CO5700712A2 - PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE - Google Patents
PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASEInfo
- Publication number
- CO5700712A2 CO5700712A2 CO05056010A CO05056010A CO5700712A2 CO 5700712 A2 CO5700712 A2 CO 5700712A2 CO 05056010 A CO05056010 A CO 05056010A CO 05056010 A CO05056010 A CO 05056010A CO 5700712 A2 CO5700712 A2 CO 5700712A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- propyl
- butyl
- ethyl
- bile acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
1.- Aplicación de compuestos inhibidores de recaptura de ácidos biliares para la preparación de un medicamento que permita prevenir o tratar la enfermedad de Alzheimer.2.- Aplicación según la reivindicación 1, caracterizada porque los inhibidores de recaptura de ácidos biliares son compuestos de fórmula (lA):en la cual:R1 representa metilo, etilo, propilo o butilo;R2 representa H, OH, NH2 o NH-alquilo C1-C6;R3 es un monosacárido, bisacárido, trisacárido o tetrasacárido, en que dicho radical está sin sustituir o mono- o poli-sustituido con un grupo protector de azúcares;R4 es metilo, etilo, propilo o butilo;R5 es metilo, etilo, propilo o butilo;Z es (C=O)n-alquilo (C0-C16); (C=O)n-alquilo (CO-C16)-NH; (C=O)n-alquilo (C0-C16)-O; (C=O)n-alquilo (C0-C16)-(C=O)- o un enlace covalente;n es 0 ó 1;m es 0 ó 1;así como sus sales por adiciones farmacéuticamente aceptables.3.- Aplicación según la reivindicación 1 ó 2, caracterizada porque el inhibidor de recaptura de ácidos biliares es el compuesto de fórmula (lA) siguiente:1. Application of bile acid recapture inhibitor compounds for the preparation of a medicament for preventing or treating Alzheimer's disease. 2. Application according to claim 1, characterized in that the bile acid recapture inhibitors are compounds of formula (lA): in which: R1 represents methyl, ethyl, propyl or butyl; R2 represents H, OH, NH2 or NH-C1-C6 alkyl; R3 is a monosaccharide, bisaccharide, trisaccharide or tetrasaccharide, in which said radical is without substitute or mono- or poly-substituted with a sugar protecting group; R4 is methyl, ethyl, propyl or butyl; R5 is methyl, ethyl, propyl or butyl; Z is (C = O) n-alkyl (C0-C16) ; (C = O) n-alkyl (CO-C16) -NH; (C = O) n (C0-C16) -O-alkyl; (C = O) n-C0-C16 alkyl - (C = O) - or a covalent bond; n is 0 or 1; m is 0 or 1; as well as its salts by pharmaceutically acceptable additions. 3.- Application according to claim 1 or 2, characterized in that the bile acid recapture inhibitor is the compound of formula (lA) as follows:
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0215722A FR2848452B1 (en) | 2002-12-12 | 2002-12-12 | APPLICATION OF INTESTINAL BILIARY ACID RECAPTURE INHIBITORS FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5700712A2 true CO5700712A2 (en) | 2006-11-30 |
Family
ID=32338722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05056010A CO5700712A2 (en) | 2002-12-12 | 2005-06-09 | PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1572174A1 (en) |
| JP (1) | JP2006514063A (en) |
| KR (1) | KR20050084250A (en) |
| CN (1) | CN1726016A (en) |
| AR (1) | AR042354A1 (en) |
| AU (1) | AU2003296802A1 (en) |
| BR (1) | BR0317280A (en) |
| CA (1) | CA2507945A1 (en) |
| CO (1) | CO5700712A2 (en) |
| FR (1) | FR2848452B1 (en) |
| HR (1) | HRP20050534A2 (en) |
| MA (1) | MA27500A1 (en) |
| MX (1) | MXPA05005556A (en) |
| NO (1) | NO20053341L (en) |
| NZ (1) | NZ540496A (en) |
| PE (1) | PE20040770A1 (en) |
| PL (1) | PL377110A1 (en) |
| RS (1) | RS20050420A (en) |
| RU (1) | RU2005121909A (en) |
| TW (1) | TW200503707A (en) |
| WO (1) | WO2004062652A1 (en) |
| ZA (1) | ZA200504656B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| ZA200603165B (en) | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| WO2005075436A2 (en) | 2004-02-05 | 2005-08-18 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| CA2589102C (en) | 2004-11-02 | 2013-08-13 | Northwestern University | Pyridazine compounds and methods for using the compounds to treat inflammatory diseases |
| US8158627B2 (en) | 2006-04-28 | 2012-04-17 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| US20100298375A1 (en) * | 2007-05-22 | 2010-11-25 | Heii Arai | medicament comprising a carbostyril derivative and donepezil for treating alzheimer's disease |
