CO6541606A2 - ESPIROINDOLINONA- PIRROLIDINAS - Google Patents
ESPIROINDOLINONA- PIRROLIDINASInfo
- Publication number
- CO6541606A2 CO6541606A2 CO12086101A CO12086101A CO6541606A2 CO 6541606 A2 CO6541606 A2 CO 6541606A2 CO 12086101 A CO12086101 A CO 12086101A CO 12086101 A CO12086101 A CO 12086101A CO 6541606 A2 CO6541606 A2 CO 6541606A2
- Authority
- CO
- Colombia
- Prior art keywords
- pirrolidinas
- espiroindolinona
- compounds
- nicancerous
- esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
Abstract
Se proporcionan compuestos de la fórmula (I)en la que X, Y y de R1 a R8 tienen los significados aquí definidos, junto con, los enantiómeros, las sales y los esteres farmacéuticamente aceptables de los mismos. Estos compuestos son útiles como agentes nticancerosos.Compounds of the formula (I) are provided in which X, Y and R1 to R8 have the meanings defined herein, together with, the pharmaceutically acceptable enantiomers, salts and esters thereof. These compounds are useful as nicancerous agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26579209P | 2009-12-02 | 2009-12-02 | |
US38805410P | 2010-09-30 | 2010-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6541606A2 true CO6541606A2 (en) | 2012-10-16 |
Family
ID=43608656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12086101A CO6541606A2 (en) | 2009-12-02 | 2012-05-24 | ESPIROINDOLINONA- PIRROLIDINAS |
Country Status (26)
Country | Link |
---|---|
US (1) | US8088815B2 (en) |
EP (1) | EP2507243B1 (en) |
JP (1) | JP5647262B2 (en) |
KR (1) | KR101418191B1 (en) |
CN (1) | CN102741257B (en) |
AR (1) | AR079226A1 (en) |
AU (1) | AU2010326855B2 (en) |
BR (1) | BR112012012872A2 (en) |
CA (1) | CA2781823A1 (en) |
CL (1) | CL2012001405A1 (en) |
CO (1) | CO6541606A2 (en) |
CR (1) | CR20120259A (en) |
EC (1) | ECSP12011945A (en) |
ES (1) | ES2543468T3 (en) |
HK (1) | HK1173720A1 (en) |
IL (1) | IL220010A (en) |
MA (1) | MA33976B1 (en) |
MX (1) | MX2012006260A (en) |
MY (1) | MY160596A (en) |
NZ (1) | NZ600024A (en) |
PE (1) | PE20121334A1 (en) |
RU (1) | RU2571100C2 (en) |
SG (1) | SG181465A1 (en) |
TW (1) | TW201129571A (en) |
WO (1) | WO2011067185A1 (en) |
ZA (1) | ZA201204036B (en) |
Families Citing this family (49)
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JP5649825B2 (en) * | 2007-01-31 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Stabilized p53 peptides and methods of use thereof |
KR20160061439A (en) | 2007-03-28 | 2016-05-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Stitched polypeptides |
UA107814C2 (en) | 2009-11-12 | 2015-02-25 | Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган | Spiro-oxindoles antagonists mdm 2 |
US20110118283A1 (en) * | 2009-11-17 | 2011-05-19 | Qingjie Ding | Substituted Pyrrolidine-2-Carboxamides |
US8288431B2 (en) * | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
JO2998B1 (en) | 2010-06-04 | 2016-09-05 | Amgen Inc | Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer |
KR102104762B1 (en) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | Peptidomimetic macrocycles |
US20120046306A1 (en) * | 2010-08-18 | 2012-02-23 | David Joseph Bartkovitz | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists |
WO2012065022A2 (en) | 2010-11-12 | 2012-05-18 | The Regents Of The University Of Michigan | Spiro-oxindole mdm2 antagonists |
CA2829188C (en) | 2011-03-10 | 2016-10-18 | Daiichi Sankyo Company, Limited | Dispiropyrrolidine derivatives |
KR101688268B1 (en) | 2011-05-11 | 2016-12-20 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Spiro-oxindole mdm2 antagonists |
MX352672B (en) | 2011-09-27 | 2017-12-04 | Amgen Inc | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer. |
KR20140100937A (en) | 2011-10-18 | 2014-08-18 | 에일러론 테라퓨틱스 인코포레이티드 | Peptidomimetic macrocycles |
CN104144695A (en) | 2012-02-15 | 2014-11-12 | 爱勒让治疗公司 | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
