CR20200616A - Métodos para modular los niveles de plasma de metabolitos de tetrabenazina utilizando bupropión - Google Patents

Métodos para modular los niveles de plasma de metabolitos de tetrabenazina utilizando bupropión

Info

Publication number
CR20200616A
CR20200616A CR20200616A CR20200616A CR20200616A CR 20200616 A CR20200616 A CR 20200616A CR 20200616 A CR20200616 A CR 20200616A CR 20200616 A CR20200616 A CR 20200616A CR 20200616 A CR20200616 A CR 20200616A
Authority
CR
Costa Rica
Prior art keywords
bupropion
methods
modulating
plasma levels
tetrabenazine
Prior art date
Application number
CR20200616A
Other languages
English (en)
Inventor
Herriot Tabuteau
Original Assignee
Axsome Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axsome Therapeutics Inc filed Critical Axsome Therapeutics Inc
Publication of CR20200616A publication Critical patent/CR20200616A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

<p>Esta divulgación se refiere a métodos que administran bupropión, como <em>S</em>bupropión o <em>R</em>-bupropión, junto con tetrabenazina, alfa-dihidrotetrabenazina o betadihidrotetrabenazina a un ser humano. También se describen formas de dosificación, sistemas de administración de fármacos y métodos relacionados con tetrabenazina, alfadihidrotetrabenazina o beta-dihidrotetrabenazina y bupropión, como <em>S</em>-bupropión o <em>R</em>bupropión</p>
CR20200616A 2018-06-10 2019-06-10 Métodos para modular los niveles de plasma de metabolitos de tetrabenazina utilizando bupropión CR20200616A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862682998P 2018-06-10 2018-06-10
US201862683399P 2018-06-11 2018-06-11
PCT/US2019/036406 WO2019241162A1 (en) 2018-06-10 2019-06-10 Methods of modulating tetrabenazine metabolites plasma levels using bupropion

Publications (1)

Publication Number Publication Date
CR20200616A true CR20200616A (es) 2021-03-15

Family

ID=68843534

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20200616A CR20200616A (es) 2018-06-10 2019-06-10 Métodos para modular los niveles de plasma de metabolitos de tetrabenazina utilizando bupropión

Country Status (17)

Country Link
EP (1) EP3790538A4 (es)
JP (2) JP2021529826A (es)
KR (2) KR20240034871A (es)
CN (1) CN112292121A (es)
AU (2) AU2019284477B2 (es)
BR (1) BR112020025064A2 (es)
CA (1) CA3101375A1 (es)
CL (1) CL2020003189A1 (es)
CO (1) CO2021000037A2 (es)
CR (1) CR20200616A (es)
EC (1) ECSP20082568A (es)
IL (1) IL279332A (es)
MX (1) MX2020013385A (es)
NI (1) NI202000095A (es)
PE (1) PE20210370A1 (es)
SG (1) SG11202011762VA (es)
WO (1) WO2019241162A1 (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2462611A (en) * 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
JP2013501810A (ja) * 2009-08-12 2013-01-17 ヴァリーント インターナショナル（バルバドス）エスアールエル 医薬組成物
US10105327B2 (en) * 2013-11-05 2018-10-23 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphane and related pharmacodynamic effects
US9707191B2 (en) * 2013-11-05 2017-07-18 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
WO2015095713A1 (en) * 2013-12-20 2015-06-25 Deuterx, Llc Methods of treating neurological and other disorders using enantiopure deuterium-enriched bupropion
IL288712B2 (en) * 2015-03-06 2024-01-01 Auspex Pharmaceuticals Inc Methods for treating abnormal movement disorders
WO2016210180A2 (en) * 2015-06-23 2016-12-29 Neurocrine Biosciences, Inc. Vmat2 inhibitors for treating neurological diseases or disorders

Also Published As

Publication number Publication date
EP3790538A1 (en) 2021-03-17
NI202000095A (es) 2021-06-22
ECSP20082568A (es) 2021-02-26
EP3790538A4 (en) 2021-06-30
MX2020013385A (es) 2021-05-27
KR20240034871A (ko) 2024-03-14
PE20210370A1 (es) 2021-02-26
JP2021529826A (ja) 2021-11-04
AU2019284477A1 (en) 2021-01-28
SG11202011762VA (en) 2020-12-30
CL2020003189A1 (es) 2021-05-28
AU2022268331A1 (en) 2022-12-15
CA3101375A1 (en) 2019-12-19
WO2019241162A1 (en) 2019-12-19
AU2019284477B2 (en) 2022-08-11
CN112292121A (zh) 2021-01-29
BR112020025064A2 (pt) 2021-03-23
JP2024059744A (ja) 2024-05-01
IL279332A (en) 2021-01-31
CO2021000037A2 (es) 2021-01-18
KR20210018914A (ko) 2021-02-18

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