AR011101A1 - ARILSULFONYLAMINOHYDROXYAMIC ACID DERIVED COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT - Google Patents

ARILSULFONYLAMINOHYDROXYAMIC ACID DERIVED COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT

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Publication number
AR011101A1
AR011101A1 ARP980100453A ARP980100453A AR011101A1 AR 011101 A1 AR011101 A1 AR 011101A1 AR P980100453 A ARP980100453 A AR P980100453A AR P980100453 A ARP980100453 A AR P980100453A AR 011101 A1 AR011101 A1 AR 011101A1
Authority
AR
Argentina
Prior art keywords
aryl
alkyl
heteroaryl
aryloxy
alkoxy
Prior art date
Application number
ARP980100453A
Other languages
Spanish (es)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of AR011101A1 publication Critical patent/AR011101A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de formula (I) o las sales farmacéuticamente aceptables del mismo, en la que cada uno de R1 y R2 se seleccionan independientemente dealquilo C1-C6, trifluorometilo, trifluorometil (alquilo C1-C6), (alquil C1-C6) difluorometileno, (alquil C1-C3)difluorometilen-(alquilo C1-C3), arilo C6-C10,heteroarilo C2-C9, (aril C6-C10)(alquilo C1-C6) o (heteroaril C2-C9)(alquilo C1-C6), o R1 y R2 se pueden unir para formar un anillo de cicloalquilo C3-C6 ode cicloalquilo C3-C6 condensado aun benceno o un grupo de formula (II) en la que m y n son independientemente 1 o 2, y X es CF2, S, O o NR3, en el que R3 eshidrogeno, alquilo C1-C6, arilo C6-C10, heteroarilo C2-C9, (aril C6-C10) (alquilo C1-C6), (heteroaril C2-C9)(alquilo C1-C6), (alquil C1-C6)sulfonilo,(aril C6-C10) sulfonilo o acilo; y Q es alquilo C1-C6, arilo C6-C10, (ariloxi C6-C10)(arilo C6-C10), (aril C6-C10)(arilo C6-C10), (aril C6-C10)(aril C6-C10)(alquilo C1-C6), (aril C6-C10)(heteroarilo C2-C9), (ariloxi C6-C10) (heteroarilo C2-C9), heteroarilo C2-C9, (heteroaril C2-C9)(heteroarilo C2-C9),(heteroaril C2-C9)(arilo C6-C10), (alquil C1-C6)(arilo C6-C10), (alcoxi C1-C6) (arilo C6-C10), (aril C6-C10)(alcoxi C1-C6)(arilo C6-V10), (aril C6-C10)(alcoxiC1-C6)(alquilo C1-C6), (heteroariloxi C2-C9)(arilo C6-C10), (alquil C1-C6) (heteroarilo C2-C9),(alcoxi C1-C6)(heteroarilo C2-C9), (heteroariloxi C2-C9)heteroarilo C2-C9), (ariloxi C6-C10)(alquilo C1-C6), (heteroariloxi C2-C9) (alquilo C1-C6), (alquil C1-C6), (alquil C1-C6)(ariloxi C6-C10)(arilo C6-C10),(alquil C1-C6)(heteroariloxi C2-C9)(arilo C6-C10), alquil C1-C6)(ariloxi C6-C10)(heteroarilo C2-C9), (alcoxi C1-C6)(ariloxi C6-C10)(arilo C6-C10),(alcoxi C1-C6)(heteroariloxiC2-C9)(arilo C6-C10) o (alcoxi C1-C6)(ariloxi C6-C10)(heteroarilo C2-C9), en los que cada grupo arilo está sustituidoA compound of formula (I) or the pharmaceutically acceptable salts thereof, in which each of R1 and R2 are independently selected from C1-C6 alkyl, trifluoromethyl, trifluoromethyl (C1-C6 alkyl), (C1-C6 alkyl) difluoromethylene, (C1-C3 alkyl) difluoromethylene- (C1-C3 alkyl), C6-C10 aryl, C2-C9 heteroaryl, (C6-C10 aryl) (C1-C6 alkyl) or (C2-C9 heteroaryl) (C1-C6 alkyl) , or R1 and R2 can join to form a ring of C3-C6 cycloalkyl or of C3-C6 cycloalkyl fused to benzene or a group of formula (II) in which m and n are independently 1 or 2, and X is CF2, S, O or NR3, where R3 is hydrogen, C1-C6 alkyl, C6-C10 aryl, C2-C9 heteroaryl, (C6-C10 aryl) (C1-C6 alkyl), (C2-C9 heteroaryl) (C1-C6 alkyl) , (C1-C6 alkyl) sulfonyl, (C6-C10 aryl) sulfonyl or acyl; and Q is C1-C6 alkyl, C6-C10 aryl, (C6-C10 aryloxy) (C6-C10 aryl), (C6-C10 aryl) (C6-C10 aryl), (C6-C10 aryl) (C6-C10 aryl) ) (C1-C6 alkyl), (C6-C10 aryl) (C2-C9 heteroaryl), (C6-C10 aryloxy) (C2-C9 heteroaryl), C2-C9 heteroaryl, (C2-C9 heteroaryl) C2-C9 heteroaryl ), (C2-C9 heteroaryl) (C6-C10 aryl), (C1-C6 alkyl) (C6-C10 aryl), (C1-C6 alkoxy) (C6-C10 aryl), (C6-C10 aryl) (C1 alkoxy -C6) (C6-V10 aryl), (C6-C10 aryl) (C1-C6 alkoxy) (C1-C6 alkyl), (C2-C9 heteroaryloxy) (C6-C10 aryl), (C1-C6 alkyl) (C2 heteroaryl -C9), (C1-C6 alkoxy) (C2-C9 heteroaryl), (C2-C9 heteroaryloxy) C2-C9 heteroaryl), (C6-C10 aryloxy) (C1-C6 alkyl), (C2-C9 heteroaryloxy) (alkyl C1-C6), (C1-C6 alkyl), (C1-C6 alkyl) (C6-C10 aryloxy) (C6-C10 aryl), (C1-C6 alkyl) (C2-C9 heteroaryloxy) (C6-C10 aryl), C1-C6 alkyl) (C6-C10 aryloxy) (C2-C9 heteroaryl), (C1-C6 alkoxy) (C6-C10 aryloxy) (C6-C10 aryl), (C1-C6 alkoxy) (C2-C9 heteroaryloxy) (aryl C6-C10) or (C1-C6 alkoxy) (C6-C10 aryloxy) (C2-C9 heteroaryl), in which each group aryl is substituted

