CS199069B1 - Agent for individual preparing drinking water based on chlorderivate of isocyanuric acid - Google Patents

Description

It is an object of the invention to provide a means for individually preparing drinking water in an emergency situation.

In situations of emergency, especially during periods of extreme threat to the state, during war events, natural disasters and wherever an individual cannot be temporarily supplied with safe drinking water, drinking water preparation in field conditions is contemplated.

In addition to a variety of portable and portable devices and equipment for group purposes, the use of tablet formulations has been used to prepare drinking water for an individual, where a tablet for a defined volume, most commonly a standardized flask, is commonly envisaged.

Despite a wide range of disinfectants, designed and implemented for various disinfection purposes, two types of tablet formulations have been introduced for the most exposed field preparation of safe drinking water for the needs of the armed forces worldwide, differing in the active substance used, which best meet the microbiological, pharmaceutical, toxicological, hygiene and organoleptic requirements.

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Since the Second World War, p-carboxybenzenedichlorosulfonemide (halazone, pantooid) has been used as an active substance for this purpose and has been introduced into a large number of armies.

Later, it was introduced into the US Army and other armies as an active ingredient tetraglyclnhydr oper iodide (globalin).

The disadvantages of the previously introduced tablet formulations containing both p-carboxybenzene chlorosulfonamide and tetraglycinhydroperiodide are low disinfectant effect, low dissolution rate, long tablet disintegration time, disadvantageous pH of the resulting solution, and finally low stability both in dry and in solution.

Said deficiencies are eliminated by the composition according to the invention, which consists essentially of the active substance, a salt of dichloroisocyanuric acid, preferably a sodium salt, used in an amount of 7 to 14 mg per 0.75 liters of water and further auxiliaries such as stabilizer, glidant, binder, disintegrant. filler.

The use of tablets containing a salt of dichloroisocyanuric acid as the active ingredient and said excipient results in a substantially higher disinfectant efficacy than in both prior art tablets of p-carboxybenzene dichlorosulfonamide or tetraglycinhydroperiodide. The advantage is that, with the same active chlorine content, the disinfectant effect of the composition according to the invention is better than that of p-carboxybenzenedichlorosulfonamide-containing tablets, the disinfectant effect being less pH-dependent. Further advantages are good solubility, higher dissolution rate, shorter tablet disintegration time, preferred pH of the resulting solution (shifted more to neutral values) and substantially higher stability both in dry and in solution compared to both types of the introduced tablet compositions.

The composition for the individual preparation of drinking water is represented by tablets which are prepared as described in the following example.

Example 1

The blend of sieved raw materials, containing 140 parts by weight of sodium dichloroisocyanurate, 12 parts by weight of cyanuric acid, 12 parts by weight of talc, 12 parts by weight of polyvinylpyrrolidone - vinylacetate, 24 parts by weight of amylopectin and 1000 parts by weight of sodium chloride is homogenized and compressed into lentil shaped tablets with 5.5 mm diameter. and a weight of 120 mg + 6 mg.

The composition according to the invention is used in an amount of 1 tablet per 0.75 L of water (contents of a standard flask). The tablet dissolves with shaking. Water is drinkable in 0.5 hour.

Tablets of the composition of the invention dissolve at 20 ° C for 80 e, at 0 ° C for 200 s) comparable times for tablets with p-carboxybenzene dichloro-sulfonamide 800 and 1330 s, for tablets with tetraglyl hydroperiodide 400 and 1040 s).

Upon dissolution of the tablet, the pH of the solution was 5.6-5.9 (for tablets with p-carboxybenzenedichlorosulfonamide 5.2 a and tetraglycinhydroperiodide 4.7).

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The average disintegration time of the tablets in water under pharmacopoeial conditions is 11-15 e (for tablets and p-carboxybenzenedichlorosulfonamide 190 a, with 245 mg of tetraglycine hydroperiodide).

Dry stability is shown in Tab. 1, stability in aqueous solution Table 2.

The disinfection efficiency is shown in Table 3.

The toxicity of sodium dichloroisocyanurate in mice, expressed as the mean lethal dose LD 50, is 590 to 670 mg / kg. Its decomposition product - cyanuric acid has an LD ₅₀ po in mice above 7.5 g / kg.

There were no deaths or changes in their behavior when repeated maximum daily human doses were administered to mice for one week. There were no deaths or changes in behavior when the rats were dosed with maximum daily doses for humans for 14 days. Normal autopsy was found at necropsy of the sacrificed rats. Similarly, a normal morphological finding was found in a histological examination performed on the collected tissues of heart, lung, kidney, liver, stomach, small intestine and pancreas.

The composition according to the invention is intended for the preparation of drinking water by an individual in field conditions for the purposes of the armed forces and civil defense.

It can also be used in other cases of emergency and temporary preparation of drinking water even in peacetime.

Table 1

Dry stability at 60 ° C

Indicated% active chlorine relative to baseline

Means Number of days ^ 0 14 28 56 Means according to of Example 1 Tablets and β-carboxy- benzendichlorosulfone- amide Tablets and tetraglycinhydroper iodide 100 ALIGN! 100 ALIGN! 100 ALIGN! 91.5 74 70 89 60 68 88.5 59 67 86.7 49 61

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Table 2

Stability in solution (1 tablet per 10 ml) at 22 ° C Reported% active chlorine relative to baseline

Means Number of days O 7 14 28 56 Means according to of Example 1 Tablets e p-carboxy- 100 ALIGN! 84 70.5 54.5 28 benzend Ichlorsulf on- amide 100 ALIGN! 23.5 23 22.5 22nd Tablets with tetragly- cinhydroperjodide 100 ALIGN! 36 25 20.5 6

Table 3

Disinfectant efficacy (1 tablet per 0.75 L water, pH 8.3) indicated microbes / ml

Means Test microorganisms and exposure in minutes Esoheriohia coli Pseudomonas aeruginosa Staphyloc oc c us pyogenes spores of Bacillus subtilis 5 10 30 5 10 30 5 10 30 5 10 30 The composition of Example 1 0 0 0 10 ² 0 0 1 0 0 ♦ IQ ⁴ 10 ³ Tablets with p-carboxybenzene ichlorosulfonamide 10 “ ¹ 10 “ ² 0 1C “ ¹ 10 ¹ 0 1 10 ^_1 0 ++ 10 ⁴ Tablets with tetra- glyolnhydro- periodinide 0 0 0 10 ² 10 ² 0 1 10 ~ ² 0 ++ 10 ⁴ 10 ³

Note: Initial contamination of water 10 ^ to 10 ^ / ml ++ strong growth - filter colonies unreadable; + weak growth - filter colonies unaccountable

Claims (1)

SUBJECT OF THE INVENTION A composition for the individual preparation of drinking water based on isocyanuric acid chloro derivative, characterized in that it contains an alkali salt of dichloroisocyanuric acid, preferably sodium diisohloroisocyanurate in an amount of 7 to 14 mg per 0.75 l of water, further a stabilizer for cyanuric acid in an amount of up to 1%. a glidant such as talc in an amount of up to 1%, a disintegrant such as amylopectin in an amount of up to 2%, a binder, preferably vinyl acetate of polyvinylpyrrolidone in an amount of up to 1% and a filler, preferably sodium chloride in an amount of up to 83%.