CR20120493A - PARENTERAL PHARMACEUTICAL FORM, WHICH RELEASES INHIBITORS OF AROMATASE AND GESTAGENS FOR THE TREATMENT OF ENDOMETRIOSIS - Google Patents

PARENTERAL PHARMACEUTICAL FORM, WHICH RELEASES INHIBITORS OF AROMATASE AND GESTAGENS FOR THE TREATMENT OF ENDOMETRIOSIS

Info

Publication number
CR20120493A
CR20120493A CR20120493A CR20120493A CR20120493A CR 20120493 A CR20120493 A CR 20120493A CR 20120493 A CR20120493 A CR 20120493A CR 20120493 A CR20120493 A CR 20120493A CR 20120493 A CR20120493 A CR 20120493A
Authority
CR
Costa Rica
Prior art keywords
endometriosis
treatment
aromatase
gestagens
inhibitors
Prior art date
Application number
CR20120493A
Other languages
Spanish (es)
Inventor
Arto Pakkalin
Rudolf Knauthe
Heinz Schmitz
Christine Talling
Harri Jukarainen
Henriikka Korolainen
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44021822&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120493(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CR20120493A publication Critical patent/CR20120493A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

El contenido de la presente invención para el tratamiento de endometriosis consiste en proporcionar una forma farmacéutica parenteral (sistema de administración) para la liberación controlada de un inhibidor de aromatasa (AI) con una tasa de liberación diaria, que no induce una estimulación de los ovarios por reacoplamiento negativo del eje hipófisis-ovario (que provocaría una secreción de gonadotropinas y estimulación del crecimiento folicular ovárico),The content of the present invention for the treatment of endometriosis is to provide a parenteral dosage form (administration system) for the controlled release of an aromatase inhibitor (AI) with a daily release rate, which does not induce a stimulation of the ovaries. by negative re-coupling of the pituitary-ovarian axis (which would cause gonadotropin secretion and stimulation of ovarian follicular growth),

CR20120493A 2010-03-31 2012-09-27 PARENTERAL PHARMACEUTICAL FORM, WHICH RELEASES INHIBITORS OF AROMATASE AND GESTAGENS FOR THE TREATMENT OF ENDOMETRIOSIS CR20120493A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102010003494A DE102010003494A1 (en) 2010-03-31 2010-03-31 Parenteral delivery system that releases aromatase inhibitors and progestins for the treatment of endometriosis

Publications (1)

Publication Number Publication Date
CR20120493A true CR20120493A (en) 2012-11-22

Family

ID=44021822

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120493A CR20120493A (en) 2010-03-31 2012-09-27 PARENTERAL PHARMACEUTICAL FORM, WHICH RELEASES INHIBITORS OF AROMATASE AND GESTAGENS FOR THE TREATMENT OF ENDOMETRIOSIS

Country Status (41)

Country Link
US (2) US20130131027A1 (en)
EP (1) EP2552404B1 (en)
JP (2) JP6012048B2 (en)
KR (1) KR20130010047A (en)
CN (1) CN103002873B (en)
AR (1) AR080861A1 (en)
AU (1) AU2011234587B2 (en)
BR (1) BR112012024739A2 (en)
CA (1) CA2794790A1 (en)
CL (1) CL2012002722A1 (en)
CO (1) CO6630125A2 (en)
CR (1) CR20120493A (en)
CU (1) CU20120145A7 (en)
CY (1) CY1116187T1 (en)
DE (1) DE102010003494A1 (en)
DK (1) DK2552404T3 (en)
DO (1) DOP2012000255A (en)
EA (1) EA025582B1 (en)
EC (1) ECSP12012176A (en)
ES (1) ES2533101T3 (en)
GT (1) GT201200267A (en)
HK (1) HK1179531A1 (en)
HR (1) HRP20150294T1 (en)
IL (1) IL222056A (en)
MA (1) MA34099B1 (en)
ME (1) ME02159B (en)
MX (1) MX2012011329A (en)
MY (1) MY160353A (en)
NZ (1) NZ602698A (en)
PE (1) PE20130524A1 (en)
PL (1) PL2552404T3 (en)
PT (1) PT2552404E (en)
RS (1) RS53876B1 (en)
SG (1) SG184111A1 (en)
SI (1) SI2552404T1 (en)
TN (1) TN2012000468A1 (en)
TW (2) TW201632184A (en)
UA (1) UA109655C2 (en)
UY (1) UY33303A (en)
WO (1) WO2011120925A1 (en)
ZA (1) ZA201206869B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
JP6285866B2 (en) 2011-11-23 2018-02-28 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． Natural complex hormone replacement preparations and therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
KR20170005819A (en) 2014-05-22 2017-01-16 쎄러퓨틱스엠디, 인코퍼레이티드 Natural combination hormone replacement formulations and therapies
BR112017025097B1 (en) * 2015-05-27 2021-05-11 Quest Diagnostics Investments Llc method for mass spectrometric quantification of analytes extracted from a microsampling device
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
CN108430453B (en) * 2015-12-21 2023-03-17 拜耳股份有限公司 Method of manufacturing a drug delivery device and drug delivery device manufactured according to the method
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
GB201614179D0 (en) * 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
CN109248166A (en) * 2017-07-13 2019-01-22 国家卫生计生委科学技术研究所 The preparation and application of Anastrozole depot pesseulum
US10918649B2 (en) 2019-06-21 2021-02-16 The Population Council, Inc. System for providing birth control
WO2022174074A1 (en) * 2021-02-12 2022-08-18 The Regents Of The University Of California Endometriosis-related methods and compositions
CN115804762B (en) * 2022-12-20 2024-05-31 浙江大学 Macrophage membrane coated ectopic endometrium targeting nanoparticle, preparation method and application

