CS202733B1 - Gel for massaging the paradenthose gums - Google Patents

Description

The invention relates to a gel for the massage of periodontal gums using a tampon or a soft brush.

As is known, periodontal diseases in their chronic forms are among the most common diseases of the oral cavity, especially in middle and older age, where the damage to the teeth by loss of teeth is approximately the same as caries (M. Brion, A. Chaput, No. 4 (11), 815, 1975; H. Houbova, L. Skrabankova, Prakt. Lékař 46, 426, 1966).

A number of preparations have been developed for the symptomatic treatment of periodontitis, which, when applied topically to the gums, are designed to prevent bleeding and to disinfect any suppurative foci present. These are predominantly liquid preparations with astringent action, in particular containing tannins or aluminum compounds, such as, for example, a solution of aluminum acetovinate or various tinctures (tinctura myrrhae, tinctura gallarum, ratanhiae, etc.) which have a short duration of action and vary in intensity. (S. Masák, L. Urbánek, Study Report of the VÚFB TEI 1976; CH Fischer, Zahnarztliche Mitteilung, Ausgabe A, 64/6 /, 293, 1974; E. Fröhlich, Med. Welt 1965, 80; R. Lindner, Dtsch. Apoth, Ztg., 111, 33, 1240 (1971).

Systematic investigation of properties of individual astringent and disinfectants, selection of various types of excipients, preparation of samples of emulsion preparations, gel-like202 733

202,733 of paste-like character, an optimum gel composition has been found for the massage of periodontal gums according to the invention, which consists in that it contains 4 to 7% by weight. % of an adatringent active ingredient based on at least one complex compound of hydrated alumina, preferably dihydrate of diallyl pentahydroxy chloride, 6 to 10 wt. % colloidal dispersed silica, 0.5 to 1.5 wt. % disinfectants, in particular of the higher quaternary ammonium salt type, preferably carbathoxypentadecyltrimetbylammonium bromide, and up to 100 wt. a hydrophilic vehicle, for example water and / or a physiologically acceptable C 2 -C 4 aliphatic polyol or their amSs, preferably glycerin, and optional flavoring and / or perfume and / or colorant additives.

The paradoxical gum massage oil according to the invention has proved to be very effective as a form of administration and has shown a number of advantages. The presence of dialpentahydroxy chloride dihydrate gives it a strong astringent effect that reliably prevents gum bleeding. In addition, this aluminum compound has a mild antiseptic effect. According to previous reports and experience with this substance, used locally in the form of a substance, it could not be expected that it could be processed into a gel and that it would retain its favorable properties in this form (EL Roehl, Kosmetik und Aerosole 46, 155, 1973) ). A further component of the formulation, a quaternary ammonium salt disinfectant, preferably carbethoxypentadecyltrimethylammonium bromide, of a cationic nature, disinfects or suppresses the resulting purulent deposits. It enters the reaction of the enzymatic apparatus of microorganisms, thereby stopping or weakening their metabolic activity and ultimately decompose their protoplasm.

The composition of the invention, forming a gel of colloidal dispersed silica containing glycerin, was selected as the most suitable of the many gels tested. This form allows a gentle but effective massage using a swab or soft brush. Because colloidal dispersed silica has mild abrasive effects, the gel of the present invention can also be used to clean teeth. The product is easy to spread and easy to wash off with water.

There are numerous reports in the literature of the use of silicon dioxide as a gel forming agent. Swiss Patent Specification No. 562613 discloses a carrier composition for pharmaceutical and cosmetic compositions containing 126 parts by weight. polyethylene glycol (molecular weight 200 to 6000) and 2 to 30 parts by weight of polyethylene glycol. silicon dioxide. In the article Applications of eolloid Silicon dioxide in pharmaceutical technology, I. Bros. sp. (Qyogyszereszet 1975, 19 (8), 290-295) the properties of gels formed by colloidal dispersed silica.

The advantageous properties of the composition according to the invention consist in a suitable combination of astringent and glycerin and hydrophilic colloidal dispersed silica.

Oel according to embodiment 1 to 5 showed a favorable effect on the hygiene of the wound cavity monitored by the Vermilion index and on the degree of gingiva inflammation by the Shour-Maaaler index in a clinical trial. A solution of aluminum acetovinate and water served as a reference. After application of the composition of the invention, which was generally well

202 733 tolerated beside unwanted side reactions, there was a significant improvement of the monitored indicators, as shown in the table:

Gel according to the invention

Number patients Group I improvement after 14 days Group II improvements after others 14 days from group I Group III improvements after others 14 days from group I Not improved 65 57 (92%) 14 4 1 Acetovinate solution aluminum 50 33 9

(75 #)

In the following examples, the preparation according to the invention is closer.

