CO2024009334A2 - Inhibidores de bcl-2 de 1,3,4,7-tetrahidro-2h-pirrolo[3',2':5,6]pirido[2,3-b][1,4]oxazepina - Google Patents

Inhibidores de bcl-2 de 1,3,4,7-tetrahidro-2h-pirrolo[3',2':5,6]pirido[2,3-b][1,4]oxazepina

Info

Publication number
CO2024009334A2
CO2024009334A2 CONC2024/0009334A CO2024009334A CO2024009334A2 CO 2024009334 A2 CO2024009334 A2 CO 2024009334A2 CO 2024009334 A CO2024009334 A CO 2024009334A CO 2024009334 A2 CO2024009334 A2 CO 2024009334A2
Authority
CO
Colombia
Prior art keywords
oxazepine
pyrido
bcl
pyrrolo
tetrahydro
Prior art date
Application number
CONC2024/0009334A
Other languages
English (en)
Spanish (es)
Inventor
George A Doherty
Vikram Bhat
Patrick Brady
Yujia Dai
Jianchun Gong
Andrew S Judd
Andrew J Souers
Yiyun Yu
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CO2024009334A2 publication Critical patent/CO2024009334A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CONC2024/0009334A 2022-01-21 2024-07-15 Inhibidores de bcl-2 de 1,3,4,7-tetrahidro-2h-pirrolo[3',2':5,6]pirido[2,3-b][1,4]oxazepina CO2024009334A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263267018P 2022-01-21 2022-01-21
PCT/US2023/060944 WO2023141536A1 (en) 2022-01-21 2023-01-20 1,3,4,7-tetrahydro-2h-pyrrolo [3',2':5,6] pyrido[2,3-b] [1,4] oxazepine bc1-2 inhibitors

Publications (1)

Publication Number Publication Date
CO2024009334A2 true CO2024009334A2 (es) 2024-07-18

Family

ID=85382827

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2024/0009334A CO2024009334A2 (es) 2022-01-21 2024-07-15 Inhibidores de bcl-2 de 1,3,4,7-tetrahidro-2h-pirrolo[3',2':5,6]pirido[2,3-b][1,4]oxazepina

Country Status (13)

Country Link
US (3) US11964990B2 (https=)
EP (1) EP4466273A1 (https=)
JP (2) JP7714811B2 (https=)
KR (1) KR20240136972A (https=)
CN (1) CN119053610A (https=)
AR (1) AR128310A1 (https=)
AU (1) AU2023210279A1 (https=)
CA (1) CA3242074A1 (https=)
CO (1) CO2024009334A2 (https=)
IL (1) IL312709A (https=)
MX (1) MX2024008840A (https=)
TW (1) TW202340210A (https=)
WO (1) WO2023141536A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11964990B2 (en) * 2022-01-21 2024-04-23 Abbvie Inc. 1,3,4,7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[2,3-b][1,4]oxazepine bcl-2 inhibitors
CN117820134A (zh) * 2024-01-10 2024-04-05 山东盛安贝新材料有限公司南京分公司 一种顺式-3-甲氧基环丁胺盐酸盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018322059C1 (en) 2017-08-23 2024-09-12 Guangzhou Lupeng Pharmaceutical Company Ltd. BCL-2 inhibitors
US12220419B2 (en) 2018-08-22 2025-02-11 Newave Pharmaceutical Inc. BCL-2 inhibitors
WO2020140005A2 (en) 2018-12-29 2020-07-02 Newave Pharmaceutical Inc. Bcl-2 inhibitors
WO2021066873A1 (en) 2019-10-03 2021-04-08 Newave Pharmaceutical Inc. Condensed heterocycles as bcl-2 inhibitors
WO2021083135A1 (en) 2019-10-28 2021-05-06 Beigene, Ltd. Bcl-2 INHIBITORS
WO2021133817A1 (en) 2019-12-27 2021-07-01 Guangzhou Lupeng Pharmaceutical Company Ltd. 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
KR20220158725A (ko) 2020-02-24 2022-12-01 광조우 루펭 파마슈티칼 컴퍼니 엘티디. Bcl2 억제제를 함유하는 핫 멜트 압출 고체 분산체
US11964990B2 (en) * 2022-01-21 2024-04-23 Abbvie Inc. 1,3,4,7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[2,3-b][1,4]oxazepine bcl-2 inhibitors

Also Published As

Publication number Publication date
KR20240136972A (ko) 2024-09-19
WO2023141536A1 (en) 2023-07-27
US11964990B2 (en) 2024-04-23
JP7714811B2 (ja) 2025-07-29
IL312709A (en) 2024-07-01
CN119053610A (zh) 2024-11-29
JP2025160251A (ja) 2025-10-22
AR128310A1 (es) 2024-04-17
AU2023210279A1 (en) 2024-05-23
US20250066388A1 (en) 2025-02-27
US20260028356A1 (en) 2026-01-29
EP4466273A1 (en) 2024-11-27
JP2025504382A (ja) 2025-02-12
MX2024008840A (es) 2024-07-25
TW202340210A (zh) 2023-10-16
US20230234971A1 (en) 2023-07-27
CA3242074A1 (en) 2023-07-27

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