CR20190012A - SPECIFIC ANTIBODIES FOR HYPERPHOSPHORILED TAUY AND ITS METHODS OF USE - Google Patents

SPECIFIC ANTIBODIES FOR HYPERPHOSPHORILED TAUY AND ITS METHODS OF USE

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Publication number
CR20190012A
CR20190012A CR20190012A CR20190012A CR20190012A CR 20190012 A CR20190012 A CR 20190012A CR 20190012 A CR20190012 A CR 20190012A CR 20190012 A CR20190012 A CR 20190012A CR 20190012 A CR20190012 A CR 20190012A
Authority
CR
Costa Rica
Prior art keywords
methods
hyperphosphoriled
tauy
specific antibodies
tau
Prior art date
Application number
CR20190012A
Other languages
Spanish (es)
Inventor
Christiane; Volbracht
Ayodeji Abdur-Rasheed; Asuni
Jan Torleif Pedersen
Lars Østergaard; Pedersen
Justus Claus Alfred Daechsel
Søren; Christensen
Nina Helen Rosenqvist
Lena; Tagmose
Mauro Marigo
Laurent David
Lone Helbo
Kristian; Kjærgaard
Karsten; Juhl
Thomas; Jensen
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Priority claimed from PCT/EP2017/067067 external-priority patent/WO2018011073A1/en
Publication of CR20190012A publication Critical patent/CR20190012A/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a una clase de anticuerpo monoclonal que se une de manera específica al residuo fosforilado de serina 396 en la tau patológica hiperfosforilada (PHF) (pS396) con una afinidad mejorada, así como también a métodos de uso de estas moléculas y sus fragmentos de unión a tau en el tratamiento de la enfermedad de Alzheimer y otras tauopatías.The present invention relates to a class of monoclonal antibody that specifically binds to phosphorylated serine residue 396 in hyperphosphorylated pathological tau (PHF) (pS396) with improved affinity, as well as methods of using these molecules and its tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

CR20190012A 2016-07-12 2017-07-07 SPECIFIC ANTIBODIES FOR HYPERPHOSPHORILED TAUY AND ITS METHODS OF USE CR20190012A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA201600416 2016-07-12
DKPA201700005 2017-01-04
DKPA201700179 2017-03-14
PCT/EP2017/067067 WO2018011073A1 (en) 2016-07-12 2017-07-07 Antibodies specific for hyperphosphorylated tau and methods of use thereof

Publications (1)

Publication Number Publication Date
CR20190012A true CR20190012A (en) 2019-04-04

Family

ID=66592654

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20190012A CR20190012A (en) 2016-07-12 2017-07-07 SPECIFIC ANTIBODIES FOR HYPERPHOSPHORILED TAUY AND ITS METHODS OF USE

Country Status (1)

Country Link
CR (1) CR20190012A (en)

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