CO5271712A1 - CHEMICAL AND INTERMEDIARY PROCESSES - Google Patents

CHEMICAL AND INTERMEDIARY PROCESSES

Info

Publication number
CO5271712A1
CO5271712A1 CO00090190A CO00090190A CO5271712A1 CO 5271712 A1 CO5271712 A1 CO 5271712A1 CO 00090190 A CO00090190 A CO 00090190A CO 00090190 A CO00090190 A CO 00090190A CO 5271712 A1 CO5271712 A1 CO 5271712A1
Authority
CO
Colombia
Prior art keywords
group
primary
ch2ch
formation
chemical
Prior art date
Application number
CO00090190A
Other languages
Spanish (es)
Inventor
Michael Barry Gravestock
Kenneth Edwin Herbert
Angela Charlotte Currie
Debra Ainge
David Simon Ennis
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5271712A1 publication Critical patent/CO5271712A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Un proceso para la formación de un grupo primario mono-fosforilo (OPO(OH)2) en una funcionalidad terminal 1,2-diol-propanoil (HO-CH2CH(OH)-CO-) que comprende los pasos de: (i) formación de una especie protegida primaria 1,2-diol (PgO-CH2CH(OH)-CO-);(ii) formación de un grupo fosforilo secundario (opcionalmente protegido) y (iii) tratamiento de este grupo fosforilo secundario con ácido para desproteger la función de alcohol protegido primario y volver a arreglar el grupo fosforilo secundario a un grupo fosforilo primario (para dar una (HO)2OPO-CH2CH(OH)-CO-fundionalidad); donde Pg es un grupo de protección.A process for the formation of a mono-phosphoryl (OPO (OH) 2) primary group in a 1,2-diol-propanoyl (HO-CH2CH (OH) -CO-) terminal functionality comprising the steps of: (i) formation of a primary protected species 1,2-diol (PgO-CH2CH (OH) -CO -); (ii) formation of a secondary phosphoryl group (optionally protected) and (iii) treatment of this secondary phosphoryl group with acid to deprotect the function of primary protected alcohol and rearrange the secondary phosphoryl group to a primary phosphoryl group (to give a (HO) 2OPO-CH2CH (OH) -CO-foundry); where Pg is a protection group.

CO00090190A 1999-12-03 2000-11-24 CHEMICAL AND INTERMEDIARY PROCESSES CO5271712A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9928499.4A GB9928499D0 (en) 1999-12-03 1999-12-03 Chemical processes and intermediates

Publications (1)

Publication Number Publication Date
CO5271712A1 true CO5271712A1 (en) 2003-04-30

Family

ID=10865576

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00090190A CO5271712A1 (en) 1999-12-03 2000-11-24 CHEMICAL AND INTERMEDIARY PROCESSES

Country Status (22)

Country Link
EP (1) EP1237895A2 (en)
JP (1) JP2003515539A (en)
KR (1) KR20020058072A (en)
CN (1) CN1433421A (en)
AR (1) AR026700A1 (en)
AU (1) AU762241B2 (en)
BG (1) BG106728A (en)
BR (1) BR0016087A (en)
CA (1) CA2395052A1 (en)
CO (1) CO5271712A1 (en)
CZ (1) CZ20021912A3 (en)
EE (1) EE200200282A (en)
GB (1) GB9928499D0 (en)
HU (1) HUP0204052A2 (en)
IL (1) IL149641A0 (en)
IS (1) IS6401A (en)
MX (1) MXPA02005396A (en)
NO (1) NO20022605L (en)
PL (1) PL364762A1 (en)
SK (1) SK7862002A3 (en)
WO (1) WO2001040236A2 (en)
ZA (1) ZA200203876B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0113297D0 (en) * 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
EP1427711B1 (en) 2001-09-11 2005-07-13 AstraZeneca AB Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials
AR038536A1 (en) 2002-02-25 2005-01-19 Upjohn Co N-ARIL-2-OXAZOLIDINONA-5- CARBOXAMIDS AND ITS DERIVATIVES
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
US7473699B2 (en) 2002-02-28 2009-01-06 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and their use as antibacterial agents
EP1480975A2 (en) 2002-02-28 2004-12-01 Astrazeneca AB Chemical compounds
US7094900B2 (en) 2002-08-12 2006-08-22 Pharmacia & Upjohn Company Llc N-Aryl-2-oxazolidinones and their derivatives
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
EP1565186B1 (en) 2002-11-21 2006-11-02 Pharmacia & Upjohn Company LLC N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
EP2492264A3 (en) 2003-06-03 2012-12-19 Rib-X Pharmaceuticals, Inc. Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
TW200526649A (en) 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
JP5383037B2 (en) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド Macrocyclic compounds and methods of making and using them
JP5534497B2 (en) 2005-06-08 2014-07-02 メリンタ セラピューティクス，インコーポレイテッド Method for synthesizing triazoles
CA2664572C (en) 2006-09-25 2015-06-16 Wockhardt Research Centre Substituted piperidinophenyl oxazolidinones
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1311787A (en) * 1998-06-05 2001-09-05 阿斯特拉曾尼卡有限公司 Oxazolidinone derivatives, process for their prepn. and pharmaceutical compositions contg. same

Also Published As

Publication number Publication date
WO2001040236A2 (en) 2001-06-07
IL149641A0 (en) 2002-11-10
CZ20021912A3 (en) 2002-08-14
WO2001040236A3 (en) 2002-05-10
NO20022605L (en) 2002-06-26
JP2003515539A (en) 2003-05-07
BR0016087A (en) 2002-08-06
AU762241B2 (en) 2003-06-19
BG106728A (en) 2003-02-28
EE200200282A (en) 2003-06-16
CN1433421A (en) 2003-07-30
EP1237895A2 (en) 2002-09-11
MXPA02005396A (en) 2002-11-29
ZA200203876B (en) 2003-08-15
NO20022605D0 (en) 2002-05-31
SK7862002A3 (en) 2003-02-04
KR20020058072A (en) 2002-07-12
IS6401A (en) 2002-05-28
AU1715601A (en) 2001-06-12
HUP0204052A2 (en) 2003-03-28
CA2395052A1 (en) 2001-06-07
AR026700A1 (en) 2003-02-26
GB9928499D0 (en) 2000-02-02
PL364762A1 (en) 2004-12-13

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