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
JP2602456B2 (en) * 1990-04-12 1997-04-23 雪印乳業株式会社 Endometriosis treatment
FI95768C (en) * 1993-06-17 1996-03-25 Leiras Oy Intravaginal dosing system
US7744916B2 (en) * 1997-06-11 2010-06-29 Umd, Inc. Coated vaginal device for delivery of anti-migraine and anti-nausea drugs
FI20000572A (en) * 2000-03-13 2001-09-14 Leiras Oy Device intended for application of implants
CA2434611A1 (en) * 2001-01-26 2002-09-19 Pharmacia Italia Spa Combined method for treating hormono-dependent disorders
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
WO2003017973A1 (en) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. A method of treating benign gynaecological disorders and a drug delivery vehicle for use in such a method
GB0302572D0 (en) * 2003-02-05 2003-03-12 Astrazeneca Ab Method of treatment
GB0320238D0 (en) * 2003-08-29 2003-10-01 Medical Res Council Treatment of disease
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
TW200930343A (en) * 2007-09-21 2009-07-16 Organon Nv Drug delivery system
TW200927141A (en) * 2007-11-22 2009-07-01 Bayer Schering Pharma Oy Vaginal delivery system
US20110033519A1 (en) * 2009-08-07 2011-02-10 Leong Madeline Device with Aromatase Inhibitor for the Treatment and Prevention of Uterine Fibroids and Method of Use

Also Published As

Publication number Publication date
MA34099B1 (en) 2013-03-05
SI2552404T1 (en) 2015-04-30
MX2012011329A (en) 2012-11-30
PT2552404E (en) 2015-03-30
DK2552404T3 (en) 2015-03-30
DE102010003494A1 (en) 2011-10-06
HRP20150294T1 (en) 2015-06-19
ES2533101T3 (en) 2015-04-07
SG184111A1 (en) 2012-10-30
AR080861A1 (en) 2012-05-16
CN103002873A (en) 2013-03-27
KR20130010047A (en) 2013-01-24
GT201200267A (en) 2014-06-04
EP2552404A1 (en) 2013-02-06
RS53876B1 (en) 2015-08-31
ME02159B (en) 2015-10-20
BR112012024739A2 (en) 2016-06-07
WO2011120925A1 (en) 2011-10-06
US20130131027A1 (en) 2013-05-23
UA109655C2 (en) 2015-09-25
TW201201799A (en) 2012-01-16
IL222056A (en) 2016-03-31
EP2552404B1 (en) 2015-01-21
TN2012000468A1 (en) 2014-01-30
PL2552404T3 (en) 2015-05-29
TWI576107B (en) 2017-04-01
US20150359802A1 (en) 2015-12-17
JP2013523683A (en) 2013-06-17
DOP2012000255A (en) 2013-04-30
UY33303A (en) 2011-10-31
CA2794790A1 (en) 2011-10-06
PE20130524A1 (en) 2013-04-26
TW201632184A (en) 2016-09-16
CO6630125A2 (en) 2013-03-01
NZ602698A (en) 2014-08-29
EA201201358A1 (en) 2013-04-30
MY160353A (en) 2017-02-28
JP2016164200A (en) 2016-09-08
HK1179531A1 (en) 2013-10-04
CU20120145A7 (en) 2013-05-31
AU2011234587B2 (en) 2015-07-09
CY1116187T1 (en) 2017-02-08
CN103002873B (en) 2015-02-18
CL2012002722A1 (en) 2013-01-18
ECSP12012176A (en) 2012-10-30
ZA201206869B (en) 2016-01-27
JP6012048B2 (en) 2016-10-25
AU2011234587A1 (en) 2012-10-25
EA025582B1 (en) 2017-01-30

