CO4410186A1 - DERIVATIVES OF INDANO AND TETRAHIDRONAFTALINA - Google Patents

DERIVATIVES OF INDANO AND TETRAHIDRONAFTALINA

Info

Publication number
CO4410186A1
CO4410186A1 CO95030945A CO95030945A CO4410186A1 CO 4410186 A1 CO4410186 A1 CO 4410186A1 CO 95030945 A CO95030945 A CO 95030945A CO 95030945 A CO95030945 A CO 95030945A CO 4410186 A1 CO4410186 A1 CO 4410186A1
Authority
CO
Colombia
Prior art keywords
compound
formula
sup
sub
defined before
Prior art date
Application number
CO95030945A
Other languages
Spanish (es)
Inventor
Orlek Barry Sidney
John David Harling
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to CO95030945A priority Critical patent/CO4410186A1/en
Publication of CO4410186A1 publication Critical patent/CO4410186A1/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN COMPUESTO DE LA FORMULA (I) FIGURA N.1 DONDE n SUB(1) ES 1 SUB(2), 2 o 3; R SUP(1) Y R SUP(2) CADA UNO INDEPENDIENTEMENTE REPRESENTA HIDROGENO, ALQUILO C SB(1-6), CICLOAL- QUILO SUB(C3-6) ALQUILO C SUB(1-4); X REPRESENTA O, S , NH O UN ENLACE, SIEMPRE Y CUANDO LA SUMA DE P Y Q SEA POR LO MENOS 1; Y AR REPRESENTA FENILO SUSTITUIDO POR -Y-CR SUP(3)R(4) PH, DONDE Y ES OXIGENO O UN ENLACE, R SUP (3) Y R SUP(4) SON INDEPENDIENTEMENTE, H, METILO O ETILO SIEMPRE Y CUANDO QUE R SUP(4) NO SEAN AMBOS H, Y PH ES FENILO OPCIONALMENTE SUSTITUIDO; O UNA SAL DEL MISMO. 1UN PROCESO PARA LA ELABORACION DE UN COMPUES- TO DE ACUERDO CON CUALQUIERA DE LAS REIVINDICACIO- NES 1 A 14 QUE COMPRENDE: (A) PREPARAR UN COMPUESTO DE LA FORMULA (I) DONDE R SUP (2) ES METILO, REDUCCCION DE UN COMPUESTO DE LA FORMULA II. FIGURA N.2 DONDE n,p,q,R1,Ar Y X SON SEGUN SE DEFINEN ANTES Y Alk ES UN GRUPO ALQUILOC SUB(1-4); (B) PREPARAR UN COMPUESTO DE LA FORMULA (I) DONDE POR LO MENOS R SUP(1) O R SUP(2) ES HIDROGENO, DESPROCTECCION DE UN COMPUESTO DE LA FORMULA(II); (C) PREPARAR UN COMPUESTO DE LA FORMULA (I) DONDE R SUP(1) Y R SUP(2) SON AMBOS HIDROGENO Y P ES 1 A 4, REDUCCION DE UN COMPUESTO DE LA FORMULA (III); FIGURA N.3 DONDE n,q, X y Ar SON SEGUN SE DEFINE ANTES Y R5 ES HIDROGENO, ALQUILO C1-4 O FENILC1-4ALQUILO (ES DECIR, BENCILO); (d) PARA PREPARAR UN COMPUESTO DONDE X ES O, S o NH, REACCION DE UN COMPUESTO DE LA FORMULA IV: FIGURA N.4 DONDE R1, R2, p Y n SON SEGUN SE DEFINE ANTES Y X1 ES O, S o NH, CON UN COMPUESTO DE LA FORMULA L(CH2 )qAr, DONDE L ES UN GRUPO SALIENTE Y q Y Ar SON SEGUN SE DEFINE ANTES; (e) PREPARAR UN COMPUESTO DONDE X ES O, S o NH, REACCION DE UN COMPUESTO DE LA FORMULA (V): FIGURA N.5 DONDE R1, R2, p Y n SON SEGUN SE DEFINE ANTES Y L1 ES UN GRUPO DESPLAZABLE POR UN NUCLEOFILO, CON UN COMPUESTO HX(CH2)qAr DONDE X, q Y Ar SON SEGUN SE DEFINE ANTES; (f) CONVERSION DE UN GRUPO BENZOILO EN UN COM- PUESTO