CR7795A - TETRALINOS AND INDANES SUBSTITUTES - Google Patents
TETRALINOS AND INDANES SUBSTITUTESInfo
- Publication number
- CR7795A CR7795A CR7795A CR7795A CR7795A CR 7795 A CR7795 A CR 7795A CR 7795 A CR7795 A CR 7795A CR 7795 A CR7795 A CR 7795A CR 7795 A CR7795 A CR 7795A
- Authority
- CR
- Costa Rica
- Prior art keywords
- tetralinos
- indanes
- substitutes
- tetralin
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención tiene como caracteristica compuestos de tetralina e indano, composiciones que los contienen y métodos de uso de los mismos como moduladores del PPAR alfa, para tratar o inhibir la progresión de por ejemplo la diabetes.The invention has as its characteristic tetralin and indane compounds, compositions containing them and methods of use thereof as modulators of PPAR alpha, to treat or inhibit the progression of, for example, diabetes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41993502P | 2002-10-21 | 2002-10-21 | |
US49527003P | 2003-08-15 | 2003-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR7795A true CR7795A (en) | 2012-10-25 |
Family
ID=32179771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR7795A CR7795A (en) | 2002-10-21 | 2005-04-18 | TETRALINOS AND INDANES SUBSTITUTES |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1569897A1 (en) |
JP (1) | JP2006503916A (en) |
KR (1) | KR20050055773A (en) |
AU (1) | AU2003277441B2 (en) |
BR (1) | BR0315596A (en) |
CA (1) | CA2502661A1 (en) |
CR (1) | CR7795A (en) |
EA (1) | EA009553B1 (en) |
EG (1) | EG24842A (en) |
HR (1) | HRP20050335A2 (en) |
MX (1) | MXPA05004191A (en) |
NO (1) | NO20052199L (en) |
NZ (1) | NZ539510A (en) |
PL (1) | PL376325A1 (en) |
RS (1) | RS20050318A (en) |
TW (1) | TW200418773A (en) |
WO (1) | WO2004037778A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ539432A (en) * | 2002-10-21 | 2008-04-30 | Janssen Pharmaceutica Nv | Treating syndrome X with substituted tetralins and indanes |
EP1554240B1 (en) * | 2002-10-21 | 2009-05-06 | Janssen Pharmaceutica N.V. | Substituted tetralins and indanes and their use |
AR048931A1 (en) * | 2004-04-21 | 2006-06-14 | Janssen Pharmaceutica Nv | PROCESS FOR THE PREPARATION OF SUBSTITUTED AND INDIAN TETRALIN DERIVATIVES AND PREPARATION OF SYNTHESIS INTERMEDIARIES |
US20090239841A1 (en) * | 2004-10-27 | 2009-09-24 | Hutchison Alan J | Diaryl Ureas as CB1 Antagonists |
BRPI0620468A2 (en) | 2005-12-22 | 2011-11-08 | Transtech Pharma Inc | acetic phenoxy acids as activators of delta ppar |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9606805D0 (en) * | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
GB9822473D0 (en) * | 1998-10-16 | 1998-12-09 | Glaxo Group Ltd | Chemical compounds |
EP1259494A4 (en) * | 2000-02-18 | 2004-09-15 | Merck & Co Inc | Aryloxyacetic acids for diabetes and lipid disorders |
EE200300140A (en) * | 2000-10-05 | 2003-08-15 | Bayer Aktiengesellschaft | Propanoic acid derivatives with PPAR alpha-activating properties |
AU2002222549A1 (en) * | 2000-11-29 | 2002-06-11 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
WO2002046146A1 (en) * | 2000-12-05 | 2002-06-13 | Kyorin Pharmaceutical Co., Ltd. | Substituted carboxylic acid derivatives |
US7091225B2 (en) * | 2000-12-20 | 2006-08-15 | Smithkline Beecham Corporation | Substituted oxazoles and thiazoles as hPPAR alpha agonists |
BR0207227A (en) * | 2001-02-15 | 2004-02-10 | Pfizer Prod Inc | Ppar proliferating activated receptor compounds |
UA82835C2 (en) * | 2001-12-03 | 2008-05-26 | Reddys Lab Ltd Dr | ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon |
NZ539432A (en) * | 2002-10-21 | 2008-04-30 | Janssen Pharmaceutica Nv | Treating syndrome X with substituted tetralins and indanes |
EP1554240B1 (en) * | 2002-10-21 | 2009-05-06 | Janssen Pharmaceutica N.V. | Substituted tetralins and indanes and their use |
-
2003
- 2003-10-17 JP JP2005501629A patent/JP2006503916A/en not_active Withdrawn
- 2003-10-17 PL PL03376325A patent/PL376325A1/en not_active Application Discontinuation
- 2003-10-17 NZ NZ539510A patent/NZ539510A/en not_active IP Right Cessation
- 2003-10-17 EP EP03809577A patent/EP1569897A1/en not_active Withdrawn
- 2003-10-17 CA CA002502661A patent/CA2502661A1/en not_active Withdrawn
- 2003-10-17 KR KR1020057006795A patent/KR20050055773A/en not_active Application Discontinuation
- 2003-10-17 RS YUP-2005/0318A patent/RS20050318A/en unknown
- 2003-10-17 AU AU2003277441A patent/AU2003277441B2/en not_active Ceased
- 2003-10-17 MX MXPA05004191A patent/MXPA05004191A/en active IP Right Grant
- 2003-10-17 BR BR0315596-0A patent/BR0315596A/en not_active IP Right Cessation
- 2003-10-17 WO PCT/US2003/033090 patent/WO2004037778A1/en active Application Filing
- 2003-10-17 EA EA200500515A patent/EA009553B1/en not_active IP Right Cessation
- 2003-10-21 TW TW092129192A patent/TW200418773A/en unknown
-
2005
- 2005-04-14 HR HR20050335A patent/HRP20050335A2/en not_active Application Discontinuation
- 2005-04-18 CR CR7795A patent/CR7795A/en not_active Application Discontinuation
- 2005-04-20 EG EGNA2005000152 patent/EG24842A/en active
- 2005-05-04 NO NO20052199A patent/NO20052199L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HRP20050335A2 (en) | 2006-05-31 |
MXPA05004191A (en) | 2006-01-27 |
TW200418773A (en) | 2004-10-01 |
AU2003277441A1 (en) | 2004-05-13 |
NO20052199L (en) | 2005-06-24 |
EA200500515A1 (en) | 2005-10-27 |
RS20050318A (en) | 2007-09-21 |
KR20050055773A (en) | 2005-06-13 |
BR0315596A (en) | 2005-09-06 |
EP1569897A1 (en) | 2005-09-07 |
AU2003277441B2 (en) | 2009-05-07 |
WO2004037778A1 (en) | 2004-05-06 |
PL376325A1 (en) | 2005-12-27 |
EA009553B1 (en) | 2008-02-28 |
JP2006503916A (en) | 2006-02-02 |
CA2502661A1 (en) | 2004-05-06 |
NZ539510A (en) | 2008-01-31 |
EG24842A (en) | 2010-10-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |