CO7061042A2 - Neisseria meningitidis compositions and methods thereof - Google Patents

Neisseria meningitidis compositions and methods thereof

Info

Publication number
CO7061042A2
CO7061042A2 CO14198149A CO14198149A CO7061042A2 CO 7061042 A2 CO7061042 A2 CO 7061042A2 CO 14198149 A CO14198149 A CO 14198149A CO 14198149 A CO14198149 A CO 14198149A CO 7061042 A2 CO7061042 A2 CO 7061042A2
Authority
CO
Colombia
Prior art keywords
methods
neisseria meningitidis
meningitidis compositions
compositions
neisseria
Prior art date
Application number
CO14198149A
Other languages
Spanish (es)
Inventor
Annaliesa Sybil Anderson
Susan Kay Hoiseth
Kathrin Ute Jansen
Justin Keith Moran
Mark Ruppen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO7061042A2 publication Critical patent/CO7061042A2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102Mutagenizing nucleic acids
    • C12N15/1031Mutagenizing nucleic acids mutagenesis by gene assembly, e.g. assembly by oligonucleotide extension PCR
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018Lipids, e.g. in lipopeptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/36Neisseria
CO14198149A 2012-03-09 2014-09-08 Neisseria meningitidis compositions and methods thereof CO7061042A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261609257P 2012-03-09 2012-03-09

Publications (1)

Publication Number Publication Date
CO7061042A2 true CO7061042A2 (en) 2014-09-19

Family

ID=48182966

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14198149A CO7061042A2 (en) 2012-03-09 2014-09-08 Neisseria meningitidis compositions and methods thereof

Country Status (21)

Country Link
US (3) US8986710B2 (en)
EP (3) EP4043029A1 (en)
JP (2) JP5925342B2 (en)
KR (5) KR101784644B1 (en)
CN (3) CN104334187B (en)
AR (3) AR090294A1 (en)
AU (5) AU2013229063B2 (en)
BR (2) BR122016004924A2 (en)
CA (4) CA2960030C (en)
CO (1) CO7061042A2 (en)
HK (1) HK1206625A1 (en)
IL (4) IL234555B (en)
MX (3) MX351993B (en)
MY (2) MY167723A (en)
NZ (2) NZ628449A (en)
PE (2) PE20190458A1 (en)
PH (2) PH12014501887B1 (en)
RU (2) RU2665841C2 (en)
SG (3) SG10201911003QA (en)
TW (5) TWI627181B (en)
WO (1) WO2013132452A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX339524B (en) 2001-10-11 2016-05-30 Wyeth Corp Novel immunogenic compositions for the prevention and treatment of meningococcal disease.
HUE052850T2 (en) 2010-08-23 2021-05-28 Wyeth Llc Stable formulations of neisseria meningitidis rlp2086 antigens
ES2585328T5 (en) 2010-09-10 2022-12-14 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
SA115360586B1 (en) 2012-03-09 2017-04-12 فايزر انك Neisseria meningitidis compositions and methods thereof
MY167723A (en) 2012-03-09 2018-09-21 Pfizer Neisseria meningitidis compositions and methods thereof
JP6446377B2 (en) 2013-03-08 2018-12-26 ファイザー・インク Immunogenic fusion polypeptide
CA2923129C (en) 2013-09-08 2020-06-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
MX2016011176A (en) 2014-02-28 2017-02-23 Glaxosmithkline Biologicals Sa Modified meningococcal fhbp polypeptides.
US10266572B2 (en) * 2014-07-23 2019-04-23 Children's Hospital & Research Center At Oakland Factor H binding protein variants and methods of use thereof
BR112017017460A2 (en) 2015-02-19 2018-04-10 Pfizer Inc. neisseria meningitidis compositions and methods thereof
CN108367060B (en) * 2015-08-11 2022-07-19 奥比思健康解决方案有限责任公司 Bacterial and viral vaccine strategies
US20180228885A1 (en) * 2016-03-04 2018-08-16 Orbis Health Solutions Llc Bacterial and viral vaccine strategy
CN109890413B (en) 2016-09-02 2024-04-16 赛诺菲巴斯德股份有限公司 Neisseria meningitidis vaccine
US10183070B2 (en) * 2017-01-31 2019-01-22 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2020165711A1 (en) 2019-02-11 2020-08-20 Pfizer Inc. Neisseria meningitidiscompositions and methods thereof
US20220401544A1 (en) 2019-09-27 2022-12-22 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
IL305313A (en) 2021-02-19 2023-10-01 Sanofi Pasteur Meningococcal b recombinant vaccine
WO2024030931A1 (en) 2022-08-03 2024-02-08 Sanofi Pasteur Inc. Adjuvanted immunogenic composition against neisseria meningitidis b

