BRPI0912815A8 - solução aquosa para a preservação de tecidos e órgãos - Google Patents
solução aquosa para a preservação de tecidos e órgãos Download PDFInfo
- Publication number
- BRPI0912815A8 BRPI0912815A8 BRPI0912815A BRPI0912815A BRPI0912815A8 BR PI0912815 A8 BRPI0912815 A8 BR PI0912815A8 BR PI0912815 A BRPI0912815 A BR PI0912815A BR PI0912815 A BRPI0912815 A BR PI0912815A BR PI0912815 A8 BRPI0912815 A8 BR PI0912815A8
- Authority
- BR
- Brazil
- Prior art keywords
- tissue
- organ preservation
- aqueous solution
- preservation solution
- organ
- Prior art date
Links
- 239000007864 aqueous solution Substances 0.000 title 1
- 239000000082 organ preservation Substances 0.000 title 1
- 239000000162 organ preservation solution Substances 0.000 abstract 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 1
- UHWVSEOVJBQKBE-UHFFFAOYSA-N Trimetazidine Chemical compound COC1=C(OC)C(OC)=CC=C1CN1CCNCC1 UHWVSEOVJBQKBE-UHFFFAOYSA-N 0.000 abstract 1
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 abstract 1
- 229960004195 carvedilol Drugs 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000003761 preservation solution Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 229960001967 tacrolimus Drugs 0.000 abstract 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 1
- 229960001177 trimetazidine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
solução aquosa para a preservação de tecidos e órgãos proporciona-se uma solução aquosa aperfeiçoada para a preservação de tecidos e órgãos que compreende 5 carvedilol, tacrolimus, e trimetazidina. observa-se um efeito sinérgico para esta solução de preservação que é particularmente efetivo em órgãos marginais, tais como fígados esteatósicos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ESP200801560 | 2008-05-19 | ||
ES200801560A ES2330404B1 (es) | 2008-05-19 | 2008-05-19 | Solucion acuosa para la preservacion de tejidos y organos. |
PCT/ES2009/000267 WO2009141470A1 (es) | 2008-05-19 | 2009-05-18 | Solución acuosa para la preservación de tejidos y órganos |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0912815A2 BRPI0912815A2 (pt) | 2019-11-19 |
BRPI0912815A8 true BRPI0912815A8 (pt) | 2020-01-14 |
BRPI0912815B1 BRPI0912815B1 (pt) | 2020-11-24 |
Family
ID=41339803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0912815-8A BRPI0912815B1 (pt) | 2008-05-19 | 2009-05-18 | solução aquosa para a preservação de tecidos e órgãos |
Country Status (16)
Country | Link |
---|---|
US (1) | US8748086B2 (pt) |
EP (1) | EP2298071B1 (pt) |
JP (1) | JP2011520945A (pt) |
CN (1) | CN102098911A (pt) |
BR (1) | BRPI0912815B1 (pt) |
CA (1) | CA2725020C (pt) |
CO (1) | CO6382164A2 (pt) |
CY (1) | CY1113429T1 (pt) |
DK (1) | DK2298071T3 (pt) |
ES (2) | ES2330404B1 (pt) |
MX (1) | MX2010012638A (pt) |
PL (1) | PL2298071T3 (pt) |
PT (1) | PT2298071E (pt) |
RU (1) | RU2479999C2 (pt) |
SI (1) | SI2298071T1 (pt) |
WO (1) | WO2009141470A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103966156B (zh) * | 2013-01-25 | 2016-04-06 | 中国医科大学附属盛京医院 | 一种应用于胰岛移植中胰岛分离提纯的分离纯化液及其制备方法 |
CN106857501B (zh) * | 2017-02-22 | 2021-09-24 | 单纯 | 用于保存大鼠肝匀浆s9的储存液及其制备方法 |
CN107183010A (zh) * | 2017-06-26 | 2017-09-22 | 苏州卡睿知光电科技有限公司 | 一种离体组织保存液 |
CA3070212A1 (en) * | 2017-07-20 | 2019-01-24 | Riken | Method for preserving neural tissue |
CN108619152A (zh) * | 2018-06-27 | 2018-10-09 | 余祖江 | 曲美他嗪作为免疫抑制剂在治疗免疫相关疾病中的应用 |
