CO4810303A1 - DERIVATIVES OF N- [3- [2 - [(2,3-DIHYDRO-1H-INDEN-2-IL) ALKYLAMI- NO] -ETHYL] FENYL] CARBOXAMIDE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents

DERIVATIVES OF N- [3- [2 - [(2,3-DIHYDRO-1H-INDEN-2-IL) ALKYLAMI- NO] -ETHYL] FENYL] CARBOXAMIDE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

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Publication number
CO4810303A1
CO4810303A1 CO99029058A CO99029058A CO4810303A1 CO 4810303 A1 CO4810303 A1 CO 4810303A1 CO 99029058 A CO99029058 A CO 99029058A CO 99029058 A CO99029058 A CO 99029058A CO 4810303 A1 CO4810303 A1 CO 4810303A1
Authority
CO
Colombia
Prior art keywords
group
inden
dihydro
optionally substituted
methoxy
Prior art date
Application number
CO99029058A
Other languages
Spanish (es)
Inventor
Evanno Yannick
Benoit Marabout
Mireille Sevrin
Genevieve Estenne-Bouh
Emmanuelle Dachary
Veronique Corinne
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of CO4810303A1 publication Critical patent/CO4810303A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuesto que responden a la fórmula general (I)en la cualR1 representa un grupo 2,3-dihidro-1H-inden-2-ilo, eventualmente substituido por uno o dos grupos metoxi, R2 representa un grupo alquilo de 1 a 4 átomos de carbono, y R3 representa ó bien un grupo alquilo de 1 a 6 átomos de carbono, ó bien un grupo fenilo eventualmente substituido por uno o varios átomos de flúor o por uno o varios grupos alquilo de 1 a 6 átomos de carbono, metoxi, metoximetilo, ciano, carbamoilo, fenilo, oxazol-5-ilo, imidazol-1-ilo, cicloalquilo de 5 a 6 átomos de carbono, pirimidin-2-ilo o furanilo, ó bien un grupo ciclohexilo eventualmente substituido por un grupo metoxi, ó bien un grupo naftilo, ó bien un grupo furanilo o benzofuranilo, ó bien un grupo piridinilo,en estado de base libre o de sal de adición con un ácido.Compound corresponding to the general formula (I) in which R1 represents a 2,3-dihydro-1H-inden-2-yl group, optionally substituted by one or two methoxy groups, R2 represents an alkyl group of 1 to 4 atoms of carbon, and R3 represents either an alkyl group of 1 to 6 carbon atoms, or a phenyl group optionally substituted by one or more fluorine atoms or by one or more alkyl groups of 1 to 6 carbon atoms, methoxy, methoxymethyl , cyano, carbamoyl, phenyl, oxazol-5-yl, imidazol-1-yl, cycloalkyl of 5 to 6 carbon atoms, pyrimidin-2-yl or furanyl, or a cyclohexyl group optionally substituted by a methoxy group, or a naphthyl group, or a furanyl or benzofuranyl group, or a pyridinyl group, in the free base or acid addition salt state.

CO99029058A 1998-05-12 1999-05-11 DERIVATIVES OF N- [3- [2 - [(2,3-DIHYDRO-1H-INDEN-2-IL) ALKYLAMI- NO] -ETHYL] FENYL] CARBOXAMIDE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS CO4810303A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9805935A FR2778658B1 (en) 1998-05-12 1998-05-12 N- [3- [2 - [(2,3-DIHYDRO-1H-INDEN-2-YL) ALKYLAMINO] - ETHYL] PHENYL] CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
CO4810303A1 true CO4810303A1 (en) 1999-06-30

Family

ID=9526237

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99029058A CO4810303A1 (en) 1998-05-12 1999-05-11 DERIVATIVES OF N- [3- [2 - [(2,3-DIHYDRO-1H-INDEN-2-IL) ALKYLAMI- NO] -ETHYL] FENYL] CARBOXAMIDE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Country Status (5)

Country Link
AR (1) AR019841A1 (en)
AU (1) AU3527199A (en)
CO (1) CO4810303A1 (en)
FR (1) FR2778658B1 (en)
WO (1) WO1999058477A2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272157A (en) * 1990-03-07 1993-12-21 Synthelabo Derivatives of 4-(aminomethyl) piperidine, their preparation and their therapeutic application
FR2681320B1 (en) * 1991-09-12 1994-01-14 Synthelabo DERIVATIVES OF N- (4,7DIMETHOXYINDAN-2-YL) -1- (PHENYLCARBONYL) -N-PROPYL-PIPERIDINE-4-METHANAMINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.

Also Published As

Publication number Publication date
AR019841A1 (en) 2002-03-20
WO1999058477A3 (en) 2000-01-27
AU3527199A (en) 1999-11-29
FR2778658B1 (en) 2000-06-30
FR2778658A1 (en) 1999-11-19
WO1999058477A2 (en) 1999-11-18

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