CL2022003725A1 - Use of a glutarimide derivative for the treatment of diseases associated with aberrant interleukin-6 activity. - Google Patents
Use of a glutarimide derivative for the treatment of diseases associated with aberrant interleukin-6 activity.Info
- Publication number
- CL2022003725A1 CL2022003725A1 CL2022003725A CL2022003725A CL2022003725A1 CL 2022003725 A1 CL2022003725 A1 CL 2022003725A1 CL 2022003725 A CL2022003725 A CL 2022003725A CL 2022003725 A CL2022003725 A CL 2022003725A CL 2022003725 A1 CL2022003725 A1 CL 2022003725A1
- Authority
- CL
- Chile
- Prior art keywords
- treatment
- activity
- diseases associated
- aberrant
- interleukin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a la medicina y se refiere al tratamiento de enfermedades asociadas con la actividad aberrante de la interleucina-6 y el desarrollo del síndrome de liberación de citocinas (tormenta de citocinas), preferentemente el tratamiento de COVID-19, así como otras enfermedades complicadas por la actividad aberrante de interleucina-6 y el desarrollo del síndrome de liberación de citocinas, utilizando el compuesto 1-(2-(1-metil-1Himidazol-4-il)etil)piperidina-2,6-diona (fórmula I). La invención proporciona la creación de un nuevo fármaco eficaz para el tratamiento de enfermedades asociadas con el desarrollo del síndrome de liberación de citocinas.The present invention relates to medicine and concerns the treatment of diseases associated with aberrant interleukin-6 activity and the development of cytokine release syndrome (cytokine storm), preferably the treatment of COVID-19, as well as other diseases complicated by aberrant interleukin-6 activity and the development of cytokine release syndrome, using the compound 1-(2-(1-methyl-1Himidazol-4-yl)ethyl)piperidine-2,6-dione ( formula I). The invention provides for the creation of a new effective drug for the treatment of diseases associated with the development of cytokine release syndrome.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2020121363A RU2774928C2 (en) | 2020-06-26 | Use of glutarimide derivative for therapy of diseases associated with aberrant activity of interleukin-6 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2022003725A1 true CL2022003725A1 (en) | 2023-05-19 |
Family
ID=79281595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022003725A CL2022003725A1 (en) | 2020-06-26 | 2022-12-22 | Use of a glutarimide derivative for the treatment of diseases associated with aberrant interleukin-6 activity. |
Country Status (6)
Country | Link |
---|---|
CN (1) | CN115803026A (en) |
BR (1) | BR112022026356A2 (en) |
CL (1) | CL2022003725A1 (en) |
CO (1) | CO2023000604A2 (en) |
MA (1) | MA58653B1 (en) |
WO (1) | WO2021262040A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023177329A1 (en) * | 2022-03-18 | 2023-09-21 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Use of 1-(2-(1н-imidazole-4-yl)ethyl)piperidine-2,6-dione to treat cough caused by viral infections |
WO2023249516A1 (en) * | 2022-06-24 | 2023-12-28 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Novel crystalline form of 1-[2-(1-methylimidazole-4-yl)ethyl]perhydroazine-2,6-dione and pharmaceutical use thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2112716A1 (en) * | 1971-03-17 | 1972-10-05 | Thomae Gmbh Dr K | Biphenylyl-butyric acid derivs. - anti phlogistics |
DE10002509A1 (en) * | 2000-01-21 | 2001-07-26 | Gruenenthal Gmbh | New substituted glutarimide derivatives are IL-12 antagonists, are useful as immunomodulators and for the treatment of angiopathy, hematological or oncological disorders |
UA115431C2 (en) * | 2011-10-11 | 2017-11-10 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Use of glutaryl histamine to treat respiratory tract infections |
CN102432544B (en) * | 2011-11-17 | 2014-05-21 | 天津医科大学 | 5-substituted benzyl methylene imidazole alkyl-2,4-diketone derivative and application thereof |
BR122020010204B1 (en) * | 2013-04-12 | 2022-03-03 | Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises" | COMPOUND DERIVED FROM GLUTARIMIDE, ITS USE, PHARMACEUTICAL COMPOSITION AND METHOD OF PREPARATION |