CN107216380A (en) | 2012-02-15 | 2017-09-29 | 爱勒让治疗公司 | Peptidomimetic macrocyclic compound |
TWI586668B (en) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | Crystals of dispiropyrrolidine derivative |
KR20150082307A (en) | 2012-11-01 | 2015-07-15 | 에일러론 테라퓨틱스 인코포레이티드 | Disubstituted amino acids and methods of preparation and use thereof |
AU2013361694B2 (en) | 2012-12-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as HDM2 inhibitors |
US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
WO2014134201A1 (en) * | 2013-02-28 | 2014-09-04 | Amgen Inc. | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
EP2970237B1 (en) | 2013-03-14 | 2017-09-27 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
JOP20200296A1 (en) | 2013-06-10 | 2017-06-16 | Amgen Inc | Processes of Making and Crystalline Forms of a MDM2 Inhibitor |
CN103342672B (en) * | 2013-07-02 | 2015-12-23 | 扬州大学 | The novel synthesis of substituted pyrrolidin-2-ketone |
SG10201913742TA (en) | 2014-04-17 | 2020-03-30 | Univ Michigan Regents | Mdm2 inhibitors and therapeutic methods using the same |
EP3164401B1 (en) | 2014-07-03 | 2018-12-26 | Boehringer Ingelheim International GmbH | New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors |
US9701685B2 (en) | 2014-08-18 | 2017-07-11 | Hudson Biopharma Inc. | Spiropyrrolidines as MDM2 inhibitors |
BR112017005598A2 (en) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | peptidomimetic macrocycles and their uses |
SG10201902598VA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
EP3294318A4 (en) | 2015-03-20 | 2019-04-03 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
RU2629750C2 (en) * | 2015-04-09 | 2017-09-01 | Ян Андреевич Иваненков | NEW DISPIRO-INDOLINONES, MDM2/p53 INTERACTION INHIBITORS, METHOD FOR PRODUCTION AND APPLICATION |
WO2017044633A1 (en) | 2015-09-10 | 2017-03-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
UA123905C2 (en) | 2015-10-09 | 2021-06-23 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors |
GB201603779D0 (en) * | 2016-03-04 | 2016-04-20 | Mission Therapeutics Ltd | Novel compounds |
RU2021102253A (en) * | 2016-04-06 | 2021-03-03 | Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган | DESTRUCTORS OF MDM2 PROTEIN |
CN105949221B (en) * | 2016-05-11 | 2017-08-25 | 湖南科技大学 | Ketone derivatives of a kind of indoles containing spiral shell 2 and preparation method thereof and it is used as the application of cancer therapy drug |
WO2017201449A1 (en) | 2016-05-20 | 2017-11-23 | Genentech, Inc. | Protac antibody conjugates and methods of use |
JP6848047B2 (en) * | 2016-08-08 | 2021-03-24 | フェイ シアオ, | Spiroindron polyethylene glycol carbonate-based compound and its composition, preparation method and its use |
EP3511334A1 (en) * | 2018-01-16 | 2019-07-17 | Adamed sp. z o.o. | 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53 |
RU2730287C1 (en) * | 2019-08-30 | 2020-08-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Novel 2',5'-diarylspiro[indole-3,3'-pyrrolidine]-2(1h)-ones and a method for production thereof |
GB201919219D0 (en) | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
CA3181715A1 (en) | 2020-08-27 | 2022-03-03 | Otsuka Pharmaceutical Co., Ltd. | Biomarkers for cancer therapy using mdm2 antagonists |
WO2022159644A1 (en) * | 2021-01-23 | 2022-07-28 | Newave Pharmaceutical Inc. | Spirocyclic mdm2 modulator and uses thereof |
GB202103080D0 (en) | 2021-03-04 | 2021-04-21 | Otsuka Pharma Co Ltd | Cancer biomarkers |
CN115215872A (en) * | 2021-04-15 | 2022-10-21 | 中国科学院上海药物研究所 | Small molecule compound with substituted phenyl spiro [ indoline-3, 3' -pyrrolidine ] structure |
CN113387957B (en) * | 2021-06-09 | 2022-08-09 | 江苏亚尧生物科技有限公司 | Spirocyclic indolone-pyrrolidine carbonate compound and composition, preparation method and application thereof |
WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
WO2023086400A1 (en) * | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
US11993600B2 (en) | 2021-12-08 | 2024-05-28 | Enanta Pharmaceuticals, Inc. | Saturated spirocyclics as antiviral agents |
CN114773327B (en) * | 2022-04-18 | 2023-08-18 | 广东优康精细化工有限公司 | Preparation method of penthiopyrad intermediate |
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UA107814C2 (en) * | 2009-11-12 | 2015-02-25 | Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган | Spiro-oxindoles antagonists mdm 2 |
JP2013523820A (en) * | 2010-04-09 | 2013-06-17 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン | Biomarkers of MDM2 inhibitors for use in treating diseases |
-
2010
- 2010-11-04 US US12/939,234 patent/US8088815B2/en not_active Expired - Fee Related
- 2010-11-29 MX MX2012006260A patent/MX2012006260A/en active IP Right Grant
- 2010-11-29 BR BR112012012872A patent/BR112012012872A2/en not_active Application Discontinuation
- 2010-11-29 MY MYPI2012002434A patent/MY160596A/en unknown
- 2010-11-29 RU RU2012125763/04A patent/RU2571100C2/en not_active IP Right Cessation
- 2010-11-29 ES ES10793189.1T patent/ES2543468T3/en active Active
- 2010-11-29 CA CA2781823A patent/CA2781823A1/en not_active Abandoned
- 2010-11-29 KR KR1020127016926A patent/KR101418191B1/en not_active IP Right Cessation
- 2010-11-29 EP EP10793189.1A patent/EP2507243B1/en not_active Not-in-force
- 2010-11-29 TW TW099141297A patent/TW201129571A/en unknown
- 2010-11-29 MA MA34939A patent/MA33976B1/en unknown
- 2010-11-29 CN CN201080062931.4A patent/CN102741257B/en not_active Expired - Fee Related
- 2010-11-29 SG SG2012040341A patent/SG181465A1/en unknown
- 2010-11-29 AU AU2010326855A patent/AU2010326855B2/en not_active Ceased
- 2010-11-29 JP JP2012541424A patent/JP5647262B2/en not_active Expired - Fee Related
- 2010-11-29 PE PE2012000748A patent/PE20121334A1/en not_active Application Discontinuation
- 2010-11-29 NZ NZ600024A patent/NZ600024A/en not_active IP Right Cessation
- 2010-11-29 WO PCT/EP2010/068353 patent/WO2011067185A1/en active Application Filing
- 2010-11-30 AR ARP100104410A patent/AR079226A1/en unknown
-
2012
- 2012-05-18 CR CR20120259A patent/CR20120259A/en unknown
- 2012-05-24 CO CO12086101A patent/CO6541606A2/en not_active Application Discontinuation
- 2012-05-24 IL IL220010A patent/IL220010A/en not_active IP Right Cessation
- 2012-05-30 CL CL2012001405A patent/CL2012001405A1/en unknown
- 2012-06-01 ZA ZA2012/04036A patent/ZA201204036B/en unknown
- 2012-06-01 EC ECSP12011945 patent/ECSP12011945A/en unknown
-
2013
- 2013-01-09 HK HK13100292.0A patent/HK1173720A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2010326855A1 (en) | 2012-06-21 |
NZ600024A (en) | 2014-08-29 |
ECSP12011945A (en) | 2012-07-31 |
MA33976B1 (en) | 2013-02-01 |
IL220010A (en) | 2014-03-31 |
TW201129571A (en) | 2011-09-01 |
AR079226A1 (en) | 2012-01-04 |
CL2012001405A1 (en) | 2012-09-28 |
SG181465A1 (en) | 2012-07-30 |
KR20120101481A (en) | 2012-09-13 |
ES2543468T3 (en) | 2015-08-19 |
IL220010A0 (en) | 2012-07-31 |
EP2507243A1 (en) | 2012-10-10 |
BR112012012872A2 (en) | 2017-10-10 |
AU2010326855B2 (en) | 2015-10-29 |
US8088815B2 (en) | 2012-01-03 |
US20110130398A1 (en) | 2011-06-02 |
KR101418191B1 (en) | 2014-07-09 |
RU2571100C2 (en) | 2015-12-20 |
EP2507243B1 (en) | 2015-06-10 |
JP5647262B2 (en) | 2014-12-24 |
JP2013512869A (en) | 2013-04-18 |
ZA201204036B (en) | 2013-02-27 |
CA2781823A1 (en) | 2011-06-09 |
RU2012125763A (en) | 2014-01-10 |
MY160596A (en) | 2017-03-15 |
PE20121334A1 (en) | 2012-10-12 |
CN102741257A (en) | 2012-10-17 |
CN102741257B (en) | 2015-03-04 |
CR20120259A (en) | 2012-07-12 |
MX2012006260A (en) | 2012-06-19 |
HK1173720A1 (en) | 2013-05-24 |
WO2011067185A1 (en) | 2011-06-09 |
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