Similar Documents

Publication Publication Date Title
CR20120493A (en) PARENTERAL PHARMACEUTICAL FORM, WHICH RELEASES INHIBITORS OF AROMATASE AND GESTAGENS FOR THE TREATMENT OF ENDOMETRIOSIS
AR117670A2 (en) ANDROGEN RECEPTOR MODULATOR AND ITS USES
CO7240407A2 (en) Crystal forms of an androgenic receptor modulator
CL2016003295A1 (en) Intermittent dosing of an mdm2 inhibitor.
AR097619A1 (en) USE OF ACETIL-COA CARBOXYLASE INHIBITORS TO TREAT ACNÉ VULGARIS
UY34132A (en) COMBINED THERAPIES FOR THE TREATMENT OF HEMATOLOGICAL MALIGNAL NEOPLASIAS USING PI3K / MTOR PYRIDOPIRIMIDINONE INHIBITORS WITH BENDAMUSTINE AND / OR RITUXIMAB.
ECSP12012167A (en) Procedures for the formation of cyclodextrin complexes to formulate peptide proteasome inhibitors
PE20142239A1 (en) INTRAUTERINE SYSTEMS, IUD INSERTION DEVICES, AND RELATED METHODS AND KITS THEREOF
BR112016008576A2 (en) STABLE AQUEOUS FORMULATIONS OF ANTIBODIES AND PHARMACEUTICAL UNIT DOSAGE FORM
BR112013004440A2 (en) method for parenteral administration of a composition, pharmaceutical composition for parenteral administration, kit and pharmaceutical system for parenteral administration
AR077225A1 (en) INJECTABLE FORMULATIONS CONTAINING ASENAPINE AND TREATMENT METHOD THAT USES THEM
EA201400737A1 (en) DELIVERY SYSTEM ON THE BASIS OF A PELLET SET WITH IMMEDIATE release of an ACTIVE SUBSTANCE
PE20150190A1 (en) PHARMACEUTICAL FORMULATION
UY34178A (en) DOSAGE AND ADMINISTRATION OF ANTI-ERBB3 ANTIBODIES IN COMBINATION WITH PACLITAXEL FOR THE TREATMENT OF GYNECOLOGICAL CANCER.
CL2016001094A1 (en) Microporous zirconium silicate for the treatment of hyperkalemia.
MX337464B (en) Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents.
AR100365A1 (en) WATERPROOF COMPOSITION INCLUDING IBUPROFEN AND PARACETAMOL IN COMBINATION, PROCESS TO MANUFACTURE AND INJECTOR DEVICE FOR ADMINISTRATE
EA201490862A1 (en) OSMOTICALLY ACTIVE VAGINAL DELIVERY SYSTEM
AR091886A1 (en) DISPENSING DEVICE
UY34154A (en) DOSAGE AND ADMINISTRATION OF ANTI-ERBB3 ANTIBODIES IN COMBINATION WITH PACLITAXEL.
AR095834A1 (en) DOSAGE FORM OF A PROGESTERONE RECEIVER ANTAGONIST, PHARMACEUTICAL COMPOSITION
UY35004A (en) STABILIZED AMORFA FORM OF AGOMELATIN, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
AR125339A2 (en) NOTCH PATH SIGNALING INHIBITOR COMPOUND
EA201592232A1 (en) APPLICATION OF DENTSIKHIN IN OBTAINING A MEDICINE FOR THE TREATMENT OF THROMBOCYTOPIA
UA97716U (en) MEDICINE IN THE FORM OF SYRUP CONTAINING FENSPIRIDE HYDROCHLORIDE