CR7672A - MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 11- ALFA- HYDROXIESTEROIDS 7- ALFA SUBSTITUTED - Google Patents

MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 11- ALFA- HYDROXIESTEROIDS 7- ALFA SUBSTITUTED

Info

Publication number
CR7672A
CR7672A CR7672A CR7672A CR7672A CR 7672 A CR7672 A CR 7672A CR 7672 A CR7672 A CR 7672A CR 7672 A CR7672 A CR 7672A CR 7672 A CR7672 A CR 7672A
Authority
CR
Costa Rica
Prior art keywords
alfa
substituted
hydroxiesteroids
production
microbiological method
Prior art date
Application number
CR7672A
Other languages
Spanish (es)
Inventor
Zorn Ludwig
Bohlmann Rolf
Gallus Norbert
Kunzer Hermann
Muhn Hans-Peter
Nubbemeyer Reinhard
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10233723A external-priority patent/DE10233723A1/en
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of CR7672A publication Critical patent/CR7672A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se refiere a procedimientos microbiologicos para preparar 11a-hidroxiesteroides 7a-sustituidos, a 11B -halogenesteroides 7a, 17a-sustituidos que se pueden obtener de aquellos, a procedimientos para la preparacion de estos ultimos compuestos y a su uso, asi como a preparaciones farmaceuticas que contienen estos compuestos.It refers to microbiological procedures for preparing 11a-substituted 7a-hydroxysteroids, 11B-7a, 17a-substituted halogenesteroids that can be obtained therefrom, procedures for the preparation of these latter compounds and their use, as well as pharmaceutical preparations containing these compounds.

CR7672A 2002-07-24 2005-02-03 MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 11- ALFA- HYDROXIESTEROIDS 7- ALFA SUBSTITUTED CR7672A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10233723A DE10233723A1 (en) 2002-07-24 2002-07-24 Preparation of 7 alpha-substituted 11 alpha-hydroxy-steroids, useful as precursors for new androgenic 7 alpha,17 alpha-substituted 11 beta-halo-steroids, by microbiological conversion of 7 alpha-substituted steroids
US40295302P 2002-08-14 2002-08-14

Publications (1)

Publication Number Publication Date
CR7672A true CR7672A (en) 2006-05-29

Family

ID=31189296

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7672A CR7672A (en) 2002-07-24 2005-02-03 MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 11- ALFA- HYDROXIESTEROIDS 7- ALFA SUBSTITUTED

Country Status (20)

Country Link
EP (1) EP1523568A2 (en)
JP (1) JP4417838B2 (en)
KR (1) KR101041328B1 (en)
CN (1) CN100339486C (en)
BR (1) BR0313210A (en)
CA (1) CA2492079C (en)
CO (1) CO5690563A2 (en)
CR (1) CR7672A (en)
EA (2) EA008147B1 (en)
EC (1) ECSP055630A (en)
HK (1) HK1081999A1 (en)
HR (1) HRP20050172A2 (en)
IL (1) IL166358A0 (en)
MX (1) MXPA05001024A (en)
NO (1) NO20050980L (en)
NZ (2) NZ537871A (en)
PH (1) PH12005500143B1 (en)
PL (1) PL373808A1 (en)
RS (1) RS51855B (en)
WO (1) WO2004011663A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100982540B1 (en) * 2005-10-27 2010-09-16 다이호야쿠힌고교 가부시키가이샤 Process for production of steroid compound
CN103834712B (en) * 2012-11-26 2016-03-30 复旦大学 The optimization method of desogestrel intermediate nanometer liposome bio-transformation
CN103214543B (en) * 2012-12-25 2015-09-02 中国人民解放军海军医学研究所 New Crategolic acid derivative, its preparation method and the application in antitumor drug thereof
CN104862323B (en) * 2015-06-02 2018-01-16 中国农业科学院生物技术研究所 Modify the '-hydroxylase gene of diphenol compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE496261A (en) 1949-06-11
US2658023A (en) * 1953-04-21 1953-11-03 Pfizer & Co C Oxygenation of steroids
US2985563A (en) * 1958-11-13 1961-05-23 Schering Corp 11alpha-hydroxylation of steroids by glomerella
US3004047A (en) * 1959-03-13 1961-10-10 Olin Mathieson 6alpha-halo-11alpha-hydroxy steroids of the pregnane series and esters thereof
US3341557A (en) * 1961-06-05 1967-09-12 Upjohn Co 7-methyltestosterones
US3203869A (en) * 1962-10-11 1965-08-31 Syntex Corp 11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section
US5342834A (en) 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
EP1167380A3 (en) * 1995-12-11 2004-12-08 G.D. Searle & Co. 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation
GB9525194D0 (en) 1995-12-12 1996-02-07 Zeneca Ltd Pharmaceutical composition
ES2175175T3 (en) 1995-12-12 2002-11-16 Akzo Nobel Nv A MICROBIAL METHOD FOR THE 11ALFA-HYDROXYLATION OF STEROIDS.
US20020012694A1 (en) * 1997-09-17 2002-01-31 Alfred J. Moo-Young Transdermal administration of ment
US6767902B2 (en) 1997-09-17 2004-07-27 The Population Council, Inc. Androgen as a male contraceptive and non-contraceptive androgen replacement
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
JP2003522795A (en) 2000-02-15 2003-07-29 シェーリング アクティエンゲゼルシャフト Male contraceptive formulation consisting of norethisterone
DE10104327A1 (en) 2001-01-24 2002-07-25 Schering Ag New 11beta-halo-testosterone derivatives useful in male hormone replacement therapy and in male fertility control
CN1671394A (en) * 2002-07-25 2005-09-21 舍林股份公司 Composition containing an androgenous 11beta-halogen steroid and a progestational hormone, and male contraceptive based on said composition