JP2020002062A (ja) * | 2018-06-28 | 2020-01-09 | 株式会社Screenホールディングス | 灌流装置および灌流方法 |
ES2949014T3 (es) * | 2019-01-23 | 2023-09-25 | Carnamedica Sp Z O O | Uso de una disolución que comprende PEG para la conservación de células madre |
FR3101227B1 (fr) * | 2019-09-27 | 2021-09-10 | Inst Georges Lopez | Solution de préservation et/ou de rincage d’organe a transplanter |
JPWO2021177344A1 (pt) * | 2020-03-05 | 2021-09-10 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2134962C1 (ru) * | 1994-03-04 | 1999-08-27 | Майер Берндт | Способ и устройство консервации органов, конечностей и тканевых лоскутов |
DE19833119A1 (de) * | 1998-07-23 | 2000-01-27 | Roche Diagnostics Gmbh | Spritzfertige Injektionslösungen enthaltend Carvedilol |
GB9905503D0 (en) * | 1999-03-10 | 1999-05-05 | Adprotech Plc | Novel compound formulations and methods of delivery |
US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
EP1426051B1 (en) * | 2001-09-11 | 2008-07-16 | Asahi Kasei Pharma Corporation | Medicinal composition for prevention of or treatment for cerebrovascular disorder |
CN100508749C (zh) * | 2004-09-01 | 2009-07-08 | 浙江大学 | 器官保存液及其制法和应用 |
EP1809101B1 (en) * | 2004-11-12 | 2016-11-02 | Organoflush B.V. | Composition for cold preservation and perfusion of organs |
GB0612877D0 (en) * | 2006-06-29 | 2006-08-09 | Univ Edinburgh | Organ preservation solution |
-
2008
- 2008-05-19 ES ES200801560A patent/ES2330404B1/es not_active Expired - Fee Related
-
2009
- 2009-05-18 JP JP2011510010A patent/JP2011520945A/ja active Pending
- 2009-05-18 CA CA2725020A patent/CA2725020C/en active Active
- 2009-05-18 US US12/993,292 patent/US8748086B2/en active Active
- 2009-05-18 PT PT09749954T patent/PT2298071E/pt unknown
- 2009-05-18 ES ES09749954T patent/ES2394559T3/es active Active
- 2009-05-18 BR BRPI0912815-8A patent/BRPI0912815B1/pt active IP Right Grant
- 2009-05-18 WO PCT/ES2009/000267 patent/WO2009141470A1/es active Application Filing
- 2009-05-18 DK DK09749954.5T patent/DK2298071T3/da active
- 2009-05-18 PL PL09749954T patent/PL2298071T3/pl unknown
- 2009-05-18 EP EP09749954A patent/EP2298071B1/en active Active
- 2009-05-18 MX MX2010012638A patent/MX2010012638A/es active IP Right Grant
- 2009-05-18 RU RU2010151977/13A patent/RU2479999C2/ru active
- 2009-05-18 CN CN2009801280948A patent/CN102098911A/zh active Pending
- 2009-05-18 SI SI200930357T patent/SI2298071T1/sl unknown
-
2010
- 2010-12-17 CO CO10158861A patent/CO6382164A2/es not_active Application Discontinuation
-
2012
- 2012-11-28 CY CY20121101161T patent/CY1113429T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CO6382164A2 (es) | 2012-02-15 |
RU2479999C2 (ru) | 2013-04-27 |
EP2298071A1 (en) | 2011-03-23 |
PT2298071E (pt) | 2012-11-20 |
US20130059285A1 (en) | 2013-03-07 |
US8748086B2 (en) | 2014-06-10 |
ES2394559T3 (es) | 2013-02-01 |
ES2330404A1 (es) | 2009-12-09 |
EP2298071A4 (en) | 2011-10-12 |
CA2725020A1 (en) | 2009-11-26 |
SI2298071T1 (sl) | 2012-12-31 |
CN102098911A (zh) | 2011-06-15 |
CY1113429T1 (el) | 2016-06-22 |
EP2298071B1 (en) | 2012-09-05 |
PL2298071T3 (pl) | 2013-06-28 |
MX2010012638A (es) | 2011-03-04 |
ES2330404B1 (es) | 2010-09-22 |
BRPI0912815B1 (pt) | 2020-11-24 |
DK2298071T3 (da) | 2013-01-02 |
BRPI0912815A2 (pt) | 2019-11-19 |
RU2010151977A (ru) | 2012-06-27 |
JP2011520945A (ja) | 2011-07-21 |
WO2009141470A1 (es) | 2009-11-26 |
CA2725020C (en) | 2018-06-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/11/2020, OBSERVADAS AS CONDICOES LEGAIS. |