DE LA FORMULA (VI): FIGURA N.6 DONDE n, R1, R2, X, p Y q SON SEGUN SE DEFINE EN LA FORMULA (I) y Ar1 ES FENILO SUSTITUIDO POR BEN- ZOILO OPCIONALMENTE SUSTITUIDO, EN UN GRUPO -CR3R4 -PhP Y N SO; (g) INTERCONVERSION DE UN COMPUESTO DE LA FORMULA (I) A UN COMPUESTO DIFERENTE DE FORMULA (I); Y OPCIONALMENTE, DESPUES DE CUALQUIERA DE LOS PRO- CESOS ANTERIORES, SI SE REQUIERE O DESEA, SEPARAR UNA MEZCLA DE ENANTIOMEROS Y/O FORMAR UNA SAL DE LA FORMULA (I).A COMPOUND OF FORMULA (I) FIGURE N.1 WHERE n SUB (1) IS 1 SUB (2), 2 or 3; R SUP (1) AND R SUP (2) EACH INDEPENDENTLY REPRESENTS HYDROGEN, ALKYL C SB (1-6), CICLOAL- QUILO SUB (C3-6) ALKYL C SUB (1-4); X REPRESENTS O, S, NH OR A LINK, ALWAYS AND WHEN THE SUM OF P AND Q IS AT LEAST 1; AND AR REPRESENTS PHENYL SUBSTITUTED BY -Y-CR SUP (3) R (4) PH, WHERE Y IS OXYGEN OR A LINK, R SUP (3) AND R SUP (4) ARE INDEPENDENTLY, H, METHYL OR ETHYL ALWAYS AND WHEN THAT R SUP (4) ARE NOT BOTH H, AND PH IS OPENLY SUBSTITUTED PHENYL; OR A SALT OF THE SAME. 1A PROCESS FOR THE PREPARATION OF A COMPOUND IN ACCORDANCE WITH ANY OF THE CLAIMS 1 TO 14 WHICH INCLUDES: (A) PREPARING A COMPOUND OF THE FORMULA (I) WHERE R SUP (2) IS METHYL, REDUCTION OF A COMPOUND OF THE FORMULA II. FIGURE N.2 WHERE n, p, q, R1, Ar and X ARE AS DEFINED BEFORE AND Alk IS A SUB RENTAL GROUP (1-4); (B) PREPARE A COMPOUND OF FORMULA (I) WHERE AT LEAST R SUP (1) OR R SUP (2) IS HYDROGEN, DESPROCTECTION OF A COMPOUND OF FORMULA (II); (C) PREPARE A COMPOUND OF FORMULA (I) WHERE R SUP (1) AND R SUP (2) ARE BOTH HYDROGEN AND P IS 1 TO 4, REDUCTION OF A COMPOUND OF FORMULA (III); FIGURE N.3 WHERE n, q, X and Ar ARE AS DEFINED BEFORE AND R5 IS HYDROGEN, ALKYL C1-4 OR FENYLC1-4ALKYL (THAT IS, BENCILO); (d) TO PREPARE A COMPOUND WHERE X IS O, S or NH, REACTION OF A COMPOUND FROM FORMULA IV: FIGURE N.4 WHERE R1, R2, p Y n ARE AS DEFINED BEFORE AND X1 IS O, S or NH , WITH A COMPOUND OF THE FORMULA L (CH2) qAr, WHERE L IS AN OUTGOING GROUP AND q AND Ar ARE AS DEFINED BEFORE; (e) PREPARE A COMPOUND WHERE X IS O, S or NH, REACTION OF A COMPOUND FROM FORMULA (V): FIGURE N.5 WHERE R1, R2, p AND n ARE AS DEFINED BEFORE AND L1 IS A DISPLACABLE GROUP BY A NUCLEOPHIL, WITH A COMPOUND HX (CH2) qAr WHERE X, q AND Ar ARE AS DEFINED BEFORE; (f) CONVERSION OF A BENZOIL GROUP IN A COMPOUND OF THE FORMULA (VI): FIGURE N.6 WHERE n, R1, R2, X, p AND q ARE AS DEFINED IN FORMULA (I) and Ar1 IS PHENYL REPLACED BY BENZOILO OPTIONALLY REPLACED, IN A GROUP -CR3R4 -PhP YN SO; (g) INTERCONVERSION OF A COMPOUND FROM FORMULA (I) TO A DIFFERENT COMPOUND FROM FORMULA (I); AND OPTIONALLY, AFTER ANY OF THE ABOVE PROCESSES, IF REQUIRED OR DESIRED, SEPARATE A MIXTURE OF ENANTIOMERS AND / OR FORM A SALT FROM THE FORMULA (I).