Examples

Ingredients:

1) carbethoxypentadecyltrimethylammonium bromide dialuminium pentahydroxychloride dihydrate glycerin colloidal disperse silica perfume saccharin crystallized 450 yellow lemon clarify the composition and method

4,5 kg 1.0 kg 85.3 kg 8.0 kg 1.0 kg

0,18 kg 0,02 kg or

2) dialuminium pentahydroxychloride dihydrate 6.0 kg carbethoxypentadecyltrimethylammonium bromide 1.0 kg glycerin 83.3 kg colloidal dispersed silica 10.0 kg saccharin crystallized 450 0.18 kg food color 0.02 kg taste correction 0.50 kg or

3) Capethoxypentaethyldimethyl ammonium bromide dihydrate glycerine

4,50 kg

0,60 kg

41.67 kg

202 733

propylene glycol 40,00 kg colloidal dispersed silica 10,00 kg chuíové korigens 0,60 kg Artificial sweetener 0,10 kg food coloring 0,03 kg

or

4) Dialuminium pentahydroxy chloride dihydrate 5,00 kg carbethoxypentadecyltrimethylammoniumbrouid 1,00 kg colloidal dispersed silica 8,00 kg glycerine 70,92 kg propylene glycol 14,00 kg tartrazine 0,02 kg perfume 1,00 kg non-toxic artificial sweetener 0,06 kg

or

5) Dialuminium pentahydroxy chloride dihydrate 4,00 kg carbethoxypentadecyltrimethylammonium bromide 1,50 kg colloidal dispersed silica 9,50 kg glycerine 44.18 kg propylene glycol 40,00 kg food coloring 0,02 kg taste corrigents 0,80 kg.

Manufacturing process:

First, a gel of colloidal dispersed silica is prepared by pouring 68.3-72.8 kg of glycerin into a homogenization boiler and then aspirating the silica. Stir 120 min. under vacuum with a high-speed stirrer (1400 rpm) and a slow counter-stirrer (40 rpm). The boiler contents are then left to stand for about 14 hours.

The solution is dialysed with a solution of dialuminium pentahydroxy chloride dihydrate by adding all of it to a stainless steel pot containing 9.0 to 10.0 kg of glycerin preheated to 110 to 120 ° C with continuous vigorous stirring. Dissolution takes about 60 minutes. In case the dialuminium pentahydroxychloride dihydrate does not contain the required amount of crystalline water and if the dissolution is slow, about 2 kg of water is added to the mixture which evaporates during heating. The evaporated glycerin is replenished.

Dye, saccharin and perfume are dissolved in 2.0 kg of glycerine from the total prescribed amount.

202 73:

Carbethoxypentadecyltrimethylaluminium bromide is dissolved in 2.0 kg of glycerol at 45 ° C in a stainless steel pot.

A solution of dye, saccharin, perfume or flavor correction is slowly blended into the clear silica gel. Thereafter, a dialkyl pentahydroxy chloride dihydrate solution is added, followed by a disinfectant solution, which thickens. Finally, the mixture is stirred for 10 minutes with a counter-rotating stirrer (20 rpm).

After cooling to room temperature, the resulting gel is filled into containers such as tubes.

When using a mixture of glycerine with propylene glycol, the manufacturing process is the same as above, except that the amounts of glycerine itself are replaced by the same amount of its mixture with propylene glycol, according to Examples 3-5.

Claims (1)

SUBJECT OF THE INVENTION Gel for periodontal gum massage, characterized in that it contains 4 to 7 wt. % of an astringent active ingredient based on at least one complex compound of hydrated alumina, preferably di-pentahydroxychloride dihydrate, 6 to 10 wt. % colloidal dispersed silica, 0.5 to 1.5 wt. % disinfectants, in particular of the higher quaternary ammonium salt type, preferably carbethoxypentadecyltrimethylammonium bromide, and up to 100 wt. a hydrophilic vehicle, for example water and / or a physiologically acceptable C 2 -C 4 aliphatic polyol or a mixture thereof, preferably glycerin, and optionally an additive of flavorings and / or perfume and / or colorant.