Family Cites Families (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
CH660375A5 (en) 1983-02-08 1987-04-15 Sclavo Spa PROCEDURE FOR THE PRODUCTION OF PROPHINES RELATED TO DIPHTERIC TOXIN.
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8424757D0 (en) 1984-10-01 1984-11-07 Pasteur Institut Retroviral vector
SE8405493D0 (en) 1984-11-01 1984-11-01 Bror Morein IMMUNOGENT COMPLEX AND KITCHEN FOR PREPARING IT AND USING IT AS IMMUNOSTIMENTING AGENTS
FR2573436B1 (en) 1984-11-20 1989-02-17 Pasteur Institut RECOMBINANT DNA COMPRISING A NUCLEOTIDE SEQUENCE ENCODING A DETERMINED POLYPEPTIDE UNDER THE CONTROL OF AN ADENOVIRUS PROMOTER, VECTORS CONTAINING THIS RECOMBINANT DNA, EUKARYOT CELLS TRANSFORMED BY THIS RECOMBINANT DNA, THE CONSTITUTION OF VACCINES
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4666829A (en) 1985-05-15 1987-05-19 University Of California Polypeptide marker for Alzheimer's disease and its use for diagnosis
EP0232262A4 (en) 1985-08-15 1989-09-19 Stauffer Chemical Co Tryptophan producing microorganism.
US5078996A (en) 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
DE3689123T2 (en) 1985-11-01 1994-03-03 Xoma Corp MODULAR UNIT OF ANTIBODY GENES, ANTIBODIES MADE THEREOF AND USE.
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US5514581A (en) 1986-11-04 1996-05-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
US4980289A (en) 1987-04-27 1990-12-25 Wisconsin Alumni Research Foundation Promoter deficient retroviral vector
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
JPH01125328A (en) 1987-07-30 1989-05-17 Centro Natl De Biopreparados Meningococcus vaccine
AU3069189A (en) 1988-02-05 1989-08-25 Trustees Of Columbia University In The City Of New York, The Retroviral packaging cell lines and processes of using same
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
JP3082204B2 (en) 1988-09-01 2000-08-28 ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ Recombinant retrovirus with an amphotropic and ecotropic host range
US7118757B1 (en) 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
US5124263A (en) 1989-01-12 1992-06-23 Wisconsin Alumni Research Foundation Recombination resistant retroviral helper cell and products produced thereby
KR100188323B1 (en) 1989-03-09 1999-06-01 이곤 이이 버어그 Vaccines for nontypable haemophilus influenzae
US5354844A (en) 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
CA2039921A1 (en) 1990-04-16 1991-10-17 Xandra O. Breakefield Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1991018088A1 (en) 1990-05-23 1991-11-28 The United States Of America, Represented By The Secretary, United States Department Of Commerce Adeno-associated virus (aav)-based eucaryotic vectors
IE912559A1 (en) 1990-07-19 1992-01-29 Merck & Co Inc The class ii protein of the outer membrane of neisseria¹meningitidis, and vaccines containing same
WO1992005263A1 (en) 1990-09-25 1992-04-02 Cantab Pharmaceuticals Research Limited Viral defective vaccine produced by transcomplementing cell line
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
IL101715A (en) 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
CA2121493A1 (en) 1991-10-21 1993-04-29 Charles K. Stover Bacterial expression vectors containing dna encoding secretion signals of lipoproteins
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
IT1253009B (en) 1991-12-31 1995-07-10 Sclavo Ricerca S R L DETOXIFIED IMMUNOGENIC MUTANTS OF COLERIC TOXIN AND TOXIN LT, THEIR PREPARATION AND USE FOR THE PREPARATION OF VACCINES
WO1993015115A1 (en) 1992-01-24 1993-08-05 Cornell Research Foundation, Inc. E. coli dna polymerase iii holoenzyme and subunits
EP1024198A3 (en) 1992-12-03 2002-05-29 Genzyme Corporation Pseudo-adenoviral vectors for the gene therapy of haemophiliae
ATE280235T1 (en) 1993-03-05 2004-11-15 Wyeth Corp PLASMID FOR PRODUCING CRM PROTEIN AND DIPHTHERIA TOXIN
CA2158148A1 (en) 1993-03-19 1994-09-29 Stephen Charles Inglis Defective mutant non-retroviral virus (e.g. hsv) as vaccine
