CO4920218A1 - THERAPEUTIC AGENTS BASED ON IDOXIFENO, USEFUL IN THE TREATMENT OF OSTEOPOROSIS - Google Patents

THERAPEUTIC AGENTS BASED ON IDOXIFENO, USEFUL IN THE TREATMENT OF OSTEOPOROSIS

Info

Publication number
CO4920218A1
CO4920218A1 CO97051287A CO97051287A CO4920218A1 CO 4920218 A1 CO4920218 A1 CO 4920218A1 CO 97051287 A CO97051287 A CO 97051287A CO 97051287 A CO97051287 A CO 97051287A CO 4920218 A1 CO4920218 A1 CO 4920218A1
Authority
CO
Colombia
Prior art keywords
idoxifeno
osteoporosis
useful
treatment
therapeutic agents
Prior art date
Application number
CO97051287A
Other languages
Spanish (es)
Inventor
Jeremy N Bradbeer
Maxine Gowen
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CO4920218A1 publication Critical patent/CO4920218A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un método de prevenir y tratar enfermedades post-menopáusicas, quecomprende administrar a un sujeto que lo necesita una cantidad eficaz de un compuesto de fórmula I.Un uso según la reivindicación 1, en el que el compuesto de fórmula (I) es (E)-1-[2-[4-[1-(4-yodofenil)-2-fenil-1-butenil]-fenoxi]etil]pirrolidina.A method of preventing and treating postmenopausal diseases, comprising administering to a subject in need an effective amount of a compound of formula I. A use according to claim 1, wherein the compound of formula (I) is (E) -1- [2- [4- [1- (4-iodophenyl) -2-phenyl-1-butenyl] -phenoxy] ethyl] pyrrolidine.

CO97051287A 1996-09-06 1997-09-04 THERAPEUTIC AGENTS BASED ON IDOXIFENO, USEFUL IN THE TREATMENT OF OSTEOPOROSIS CO4920218A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2543996P 1996-09-06 1996-09-06
US5066697P 1997-06-24 1997-06-24

Publications (1)

Publication Number Publication Date
CO4920218A1 true CO4920218A1 (en) 2000-05-29

Family

ID=26699738

Family Applications (2)

Application Number Title Priority Date Filing Date
CO97051287A CO4920218A1 (en) 1996-09-06 1997-09-04 THERAPEUTIC AGENTS BASED ON IDOXIFENO, USEFUL IN THE TREATMENT OF OSTEOPOROSIS
CO97051289A CO5070658A1 (en) 1996-09-06 1997-09-04 USEFUL THERAPEUTIC AGENTS FOR THE TREATMENT AND PREVENTION OF CARDIO VASCULAR DISEASES IN POSMENOPAUSIAN WOMEN

Family Applications After (1)

Application Number Title Priority Date Filing Date
CO97051289A CO5070658A1 (en) 1996-09-06 1997-09-04 USEFUL THERAPEUTIC AGENTS FOR THE TREATMENT AND PREVENTION OF CARDIO VASCULAR DISEASES IN POSMENOPAUSIAN WOMEN

Country Status (16)

Country Link
EP (2) EP0927029A4 (en)
JP (2) JP2002515046A (en)
KR (2) KR20000068472A (en)
CN (2) CN1236299A (en)
AR (1) AR008155A1 (en)
AU (2) AU4247397A (en)
BR (2) BR9711676A (en)
CA (2) CA2264943A1 (en)
CO (2) CO4920218A1 (en)
CZ (1) CZ76699A3 (en)
IL (1) IL128645A0 (en)
NO (2) NO991097L (en)
PL (2) PL332278A1 (en)
TR (2) TR199900504T2 (en)
TW (1) TW411273B (en)
WO (2) WO1998009519A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998034608A1 (en) * 1997-02-11 1998-08-13 Novo Nordisk A/S Methods for treatment or prophylaxis of menopausal symptoms
GB9827121D0 (en) * 1998-12-09 1999-02-03 Orion Corp Agent for lowering endothelin levels
DE19905961A1 (en) * 1999-02-12 2000-08-17 Stefan Neubauer Use of estrogens to treat cardiac insufficiency and left ventricular dysfunction following myocardial infarction
US6528681B2 (en) * 2000-04-05 2003-03-04 Bristol-Meyers Squibb Pharma Company Halogenated triphenylethylene derivatives as selective estrogen receptor modulators
TWI303990B (en) 2000-10-17 2008-12-11 Pfizer Prod Inc New use of estrogen agonists/antagonists for improving vascular health

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0260066B1 (en) * 1986-09-11 1990-05-09 National Research Development Corporation Tamoxifen derivatives
DE69316633T2 (en) * 1992-09-15 1998-05-20 Merrell Dow Pharma NON-METABOLIZABLE CLOMIPHENE ANALOGS FOR THE TREATMENT OF TAMOXIFEN-RESISTANT TUMORS
US5681835A (en) * 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US5604248A (en) * 1994-05-05 1997-02-18 Eli Lilly And Company Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs
US5470883A (en) * 1994-05-23 1995-11-28 Stromberg; Brent V. Method of treating peripheral vasoconstriction with tamoxifen citrate
JPH11510479A (en) * 1995-06-07 1999-09-14 ネオルックス コーポレイション Prevention and treatment of cardiovascular disease with tamoxifen analogs
HN1996000101A (en) * 1996-02-28 1997-06-26 Inc Pfizer COMBINED THERAPY FOR OSTEOPOROSIS
US6069175A (en) * 1996-11-15 2000-05-30 Pfizer Inc. Estrogen agonist/antagonists treatment of atherosclerosis

Also Published As

Publication number Publication date
KR20000068473A (en) 2000-11-25
AU4247397A (en) 1998-03-26
NO991096L (en) 1999-03-05
CA2264943A1 (en) 1998-03-12
PL332038A1 (en) 1999-08-16
NO991097D0 (en) 1999-03-05
AR008155A1 (en) 1999-12-09
TW411273B (en) 2000-11-11
BR9711676A (en) 1999-08-24
NO991097L (en) 1999-03-05
JP2002515046A (en) 2002-05-21
TR199900506T2 (en) 1999-07-21
WO1998009519A1 (en) 1998-03-12
NO991096D0 (en) 1999-03-05
IL128645A0 (en) 2000-01-31
JP2002515047A (en) 2002-05-21
AU4409797A (en) 1998-03-26
BR9711681A (en) 1999-08-24
EP0929216A4 (en) 2001-04-04
EP0927029A1 (en) 1999-07-07
CA2264775A1 (en) 1998-03-12
CZ76699A3 (en) 1999-08-11
EP0929216A1 (en) 1999-07-21
CN1236299A (en) 1999-11-24
PL332278A1 (en) 1999-08-30
TR199900504T2 (en) 1999-06-21
EP0927029A4 (en) 2001-06-13
KR20000068472A (en) 2000-11-25
CO5070658A1 (en) 2001-08-28
CN1236313A (en) 1999-11-24
WO1998009619A1 (en) 1998-03-12

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