Also Published As

Publication number Publication date
ECSP055630A (en) 2005-04-18
PH12005500143B1 (en) 2011-03-25
CN1671858A (en) 2005-09-21
NZ537871A (en) 2006-10-27
WO2004011663A2 (en) 2004-02-05
JP4417838B2 (en) 2010-02-17
EA200500224A1 (en) 2005-08-25
BR0313210A (en) 2005-06-28
PL373808A1 (en) 2005-09-19
AU2003281677A1 (en) 2004-02-16
HRP20050172A2 (en) 2005-04-30
MXPA05001024A (en) 2005-05-16
MX260952B (en) 2008-10-01
KR101041328B1 (en) 2011-06-14
EA010572B1 (en) 2008-10-30
CA2492079A1 (en) 2004-02-05
NZ549529A (en) 2008-04-30
EP1523568A2 (en) 2005-04-20
RS51855B (en) 2012-02-29
RS20050045A (en) 2007-06-04
IL166358A0 (en) 2006-01-16
KR20050026507A (en) 2005-03-15
EA008147B1 (en) 2007-04-27
JP2006503813A (en) 2006-02-02
NO20050980L (en) 2005-02-23
WO2004011663A3 (en) 2004-07-15
CN100339486C (en) 2007-09-26
HK1081999A1 (en) 2006-05-26
CA2492079C (en) 2012-01-10
CO5690563A2 (en) 2006-10-31
EA200601030A1 (en) 2006-10-27
WO2004011663A9 (en) 2004-05-06

Similar Documents

Publication Publication Date Title
SV2002000249A (en) DERIVATIVES OF TIAZOLILAMIDA REF, LEA 34082-SV
ECSP077271A (en) PIRIMIDINE DERIVATIVES
DK1881967T3 (en) Substituted benzo (D) isoaxol-3-yl-amine compounds as analgesics
ECSP077259A (en) PIRIMIDINE DERIVATIVES
HN2003000196A (en) INDOLINFENYL SULFONAMIDE DERIVATIVES
UY27571A1 (en) 2-TIO-3, 5-DICIAN-4-PHENYL-6-REPLACED AMINOPIRIDINS AND THEIR USE
SE0002102D0 (en) Chemical compound
AR027060A1 (en) MANNICH BASES OF 1-NAFTOL AND 2-NAFTOL SUBSTITUTED, PROCEDURE FOR PREPARATION, MEDICATIONS CONTAINING THESE COMPOUNDS, AS WELL AS THE USE OF THESE COMPOUNDS FOR THE MANUFACTURE OF MEDICINES
CR8765A (en) PREGABALINE PREPARATION AND RELATED COMPOUNDS
CL2008003684A1 (en) Pharmaceutical composition comprising an aluminum salt, having a molar ratio of aluminum to chloride from about 0.3: 1 to 3: 1, further comprising zirconium; method of preparing the composition; use as an antiperspirant.
UY30711A1 (en) NEW DERIVATIVES OF 1,4-BENZOTIEPINA-1, 1-CIOXIDE, METHOD FOR PREPARATION, PHARMACEUTICAL PRODUCTS THAT INCLUDE THESE COMPOUNDS AND THEIR USE.-
UY29003A1 (en) NEW HIDANTOINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THERAPY
PA8575601A1 (en) PROCEDURE FOR PREPARATION, MEDICATIONS THAT INCLUDE THESE COMPOUNDS AND THEIR USE
ECSP11011095A (en) 4- (1,2,3,4-tetrahydroisoquinoline-2-yl) -4-oxobutyric acid amides substituted as modulators of KCNQ2 / 3.
CR9182A (en) DERIVATIVE OF QUINOLINA, ITS USE, PREPARATION AND MEDICINAL PRODUCT CONTAINING IT
ECSP045219A (en) DERIVATIVES OF QUINAZOLINONA AND ITS USE AS CB AGONISTS
ECSP034531A (en) SUBSTITUTED DERIVATIVES OF C-CICLOHEXILMETILAMINA
AR029795A1 (en) ACID DERIVATIVES 1,2,3,4-TETRAHYDROQUINOLIN-2-CARBOXILICO REPLACED, PROCEDURES FOR THEIR PREPARATION, ITS USE FOR THE PREPARATION OF MEDICINES AND MEDICINES CONTAINING THESE COMPOUNDS
AR048672A1 (en) DISINTEGRATION TABLETS THAT INCLUDE LICARBAZEPINA
ECSP034754A (en) DERIVATIVES OF BETA-CARBOLINA AND ITS PHARMACEUTICAL USE AGAINST DEPRESSION AND ANXIETY
CR7672A (en) MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 11- ALFA- HYDROXIESTEROIDS 7- ALFA SUBSTITUTED
CL2009001342A1 (en) Pregn-4-en-21,17-carbolactones substituted in ring c; pharmaceutical preparations containing it; compound 11 alpha-hydroxy-15 beta, 16 beta-methylene-androst-4-en-3,17-dione; process for preparing said compound comprising the use of microorganisms.
CR7989A (en) 7-ALQUINILAMINO- TRIAZOLOPIRIMIDINAS, PROCEDURES FOR ITS OBTAINING AND THE USE OF THE SAME TO CONTROL HARMFUL FUNGES, AS WELL AS PRODUCTS THAT CONTAIN IT
CL2008001325A1 (en) Compounds derived from pyrazole-pyridinone; preparation process of said compounds; pharmaceutical composition that includes them; and its use to treat inflammation, paget disease, osteoarthritis, Alzheimer's, among other diseases.
DE602006014001D1 (en) Preparation of 2-aminothiazole-5-carboxylic acid derivatives

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)