PT624376E (en) 1993-05-13 2000-07-31 American Cyanamid Co PREPARATION AND UTILIZATION OF EXTERNAL MEMBRANE PROTEINS DEFICIATED IN GRAM-NEGATIVE COCONUTS
FR2705361B1 (en) 1993-05-18 1995-08-04 Centre Nat Rech Scient Viral vectors and use in gene therapy.
FR2705686B1 (en) 1993-05-28 1995-08-18 Transgene Sa New defective adenoviruses and corresponding complementation lines.
CZ287157B6 (en) 1993-07-13 2000-10-11 Rhone Poulenc Rorer Sa Defective recombinant adenovirus and pharmaceutical preparation in which said adenovirus is comprised
JPH09501055A (en) 1993-07-30 1997-02-04 ユニバーシティ オブ メディシン アンド デンティストリー オブ ニュージャージー Efficient gene transfer to primary lymphocytes
FR2708622B1 (en) 1993-08-02 1997-04-18 Raymond Hamers Recombinant vector containing a sequence of a structural lipoprotein gene for the expression of nucleotide sequences.
US5550213A (en) 1993-12-27 1996-08-27 Rutgers, The State University Of New Jersey Inhibitors of urokinase plasminogen activator
FR2714830B1 (en) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition containing nucleic acids, preparation and uses.
FR2715847B1 (en) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition containing nucleic acids, preparation and uses.
FR2716459B1 (en) 1994-02-22 1996-05-10 Univ Paris Curie Host-vector system usable in gene therapy.
AU2194895A (en) 1994-03-25 1995-10-17 Uab Research Foundation, The Composition and methods for creating syngeneic recombinant virus-producing cells
US5739118A (en) 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
CA2187818A1 (en) 1994-04-15 1995-10-26 Robert W. Overell Gene delivery fusion proteins
US5571515A (en) 1994-04-18 1996-11-05 The Wistar Institute Of Anatomy & Biology Compositions and methods for use of IL-12 as an adjuvant
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5565204A (en) 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
US5837533A (en) 1994-09-28 1998-11-17 American Home Products Corporation Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
GB9422096D0 (en) 1994-11-02 1994-12-21 Biocine Spa Combined meningitis vaccine
FR2727679B1 (en) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa NEW TRANSFECTION AGENTS AND THEIR PHARMACEUTICAL APPLICATIONS
BE1008978A5 (en) 1994-12-27 1996-10-01 Solvay Adjuvants for vaccines.
IL116816A (en) 1995-01-20 2003-05-29 Rhone Poulenc Rorer Sa Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
FR2730637B1 (en) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa PHARMACEUTICAL COMPOSITION CONTAINING NUCLEIC ACIDS, AND USES THEREOF
IL117483A (en) 1995-03-17 2008-03-20 Bernard Brodeur Proteinase k resistant surface protein of neisseria meningitidis
AU6043396A (en) 1995-06-05 1996-12-24 University Of Alabama At Birmingham Research Foundation, The Composition and methods for creating syngeneic recombinant v irus-producing cells
CA2223300C (en) 1995-06-07 2010-07-27 Connaught Laboratories, Inc. Expression of lipoproteins
FR2741358B1 (en) 1995-11-17 1998-01-02 Centre Nat Rech Scient PRODUCTION OF RETROVIRAL VECTORS VIA DNA VIRUS-BASED VIRAL VECTORS
US6355255B1 (en) 1998-12-07 2002-03-12 Regents Of The University Of Minnesota Streptococcal C5a peptidase vaccine
US5846547A (en) 1996-01-22 1998-12-08 Regents Of The University Of Minnesota Streptococcal C5a peptidase vaccine
JP4150082B2 (en) 1996-08-27 2008-09-17 カイロン コーポレイション Monoclonal antibodies defining unique meningococcal B epitopes and their use in the preparation of vaccine compositions
ATE208629T1 (en) 1996-08-27 2001-11-15 Chiron Corp NEISSERIA MENINGITIDIS SEROGROUP B GLYCOCONJUGATES AND METHOD FOR USE THEREOF
GB9622159D0 (en) 1996-10-24 1996-12-18 Solvay Sociutu Anonyme Polyanionic polymers as adjuvants for mucosal immunization
WO1998017805A2 (en) 1996-10-24 1998-04-30 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, c/o Centers for Disease Control and Prevention, Technology Transfer Office Invasion associated genes from neisseria meningitidis serogroup b
