CO4410257A1 - HERPES VIRUS POLYNUCLEOTIDE VACCINE - Google Patents

HERPES VIRUS POLYNUCLEOTIDE VACCINE

Info

Publication number
CO4410257A1
CO4410257A1 CO95031727A CO95031727A CO4410257A1 CO 4410257 A1 CO4410257 A1 CO 4410257A1 CO 95031727 A CO95031727 A CO 95031727A CO 95031727 A CO95031727 A CO 95031727A CO 4410257 A1 CO4410257 A1 CO 4410257A1
Authority
CO
Colombia
Prior art keywords
vhs
genes
polynucleotide
promoter
transcription
Prior art date
Application number
CO95031727A
Other languages
Spanish (es)
Inventor
Marcy E Armstrong
Robert D Keys
John A Lewis
Margaret A Liu
William L Mcclements
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CO4410257A1 publication Critical patent/CO4410257A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

REIVINDICACION NUMERO UN POLINUCLEOTIDO QUE INDUCE ANTICUERPOS ANTI-VHS O REPUESTAS INMUNOPROTECTORAS AL SER INTRODUCIDO EN TEJIDO DE VERTEBRADOS , EL POLINUCLEOTIDO COMPRENDE UNO O MAS GENES QUE CODIFICAN UNA O MAS PROTEINAS DE VHS, O SUS EQUIVALENTES FUNCIONALES; ESTOS GENES ESTAN OPERACIONALMENTE LIGADOS A UN PROMOTOR DE TRANSCRIPCION. REIVINDICACION N. 5- UN METODO PARA INDUCIR INMUNO-RESPUESTAS CONTRA VHS, EL CUAL COMPRENDE LA INTRODUCCION DENTROE DE EL TEJIDO DE UN VERTEBRADO, DE UNO O MAS GENES DE VHS, AISLADOS Y PURIFICADOS, QUE EDUCEN UNA INMUNO-RESPUESTA LA CUAL PREVIENE LA INFECCION Y/O DISMINUYE LA ENFERMEDAD CAUSADA POR EL VHS. REIVINDICACION N. 6- UN POLINUCLEOTIDO QUE COMPRENDE: A) UN PROMOTOR DE TRANSCRIPCION EUCARIOTO; B) UNA MATRIZ DE LECTURA ABIERTA OPERABLEMENTE LI- GADA AL PROMOTOR, LA QUE CODIFICA UNO O MAS EPITO- POS DE VHS Y UNA SENAL DE TERMINACION DE LA TRA- DUCCION; Y C)OPCIONALMENTE CONTIENE UNO O MAS IRES OPERABLE- MENTE LIGADOS, UNO O MAS MATRICES DE LECTURA A - BIERTA QUE CODIFICAN A UNO O MAS GENES ADICIONA- LES Y, UNA O MAS SENALES DE TERMINACION DE LA TRANSCRIPCION.CLAIMED NUMBER A POLYNUCLEOTIDE THAT INDUCES ANTI-HSV ANTIBODIES OR IMMUNOPROTECTORAL REPLIES WHEN INTRODUCED IN VERTEBRATE TISSUE, THE POLYNUCLEOTIDE INCLUDES ONE OR MORE GENES THAT CODE ONE OR MORE VHS PROTEINS, OR THEIR EQUIVALENTS THESE GENES ARE OPERATIONALLY LINKED TO A TRANSCRIPT PROMOTER. CLAIM N. 5 - A METHOD TO INDUCE IMMUNO-RESPONSES AGAINST VHS, WHICH INCLUDES THE INTRODUCTION WITHIN THE TISSUE OF A VERTEBRATE, OF ONE OR MORE GENES OF VHS, ISOLATED AND PURIFIED, WHICH EDUCATES AN IMMUNO-RESPONSE WHICH PREVENTS INFECTION AND / OR DECREASES THE DISEASE CAUSED BY HSV. CLAIM N. 6 - A POLYNUCLEOTIDE THAT INCLUDES: A) A PROMOTER OF EUCHARIOT TRANSCRIPTION; B) AN OPERATELY OPEN READING MATRIX LINKED TO THE PROMOTER, WHICH CODES ONE OR MORE VHS EPITODES AND A SIGNAL OF TERMINATION OF TRANSLATION; AND C) OPTIONALLY CONTAINS ONE OR MORE OPERATIONALLY LINKED IRES, ONE OR MORE READING MATRICES A - BIERTA CODING ONE OR MORE ADDITIONAL GENES AND, ONE OR MORE SIGNALS OF TERMINATION OF TRANSCRIPTION.

