CO6390073A2 - KUNITZ TYPE RECOMBINING INHIBITOR - Google Patents

KUNITZ TYPE RECOMBINING INHIBITOR

Info

Publication number
CO6390073A2
CO6390073A2 CO09114280A CO09114280A CO6390073A2 CO 6390073 A2 CO6390073 A2 CO 6390073A2 CO 09114280 A CO09114280 A CO 09114280A CO 09114280 A CO09114280 A CO 09114280A CO 6390073 A2 CO6390073 A2 CO 6390073A2
Authority
CO
Colombia
Prior art keywords
inhibitor
recombining
kunitz type
kunitz
type
Prior art date
Application number
CO09114280A
Other languages
Spanish (es)
Inventor
Ana Marisa Chudzinski-Tabassi
Durvanei Augusto Maria
Batista Isabel De Fatima Cprreoa
Original Assignee
Uniao Quimica Farmaceutica Nac S A
Fundacao De Amparo A Pesquisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/724,557 external-priority patent/US8440795B2/en
Application filed by Uniao Quimica Farmaceutica Nac S A, Fundacao De Amparo A Pesquisa filed Critical Uniao Quimica Farmaceutica Nac S A
Publication of CO6390073A2 publication Critical patent/CO6390073A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención presenta un inhibidor recombinante tipo Kunitz obtenido de un gen donado a partir de una biblioteca de cADN de glándulas salivales de la Amblyomma cajennense, y el inhibidor denominado Amblyomin-X tiene una masa molecular de 13,500 Da.The present invention presents a recombinant Kunitz-like inhibitor obtained from a gene donated from a cDNA library of salivary glands of Amblyomma cajennense, and the inhibitor called Amblyomin-X has a molecular mass of 13,500 Da.

CO09114280A 2007-03-14 2009-10-14 KUNITZ TYPE RECOMBINING INHIBITOR CO6390073A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/724,557 US8440795B2 (en) 2004-09-15 2007-03-14 Kunitz-type recombinant inhibitor

Publications (1)

Publication Number Publication Date
CO6390073A2 true CO6390073A2 (en) 2012-02-29

Family

ID=39758936

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09114280A CO6390073A2 (en) 2007-03-14 2009-10-14 KUNITZ TYPE RECOMBINING INHIBITOR

Country Status (4)

Country Link
EP (1) EP2134843A4 (en)
AU (1) AU2008226358A1 (en)
CO (1) CO6390073A2 (en)
WO (1) WO2008109976A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102018074043A2 (en) * 2018-11-22 2020-06-02 Inst Butantan compound for modulating rlr, tlr, oas and / or oncostatin m pathways, use of it for the preparation of a drug, composition and method for modulating said pathways
BR102018074037A2 (en) * 2018-11-22 2021-05-11 Inst Butantan compound to target molecular entities to the intracellular domain of neoplastic cells, active pharmaceutical ingredient comprising said compound, pharmaceutical composition, method for the diagnosis, prognosis and/or treatment of cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0406057B1 (en) * 2004-09-15 2021-10-26 União Química Farmacêutica Nacional S/A NUCLEOTIDE SEQUENCE OF A KUNITZ TYPE PROTEASE INHIBITOR OBTAINED FROM A CDNA LIBRARY OF AMBLYOMMA CAJENNESE SALIVARAR GLANDS OF AMBLYOMMA CAJENNESE USE OF RECOMBINANT PROTEIN

Also Published As

Publication number Publication date
WO2008109976A1 (en) 2008-09-18
EP2134843A4 (en) 2011-01-19
EP2134843A1 (en) 2009-12-23
AU2008226358A1 (en) 2008-09-18

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Legal Events

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