ARP980100453A 1997-02-03 1998-02-02 ARILSULFONYLAMINOHYDROXYAMIC ACID DERIVED COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT AR011101A1 (en)

Applications Claiming Priority (1)

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US3685797P 1997-02-03 1997-02-03

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Country Link
US (1) US6303636B1 (en)
EP (1) EP0977733B1 (en)
JP (1) JP3765584B2 (en)
KR (1) KR100317146B1 (en)
CN (1) CN1113862C (en)
AP (1) AP826A (en)
AR (1) AR011101A1 (en)
AT (1) ATE248812T1 (en)
AU (1) AU721748B2 (en)
BG (1) BG64308B1 (en)
BR (1) BR9807815A (en)
CA (1) CA2279276C (en)
CO (1) CO4920234A1 (en)
DE (1) DE69817801T2 (en)
DK (1) DK0977733T3 (en)
DZ (1) DZ2410A1 (en)
EA (1) EA002594B1 (en)
ES (1) ES2202796T3 (en)
GT (1) GT199800025A (en)
HK (1) HK1026203A1 (en)
HN (1) HN1998000011A (en)
HR (1) HRP980058B1 (en)
HU (1) HUP0000852A2 (en)
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IL (2) IL131042A (en)
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TN (1) TNSN98019A1 (en)
TR (1) TR199901849T2 (en)
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UA (1) UA63935C2 (en)
UY (1) UY24866A1 (en)
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