CO4920249A1 - ANTAGONISTS OF AN IL-8 RECEPTOR - Google Patents
ANTAGONISTS OF AN IL-8 RECEPTORInfo
- Publication number
- CO4920249A1 CO4920249A1 CO98003009A CO98003009A CO4920249A1 CO 4920249 A1 CO4920249 A1 CO 4920249A1 CO 98003009 A CO98003009 A CO 98003009A CO 98003009 A CO98003009 A CO 98003009A CO 4920249 A1 CO4920249 A1 CO 4920249A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkenyl
- aryl
- alkyl
- 4alkyl
- heteroaryl
- Prior art date
Links
- 108090001007 Interleukin-8 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 4
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- -1 hydroxy- C1-10alkyl Chemical group 0.000 abstract 3
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004447 heteroarylalkenyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un compuesto de la fórmula:en la queR es -NH-C(X2 )-NH-(CR13 R14 )v -Z;Z es W, HET, , alquilo C1-10 opcionalmente sustituido, alquenilo C2-10 opcionalmente sustituido o alquinilo C2-10 opcionalmente sustituido;X es C(X1 )2 , O, N-R18 , C=O, ó S(O)m´ ;X1 es hidrógeno, halógeno, alquilo C1 -10 , NR4 R5 , C(O)NR4 R5 , alquilo C1-10 opcionalmente sustituido, alcoxi C1-10 , alcoxi C1-10 sustituido con halo, hidroxi, arilo, aril-alquilo C1-4 , ariloxi, aril-alquil C1-4 -oxi, heteroarilo, heteroarilalquilo, heterocíclico, heterocíclico- alquilo C1-4 o heteroaril-alquil C1-4 oxi;X2 es =O ó =S;A es CH2 , C(O) ó C(S);R1 se selecciona independientemente entre hidrógeno, halógeno, nitro, ciano, alquilo C1-10 sustituido con halo, alquilo C1-10 , alquenilo C2-10 , alcoxi C1-10 , alcoxi C1-10 sustituido con halo, azido, (CR8 R8 )q S(O)t R4 , hidroxi, hidroxi-alquilo C1-10 , arilo, aril-alquilo C1-4 , ariloxi, aril-alquil C1-4 -oxi, heteroarilo, heteroarilalquilo, heterocíclico, heterocíclico-alquilo C1-4 , heteroaril-alquil C1-4 -oxi, aril-alquenilo C2-10 , heteroaril-alquenilo C2-10 , heterocíclico-alquenilo C2-10 , (CR8 R8 )q NR4 R5 , alquenil C2-10 -C(O)-NR4 R5 , (CR8 R8 )q C(O)NR4 R5 , (CR8 R8 )q C(O)NR4 R10 , S(O)3 H, S(O)3 R8 , (CR8 R8 )q C(O)R11 , alquenil C2-10 -C(O)R11 , alquenil C2-10 -C(O)OR11 , C(O)R11 , (CR8 R8 )q C(O)OR12 , (CR8 R8 )q OC(O)R11 , (CR8 R8 )q NR4 C(O)R11 , (CR8 R8 )q-NHS(O)2 R17 ó (CR8 R8 )q S(O)2 NR4 R5 , o dos restos R1 en común pueden formar O-(CH2 )s -O- o un anillo saturado o insaturado de 5 a 6 miembros; y en que los anillos que contienen arilo, heteroarilo y heterocíclico pueden todos ellos estar opcionalmente sustituidos;n es un número entero que tiene un valor de 1 a 3;m es un número entero que tiene un valor de 1 a 3;...A compound of the formula: wherein R is -NH-C (X2) -NH- (CR13 R14) v -Z; Z is W, HET, optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl, or alkynyl Optionally substituted C2-10; X is C (X1) 2, O, N-R18, C = O, or S (O) m '; X1 is hydrogen, halogen, C1-10 alkyl, NR4 R5, C (O) NR4 R5, optionally substituted C 1-10 alkyl, C 1-10 alkoxy, C 1-10 alkoxy substituted with halo, hydroxy, aryl, aryl-C 1-4 alkyl, aryloxy, aryl-C 1-4 alkyl -oxy, heteroaryl, heteroarylalkyl, heterocyclic , heterocyclic-C1-4alkyl or heteroaryl-C1-4alkyl oxy; X2 is = O or = S; A is CH2, C (O) or C (S); R1 is independently selected from hydrogen, halogen, nitro, cyano , C1-10 alkyl substituted with halo, C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxy, C1-10 alkoxy substituted with halo, azido, (CR8 R8) q S (O) t R4, hydroxy, hydroxy- C1-10alkyl, aryl, aryl-C1-4alkyl, aryloxy, aryl-C1-4alkyl -oxy, heteroaryl, heteroarylalkyl, heterocyclic, heterocyclic lico-C1-4alkyl, heteroaryl-C1-4alkyl -oxy, aryl-alkenyl C2-10, heteroaryl-alkenyl C2-10, heterocyclic-alkenyl C2-10, (CR8 R8) q NR4 R5, alkenyl C2-10 - C (O) -NR4 R5, (CR8 R8) q C (O) NR4 R5, (CR8 R8) q C (O) NR4 R10, S (O) 3 H, S (O) 3 R8, (CR8 R8) q C (O) R11, C2-10 alkenyl -C (O) R11, C2-10 alkenyl -C (O) OR11, C (O) R11, (CR8 R8) q C (O) OR12, (CR8 R8) q OC (O) R11, (CR8 R8) q NR4 C (O) R11, (CR8 R8) q-NHS (O) 2 R17 or (CR8 R8) q S (O) 2 NR4 R5, or two residues R1 in common they can form O- (CH2) s -O- or a 5-6 membered saturated or unsaturated ring; and in that aryl, heteroaryl and heterocyclic containing rings may all be optionally substituted; n is an integer having a value of 1 to 3; m is an integer having a value of 1 to 3; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3599097P | 1997-01-23 | 1997-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4920249A1 true CO4920249A1 (en) | 2000-05-29 |
Family
ID=21885958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98003009A CO4920249A1 (en) | 1997-01-23 | 1998-01-23 | ANTAGONISTS OF AN IL-8 RECEPTOR |
Country Status (2)
| Country | Link |
|---|---|
| CO (1) | CO4920249A1 (en) |
| ZA (1) | ZA98519B (en) |
-
1998
- 1998-01-22 ZA ZA98519A patent/ZA98519B/en unknown
- 1998-01-23 CO CO98003009A patent/CO4920249A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA98519B (en) | 1998-10-23 |
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