BG106728A - Chemical methods and intermediate compounds - Google Patents

Chemical methods and intermediate compounds

Info

Publication number
BG106728A
BG106728A BG106728A BG10672802A BG106728A BG 106728 A BG106728 A BG 106728A BG 106728 A BG106728 A BG 106728A BG 10672802 A BG10672802 A BG 10672802A BG 106728 A BG106728 A BG 106728A
Authority
BG
Bulgaria
Prior art keywords
chemical methods
preparation
intermediate compounds
intermediates
relates
Prior art date
Application number
BG106728A
Other languages
Bulgarian (bg)
Inventor
Michael Gravestock
Kenneth Warren
David Ennis
Angela CURRIE
Debra Ainge
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BG106728A publication Critical patent/BG106728A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретението се отнася до химични методи и междинни химически съединения, които се използват при селективното формиране на първична монофосфорилна група (-ОРО(ОН2)) в система, съдържаща терминален-1,2-диол-пропаноил (НО-СН2СН(ОН)-СО-). Изобретението се отнася и до химични методи и междинни химически съединения, както и до методи за получаването им, които по-специално се използват за получаванетона оксазолидинонови средства срещу грамположителнибактерии, съдържащи такива функционални групи, по-специално за получаването на 5(R)-изоксазол-3-илоксиметил-3-(4-(1-(2(S)-хидрокси-3-фосфорилпропаноил)-1,2,5,6-тетрахидропирид-4-ил)-3,5-дифлуорфенил)-оксазолидин-2-он.The invention relates to chemical methods and intermediates which are used in the selective formation of a primary monophosphoryl group (-OPO (OH)) in a system comprising a terminal 1,2-diol-propanoyl (HO-CH2CH (OH) -). The invention also relates to chemical methods and intermediates, as well as methods for their preparation, which are especially useful for the preparation of oxazolidinone agents against gram-positive bacteria containing such functional groups, in particular for the preparation of 5 (R) -isoxazole -3-yloxymethyl-3- (4- (1- (2 (S) -hydroxy- 3- phosphorylpropanoyl) -1,2,5,6- tetrahydropyrid- 4- yl- 3, 5- difluorophenyl) 2-one.

BG106728A 1999-12-03 2002-05-20 Chemical methods and intermediate compounds BG106728A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9928499.4A GB9928499D0 (en) 1999-12-03 1999-12-03 Chemical processes and intermediates
PCT/GB2000/004527 WO2001040236A2 (en) 1999-12-03 2000-11-28 Phosphorylation of terminal primary alcohol groups

Publications (1)

Publication Number Publication Date
BG106728A true BG106728A (en) 2003-02-28

Family

ID=10865576

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106728A BG106728A (en) 1999-12-03 2002-05-20 Chemical methods and intermediate compounds

Country Status (22)

