CO5580781A2 - BENZOXAZINE AND BENZOTIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

BENZOXAZINE AND BENZOTIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
CO5580781A2
CO5580781A2 CO04035089A CO04035089A CO5580781A2 CO 5580781 A2 CO5580781 A2 CO 5580781A2 CO 04035089 A CO04035089 A CO 04035089A CO 04035089 A CO04035089 A CO 04035089A CO 5580781 A2 CO5580781 A2 CO 5580781A2
Authority
CO
Colombia
Prior art keywords
derivatives
substituted
thio
unsubstituted
aryl
Prior art date
Application number
CO04035089A
Other languages
Spanish (es)
Inventor
Debnath Bhuniya
Kumar Das Saibal
Gurram Ranga Madhavan
Javed Iqbal
Ranjan Chakrabarti
Original Assignee
Reddys Lab Ltd Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Ltd Dr filed Critical Reddys Lab Ltd Dr
Publication of CO5580781A2 publication Critical patent/CO5580781A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1.- Nuevos compuestos caracterizados porque son de la fórmula (I) sus derivados, sus análogos, sus formas tautoméricas, sus estereoisómeros, sus polimorfos, sus sales farmacéuticamente aceptables, sus solvatos farmacéuticamente aceptables, donde R1, R2 y R3, R4 cuando se unen al átomo de carbono, pueden ser los mismos o diferentes y representan hidrógeno, halógeno, hidroxi, nitro, ciano, formilo o grupos substituidos o insubstituidos seleccionados de alquilo, cicloalquilo, alcoxi, cicloalcoxi, arilo, ariloxi, aralquilo, aralcoxi, heterociclilo, heteroarilo, heteroaralquilo, heteroariloxi, heteroaralcoxi, acilo, aciloxi, hidroxialquilo, amino, acilamino, monoalquilamino, dialquilamino, arilamino, aralquilamino, alcoxicarbonilo, ariloxicarbonilo, aralcoxicarbonilo, alcoxialquilo, ariloxialquilo, aralcoxialquilo, alquiltio, tioalquilo, alcoxicarbonilamino, ariloxicarbonilamino, aralcoxicarbonilamino, ácido carboxílico o sus derivados, o ácido sulfónico o sus derivados; uno o ambos de R3 y R4 pueden representar un grupo oxo o tioxo cuando están unidos a un átomo de carbono; R3 y R4 cuando están unidos a un átomo de nitrógeno representan hidrógeno, hidroxi, formilo o grupos substituidos o insubstituidos seleccionados de grupos alquilo, cicloalquilo, alcoxi, cicloalcoxi, arilo, aralquilo, heterociclilo, heteroarilo, heteroaralquilo, acilo, aciloxi, hidroxialquilo, amino, acilamino, monoalquilamino, dialquilamino, arilamino, aralquilamino, aminoalquilo, ariloxi, aralcoxi, heteroariloxi, heteroaralcoxi, alcoxicarbonilo, ariloxicarbonilo, aralcoxicarbonilo, alcoxialquilo, ariloxialquilo, aralcoxialquilo, alquiltio, tioalquilo, derivados de ácido carboxílico, o derivados de ácido sulfónico; X representa un heteroátomo seleccionado de oxígeno o azufre; W representa NR12, -C(=O)-(CR10R11)o-NR12, -O-arilo-(CR10R11)o-NR12, en donde R12 representa hidrógeno o un grupo substituido o insubstituido seleccionado de grupos alquilo, arilo o aralquilo; o es un entero que varía de 0-6; R10 y R11 pueden ser los mismos o diferentes y representan hidrógeno o un grupo substituido o insubstituido seleccionado del grupo alquilo, alcoxi, arilo o aralquilo; Ar representa un grupo aromático o heterocíclico substituido o insubstituido divalente único o fusionado seleccionado del grupo fenileno, naftileno, pirrolilo, piridilo, quinolilo, benzofurilo, dihidrobenzofurilo, benzopiranilo, dihidrobenzopiranilo, indolilo, indolinilo, ...1.- New compounds characterized in that they are of the formula (I) their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, where R1, R2 and R3, R4 when bind to the carbon atom, may be the same or different and represent hydrogen, halogen, hydroxy, nitro, cyano, formyl or substituted or unsubstituted groups selected from alkyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyalkyl, amino, acylamino, monoalkylamino, dialkylamino, arylamino, aralkylamino, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, alkylthio, thioalkyl, alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, carboxylic acid or its derivatives, or sulfonic acid or its derivatives; one or both of R3 and R4 may represent an oxo or thioxo group when attached to a carbon atom; R3 and R4 when attached to a nitrogen atom represent hydrogen, hydroxy, formyl or substituted or unsubstituted groups selected from alkyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, aralkyl, heterocyclyl, heteroaryl, heteroaralkyl, acyl, acyloxy, hydroxyalkyl, amino groups , acylamino, monoalkylamino, dialkylamino, arylamino, aralkylamino, aminoalkyl, aryloxy, aralkoxy, heteroaryloxy, heteroaralkoxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, alkylthio, carboxylic acid, thio derivatives, thio derivatives, thio derivatives, thio derivatives, thio derivatives, thio derivatives, thio derivatives, thio, derivatives X represents a heteroatom selected from oxygen or sulfur; W represents NR12, -C (= O) - (CR10R11) or-NR12, -O-aryl- (CR10R11) or-NR12, wherein R12 represents hydrogen or a substituted or unsubstituted group selected from alkyl, aryl or aralkyl groups; or is an integer that varies from 0-6; R10 and R11 may be the same or different and represent hydrogen or a substituted or unsubstituted group selected from the alkyl, alkoxy, aryl or aralkyl group; Ar represents a single or fused substituted or unsubstituted substituted or unsubstituted aromatic or heterocyclic group selected from the phenylene, naphthylene, pyrrolyl, pyridyl, quinolyl, benzofuryl, dihydrobenzofuryl, benzopyranyl, dihydrobenzopyranyl, indolyl, indolinyl, ... group.

