CO5090852A1 - PROCESS FOR THE PRODUCTION OF AMORPH PRODUCTS BY DRYING BY CONVECTION - Google Patents

PROCESS FOR THE PRODUCTION OF AMORPH PRODUCTS BY DRYING BY CONVECTION

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Publication number
CO5090852A1
CO5090852A1 CO98063875A CO98063875A CO5090852A1 CO 5090852 A1 CO5090852 A1 CO 5090852A1 CO 98063875 A CO98063875 A CO 98063875A CO 98063875 A CO98063875 A CO 98063875A CO 5090852 A1 CO5090852 A1 CO 5090852A1
Authority
CO
Colombia
Prior art keywords
polar
derivatives
production
convection
products
Prior art date
Application number
CO98063875A
Other languages
Spanish (es)
Inventor
Gabel Rolf-Dieter
Markus Mattern
Gerhard Winter
Alexander Wirl
Heinrich Woog
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of CO5090852A1 publication Critical patent/CO5090852A1/en

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  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Proceso para la producción de productos amorfos secos que, además de material biológicamente activo, en particular material terapéuticamente activo, contienen mezclas de substancias para la estabilización, caracterizado porque una solución o suspensión de material biológico y una mezcla de substancias que consiste en: (a) un carbohidrato y al menos un zwitterión con un radical polar o apolar o derivados del mismo, y/o (b) al menos dos zwitteriones con radicales polares o apolares o derivados de los mismos, y/o (c) al menos un zwitterión con un radical polar o apolar o una pluralidad de zwitteriones con radicales polares o apolares o derivados de los mismos, se produce y se seca mediante secado por convección con ajuste del contenido en humedad relativa a ANDlt; 70% en la fase estacionaria, y una temperatura de entrada de flujo de aire de 50 - 300°C.Process for the production of dry amorphous products that, in addition to biologically active material, in particular therapeutically active material, contain mixtures of substances for stabilization, characterized in that a solution or suspension of biological material and a mixture of substances consisting of: (a ) a carbohydrate and at least one zwitterion with a polar or apolar radical or derivatives thereof, and / or (b) at least two zwitterions with polar or apolar radicals or derivatives thereof, and / or (c) at least one zwitterion with a polar or non-polar radical or a plurality of zwitterions with polar or non-polar radicals or derivatives thereof, it is produced and dried by convection drying with adjustment of the moisture content relative to ANDlt; 70% in the stationary phase, and an air flow inlet temperature of 50-300 ° C.

CO98063875A 1997-11-03 1998-10-30 PROCESS FOR THE PRODUCTION OF AMORPH PRODUCTS BY DRYING BY CONVECTION CO5090852A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97119112 1997-11-03

Publications (1)

Publication Number Publication Date
CO5090852A1 true CO5090852A1 (en) 2001-10-30

Family

ID=40943326

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98063875A CO5090852A1 (en) 1997-11-03 1998-10-30 PROCESS FOR THE PRODUCTION OF AMORPH PRODUCTS BY DRYING BY CONVECTION

Country Status (1)

Country Link
CO (1) CO5090852A1 (en)

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