolefins according to the invention, which is based on the application of 0.01-5% alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol or a mixture thereof into polyolefins.
Polyolefiny stabilizované tokoferolem mají podstatně větší odolnost proti termooxidační degradaci jak při teplotách technického použití těchto materiálů, tak při teplotách zpracovatelských. Mají vyšší odolnost proti fotooxidační degradaci, která se projevuje vyšší životností při expozici polyPlefinů stabilizovaných tokoferolem v přírodních povětrnostních podmínkách. Jsou zdravotně nezávadné. Lze je použít ve styku s potravinami. Nevyvolávají nepříznivé reakce tkání, jestliže jsou takto stabilizované polyolefiny použity jako implantáty v organismu. Mají naopak příznivý vliv na vhojovací procesy.The tocopherol-stabilized polyolefins have significantly greater resistance to thermo-oxidative degradation at both the technical and processing temperatures of these materials. They have a higher resistance to photooxidative degradation, which results in higher durability when exposed to tocopherol-stabilized polyPlefin under natural weather conditions. They are harmless to health. They can be used in contact with food. They do not induce adverse tissue responses when such stabilized polyolefins are used as implants in the body. On the contrary, they have a beneficial effect on healing processes.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS973681A CS221403B1 (en) | 1981-12-23 | 1981-12-23 | Method of hygienic faultless stabilization of the polyolefine against thermooxidation and photooxidation degradation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS973681A CS221403B1 (en) | 1981-12-23 | 1981-12-23 | Method of hygienic faultless stabilization of the polyolefine against thermooxidation and photooxidation degradation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS221403B1 true CS221403B1 (en) | 1983-04-29 |
Family
ID=5446301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS973681A CS221403B1 (en) | 1981-12-23 | 1981-12-23 | Method of hygienic faultless stabilization of the polyolefine against thermooxidation and photooxidation degradation |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS221403B1 (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0995450A1 (en) * | 1998-10-21 | 2000-04-26 | Sulzer Orthopädie AG | UHMW-polyethylene for implants |
| EP0995449A1 (en) * | 1998-10-21 | 2000-04-26 | Sulzer Orthopädie AG | UHMW-polyethylene for implants |
| US7498365B2 (en) | 2003-01-16 | 2009-03-03 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US7833452B2 (en) | 2004-05-11 | 2010-11-16 | The General Hospital Corporation | Method for making oxidation resistant polymeric material |
| US7846376B2 (en) | 2005-08-18 | 2010-12-07 | Zimmer Gmbh | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| US8129440B2 (en) | 2007-04-10 | 2012-03-06 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US8303657B2 (en) | 2008-08-05 | 2012-11-06 | Howmedica Osteonics Corp. | Polyethylene cross-linked with an anthocyanin |
| US8399535B2 (en) | 2010-06-10 | 2013-03-19 | Zimmer, Inc. | Polymer [[s]] compositions including an antioxidant |
| US8652212B2 (en) | 2008-01-30 | 2014-02-18 | Zimmer, Inc. | Orthopedic component of low stiffness |
| US8664290B2 (en) | 2007-04-10 | 2014-03-04 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US9708467B2 (en) | 2013-10-01 | 2017-07-18 | Zimmer, Inc. | Polymer compositions comprising one or more protected antioxidants |
| US10184031B2 (en) | 2014-03-12 | 2019-01-22 | Zimmer, Inc. | Melt-stabilized ultra high molecular weight polyethylene and method of making the same |
| US10265891B2 (en) | 2014-12-03 | 2019-04-23 | Zimmer, Inc. | Antioxidant-infused ultra high molecular weight polyethylene |
-
1981
- 1981-12-23 CS CS973681A patent/CS221403B1/en unknown
Cited By (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0995449A1 (en) * | 1998-10-21 | 2000-04-26 | Sulzer Orthopädie AG | UHMW-polyethylene for implants |
| EP0995450A1 (en) * | 1998-10-21 | 2000-04-26 | Sulzer Orthopädie AG | UHMW-polyethylene for implants |
