CO4700288A1 - NEW SULPHONAMIDES - Google Patents

NEW SULPHONAMIDES

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Publication number
CO4700288A1
CO4700288A1 CO95060149A CO95060149A CO4700288A1 CO 4700288 A1 CO4700288 A1 CO 4700288A1 CO 95060149 A CO95060149 A CO 95060149A CO 95060149 A CO95060149 A CO 95060149A CO 4700288 A1 CO4700288 A1 CO 4700288A1
Authority
CO
Colombia
Prior art keywords
signifies
hydrogen
stands
lower alkyl
substituted
Prior art date
Application number
CO95060149A
Other languages
Spanish (es)
Inventor
Breu Volker
Burri Kaspar
Jean Marie Cassal
Martine Clozel
Georges Hirth
Bernd-Michae Loffler
Marcel Muller
Werner Neidhart
Henri Ramuz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO4700288A1 publication Critical patent/CO4700288A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmulaen donde R1 significa arilo o heterociclilo;R2 significa tetrazolilo, tetrazolilo substituido con alquilo inferior, ciano, carboxilo, alcoxicarbonilo inferior, hidroximetilo, formilo, carbamoilo, tiocarbamoilo, amidino o hidroxiamidino; R3 significa un radical -O-(CRa Rb )n -OR9 ; R4 -R8 significa hidrógeno, alcoxilo inferior o halógeno;R9 significa hidrógeno, arilo, aralquilo inferior, heterociclilo o un radical -C(O)NHR10 ; R10 significa alquilo inferior, fenilo, fenilo substituido, piridilo o piridilo substituido;Ra y Rb significan hidrógeno o alquilo inferior; n significa 2, 3 o 4; y A y B significan CH; o uno de los símbolos A o B significa nitrógeno y el otro significa CH; oR2 significa hidrógeno y uno de los símbolos A o B significa N-óxido (N - O) y el otro significa CH,y las sales farmacéuticamente utilizables de compuestos de fórmula I.Compounds of the formula wherein R1 signifies aryl or heterocyclyl, R2 signifies tetrazolyl, tetrakyl substituted with lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, hydroxymethyl, formyl, carbamoyl, thiocarbamoyl, amidino or hydroxyamidino; R3 signifies a radical -O- (CRa Rb) n -OR9; R4 -R8 signifies hydrogen, lower alkoxy or halogen; R9 signifies hydrogen, aryl, lower aralkyl, heterocyclyl or a radical -C (O) NHR10; R10 signifies lower alkyl, phenyl, substituted phenyl, pyridyl or substituted pyridyl, Ra and Rb signify hydrogen or lower alkyl; n means 2, 3 or 4; and A and B signify CH; or one of the symbols A or B signifies nitrogen and the other signifies CH; oR2 stands for hydrogen and one of the symbols A or B stands for N-oxide (N-O) and the other stands for CH, and the pharmaceutically usable salts of compounds of formula I.

CO95060149A 1994-12-20 1995-12-19 NEW SULPHONAMIDES CO4700288A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH383794 1994-12-20

Publications (1)

Publication Number Publication Date
CO4700288A1 true CO4700288A1 (en) 1998-12-29

Family

ID=4264545

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95060149A CO4700288A1 (en) 1994-12-20 1995-12-19 NEW SULPHONAMIDES

Country Status (8)

Country Link
AR (1) AR002258A1 (en)
CO (1) CO4700288A1 (en)
PE (1) PE60196A1 (en)
PL (1) PL188801B1 (en)
RU (1) RU2151767C1 (en)
TR (1) TR199501608A2 (en)
UY (1) UY24121A1 (en)
ZA (1) ZA9510622B (en)

Also Published As

Publication number Publication date
PL188801B1 (en) 2005-04-29
PE60196A1 (en) 1996-12-28
RU2151767C1 (en) 2000-06-27
UY24121A1 (en) 2000-12-29
AR002258A1 (en) 1998-03-11
ZA9510622B (en) 1996-06-20
PL320941A1 (en) 1997-11-24
TR199501608A2 (en) 1996-07-21

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