CR7195A - NEW DERIVATIVES OF OXAZOLIDINONES AS ANTIBACTERIALS - Google Patents

NEW DERIVATIVES OF OXAZOLIDINONES AS ANTIBACTERIALS

Info

Publication number
CR7195A
CR7195A CR7195A CR7195A CR7195A CR 7195 A CR7195 A CR 7195A CR 7195 A CR7195 A CR 7195A CR 7195 A CR7195 A CR 7195A CR 7195 A CR7195 A CR 7195A
Authority
CR
Costa Rica
Prior art keywords
antibacterials
oxazolidinones
new derivatives
derivatives
new
Prior art date
Application number
CR7195A
Other languages
Spanish (es)
Inventor
Mourelle Manzini Marisabel
Huguet Clotet Juan
Hidalgo Rodriguez Jose
Carlos Del Castillo Juan
Original Assignee
Laboratoiros Vita S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoiros Vita S A filed Critical Laboratoiros Vita S A
Publication of CR7195A publication Critical patent/CR7195A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Proporciona nuevos derivados fluorquinologicos de oxazolidinosas de formula general (I) asi como procedimientos para su obtencion , las correspondientes composiciones farmaceuticas y su utilizacion para la fabricacion de un medicamento destinado al tratamiento de infecciones microbianas. Estos nuevos compuestos son utiles como antibacterianos.It provides new fluorquinological oxazolidinous derivatives of general formula (I) as well as procedures for obtaining them, the corresponding pharmaceutical compositions and their use for the manufacture of a medicament for the treatment of microbial infections. These new compounds are useful as antibacterials.

CR7195A 2001-06-27 2003-12-10 NEW DERIVATIVES OF OXAZOLIDINONES AS ANTIBACTERIALS CR7195A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101559A ES2186550B2 (en) 2001-06-27 2001-06-27 NEW DERIVATIVES OF OXAZOLIDINONES AS ANTIBACTERIALS.

Publications (1)

Publication Number Publication Date
CR7195A true CR7195A (en) 2004-03-05

Family

ID=8498288

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7195A CR7195A (en) 2001-06-27 2003-12-10 NEW DERIVATIVES OF OXAZOLIDINONES AS ANTIBACTERIALS

Country Status (29)

Country Link
US (1) US20040147545A1 (en)
EP (1) EP1401834A1 (en)
JP (1) JP2004521147A (en)
KR (1) KR20040030712A (en)
CN (1) CN1520412A (en)
AP (1) AP2003002942A0 (en)
AR (1) AR035254A1 (en)
BG (1) BG108498A (en)
BR (1) BR0210667A (en)
CA (1) CA2450982A1 (en)
CO (1) CO5540387A2 (en)
CR (1) CR7195A (en)
CZ (1) CZ2004101A3 (en)
EA (1) EA200400086A1 (en)
EE (1) EE200400004A (en)
ES (1) ES2186550B2 (en)
HR (1) HRP20031063A2 (en)
HU (1) HUP0400370A2 (en)
IL (1) IL159434A0 (en)
IS (1) IS7088A (en)
MA (1) MA27046A1 (en)
MX (1) MXPA04000185A (en)
NO (1) NO20035791L (en)
NZ (1) NZ530206A (en)
OA (1) OA12639A (en)
PE (1) PE20030134A1 (en)
PL (1) PL365476A1 (en)
SK (1) SK572004A3 (en)
WO (1) WO2003002560A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
WO2004096221A1 (en) * 2003-04-30 2004-11-11 Morphochem Aktiengesellschaft für kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
DE10340485B4 (en) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Process for the preparation of oxazolidinone-quinolone hybrids
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
WO2005051933A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1709044B2 (en) * 2003-12-18 2013-11-20 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1557416A1 (en) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
CN101460495B (en) 2006-03-31 2013-08-14 财团法人乙卯研究所 Compound having heterocyclic ring
EP2233484A3 (en) 2007-10-02 2012-04-04 Research Foundation Itsuu Laboratory Oxazolidinone derivatives having a 7-membered heterocyclic ring
MY156304A (en) * 2008-05-09 2016-01-29 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases
US9993469B2 (en) 2013-05-28 2018-06-12 Morphochem Aktiengesellschaft Für Kombinatorishe Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
EP3517106A1 (en) 2013-05-28 2019-07-31 Morphochem Aktiengesellschaft für kombinatorische Chemie Oxazolidinone-quinolone hybrid antibacterials for the parenteral treatment or prophylaxis of bacterial diseases
CN107286111B (en) * 2016-03-30 2020-06-19 广东赛法洛药业有限公司 Preparation method of oxazolidinone compound
CN107286182A (en) * 2016-04-12 2017-10-24 李靖 Novel oxazolidinone fluoro quinolone derivative and purposes
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
GB201708606D0 (en) * 2017-05-30 2017-07-12 King S College London Antibiotic resistance breakers
EP3717490B1 (en) * 2017-11-29 2023-05-24 Bugworks Research, Inc. Anti-bacterial heterocyclic compounds and their synthesis
CN111087409B (en) * 2018-10-24 2021-06-08 江阴安博生物医药有限公司 Quinolone compound and preparation method and application thereof
CN112940038A (en) * 2019-12-11 2021-06-11 华创合成制药股份有限公司 Novel oxazolidinone compound and preparation method thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE444566B (en) * 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-DIALKYLAMINE-6-HALOGEN-4-OXO-1,4-DIHYDROQINOLINE-3-CARBOXYLIC ACID, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION OF THEREOF
DE69019859T2 (en) * 1989-03-30 1995-10-05 Wakunaga Seiyaku Kk Quinolone derivatives and their salts, processes for their preparation and antibacterial active ingredients containing them.
SK283420B6 (en) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Oxazolidinones containing a substituted diazine moiety and their use as antimicrobials
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
PT788498E (en) * 1994-10-26 2002-02-28 Upjohn Co ANTIMICROBIAL COMPOUNDS OF PHENYLXAZOLIDINONE
KR19990082201A (en) * 1996-01-31 1999-11-25 가와무라 요시부미 AIDS treatment or prevention
CZ298060B6 (en) * 1996-04-11 2007-06-06 Pharmacia & Upjohn Company Process for preparing oxazolidinones
GB9614236D0 (en) * 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
CN1520412A (en) 2004-08-11
WO2003002560A1 (en) 2003-01-09
IL159434A0 (en) 2004-06-01
EE200400004A (en) 2004-02-16
US20040147545A1 (en) 2004-07-29
EP1401834A1 (en) 2004-03-31
NZ530206A (en) 2005-07-29
EA200400086A1 (en) 2004-06-24
AP2003002942A0 (en) 2003-12-24
CO5540387A2 (en) 2005-07-29
BR0210667A (en) 2004-10-05
AR035254A1 (en) 2004-05-05
OA12639A (en) 2006-06-15
NO20035791L (en) 2004-02-19
PE20030134A1 (en) 2003-04-04
ES2186550B2 (en) 2003-11-16
HUP0400370A2 (en) 2004-08-30
CZ2004101A3 (en) 2004-07-14
CA2450982A1 (en) 2003-01-09
ES2186550A1 (en) 2003-05-01
IS7088A (en) 2003-12-22
SK572004A3 (en) 2004-08-03
MXPA04000185A (en) 2004-03-18
PL365476A1 (en) 2005-01-10
HRP20031063A2 (en) 2004-04-30
KR20040030712A (en) 2004-04-09
JP2004521147A (en) 2004-07-15
MA27046A1 (en) 2004-12-20
BG108498A (en) 2005-03-31

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Legal Events

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FA Abandonment or withdrawal (granting procedure)