CO4700436A1 - ORAL FORMULATIONS OF IBUPROFEN S (+) - - Google Patents

ORAL FORMULATIONS OF IBUPROFEN S (+) -

Info

Publication number
CO4700436A1
CO4700436A1 CO96030081A CO96030081A CO4700436A1 CO 4700436 A1 CO4700436 A1 CO 4700436A1 CO 96030081 A CO96030081 A CO 96030081A CO 96030081 A CO96030081 A CO 96030081A CO 4700436 A1 CO4700436 A1 CO 4700436A1
Authority
CO
Colombia
Prior art keywords
acid
organoleptically acceptable
pharmaceutically
contained
formulation
Prior art date
Application number
CO96030081A
Other languages
Spanish (es)
Inventor
Leslie George Humber
Gerald Louis Reuter
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of CO4700436A1 publication Critical patent/CO4700436A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Una composición farmacéutica oral organolépticamente aceptableque consta de S(+)-2-(p-isobutilfenil)-ácido propiónico substancialmente libre de R(-)-2-(p-isobutilfenil)-ácido propiónico y un componente acídico.La composición farmacéutica oral organolépticamente aceptable de la Reivindicación 1 en que el componente acídico consta de ácido cítrico, ácido tartárico, ácido málico, ácido fumárico, ácido láctico, ácido adípico, ácido ascórbico, ácido aspártico, ácido eritórbico, ácido glutámico y ácido succínico, o mezclas de los mismos.La composición farmacéutica organolépticamente aceptable de la Reivindicación 1 que consta además de un portador farmacéuticamente organolépticamente aceptable.Una composición farmacéuticamente organolépticamente aceptable de la Reivindicación 3 que está contenida dentro de una formulación granular o en polvo.Una composición farmacéuticamente organolépticamente aceptable de la Reivindicación 3 que está contenida dentro de una formulación líquida.Una composición farmaceútica organolépticamente aceptable de la Reivindicación 3 que está contenida dentro de una formulación de tableta masticable.Una composición farmacéuticamente organolépticamente aceptable de la Reivindicación 3 que está contenida dentro de una formulación efervescente.Una composición farmacéutica organolépticamente aceptable de la reivindicación 3 que está contenida dentro de una formulación de pastilla.Una composición farmacéuticamente organolépticamente aceptable de la Reivindicación 3 que está contenida dentro de una formulación de dosis sólida de desintegración rápida.Una composición farmacéuticamente organolépticamente aceptable de la Reivindicación 3 que está contenida dentro de una formulación veterinaria masticable.An organoleptically acceptable oral pharmaceutical composition consisting of S (+) - 2- (p-isobutylphenyl) -propionic acid substantially free of R (-) - 2- (p-isobutylphenyl) -propionic acid and an acidic component.The oral pharmaceutical composition organoleptically acceptable of Claim 1 in which the acidic component consists of citric acid, tartaric acid, malic acid, fumaric acid, lactic acid, adipic acid, ascorbic acid, aspartic acid, erythorbic acid, glutamic acid and succinic acid, or mixtures of the The organoleptically acceptable pharmaceutical composition of Claim 1 further consisting of a pharmaceutically organoleptically acceptable carrier A pharmaceutically organoleptically acceptable composition of Claim 3 being contained within a granular or powder formulation A pharmaceutically organoleptically acceptable composition of Claim 3 which is cont enida within a liquid formulation. An organoleptically acceptable pharmaceutical composition of Claim 3 that is contained within a chewable tablet formulation. A pharmaceutically organoleptically acceptable composition of Claim 3 that is contained within an effervescent formulation. An organoleptically acceptable pharmaceutical composition. of claim 3 which is contained within a tablet formulation. A pharmaceutically organoleptically acceptable composition of Claim 3 which is contained within a rapidly disintegrating solid dose formulation. A pharmaceutically organoleptically acceptable composition of Claim 3 which is contained within of a chewable veterinary formulation.

CO96030081A 1995-06-13 1996-06-11 ORAL FORMULATIONS OF IBUPROFEN S (+) - CO4700436A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16995P 1995-06-13 1995-06-13

Publications (1)

Publication Number Publication Date
CO4700436A1 true CO4700436A1 (en) 1998-12-29

Family

ID=40257129

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96030081A CO4700436A1 (en) 1995-06-13 1996-06-11 ORAL FORMULATIONS OF IBUPROFEN S (+) -

Country Status (3)

Country Link
KR (1) KR970000226A (en)
CO (1) CO4700436A1 (en)
PA (1) PA8175201A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100700721B1 (en) * 2000-09-08 2007-03-27 지상철 Tablets of S+-Ibuprofen having improved stability and dissolution rate
KR101004526B1 (en) * 2004-11-09 2010-12-31 주식회사 하이닉스반도체 Method for forming capacitor of semiconductor device

Also Published As

Publication number Publication date
PA8175201A1 (en) 1998-09-18
KR970000226A (en) 1997-01-21

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