| US9688004B2 (en) | 2003-01-16 | 2017-06-27 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US7498365B2 (en) | 2003-01-16 | 2009-03-03 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US8888859B2 (en) | 2003-01-16 | 2014-11-18 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US8728379B2 (en) | 2003-01-16 | 2014-05-20 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US9370878B2 (en) | 2003-01-16 | 2016-06-21 | The General Hospital Corp. | Methods for making oxidation resistant polymeric material |
| US7906064B2 (en) | 2003-01-16 | 2011-03-15 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US9943993B2 (en) | 2003-01-16 | 2018-04-17 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US10821632B2 (en) | 2003-01-16 | 2020-11-03 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US8968628B2 (en) | 2003-01-16 | 2015-03-03 | The General Hospital Corp. | Methods for making oxidation resistant polymeric material |
| US9561306B2 (en) | 2004-05-11 | 2017-02-07 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US8318065B2 (en) | 2004-05-11 | 2012-11-27 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US8865043B2 (en) | 2004-05-11 | 2014-10-21 | The General Hospital Corporation | Methods for making oxidation resistant polymeric material |
| US7833452B2 (en) | 2004-05-11 | 2010-11-16 | The General Hospital Corporation | Method for making oxidation resistant polymeric material |
| US11001680B2 (en) | 2005-08-18 | 2021-05-11 | Zimmer Gmbh | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| US8470903B2 (en) | 2005-08-18 | 2013-06-25 | Zimmer Gmbh | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| US11015030B2 (en) | 2005-08-18 | 2021-05-25 | Zimmer Gmbh | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| US7863348B2 (en) | 2005-08-18 | 2011-01-04 | Zimmer Gmbh | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| US8673202B2 (en) | 2005-08-18 | 2014-03-18 | Zimmer, Gmbh | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| US7846376B2 (en) | 2005-08-18 | 2010-12-07 | Zimmer Gmbh | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| US8178594B2 (en) | 2007-04-10 | 2012-05-15 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US9265545B2 (en) | 2007-04-10 | 2016-02-23 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US9277949B2 (en) | 2007-04-10 | 2016-03-08 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra high molecular weight polyethylene for medical device applications |
| US8669299B2 (en) | 2007-04-10 | 2014-03-11 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US8664290B2 (en) | 2007-04-10 | 2014-03-04 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US10556998B2 (en) | 2007-04-10 | 2020-02-11 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra high molecular weight polyethylene for medical device applications |
| US9822224B2 (en) | 2007-04-10 | 2017-11-21 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra high molecular weight polyethylene for medical device applications |
| US9926432B2 (en) | 2007-04-10 | 2018-03-27 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US8129440B2 (en) | 2007-04-10 | 2012-03-06 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US8652212B2 (en) | 2008-01-30 | 2014-02-18 | Zimmer, Inc. | Orthopedic component of low stiffness |
| US9718241B2 (en) | 2008-01-30 | 2017-08-01 | Zimmer, Inc. | Method of manufacturing an acetabular component |
| US8303657B2 (en) | 2008-08-05 | 2012-11-06 | Howmedica Osteonics Corp. | Polyethylene cross-linked with an anthocyanin |
| US8439975B2 (en) | 2008-08-05 | 2013-05-14 | Howmedica Osteonics Corp. | Polyethylene cross-linked with an anthocyanin |
| US8399535B2 (en) | 2010-06-10 | 2013-03-19 | Zimmer, Inc. | Polymer [[s]] compositions including an antioxidant |
| US9708467B2 (en) | 2013-10-01 | 2017-07-18 | Zimmer, Inc. | Polymer compositions comprising one or more protected antioxidants |
| US10184031B2 (en) | 2014-03-12 | 2019-01-22 | Zimmer, Inc. | Melt-stabilized ultra high molecular weight polyethylene and method of making the same |
| US10265891B2 (en) | 2014-12-03 | 2019-04-23 | Zimmer, Inc. | Antioxidant-infused ultra high molecular weight polyethylene |
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