CO95031727A 1994-07-22 1995-07-18 HERPES VIRUS POLYNUCLEOTIDE VACCINE CO4410257A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27945994A 1994-07-22 1994-07-22

Publications (1)

Publication Number Publication Date
CO4410257A1 true CO4410257A1 (en) 1997-01-09

Family

ID=23069059

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95031727A CO4410257A1 (en) 1994-07-22 1995-07-18 HERPES VIRUS POLYNUCLEOTIDE VACCINE

Country Status (10)

Country Link
EP (1) EP0772680A1 (en)
JP (1) JPH10503649A (en)
AU (1) AU708460B2 (en)
CA (1) CA2195099A1 (en)
CO (1) CO4410257A1 (en)
HR (1) HRP950412A2 (en)
IL (1) IL114576A0 (en)
WO (1) WO1996003510A1 (en)
YU (1) YU49995A (en)
ZA (1) ZA956106B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849719A (en) * 1993-08-26 1998-12-15 The Regents Of The University Of California Method for treating allergic lung disease
US7094767B2 (en) 1994-07-22 2006-08-22 Merck & Co., Inc. Polynucleotide herpes virus vaccine
AU738835B2 (en) * 1994-07-22 2001-09-27 Merck & Co., Inc. A polynucleotide herpes virus vaccine
CA2267645A1 (en) * 1996-10-01 1998-04-09 Merck & Co., Inc. A polynucleotide herpes virus vaccine
JP2001503258A (en) * 1996-10-18 2001-03-13 バレンティス・インコーポレーテッド Gene expression and delivery systems and applications
CA2268365A1 (en) * 1996-10-18 1998-04-30 Jeff Nordstrom Il-12 gene expression and delivery systems and uses
GB9720633D0 (en) * 1997-09-29 1997-11-26 Univ Bristol BHV-2 vector
US6488936B1 (en) * 1998-02-12 2002-12-03 Wyeth Immunogenic composition of interleukin-12 (IL-12), alum, herpes simplex viral (HSV) antigen, and method thereof
US6867000B2 (en) * 2000-12-07 2005-03-15 Wyeth Holdings Corporation Method of enhancing immune responses to herpes
US9012349B1 (en) 2013-11-01 2015-04-21 Ut-Battelle Llc Method of synthesizing bulk transition metal carbide, nitride and phosphide catalysts

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612983B2 (en) * 1986-08-01 1991-07-25 Australian National University, The Recombinant vaccine
DE69034078T2 (en) * 1989-03-21 2004-04-01 Vical, Inc., San Diego Expression of exogenous polynucleotide sequences in vertebrates
DE69019609T2 (en) * 1989-07-07 1995-11-30 Takeda Chemical Industries Ltd Proteins and their production.

Also Published As

Publication number Publication date
WO1996003510A1 (en) 1996-02-08
YU49995A (en) 1998-05-15
CA2195099A1 (en) 1996-02-08
HRP950412A2 (en) 1997-10-31
ZA956106B (en) 1996-04-10
AU3101295A (en) 1996-02-22
EP0772680A1 (en) 1997-05-14
AU708460B2 (en) 1999-08-05
IL114576A0 (en) 1995-11-27
JPH10503649A (en) 1998-04-07

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