Country Link
EP (1) EP1237895A2 (en)
JP (1) JP2003515539A (en)
KR (1) KR20020058072A (en)
CN (1) CN1433421A (en)
AR (1) AR026700A1 (en)
AU (1) AU762241B2 (en)
BG (1) BG106728A (en)
BR (1) BR0016087A (en)
CA (1) CA2395052A1 (en)
CO (1) CO5271712A1 (en)
CZ (1) CZ20021912A3 (en)
EE (1) EE200200282A (en)
GB (1) GB9928499D0 (en)
HU (1) HUP0204052A2 (en)
IL (1) IL149641A0 (en)
IS (1) IS6401A (en)
MX (1) MXPA02005396A (en)
NO (1) NO20022605L (en)
PL (1) PL364762A1 (en)
SK (1) SK7862002A3 (en)
WO (1) WO2001040236A2 (en)
ZA (1) ZA200203876B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0113297D0 (en) * 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
EP1427711B1 (en) 2001-09-11 2005-07-13 AstraZeneca AB Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
AR038536A1 (en) 2002-02-25 2005-01-19 Upjohn Co N-ARIL-2-OXAZOLIDINONA-5- CARBOXAMIDS AND ITS DERIVATIVES
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
CA2477379A1 (en) 2002-02-28 2003-09-04 Astrazeneca Ab Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them
BR0308056A (en) 2002-02-28 2004-12-07 Astrazeneca Ab Compound, prodrug, method for producing an antibacterial effect on a warm-blooded animal, use of a compound, pharmaceutical composition, and process for preparing a compound
ATE321760T1 (en) 2002-08-12 2006-04-15 Pharmacia & Upjohn Co Llc N-ARYL-2-OXAZOLIDINONE AND DERIVATIVES THEREOF
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
AR042086A1 (en) 2002-11-21 2005-06-08 Upjohn Co N-ARIL-2- OXAZOLIDINON -5- CARBOXAMIDS AND THEIR DERIVATIVES, USED AS ANTIBACTERIAL AGENTS
TWI378092B (en) 2003-06-03 2012-12-01 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
EP1713785A1 (en) 2003-12-17 2006-10-25 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
JP5534497B2 (en) 2005-06-08 2014-07-02 メリンタ セラピューティクス，インコーポレイテッド Method for synthesizing triazoles
KR101336510B1 (en) * 2006-09-25 2013-12-03 욱크하르트 리미티드 Substituted piperidinophenyl oxazolidinones
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK18362000A3 (en) * 1998-06-05 2001-06-11 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU1715601A (en) 2001-06-12
EP1237895A2 (en) 2002-09-11
ZA200203876B (en) 2003-08-15
WO2001040236A2 (en) 2001-06-07
IS6401A (en) 2002-05-28
CA2395052A1 (en) 2001-06-07
AR026700A1 (en) 2003-02-26
HUP0204052A2 (en) 2003-03-28
CO5271712A1 (en) 2003-04-30
BR0016087A (en) 2002-08-06
WO2001040236A3 (en) 2002-05-10
NO20022605D0 (en) 2002-05-31
MXPA02005396A (en) 2002-11-29
CN1433421A (en) 2003-07-30
SK7862002A3 (en) 2003-02-04
EE200200282A (en) 2003-06-16
GB9928499D0 (en) 2000-02-02
PL364762A1 (en) 2004-12-13
NO20022605L (en) 2002-06-26
KR20020058072A (en) 2002-07-12
JP2003515539A (en) 2003-05-07
CZ20021912A3 (en) 2002-08-14
IL149641A0 (en) 2002-11-10
AU762241B2 (en) 2003-06-19

Similar Documents

Publication Publication Date Title
BG106728A (en) Chemical methods and intermediate compounds
BG103485A (en) Ketobanzamides as calpain inhibitors
AU698620B2 (en) Hydrophilated dental impression compounds
MX9702865A (en) 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-idoles as estrogenic agents.
ATE299145T1 (en) NEW MULTIMERIZING REAGENT
BR0109922A (en) Chemical compounds
HUT77925A (en) Dihydrobenzofuranes, pharmaceuticals containing them as active agents and method for producing them.
DE60112609D1 (en) Pyrazolopyridine
SE9904652D0 (en) Novel Compounds
EA200300580A1 (en) LACTAM CONNECTIONS
MXPA02011370A (en) Substituted iminoazines.
DE60112330D1 (en) Pyrazolopyridinderivate
SE9904108D0 (en) New compounds
HK1089746A1 (en) Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof
DE69724438D1 (en) NON-PEPTIDIC G-CSF MIMETIC
MXPA02012101A (en) Process for the synthesis of (2r, 2-alpha-r, 3a)-2-[1-(3, 5 -bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
MXPA01008347A (en) Chemical compounds.
PT1513824E (en) Furancarboxamides
TR200302288T2 (en) New compounds and methods for therapy.
DE60235365D1 (en) PROCESS FOR THE PREPARATION OF 7-AMINO-SYN-3,5-DIHYDROXYHEPTANSÄUREDERIVATEN AND BETWEEN COMPOUNDS OF THIS PROCESS AND THEIR PREPARATION
WO2003024400A3 (en) Process for the preparation of 1,5-diarylpyrazoles
PL373468A1 (en) Oxathiincarboxamides
IL138638A0 (en) Processes for preparing intermediates
WO2002046152A3 (en) Coniosetin and derivatives thereof, method for producing the same and use thereof
DE69533214D1 (en) 2,3-Dihydro-1H-isoindole derivatives, process for their preparation and their use as inhibitors of serotonin reuptake