GB9622660D0 (en) 1996-10-31 1997-01-08 Biocine Spa Immunogenic detoxified mutant toxin
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
PL337584A1 (en) 1997-06-30 2000-08-28 Rhone Poulenc Rorer Sa Improved method of transferring nucleic acid to eucariotic cells of multiple-cell organisms and connection enabling accomplishment of this method
PL337583A1 (en) 1997-06-30 2000-08-28 Rhone Poulenc Rorer Sa Improved method of transferring nucleic acid to a striated muscle and connection enabling accomplishment of this method
IL133709A0 (en) 1997-06-30 2001-04-30 Rhone Poulence Rorer S A Device for optimized electrotransfer of nucleic acid vectors to tissues in vivo
JPH1144977A (en) 1997-07-25 1999-02-16 Copyer Co Ltd Image forming device
US6030619A (en) 1997-08-27 2000-02-29 Chiron Corporation Molecular mimetics of meningococcal B epitopes
DE69841807D1 (en) 1997-11-06 2010-09-16 Novartis Vaccines & Diagnostic NEISSERIAL ANTIGENE
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
DK1047784T4 (en) 1998-01-14 2015-06-15 Novartis Vaccines & Diagnostic NEISSERA meningitidis ANTIGENS
US7635486B1 (en) 1998-02-03 2009-12-22 The United States Of America As Represented By The Department Of Health And Human Services Recombinant lipidated PsaA protein, methods of preparation and use
GB9806456D0 (en) 1998-03-25 1998-05-27 Smithkline Beecham Biolog Vaccine composition
GB9808734D0 (en) 1998-04-23 1998-06-24 Smithkline Beecham Biolog Novel compounds
GB9808932D0 (en) 1998-04-27 1998-06-24 Chiron Spa Polyepitope carrier protein
EP2261351A3 (en) 1998-05-01 2012-01-11 Novartis Vaccines and Diagnostics, Inc. Neisseria meningitidis antigens and compositions
NZ508771A (en) 1998-05-29 2003-08-29 Chiron Corp Neisseria meningitidis vaccine comprising NmC oligosaccharides, NmB outer membrane proteins, and a carrier
PT1117435E (en) 1998-09-30 2008-02-21 Us Gov Univ Health Sciences Mutant cholera holotoxin as an adjuvant
ATE274353T1 (en) 1998-09-30 2004-09-15 Us Army USE OF PURIFIED INVAPLEX AS A VACCINE FOR GRAM NEGATIVE BACTERIA
AU1202200A (en) 1998-10-09 2000-05-01 Chiron Corporation Neisseria genomic sequences and methods of their use
RU2223492C2 (en) * 1998-10-09 2004-02-10 Чирон Корпорейшн Protein obtained from neisseria meningitidis (variants, its fragment, nucleic acid encoding thereof (variants), probe, primer, composition
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US6281337B1 (en) 1998-11-12 2001-08-28 Schering Corporation Methods for conversion of protein isoforms
CN1350585A (en) 1999-01-15 2002-05-22 史密丝克莱恩比彻姆生物有限公司 i(Neisseria meningitidis) polypeptide BASBO52
WO2000043518A1 (en) 1999-01-22 2000-07-27 Smithkline Beecham Biologicals S.A. Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides and protective antibodies
GB9902084D0 (en) 1999-01-29 1999-03-24 Smithkline Beecham Biolog Novel compounds
WO2000045841A2 (en) 1999-02-05 2000-08-10 Merck & Co., Inc. Human papilloma virus vaccine formulations
CA2371994C (en) 1999-02-26 2010-09-28 Guido Grandi Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs
US6245568B1 (en) 1999-03-26 2001-06-12 Merck & Co., Inc. Human papilloma virus vaccine with disassembled and reassembled virus-like particles
US7115730B1 (en) 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
ES2477194T3 (en) 1999-04-30 2014-07-16 Novartis Vaccines And Diagnostics S.R.L. Neisserial antigens conserved
DK1185691T3 (en) 1999-04-30 2009-06-22 Novartis Vaccines & Diagnostic Genomic neonatal sequences and methods for their use
EP2270172B1 (en) 1999-05-19 2016-01-13 GlaxoSmithKline Biologicals SA Combination neisserial compositions
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
US7384640B1 (en) 1999-09-30 2008-06-10 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant
CN1796404A (en) 1999-10-29 2006-07-05 启龙有限公司 Neisserial antigenic peptides
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