CO04035089A 2001-10-16 2004-04-16 BENZOXAZINE AND BENZOTIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM CO5580781A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN848MA2001 2001-10-16

Publications (1)

Publication Number Publication Date
CO5580781A2 true CO5580781A2 (en) 2005-11-30

Family

ID=35824329

Family Applications (2)

Application Number Title Priority Date Filing Date
CO04035089A CO5580781A2 (en) 2001-10-16 2004-04-16 BENZOXAZINE AND BENZOTIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CO04035096A CO5580819A2 (en) 2001-10-16 2004-04-16 NEW PROPIONIC DERIVATIVES B-FENIL-A-OXISUBSTITUIDOS: PROCESS FOR ITS PREPARATION AND ITS USE IN THE PREPARATION OF PHARMACEUTICALLY IMPORTANT COPMPUESTOS

Family Applications After (1)

Application Number Title Priority Date Filing Date
CO04035096A CO5580819A2 (en) 2001-10-16 2004-04-16 NEW PROPIONIC DERIVATIVES B-FENIL-A-OXISUBSTITUIDOS: PROCESS FOR ITS PREPARATION AND ITS USE IN THE PREPARATION OF PHARMACEUTICALLY IMPORTANT COPMPUESTOS

Country Status (9)

Country Link
KR (2) KR20040052242A (en)
CN (1) CN1982299A (en)
AU (1) AU2002341289B2 (en)
CO (2) CO5580781A2 (en)
MX (2) MXPA04003628A (en)
NZ (1) NZ532284A (en)
RS (2) RS32404A (en)
RU (2) RU2004111792A (en)
UA (1) UA78522C2 (en)

Also Published As

Publication number Publication date
RS32304A (en) 2006-12-15
RU2004111792A (en) 2005-05-27
KR20040052242A (en) 2004-06-22
MXPA04003629A (en) 2004-07-30
RS32404A (en) 2007-02-05
NZ532284A (en) 2006-02-24
AU2002341289B2 (en) 2008-07-24
MXPA04003628A (en) 2004-07-30
CO5580819A2 (en) 2005-11-30
CN1982299A (en) 2007-06-20
UA78522C2 (en) 2007-04-10
RU2004111786A (en) 2005-10-20
KR20040048960A (en) 2004-06-10

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