CO6382164A2 - Solucion acuosa para la preservacion de tejidos y organos - Google Patents
Solucion acuosa para la preservacion de tejidos y organosInfo
- Publication number
- CO6382164A2 CO6382164A2 CO10158861A CO10158861A CO6382164A2 CO 6382164 A2 CO6382164 A2 CO 6382164A2 CO 10158861 A CO10158861 A CO 10158861A CO 10158861 A CO10158861 A CO 10158861A CO 6382164 A2 CO6382164 A2 CO 6382164A2
- Authority
- CO
- Colombia
- Prior art keywords
- organs
- preservation
- microm
- fabrics
- water solution
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title abstract 2
- 238000004321 preservation Methods 0.000 title abstract 2
- 239000004744 fabric Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 2
- UHWVSEOVJBQKBE-UHFFFAOYSA-N Trimetazidine Chemical compound COC1=C(OC)C(OC)=CC=C1CN1CCNCC1 UHWVSEOVJBQKBE-UHFFFAOYSA-N 0.000 abstract 2
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 abstract 2
- 229960004195 carvedilol Drugs 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 229960001967 tacrolimus Drugs 0.000 abstract 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 2
- 229960001177 trimetazidine Drugs 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1.- Solución acuosa para la preservación de tejidos y órganos que comprende una cantidad efectiva de carvedilol, una cantidad efectiva de tacrolimus y una cantidad efectiva de trimetazidina.2.- Solución según la Reivindicación 1, que tiene una concentración de carvedilol comprendida entre 5 y 10 microM, una concentración de tacrolimus comprendida entre 5 y 10 microM, y una concentración de trimetazidina comprendida entre 0.01 microM y 10 microM.3.- Solución según cualquiera de las Reivindicaciones 1-2 que comprende adicionalmente polietilenglicol con un peso molecular superior a 15.000.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200801560A ES2330404B1 (es) | 2008-05-19 | 2008-05-19 | Solucion acuosa para la preservacion de tejidos y organos. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6382164A2 true CO6382164A2 (es) | 2012-02-15 |
Family
ID=41339803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10158861A CO6382164A2 (es) | 2008-05-19 | 2010-12-17 | Solucion acuosa para la preservacion de tejidos y organos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8748086B2 (es) |
| EP (1) | EP2298071B1 (es) |
| JP (1) | JP2011520945A (es) |
| CN (1) | CN102098911A (es) |
| BR (1) | BRPI0912815B1 (es) |
| CA (1) | CA2725020C (es) |
| CO (1) | CO6382164A2 (es) |
| CY (1) | CY1113429T1 (es) |
| DK (1) | DK2298071T3 (es) |
| ES (2) | ES2330404B1 (es) |
| MX (1) | MX2010012638A (es) |
| PL (1) | PL2298071T3 (es) |
| PT (1) | PT2298071E (es) |
| RU (1) | RU2479999C2 (es) |
| SI (1) | SI2298071T1 (es) |
| WO (1) | WO2009141470A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103966156B (zh) * | 2013-01-25 | 2016-04-06 | 中国医科大学附属盛京医院 | 一种应用于胰岛移植中胰岛分离提纯的分离纯化液及其制备方法 |
| CN106857501B (zh) * | 2017-02-22 | 2021-09-24 | 单纯 | 用于保存大鼠肝匀浆s9的储存液及其制备方法 |
| CN107183010A (zh) * | 2017-06-26 | 2017-09-22 | 苏州卡睿知光电科技有限公司 | 一种离体组织保存液 |
| CA3070212A1 (en) * | 2017-07-20 | 2019-01-24 | Riken | Method for preserving neural tissue |
| CN108619152A (zh) * | 2018-06-27 | 2018-10-09 | 余祖江 | 曲美他嗪作为免疫抑制剂在治疗免疫相关疾病中的应用 |
| JP2020002062A (ja) * | 2018-06-28 | 2020-01-09 | 株式会社Ｓｃｒｅｅｎホールディングス | 灌流装置および灌流方法 |
| ES2949014T3 (es) * | 2019-01-23 | 2023-09-25 | Carnamedica Sp Z O O | Uso de una disolución que comprende PEG para la conservación de células madre |
| FR3101227B1 (fr) * | 2019-09-27 | 2021-09-10 | Inst Georges Lopez | Solution de préservation et/ou de rincage d’organe a transplanter |
| CN115244167A (zh) * | 2020-03-05 | 2022-10-25 | 积水医疗株式会社 | 细胞含有液用保存容器以及保存液 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2134962C1 (ru) * | 1994-03-04 | 1999-08-27 | Майер Берндт | Способ и устройство консервации органов, конечностей и тканевых лоскутов |
| DE19833119A1 (de) * | 1998-07-23 | 2000-01-27 | Roche Diagnostics Gmbh | Spritzfertige Injektionslösungen enthaltend Carvedilol |
| GB9905503D0 (en) * | 1999-03-10 | 1999-05-05 | Adprotech Plc | Novel compound formulations and methods of delivery |
| US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
| US20040242565A1 (en) * | 2001-09-11 | 2004-12-02 | Yoshinori Toshima | Medicinal composition for prevention of or treatment for cerebrovascular disorder and cardiopathy |
| CN100508749C (zh) * | 2004-09-01 | 2009-07-08 | 浙江大学 | 器官保存液及其制法和应用 |
| CN101098622B (zh) * | 2004-11-12 | 2010-08-11 | 多尔灿德气动股份有限公司 | 用于器官冷藏和灌注的组合物 |
| GB0612877D0 (en) * | 2006-06-29 | 2006-08-09 | Univ Edinburgh | Organ preservation solution |
-
2008
- 2008-05-19 ES ES200801560A patent/ES2330404B1/es not_active Expired - Fee Related
-
2009
- 2009-05-18 CN CN2009801280948A patent/CN102098911A/zh active Pending
- 2009-05-18 RU RU2010151977/13A patent/RU2479999C2/ru active
- 2009-05-18 SI SI200930357T patent/SI2298071T1/sl unknown
- 2009-05-18 PL PL09749954T patent/PL2298071T3/pl unknown
- 2009-05-18 EP EP09749954A patent/EP2298071B1/en active Active
- 2009-05-18 ES ES09749954T patent/ES2394559T3/es active Active
- 2009-05-18 MX MX2010012638A patent/MX2010012638A/es active IP Right Grant
- 2009-05-18 JP JP2011510010A patent/JP2011520945A/ja active Pending
- 2009-05-18 BR BRPI0912815-8A patent/BRPI0912815B1/pt active IP Right Grant
- 2009-05-18 PT PT09749954T patent/PT2298071E/pt unknown
- 2009-05-18 DK DK09749954.5T patent/DK2298071T3/da active
- 2009-05-18 WO PCT/ES2009/000267 patent/WO2009141470A1/es active Application Filing
- 2009-05-18 US US12/993,292 patent/US8748086B2/en active Active
- 2009-05-18 CA CA2725020A patent/CA2725020C/en active Active
-
2010
- 2010-12-17 CO CO10158861A patent/CO6382164A2/es not_active Application Discontinuation
-
2012
- 2012-11-28 CY CY20121101161T patent/CY1113429T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2298071E (pt) | 2012-11-20 |
| EP2298071A4 (en) | 2011-10-12 |
| CA2725020A1 (en) | 2009-11-26 |
| WO2009141470A1 (es) | 2009-11-26 |
| BRPI0912815A8 (pt) | 2020-01-14 |
| CA2725020C (en) | 2018-06-12 |
| MX2010012638A (es) | 2011-03-04 |
| CY1113429T1 (el) | 2016-06-22 |
| ES2330404A1 (es) | 2009-12-09 |
| RU2010151977A (ru) | 2012-06-27 |
| US20130059285A1 (en) | 2013-03-07 |
| EP2298071B1 (en) | 2012-09-05 |
| EP2298071A1 (en) | 2011-03-23 |
| ES2394559T3 (es) | 2013-02-01 |
| CN102098911A (zh) | 2011-06-15 |
| BRPI0912815B1 (pt) | 2020-11-24 |
| BRPI0912815A2 (pt) | 2019-11-19 |
| SI2298071T1 (sl) | 2012-12-31 |
| DK2298071T3 (da) | 2013-01-02 |
| JP2011520945A (ja) | 2011-07-21 |
| RU2479999C2 (ru) | 2013-04-27 |
| ES2330404B1 (es) | 2010-09-22 |
| PL2298071T3 (pl) | 2013-06-28 |
| US8748086B2 (en) | 2014-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted | ||
| FD | Application lapsed |