JP4840956B2 (en) 1999-11-29 2011-12-21 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル 85kDa Neisseria antigen
EP1233784B1 (en) 1999-12-02 2008-07-09 Novartis Vaccines and Diagnostics, Inc. Compositions and methods for stabilizing biological molecules upon lyophilization
MXPA02006962A (en) 2000-01-17 2002-12-13 Chiron Spa Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins.
ATE503837T1 (en) 2000-02-28 2011-04-15 Novartis Vaccines & Diagnostic HYBRID EXPRESSION NEISSER PROTEINS
PT1296713E (en) 2000-06-08 2004-02-27 Intercell Biomediz Forschungs IMMUNOSTIMULATING OLIGODESOXINUCLEOTIDES
AT410635B (en) 2000-10-18 2003-06-25 Cistem Biotechnologies Gmbh VACCINE COMPOSITION
AP1897A (en) 2001-01-23 2008-10-10 Aventis Pasteur Multivalent Meningococcal polysaccharide-Protein Conjugate Vaccine.
GB0103424D0 (en) 2001-02-12 2001-03-28 Chiron Spa Gonococcus proteins
WO2002079246A2 (en) 2001-03-30 2002-10-10 Geneprot, Inc. Human arginine-rich protein-related compositions
AU2002258734A1 (en) 2001-04-13 2002-10-28 Wyeth Holdings Corporation Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography
CA2439428C (en) 2001-04-17 2012-01-24 Chiron Corporation Molecular mimetics of meningococcal b epitopes which elicit functionally active antibodies
CA2449663A1 (en) 2001-06-07 2002-12-12 Wyeth Holdings Corporation Mutant forms of cholera holotoxin as an adjuvant
AU2002322380B2 (en) 2001-06-07 2006-11-02 Government Of The United States Of America As Represented By The Uniformed Services University Of The Health Sciences Mutant forms of cholera holotoxin as an adjuvant
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
WO2003009869A1 (en) 2001-07-26 2003-02-06 Chiron Srl. Vaccines comprising aluminium adjuvants and histidine
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
EP1436385A4 (en) 2001-09-14 2005-12-14 Invitrogen Corp Dna polymerases and mutants thereof
MX339524B (en) 2001-10-11 2016-05-30 Wyeth Corp Novel immunogenic compositions for the prevention and treatment of meningococcal disease.
GB0129007D0 (en) 2001-12-04 2002-01-23 Chiron Spa Adjuvanted antigenic meningococcal compositions
PT1777236T (en) 2002-03-26 2017-02-13 Glaxosmithkline Biologicals Sa Modified saccharides having improved stability in water for use as a medicament
GB0302218D0 (en) 2003-01-30 2003-03-05 Chiron Sri Vaccine formulation & Mucosal delivery
AU2003239744B2 (en) 2002-05-14 2008-07-03 Novartis Vaccines And Diagnostics S.R.L. Mucosal combination vaccines for bacterial meningitis
DE60328481D1 (en) 2002-05-14 2009-09-03 Novartis Vaccines & Diagnostic SLEEP-CAPACITIVE VACCINE CONTAINING THE ADJUVANZ CHITOSAN AND MENIGOKOKKENANTIGENE
US6954446B2 (en) 2002-06-25 2005-10-11 Motorola, Inc. Multiple mode RF communication device
US7785608B2 (en) 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
GB0220198D0 (en) 2002-08-30 2002-10-09 Chiron Spa Modified saccharides,conjugates thereof and their manufacture
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
BRPI0315228A8 (en) 2002-10-11 2018-04-03 Chiron Srl Polypeptide vaccines for broad protection against hypervirulent meningococcal strains
AU2003288660A1 (en) 2002-11-15 2004-06-15 Chiron Srl Unexpected surface proteins in neisseria meningitidis
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
US20070148729A1 (en) 2003-01-15 2007-06-28 Farley John E Methods for increasing neisseria protein expression and compositions thereof
EP2172213B1 (en) 2003-01-30 2013-04-03 Novartis AG Injectable vaccines against multiple meningococcal serogroups
CA2519511A1 (en) 2003-03-17 2004-09-30 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant and an antigen carrier protein
WO2004094596A2 (en) 2003-04-16 2004-11-04 Wyeth Holdings Corporation Novel immunogenic compositions for the prevention and treatment of meningococcal disease
EP2179729B1 (en) 2003-06-02 2016-07-20 GlaxoSmithKline Biologicals SA Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen
JP2007516181A (en) 2003-06-23 2007-06-21 アヴェンティス パストゥール インコーポレイテッド Method for immunization against meningococcal serogroups A and C
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
WO2005032583A2 (en) 2003-10-02 2005-04-14 Chiron Srl Liquid vaccines for multiple meningococcal serogroups
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
CA2551896A1 (en) 2003-12-30 2005-07-21 Wyeth Formulations of hydrophobic proteins in an immunogenic composition having improved tolerability
GB0406013D0 (en) 2004-03-17 2004-04-21 Chiron Srl Analysis of saccharide vaccines without interference
GB0408978D0 (en) 2004-04-22 2004-05-26 Chiron Srl Meningococcal fermentation for preparing conjugate vaccines
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0409745D0 (en) 2004-04-30 2004-06-09 Chiron Srl Compositions including unconjugated carrier proteins
PL1740217T3 (en) 2004-04-30 2012-03-30 Novartis Ag Meningococcal conjugate vaccination
GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
GB0410220D0 (en) 2004-05-07 2004-06-09 Kirkham Lea Ann Mutant pneumolysin proteins
GB0411387D0 (en) 2004-05-21 2004-06-23 Chiron Srl Analysis of saccharide length
GB0413868D0 (en) 2004-06-21 2004-07-21 Chiron Srl Dimensional anlaysis of saccharide conjugates
CA2574375C (en) 2004-07-23 2015-03-17 Chiron Srl Polypeptides for oligomeric assembly of antigens
GB0419408D0 (en) 2004-09-01 2004-10-06 Chiron Srl 741 chimeric polypeptides
GB0419846D0 (en) 2004-09-07 2004-10-13 Chiron Srl Vaccine adjuvants for saccharides
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
GB0428394D0 (en) 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
CA2590974C (en) 2005-01-27 2017-10-03 Children's Hospital & Research Center At Oakland Gna1870-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
US20070014842A1 (en) 2005-03-07 2007-01-18 Denis Martin Pharmaceutical liposomal compositions
US8062641B2 (en) 2005-05-06 2011-11-22 Novartis Ag Immunogens for meningitidis-A vaccines
SI1896065T2 (en) 2005-06-27 2014-12-31 Glaxosmithkline Biologicals S.A. Process for manufacturing vaccines
JP5135220B2 (en) 2005-09-01 2013-02-06 ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー Multiple vaccinations including serogroup C meningococcus
EP2336777B1 (en) 2005-09-05 2013-04-03 GlaxoSmithKline Biologicals s.a. Serum bactericidal assay for N. meningitidis specific antisera
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
JP2009520771A (en) 2005-12-23 2009-05-28 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Conjugate vaccine
ES2383209T3 (en) 2006-03-22 2012-06-19 Novartis Ag Regimens for immunization with meningococcal conjugates
TW200806315A (en) 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
WO2007127668A2 (en) 2006-04-26 2007-11-08 Wyeth Novel processes for coating container means which inhibit precipitation of polysaccharide-protein conjugate formulations
ES2337309T5 (en) 2006-06-12 2013-07-30 Glaxosmithkline Biologicals S.A. Vaccine
GB0612854D0 (en) 2006-06-28 2006-08-09 Novartis Ag Saccharide analysis
NZ573931A (en) 2006-06-29 2012-03-30 Craig J Venter Inst Inc Polypeptides from neisseria meningitidis
EP2061897B1 (en) 2006-07-27 2020-03-25 Wyeth LLC High-cell density fed-batch fermentation process for producing recombinant protein
AR064642A1 (en) * 2006-12-22 2009-04-15 Wyeth Corp POLINUCLEOTIDE VECTOR THAT INCLUDES IT RECOMBINATING CELL THAT UNDERSTANDS THE VECTOR POLYPEPTIDE, ANTIBODY, COMPOSITION THAT UNDERSTANDS THE POLINUCLEOTIDE, VECTOR, RECOMBINATING CELL POLYPEPTIDE OR ANTIBODY, USE OF THE COMPOSITION AND A COMPOSITION AND A METHOD
GB0700562D0 (en) 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
AU2008259423A1 (en) 2007-06-04 2008-12-11 Novartis Ag Formulation of meningitis vaccines
GB0713880D0 (en) 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
CA2695467A1 (en) 2007-08-02 2009-03-26 Children's Hospital & Research Center At Oakland Fhbp- and lpxl1-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
US20100285069A1 (en) 2007-10-19 2010-11-11 Mario Contorni Meningococcal vaccine formulations
EP2245048B1 (en) * 2008-02-21 2014-12-31 Novartis AG Meningococcal fhbp polypeptides
CN105944095B (en) 2008-03-05 2021-04-02 赛诺菲巴斯德有限公司 A method of stabilizing an adjuvanted vaccine composition
WO2009114485A2 (en) 2008-03-10 2009-09-17 Children's Hospital & Research Center At Oakland Chimeric factor h binding proteins (fhbp) containing a heterologous b domain and methods of use
WO2009143168A2 (en) 2008-05-19 2009-11-26 Novartis Ag Vaccine assays
WO2009158142A1 (en) 2008-05-30 2009-12-30 The U.S.A., As Represented By The Secretary Of The Army, On Behalf Of Walter Reed Army Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof
CN102203276A (en) 2008-08-27 2011-09-28 奥克兰儿童医院及研究中心 Complement factor h-based assays for serum bactericidal activity against neisseria meningitidis
US8470340B2 (en) 2008-09-03 2013-06-25 Children's Hospital & Research Center Oakland Peptides presenting an epitope of a domain of factor H binding protein and methods of use
IT1394288B1 (en) 2008-09-12 2012-06-06 Novartis Vaccines & Diagnostic PROTEIN IMMUNOGENES THAT LINK THE FACTOR H.
CN104740631B (en) 2008-10-29 2019-04-16 阿布林克斯公司 The preparation of single domain antigen-binding molecule
GB0822634D0 (en) 2008-12-11 2009-01-21 Novartis Ag Meningitis vaccines
AU2009329193A1 (en) 2008-12-17 2011-07-14 Novartis Ag Meningococcal vaccines including hemoglobin receptor
BRPI1009828A2 (en) 2009-03-24 2019-03-12 Novartis Ag meningococcal h factor binding protein adjuvant
WO2010109324A1 (en) 2009-03-24 2010-09-30 Novartis Ag Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates
AU2010242905B2 (en) * 2009-04-30 2014-10-23 Children's Hospital & Research Center At Oakland Chimeric factor H binding proteins (fHbp) and methods of use
US9365885B2 (en) 2009-06-16 2016-06-14 Puiying Annie Mak High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays
CN102596240B (en) * 2009-08-27 2015-02-04 诺华股份有限公司 Hybrid polypeptides including meningococcal fHBP sequences
WO2011039631A2 (en) 2009-09-30 2011-04-07 Novartis Ag Expression of meningococcal fhbp polypeptides
GB0917647D0 (en) 2009-10-08 2009-11-25 Glaxosmithkline Biolog Sa Expression system
MX2012004850A (en) 2009-10-27 2012-05-22 Novartis Ag Modified meningococcal fhbp polypeptides.
US9173954B2 (en) 2009-12-30 2015-11-03 Glaxosmithkline Biologicals Sa Polysaccharide immunogens conjugated to E. coli carrier proteins
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
US20130011429A1 (en) 2010-03-10 2013-01-10 Jan Poolman Immunogenic composition
EP2547357A1 (en) 2010-03-18 2013-01-23 Novartis AG Adjuvanted vaccines for serogroup b meningococcus
CN110845585A (en) 2010-03-30 2020-02-28 奥克兰儿童医院及研究中心 Modified Factor H Binding Proteins (FHBP) and methods of use thereof
CA2803239A1 (en) 2010-06-25 2011-12-29 Novartis Ag Combinations of meningococcal factor h binding proteins
HUE052850T2 (en) 2010-08-23 2021-05-28 Wyeth Llc Stable formulations of neisseria meningitidis rlp2086 antigens
WO2012031271A1 (en) 2010-09-04 2012-03-08 Novartis Ag Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines
AU2011300418B2 (en) 2010-09-10 2016-05-12 Glaxosmithkline Biologicals Sa Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom
ES2585328T5 (en) 2010-09-10 2022-12-14 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
US20120070457A1 (en) 2010-09-10 2012-03-22 J. Craig Venter Institute, Inc. Polypeptides from neisseria meningitidis
GB201101665D0 (en) 2011-01-31 2011-03-16 Novartis Ag Immunogenic compositions
MY167723A (en) * 2012-03-09 2018-09-21 Pfizer Neisseria meningitidis compositions and methods thereof
JP6446377B2 (en) 2013-03-08 2018-12-26 ファイザー・インク Immunogenic fusion polypeptide
PE20160155A1 (en) * 2013-05-22 2016-04-01 Pearl Therapeutics Inc COMPOSITIONS, METHODS AND SYSTEMS FOR THE RESPIRATORY DELIVERY OF THREE OR MORE ACTIVE AGENTS
CA2923129C (en) 2013-09-08 2020-06-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof

Also Published As

Publication number Publication date
TW201704256A (en) 2017-02-01
MX2014010156A (en) 2014-09-16
AR125327A2 (en) 2023-07-05
BR112014021658A2 (en) 2017-07-11
HK1206625A1 (en) 2016-01-15
AU2017210600B2 (en) 2019-07-11
EP4043029A1 (en) 2022-08-17
AU2021201721A1 (en) 2021-04-15
RU2018129163A3 (en) 2021-12-29
PH12014501887A1 (en) 2014-11-17
IL245852A0 (en) 2016-07-31
MX359256B (en) 2018-09-19
MX351993B (en) 2017-11-03
US9561269B2 (en) 2017-02-07
IL275081B (en) 2021-10-31
AU2019204425A1 (en) 2019-07-11
KR101763625B1 (en) 2017-08-01
AU2013229063B2 (en) 2016-10-06
PH12014501887B1 (en) 2014-11-17
RU2018129163A (en) 2018-11-09
KR20160022402A (en) 2016-02-29
EP3485906A1 (en) 2019-05-22
TWI570133B (en) 2017-02-11
IL275081A (en) 2020-07-30
PH12018501517A1 (en) 2019-07-29
JP5925342B2 (en) 2016-05-25
CA2865745A1 (en) 2013-09-12
KR101716557B1 (en) 2017-03-14
TWI616455B (en) 2018-03-01
CA3195971A1 (en) 2013-09-12
NZ718108A (en) 2017-10-27
PH12018501517B1 (en) 2019-07-29
AU2017210600A1 (en) 2017-08-24
CN107056901B (en) 2021-05-07
RU2665841C2 (en) 2018-09-04
AR090294A1 (en) 2014-11-05
KR20140135811A (en) 2014-11-26
BR122016004924A2 (en) 2019-07-30
AR125326A2 (en) 2023-07-05
CA2865745C (en) 2018-01-09
US20160347797A1 (en) 2016-12-01
TWI600662B (en) 2017-10-01
IL234555B (en) 2018-07-31
CN104334187B (en) 2017-04-05
SG11201404730XA (en) 2014-10-30
KR20160092052A (en) 2016-08-03
RU2017104529A (en) 2018-08-16
TWI605827B (en) 2017-11-21
CN105693830B (en) 2021-07-06
IL260135B (en) 2019-07-31
WO2013132452A2 (en) 2013-09-12
CA3066792A1 (en) 2013-09-12
CN107056901A (en) 2017-08-18
TW201341397A (en) 2013-10-16
SG10201602558UA (en) 2016-05-30
JP2016040284A (en) 2016-03-24
WO2013132452A3 (en) 2014-01-09
KR101784644B1 (en) 2017-10-11
IL245852B (en) 2020-06-30
AU2021201721B2 (en) 2023-03-30
RU2014136401A (en) 2016-05-10
RU2739504C2 (en) 2020-12-25
TWI627181B (en) 2018-06-21
JP6250008B2 (en) 2017-12-20
CA3066792C (en) 2023-06-20
US20130243807A1 (en) 2013-09-19
CN105693830A (en) 2016-06-22
US8986710B2 (en) 2015-03-24
EP2822583A2 (en) 2015-01-14
KR20170089981A (en) 2017-08-04
US20160030543A1 (en) 2016-02-04
MY167723A (en) 2018-09-21
CA2960030A1 (en) 2013-09-12
US9724402B2 (en) 2017-08-08
MX2018011291A (en) 2023-01-31
TW201600109A (en) 2016-01-01
AU2016228316A1 (en) 2016-10-06
PE20190458A1 (en) 2019-04-01
RU2017104529A3 (en) 2020-07-02
KR20160092051A (en) 2016-08-03
JP2015514395A (en) 2015-05-21
MY198910A (en) 2023-10-02
CN104334187A (en) 2015-02-04
TW201602130A (en) 2016-01-16
KR101784142B1 (en) 2017-10-10
IL260135A (en) 2018-07-31
NZ731330A (en) 2020-11-27
CA2960030C (en) 2020-02-25
NZ747917A (en) 2022-02-25
NZ628449A (en) 2016-04-29
AU2016228316B2 (en) 2017-06-15
SG10201911003QA (en) 2020-01-30
PE20142115A1 (en) 2014-12-17
AU2013229063A1 (en) 2014-09-25
TW201806966A (en) 2018-03-01

Similar Documents

Publication Publication Date Title
FR22C1037I2 (en) GLYCOCONJUGATION METHODS AND COMPOSITIONS
CO7061042A2 (en) Neisseria meningitidis compositions and methods thereof
DK2850202T3 (en) METHODS AND GROUPS
BR112015006198A2 (en) chair set
FR2997014B1 (en) DERMO-INJECTABLE STERILE COMPOSITION
DK2911506T3 (en) Operationally reducing compositions
DK2763665T3 (en) Antimicrobial compositions and methods for their use
IL280725B (en) Neisseria meningitidis compositions and methods thereof
CO6811815A2 (en) Therapeutic nuclease compositions and methods
FR2984350B1 (en) FAT COMPOSITION
BR112015002488A2 (en) versatile tipped dental tool
BR112013014644A2 (en) pharmaceutical composition and complex
BR112014020547A2 (en) oily compositions and production methods
DK2897594T3 (en) PHARMACEUTICAL COMPOSITION
DK2704744T3 (en) COMPLEMENT FACTOR B-ANALOGS AND USES THEREOF
DK3175852T3 (en) Difluorolactam compositions for EP4-mediated osteo-related diseases and conditions
DK2849798T3 (en) OLIGONUCLEOTID-CHELAT COMPLEX-POLYPEPTIDE COMPOSITIONS AND PROCEDURES
FR2984349B1 (en) FAT COMPOSITION
CO6990712A2 (en) Antineuritic pharmaceutical combination and compositions
BR302012002627S1 (en) CONFIGURATION APPLIED IN DENTAL TRAY
ES1077209Y (en) DENTAL PROTESTIC ADDITION
ES1077195Y (en) REMOVABLE FURNITURE
TH1301004833B (en) Stand
FI20120373A (en) Study and office chair
TH1301002036B (en) Hair repair composition and related methods