RU2552929C1 (en) * | 2013-11-14 | 2015-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Pharmaceutical composition, containing derivatives of glutarimides, and their application for treatment of eosinophilic diseases |
US10739353B2 (en) * | 2014-12-31 | 2020-08-11 | Signpath Pharma, Inc. | Suppression of cytokine release and cytokine storm |
GEP20227354B (en) * | 2017-09-07 | 2022-02-25 | Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises | Use of a glutarimide derivative to treat diseases related to the aberrant activity of cytokines |
JP2023522618A (en) * | 2020-04-13 | 2023-05-31 | ユニバーシティー ヘルス ネットワーク | Methods for treating cytokine release syndrome |
EP4144728A4 (en) * | 2020-04-30 | 2023-08-23 | Shanghaitech University | Heterocycle and glutarimide skeleton-based compound and applications thereof |
-
2021
- 2021-06-18 WO PCT/RU2021/050170 patent/WO2021262040A1/en active Application Filing
- 2021-06-18 CN CN202180044905.7A patent/CN115803026A/en active Pending
- 2021-06-18 MA MA58653A patent/MA58653B1/en unknown
- 2021-06-18 BR BR112022026356A patent/BR112022026356A2/en not_active Application Discontinuation
-
2022
- 2022-12-22 CL CL2022003725A patent/CL2022003725A1/en unknown
-
2023
- 2023-01-19 CO CONC2023/0000604A patent/CO2023000604A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2020121363A (en) | 2021-12-27 |
CO2023000604A2 (en) | 2023-01-26 |
BR112022026356A2 (en) | 2023-01-17 |
MA58653A1 (en) | 2023-07-31 |
CN115803026A (en) | 2023-03-14 |
MA58653B1 (en) | 2024-02-29 |
WO2021262040A1 (en) | 2021-12-30 |
RU2020121363A3 (en) | 2021-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2022003725A1 (en) | Use of a glutarimide derivative for the treatment of diseases associated with aberrant interleukin-6 activity. | |
CL2022001625A1 (en) | Pyrazolyl derivatives useful as anti-cancer agents | |
UY32462A (en) | NEW BIFENYLL DERIVATIVES FOR HEPATITIS C 644 VIRUS INFECTION TREATMENT | |
CO6960552A2 (en) | Compounds of (hetero) arylcyclopropylamine as inhibitors of lsd1 | |
AR060536A1 (en) | GLUCOCORTICOID RECEPTOR AGONIST AND PHARMACEUTICAL COMPOSITIONS | |
ECSP12011638A (en) | PIRIDINE AND PIRAZINE DERIVATIVES AS PROTEIN KINase MODULATORS | |
ECSP066302A (en) | OMEGA-CARBOXIARIL-DIFENIL-UREA REPLACED WITH FLUORINE FOR THE TREATMENT AND PREVENTION OF DISEASES AND AFFECTIONS | |
AR077975A1 (en) | PIRAZOL PYRIMIDINE DERIVATIVES AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | |
MA37405A1 (en) | Heterocyclyl compounds | |
ECSP088973A (en) | IMIDAZOL PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE SYNTHETIC KINASE GLYCOGEN (GSK3) | |
CO7131360A2 (en) | Novel substituted cyclic n-pyridinyl amides as kinase inhibitors | |
UY32483A (en) | NEW BENCIMIDAZOL COMPOUNDS FOR THE TREATMENT OF RESPIRATORY SINCICIAL VIRUS | |
CL2015002608A1 (en) | Amino-pyrazole compound and related medicinal uses. | |
MX2020004283A (en) | Pyridine carbonyl derivatives and therapeutic uses thereof as trpc6 inhibitors. | |
DOP2024000039A (en) | QUINOLINE DERIVATIVES AS ALFA4BETA7 INTEGRIN INHIBITORS | |
RU2011138962A (en) | 4-ISOPROPYLPHENYL GLUCITITE DERIVATIVES AS SGLT1 INHIBITORS | |
EA201071039A1 (en) | NEW DERIVATIVES 1-BENZYL-3-HYDROXYMETYLINDASOL AND THEIR APPLICATION FOR THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 And P40 | |
AR124688A2 (en) | A PYRIMIDINE SULFONAMIDE OR A TAUTOMER THEREOF, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | |
EA201001857A1 (en) | PHARMACEUTICAL MEDICINE FORM FOR IMMEDIATE RELEASE OF INDOLINON DERIVATIVE | |
UY38144A (en) | INHIBITORS OF SIGNALING MEDIATED BY TYROSINE KINASE | |
CL2011002181A1 (en) | Cyclic or heterocyclic compounds (n, o, s) of phenyl (heterocyclyl) phenyl (methyl, ethyl) amine derivatives, gpr119 agonists and dpp-iv inhibitors; pharmaceutical composition; and its use for the treatment of type II diabetes, obesity, metabolic syndrome, glucose tolerance and hyperlipidemia, among other diseases. | |
UY30916A1 (en) | DERIVATIVES OF 1- [REPLACED] - 3- [REPLACED] -1-AZONA-BICICLO [2,2,2] OCTANO AND ITS ENANTIOMERS | |
EA202091604A1 (en) | INHIBITION OF THE ION CHANNEL A1 WITH A TRANSITOR RECEPTOR POTENTIAL | |
ECSP088257A (en) | AMIDA DERIVATIVES | |
MX2020004025A (en) | Epidermal growth factor receptor inhibitors. |