CR10324A - NON-PEPTIDIC MOLECULES TO DETECT AND TREAT TUMORS - Google Patents

NON-PEPTIDIC MOLECULES TO DETECT AND TREAT TUMORS

Info

Publication number
CR10324A
CR10324A CR10324A CR10324A CR10324A CR 10324 A CR10324 A CR 10324A CR 10324 A CR10324 A CR 10324A CR 10324 A CR10324 A CR 10324A CR 10324 A CR10324 A CR 10324A
Authority
CR
Costa Rica
Prior art keywords
detect
treat tumors
peptidic molecules
acidity
tumors
Prior art date
Application number
CR10324A
Other languages
Spanish (es)
Inventor
E Summerton James
Original Assignee
E Summerton James
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/395,487 external-priority patent/US20070231256A1/en
Priority claimed from US11/449,495 external-priority patent/US8084610B2/en
Priority claimed from US11/449,508 external-priority patent/US20080124274A1/en
Application filed by E Summerton James filed Critical E Summerton James
Publication of CR10324A publication Critical patent/CR10324A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una de las caracteristicas mas universales de los tumores malignos es su acidez. Las oncotools son pequenas moleculas sinteticas no peptidicas disenadas para aprovechar esta acidez para la deteccion temprana y la destruccion de tumores. Cada oncotool tiene una estructura que es anionica e hidrofila a pH 7,4 y de este modo repele las superficies cargadas negativamente de las celulas en los tejidos normales.One of the most universal characteristics of malignant tumors is their acidity. Oncotools are small synthetic non-peptide molecules designed to take advantage of this acidity for early detection and destruction of tumors. Each oncotool has a structure that is anionic and hydrophilic at pH 7.4 and thus repels negatively charged cell surfaces in normal tissues.

CR10324A 2006-03-30 2008-09-29 NON-PEPTIDIC MOLECULES TO DETECT AND TREAT TUMORS CR10324A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/395,487 US20070231256A1 (en) 2006-03-30 2006-03-30 Compositions and methods for detecting and treating tumors containing acidic areas
US11/449,495 US8084610B2 (en) 2006-06-07 2006-06-07 Compositions and methods for detecting and treating tumors containing acidic areas
US11/449,508 US20080124274A1 (en) 2006-06-07 2006-06-07 Compositions and methods for detecting and treating tumors containing acidic areas

Publications (1)

Publication Number Publication Date
CR10324A true CR10324A (en) 2008-11-26

Family

ID=39870100

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10324A CR10324A (en) 2006-03-30 2008-09-29 NON-PEPTIDIC MOLECULES TO DETECT AND TREAT TUMORS

Country Status (1)

Country Link
CR (1) CR10324A (en)

Similar Documents

Publication Publication Date Title
CY1120257T1 (en) PYROLOL [2,3b] PYRIDIN-4-GLAMES AND PYROLOL [2,3b] PYRIMIDIN-4-GLAMES AS JANUS MODELS
BRPI0814529A2 (en) 2-3-DIHYDROBENZO [1,4] DIOXIN-2-ILMETIL DERIVATIVES AS ALFA2C ANTAGONISTS FOR USE IN THE TREATMENT OF PERIPHERAL AND CENTRAL NERVOUS SYSTEM DISEASES.
ATE512024T1 (en) SHOCK ABSORPTION DEVICE AND SEAT EQUIPPED WITH SUCH DEVICE
GT200600407A (en) ACTIVE PPAR COMPOUNDS
BR112016001851A2 (en) treated three-dimensional corrugated material
UY28933A1 (en) COMBINATIONS THAT INCLUDE ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS
BRPI0607002A2 (en) therapeutic aptamers useful in the treatment of complement-related disorders
CL2007001665A1 (en) Antibody or fragment thereof with neutralizing activity of protein nr 10; agent who understands it; and its use to prevent or treat an inflammatory disease.
CY1114153T1 (en) CYCLOCOPYL PYRROLOCARZAIOL PRODUCERS AND USE THEM AS PARP, VEGFR2 AND MLK3 INHIBITORS
BR112014023005A2 (en) quick diagnosis and personalized acne treatments
CR9365A (en) COMPOUNDS AND METHODS FOR THE INHIBITION OF THE PROTEIN-CINASA RAF
BRPI0607507A2 (en) in vitro method for the identification of cancer treatment compounds
BR0014924B1 (en) process and system for illuminating the retina of an eye, and process and system for determining a wavefront aberration of an atopic element.
BRPI0715718A2 (en) ANTIBODY, METHODS OF TRIARING TO AN ANTIBODY FOR THE EXTRACELLULAR DOMAIN OF A PRLR PROTEIN, SYSTEMATICALLY CHANGING ANTIBODIES AND TRIATING TO AN ANTIBODY FOR AN EXTRACELLULAR DOMAIN, OF A CURREN ALTERNATE EXPRESSA PRLR, TO USE A HOSPITAL CELL, TO IDENTIFY AN INDIVIDUAL OF TREATMENT WITH AN ANTI-PRLR ANTIBODY, AND TO MONITOR CANCER THERAPY IN AN INDIVIDUAL, ISOLATED NUCLEIC ACID COMPLETE MOLECULES And, KIT
AR084723A1 (en) microRNA (miRNA) AS A BIOMARCATOR FOR THE IDENTIFICATION OF FAMILY AND NON-FAMILY COLORRECTAL CANCER
BRPI0606112A2 (en) 3 - heteroaryl - 3 - hydroxy - 2 - amino - propyl amines and related compounds, as well as their use and pharmaceutical composition
DOP2010000304A (en) COMPOSITIONS AND METHODS OF PREPARATION AND USE OF THE SAME
DE602005000485D1 (en) Nucleic acid detection method using multiple pairs of donor fluorophores and quenching molecules in the same probe
NO20075527L (en) Beta-2 adrenoceptor agonists for treating connective tissue diseases of the skin
BRPI0511802A (en) process for creating media for use in air / oil separators
BRPI0612424A2 (en) compositions and methods for treating conditions related to ephrine signaling with cupredoxins
CL2012002887A1 (en) Pharmaceutical combination comprising compounds derived from substituted 2,3-dihydroimidazo [1,2-c] quinazoline, compounds derived from n- (2-arylamino) arylsulfonamide and optionally other additional pharmaceutical agents; pharmaceutical kit; treatment method; and its use for the treatment or prophylaxis of cancer.
BRPI0718469A2 (en) USE OF AN INTERLEUCIN 1 ANTAGONIST (IL-1), METHOD FOR TREATING, INHIBITING OR IMPROVING PSEUDOGOTA, USE OF ONE OR MORE THERAPEUTIC AGENTS, AND, PRODUCT.
CL2009001076A1 (en) Nanoparticles comprising a particle-forming substance and a protein; composition comprising said nanoparticles; procedure for delivering a protein across the blood brain membrane; use of the composition for prophylaxis or treating diseases of the central nervous system.
AR048135A1 (en) USE OF SERICO AMYLOID GENE IN THE DIAGNOSIS AND TREATMENT OF GLAUCOMA AND IN THE IDENTIFICATION OF ANTI-GLAUCOMA AGENTS.