| EP2771003B1 (en) * | 2011-10-28 | 2017-04-19 | Lumena Pharmaceuticals LLC | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US20140323412A1 (en) * | 2011-10-28 | 2014-10-30 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2040996A1 (en) * | 1990-05-02 | 1991-11-03 | Robert L. Albright | Composition and method for controlling cholesterol |
| CA2104594C (en) * | 1991-02-22 | 2004-05-11 | Howard K. Shapiro | Use of pharmaceutical compounds in the treatment of symptoms of disorders related to neurological diseases and etiologically related symptomology |
| AU3585397A (en) * | 1996-06-27 | 1998-01-14 | G.D. Searle & Co. | Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications |
| US5985936A (en) * | 1997-12-18 | 1999-11-16 | Forbes Medi-Tech, Inc. | Method of preventing and delaying onset of Alzheimer's disease and composition therefor |
| WO1999038498A1 (en) * | 1998-01-28 | 1999-08-05 | Warner-Lambert Company | Method for treating alzheimer's disease |
| US6080778A (en) * | 1998-03-23 | 2000-06-27 | Children's Medical Center Corporation | Methods for decreasing beta amyloid protein |
| DE19825804C2 (en) * | 1998-06-10 | 2000-08-24 | Aventis Pharma Gmbh | 1,4-Benzothiepin-1,1-dioxide derivatives, processes for their preparation and medicaments containing these compounds |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| DE19845405C2 (en) * | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Aryl-substituted propanolamine derivatives and their use |
| US20010028895A1 (en) * | 2000-02-04 | 2001-10-11 | Bisgaier Charles L. | Methods of treating alzheimer's disease |
| US20020028826A1 (en) * | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| SE0104334D0 (en) * | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| TWI329111B (en) * | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
-
2002
- 2002-12-12 FR FR0215722A patent/FR2848452B1/en not_active Expired - Fee Related
-
2003
- 2003-12-10 EP EP03815109A patent/EP1572174A1/en not_active Withdrawn
- 2003-12-10 NZ NZ540496A patent/NZ540496A/en unknown
- 2003-12-10 AR ARP030104540A patent/AR042354A1/en not_active Application Discontinuation
- 2003-12-10 CA CA002507945A patent/CA2507945A1/en not_active Abandoned
- 2003-12-10 AU AU2003296802A patent/AU2003296802A1/en not_active Abandoned
- 2003-12-10 PL PL377110A patent/PL377110A1/en not_active Application Discontinuation
- 2003-12-10 BR BR0317280-5A patent/BR0317280A/en not_active IP Right Cessation
- 2003-12-10 PE PE2003001247A patent/PE20040770A1/en not_active Application Discontinuation
- 2003-12-10 KR KR1020057010595A patent/KR20050084250A/en not_active Application Discontinuation
- 2003-12-10 WO PCT/FR2003/003654 patent/WO2004062652A1/en active Application Filing
- 2003-12-10 JP JP2004566119A patent/JP2006514063A/en not_active Abandoned
- 2003-12-10 CN CNA2003801059727A patent/CN1726016A/en active Pending
- 2003-12-10 RU RU2005121909/15A patent/RU2005121909A/en not_active Application Discontinuation
- 2003-12-10 RS YUP-2005/0420A patent/RS20050420A/en unknown
- 2003-12-10 MX MXPA05005556A patent/MXPA05005556A/en not_active Application Discontinuation
- 2003-12-11 TW TW092134949A patent/TW200503707A/en unknown
-
2005
- 2005-06-07 ZA ZA200504656A patent/ZA200504656B/en unknown
- 2005-06-09 CO CO05056010A patent/CO5700712A2/en not_active Application Discontinuation
- 2005-06-10 HR HR20050534A patent/HRP20050534A2/en not_active Application Discontinuation
- 2005-06-10 MA MA28329A patent/MA27500A1/en unknown
- 2005-07-08 NO NO20053341A patent/NO20053341L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05005556A (en) | 2005-07-26 |
| PE20040770A1 (en) | 2004-12-10 |
| CA2507945A1 (en) | 2004-07-29 |
| AR042354A1 (en) | 2005-06-15 |
| FR2848452A1 (en) | 2004-06-18 |
| JP2006514063A (en) | 2006-04-27 |
| AU2003296802A1 (en) | 2004-08-10 |
| MA27500A1 (en) | 2005-08-01 |
| PL377110A1 (en) | 2006-01-23 |
| FR2848452B1 (en) | 2007-04-06 |
| RS20050420A (en) | 2007-04-10 |
| KR20050084250A (en) | 2005-08-26 |
| RU2005121909A (en) | 2006-01-20 |
| NO20053341L (en) | 2005-09-07 |
| BR0317280A (en) | 2005-11-08 |
| HRP20050534A2 (en) | 2006-11-30 |
| CN1726016A (en) | 2006-01-25 |
| WO2004062652A1 (en) | 2004-07-29 |
| NZ540496A (en) | 2008-04-30 |
| TW200503707A (en) | 2005-02-01 |
| EP1572174A1 (en) | 2005-09-14 |
| NO20053341D0 (en) | 2005-07-08 |
| ZA200504656B (en) | 2006-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |