CO2023000604A2 - Use of a glutarimide derivative for the treatment of diseases associated with aberrant interleukin-6 activity - Google Patents

Use of a glutarimide derivative for the treatment of diseases associated with aberrant interleukin-6 activity

Info

Publication number
CO2023000604A2
CO2023000604A2 CONC2023/0000604A CO2023000604A CO2023000604A2 CO 2023000604 A2 CO2023000604 A2 CO 2023000604A2 CO 2023000604 A CO2023000604 A CO 2023000604A CO 2023000604 A2 CO2023000604 A2 CO 2023000604A2
Authority
CO
Colombia
Prior art keywords
treatment
activity
diseases associated
aberrant
interleukin
Prior art date
Application number
CONC2023/0000604A
Other languages
Spanish (es)
Inventor
Vladimir Evgenievich Nebolsin
Original Assignee
Ltd “Valenta Intellekt”
Vladimir Evgenievich Nebolsin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2020121363A external-priority patent/RU2774928C2/en
Application filed by Ltd “Valenta Intellekt”, Vladimir Evgenievich Nebolsin filed Critical Ltd “Valenta Intellekt”
Publication of CO2023000604A2 publication Critical patent/CO2023000604A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Abstract

RESUMEN La presente invención se refiere a la medicina y se refiere al tratamiento de enfermedades asociadas con la actividad aberrante de la interleucina-6 y el desarrollo del síndrome de liberación de citocinas (tormenta de citocinas), preferentemente el tratamiento de COVID-19, así como otras enfermedades complicadas por la actividad aberrante de interleucina-6 y el desarrollo del síndrome de liberación de citocinas, utilizando el compuesto 1-(2-(1-metil-1H-imidazol-4-il)etil)piperidina-2,6-diona (fórmula I). La invención proporciona la creación de un nuevo fármaco eficaz para el tratamiento de enfermedades asociadas con el desarrollo del síndrome de liberación de citocinas.ABSTRACT The present invention relates to medicine and relates to the treatment of diseases associated with aberrant interleukin-6 activity and the development of cytokine release syndrome (cytokine storm), preferably the treatment of COVID-19, as well as as other diseases complicated by aberrant interleukin-6 activity and development of cytokine release syndrome, using the compound 1-(2-(1-methyl-1H-imidazol-4-yl)ethyl)piperidine-2,6 -dione (formula I). The invention provides for the creation of a new effective drug for the treatment of diseases associated with the development of cytokine release syndrome.

CONC2023/0000604A 2020-06-26 2023-01-19 Use of a glutarimide derivative for the treatment of diseases associated with aberrant interleukin-6 activity CO2023000604A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2020121363A RU2774928C2 (en) 2020-06-26 Use of glutarimide derivative for therapy of diseases associated with aberrant activity of interleukin-6
PCT/RU2021/050170 WO2021262040A1 (en) 2020-06-26 2021-06-18 Use of a glutarimide derivative for treating diseases associated with aberrant interleukin-6 activity

Publications (1)

Publication Number Publication Date
CO2023000604A2 true CO2023000604A2 (en) 2023-01-26

Family

ID=79281595

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0000604A CO2023000604A2 (en) 2020-06-26 2023-01-19 Use of a glutarimide derivative for the treatment of diseases associated with aberrant interleukin-6 activity

Country Status (6)

Country Link
CN (1) CN115803026A (en)
BR (1) BR112022026356A2 (en)
CL (1) CL2022003725A1 (en)
CO (1) CO2023000604A2 (en)
MA (1) MA58653B1 (en)
WO (1) WO2021262040A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023177329A1 (en) * 2022-03-18 2023-09-21 Общество С Ограниченной Ответственностью "Валента-Интеллект" Use of 1-(2-(1н-imidazole-4-yl)ethyl)piperidine-2,6-dione to treat cough caused by viral infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2112716A1 (en) * 1971-03-17 1972-10-05 Thomae Gmbh Dr K Biphenylyl-butyric acid derivs. - anti phlogistics
DE10002509A1 (en) * 2000-01-21 2001-07-26 Gruenenthal Gmbh New substituted glutarimide derivatives are IL-12 antagonists, are useful as immunomodulators and for the treatment of angiopathy, hematological or oncological disorders
UA115431C2 (en) * 2011-10-11 2017-11-10 Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" Use of glutaryl histamine to treat respiratory tract infections
CN102432544B (en) * 2011-11-17 2014-05-21 天津医科大学 5-substituted benzyl methylene imidazole alkyl-2,4-diketone derivative and application thereof
EA032951B1 (en) * 2013-04-12 2019-08-30 Общество С Ограниченной Ответственностью "Рсв Терапевтикс" Glutarimide derivative, use thereof, pharmaceutical composition based thereon, process for preparing same
RU2552929C1 (en) * 2013-11-14 2015-06-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Pharmaceutical composition, containing derivatives of glutarimides, and their application for treatment of eosinophilic diseases
US10739353B2 (en) * 2014-12-31 2020-08-11 Signpath Pharma, Inc. Suppression of cytokine release and cytokine storm
GEP20227402B (en) * 2017-09-07 2022-08-10 Valenta Intellekt Ltd Use of glutarimide derivative to treat diseases related to aberrant activity of cytokines
AU2021257439A1 (en) * 2020-04-13 2022-12-15 University Health Network Methods for treating cytokine release syndrome
EP4144728A4 (en) * 2020-04-30 2023-08-23 Shanghaitech University Heterocycle and glutarimide skeleton-based compound and applications thereof

Also Published As

Publication number Publication date
MA58653A1 (en) 2023-07-31
BR112022026356A2 (en) 2023-01-17
CL2022003725A1 (en) 2023-05-19
RU2020121363A (en) 2021-12-27
MA58653B1 (en) 2024-02-29
WO2021262040A1 (en) 2021-12-30
RU2020121363A3 (en) 2021-12-27
CN115803026A (en) 2023-03-14

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