CO95030945A 1995-07-13 1995-07-13 DERIVATIVES OF INDANO AND TETRAHIDRONAFTALINA CO4410186A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CO95030945A CO4410186A1 (en) 1995-07-13 1995-07-13 DERIVATIVES OF INDANO AND TETRAHIDRONAFTALINA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CO95030945A CO4410186A1 (en) 1995-07-13 1995-07-13 DERIVATIVES OF INDANO AND TETRAHIDRONAFTALINA

Publications (1)

Publication Number Publication Date
CO4410186A1 true CO4410186A1 (en) 1997-01-09

Family

ID=40909674

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95030945A CO4410186A1 (en) 1995-07-13 1995-07-13 DERIVATIVES OF INDANO AND TETRAHIDRONAFTALINA

Country Status (1)

Country Link
CO (1) CO4410186A1 (en)

Similar Documents

Publication Publication Date Title
GR82211B (en)
ES2008360A6 (en) Tetrahydro carbazolone intermediates
ATE126219T1 (en) BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF.
ES8505970A1 (en) N-(2-nitrophenyl)-4-aminopyrimidine derivatives as microbicides.
CO4480737A1 (en) PARASITICIDE COMPOUNDS
AR241531A1 (en) Indoline and 2-indolinone derivatives
DE3684225D1 (en) METHOD FOR PRODUCING 3-IMIDAZOLYLMETHYLTETRAHYDROCARBAZOLONES.
ATE67195T1 (en) PROCESS FOR THE PREPARATION OF 5-HYDROXY-3HYDROXYMETHYL-PHENYLFURAN DERIVATIVES.
ATE30314T1 (en) PROCESS FOR CLEAVING DISULFIDE BONDS.
ES8602752A1 (en) Imidazolidinones, and imidazolidinethiones, process for the preparation thereof, and use of said compounds as herbicidal agents.
ATE23536T1 (en) NEW MURAMYL PEPTIDES AND PROCESSES FOR THEIR PRODUCTION.
ATE217869T1 (en) METHOD FOR PRODUCING FLUORALKENYLTHIO HETEROCYCLIC DERIVATIVES
CO4410186A1 (en) DERIVATIVES OF INDANO AND TETRAHIDRONAFTALINA
EP0139221A3 (en) Substituted dihydroazepines useful as calcium channel blockers, methods for preparing and compositions containing the same
DE3867927D1 (en) GUANIDINE COMPOUNDS CONTAINING A SUBSTITUTED TETRAPHENYLBORATION, METHOD FOR THE PRODUCTION AND USE OF THESE COMPOUNDS DURING THE PEPTIDE SYNTHESIS.
ATE18226T1 (en) PYRROLO(2,3-D)CARBAZOL DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE.
ATE131167T1 (en) METHOD FOR PRODUCING ERGOLINE DERIVATIVES.
DE69737376D1 (en) Process for the synthesis of an oxonol compound
SE8400561L (en) HEXANOR-BRASSINOLIDE-22-ETHRES, PROCEDURE FOR THE PREPARATION OF THESE COMPOUNDS AND AGENTS CONTAINING THEM WITH GROWTH REGULATORY EFFECTS FOR VECTORS
ATE168688T1 (en) METHOD FOR PRODUCING SULFONYL UREA DERIVATIVES
ATE5077T1 (en) 22-ARYLSULFONYL-24,25-DIHYDROXY-CHOLESTANES AND PROCESS FOR THEIR PREPARATION.
ES2147316T3 (en) 1-CYCLOALQUENYLTETRAZOLINONES.
EA199700300A1 (en) METHOD OF OBTAINING PRACTICALLY PURE ISOMERS OF α-BIOXIMES
ATE39688T1 (en) PROCESS FOR THE PREPARATION OF AMINOTRIAZINONE DERIVATIVES.