CO5280032A1 - COMPOSICIONES RELACIONADAS CON ESTEAROIL-CoA DESATURASA HUMANA Y METODOS PARA TRATAR DESORDENES DE LA PIEL - Google Patents

COMPOSICIONES RELACIONADAS CON ESTEAROIL-CoA DESATURASA HUMANA Y METODOS PARA TRATAR DESORDENES DE LA PIEL

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Publication number
CO5280032A1
CO5280032A1 CO99051951A CO99051951A CO5280032A1 CO 5280032 A1 CO5280032 A1 CO 5280032A1 CO 99051951 A CO99051951 A CO 99051951A CO 99051951 A CO99051951 A CO 99051951A CO 5280032 A1 CO5280032 A1 CO 5280032A1
Authority
CO
Colombia
Prior art keywords
human
stearoyl
coa desaturase
expression
coa
Prior art date
Application number
CO99051951A
Other languages
English (en)
Inventor
Kurt Stenn
Stephen M Prouty
Parimoo Satish
Zhang Lin
Original Assignee
Johnson & Johnson Consumer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson Consumer filed Critical Johnson & Johnson Consumer
Publication of CO5280032A1 publication Critical patent/CO5280032A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con una molécula de ácido nucleico que codifica la estearoil-CoA desaturasa humana, y la proteína aislada modificada por la misma. Provee también un método de diagnóstico de un sujeto humano para un desorden de la piel caracterizado por un nivel anormal de expresión de estearoil-CoA desaturasa. Provee además un método para determinar si un agente aumenta el nivel de expresión de la estearoil-CoA desaturasa humana en las células de la piel que ya expresan la misma. Esta invención provee además métodos para determinar si un agente aumenta o disminuye el nivel de expresión o de actividad de la estearoil-CoA desaturasa humana en las células de la piel ya que expresan la misma. Esta invención provee además composiciones farmacéuticas para tratar desórdenes de la piel humana caracterizados por una expresión y/o actividad anormal de estearoil-CoA desaturasa, y métodos de tratamiento relacionados. Finalmente, esta invención provee anticuerpos relacionados, vectores para terapia génica, y ratones transgénicos.
CO99051951A 1998-08-14 1999-08-17 COMPOSICIONES RELACIONADAS CON ESTEAROIL-CoA DESATURASA HUMANA Y METODOS PARA TRATAR DESORDENES DE LA PIEL CO5280032A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9652098P 1998-08-14 1998-08-14

Publications (1)

Publication Number Publication Date
CO5280032A1 true CO5280032A1 (es) 2003-05-30

Family

ID=22257742

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99051951A CO5280032A1 (es) 1998-08-14 1999-08-17 COMPOSICIONES RELACIONADAS CON ESTEAROIL-CoA DESATURASA HUMANA Y METODOS PARA TRATAR DESORDENES DE LA PIEL

Country Status (4)

Country Link
AR (1) AR020190A1 (es)
AU (1) AU5774699A (es)
CO (1) CO5280032A1 (es)
WO (1) WO2000009754A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19955349A1 (de) * 1999-11-17 2001-08-02 Switch Biotech Ag Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankungen sowie ihre Verwendung zur Identifizierung von pharmakologisch aktiven Substanzen
AU2001247228B2 (en) 2000-02-24 2007-01-18 Wisconsin Alumni Research Foundation Stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents
US6686185B1 (en) 2000-03-07 2004-02-03 Millennium Pharmaceuticals, Inc. 25934, a novel fatty acid desaturase and uses therefor
EP1322767B1 (en) 2000-09-26 2008-07-23 Xenon Pharmaceuticals Inc. Methods and compositions employing a stearoyl-coa desaturase-hscd5
AU2002218091A1 (en) * 2000-11-17 2002-05-27 Xenon Genetics Inc Fat regulated genes, uses thereof, and compounds for modulating same
US7132529B2 (en) * 2001-07-30 2006-11-07 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
US20050043256A1 (en) 2001-07-30 2005-02-24 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
US6759208B2 (en) 2001-08-29 2004-07-06 Xenon Genetics Inc. High throughput screening assays using fatty acid synthetic enzymes
US20030215849A1 (en) * 2002-03-01 2003-11-20 Marcia Belvin PDPK1s as modifiers of the p53 pathway and methods of use
AU2003294446A1 (en) * 2002-11-21 2004-06-18 Bayer Pharmaceuticals Corporation Regulation of stearoyl-coa desaturase to treat obesity
FR2853910B1 (fr) * 2003-04-16 2007-08-24 Galderma Res & Dev Genes du psoriasis
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
US8802167B2 (en) 2010-06-11 2014-08-12 Avon Products, Inc. Use of Eclipta prostrata and other PPAR-gamma inhibitors in cosmetics and compositions thereof
RU2634862C2 (ru) 2011-05-19 2017-11-07 Торэй Индастриз, Инк. Агент, индуцирующий иммунитет
EP3719138B1 (en) * 2016-07-08 2022-09-21 Kao Corporation Method for preparing nucleic acid sample
EP4119664A4 (en) * 2020-03-11 2024-04-24 Kao Corp METHOD FOR THE PRODUCTION OF RNA FROM SKIN SURFACE LIPIDS

Also Published As

Publication number Publication date
AU5774699A (en) 2000-03-06
AR020190A1 (es) 2002-05-02
WO2000009754A3 (en) 2000-08-24
WO2000009754A2 (en) 2000-02-24

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