CO2022014154A2 - Formulaciones farmacéuticas de profármacos de adrenomedulina a base de polietilenglicol y uso - Google Patents
Formulaciones farmacéuticas de profármacos de adrenomedulina a base de polietilenglicol y usoInfo
- Publication number
- CO2022014154A2 CO2022014154A2 CONC2022/0014154A CO2022014154A CO2022014154A2 CO 2022014154 A2 CO2022014154 A2 CO 2022014154A2 CO 2022014154 A CO2022014154 A CO 2022014154A CO 2022014154 A2 CO2022014154 A2 CO 2022014154A2
- Authority
- CO
- Colombia
- Prior art keywords
- adrenomedullin
- polyethylene glycol
- pharmaceutical formulations
- prodrugs
- peg
- Prior art date
Links
- 239000002202 Polyethylene glycol Substances 0.000 title abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 title abstract 3
- 102000004379 Adrenomedullin Human genes 0.000 title abstract 2
- 101800004616 Adrenomedullin Proteins 0.000 title abstract 2
- ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 206010069351 acute lung injury Diseases 0.000 abstract 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 206010038687 Respiratory distress Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a nuevas formulaciones farmacéuticas, preferentemente para inhalación, que comprenden profármacos de adrenomedulina a base de polietilenglicol (PEG) (PEG–ADM), y a su uso para el tratamiento y/o la prevención de lesión pulmonar aguda/síndrome de dificultad respiratoria aguda (ALI/SDRA).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20168075 | 2020-04-03 | ||
PCT/EP2021/058428 WO2021198328A1 (en) | 2020-04-03 | 2021-03-31 | Pharmaceutical formulations polyethylene glycol-based prodrugs of adrenomedullin and use |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2022014154A2 true CO2022014154A2 (es) | 2022-10-31 |
Family
ID=70189768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2022/0014154A CO2022014154A2 (es) | 2020-04-03 | 2022-10-03 | Formulaciones farmacéuticas de profármacos de adrenomedulina a base de polietilenglicol y uso |
Country Status (18)
Country | Link |
---|---|
US (1) | US20230364245A1 (es) |
EP (1) | EP4126061A1 (es) |
JP (1) | JP2023520543A (es) |
KR (1) | KR20220163413A (es) |
CN (1) | CN115666654A (es) |
AU (1) | AU2021247501A1 (es) |
BR (1) | BR112022017588A2 (es) |
CA (1) | CA3177217A1 (es) |
CL (1) | CL2022002639A1 (es) |
CO (1) | CO2022014154A2 (es) |
CR (1) | CR20220500A (es) |
DO (1) | DOP2022000212A (es) |
EC (1) | ECSP22077374A (es) |
IL (1) | IL297014A (es) |
JO (1) | JOP20220251A1 (es) |
MX (1) | MX2022012318A (es) |
PE (1) | PE20231070A1 (es) |
WO (1) | WO2021198328A1 (es) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
WO2003059424A1 (en) | 2002-01-15 | 2003-07-24 | Aerogen, Inc. | Methods and systems for operating an aerosol generator |
JOP20190001B1 (ar) | 2011-11-03 | 2022-03-14 | Bayer Pharma AG | عقار أولي معتمد على جليكول عديد إثيلين من أدرينومدالين واستخدامه |
-
2021
- 2021-03-31 JO JOP/2022/0251A patent/JOP20220251A1/ar unknown
- 2021-03-31 EP EP21715281.8A patent/EP4126061A1/en active Pending
- 2021-03-31 JP JP2022560375A patent/JP2023520543A/ja active Pending
- 2021-03-31 CA CA3177217A patent/CA3177217A1/en active Pending
- 2021-03-31 CR CR20220500A patent/CR20220500A/es unknown
- 2021-03-31 AU AU2021247501A patent/AU2021247501A1/en active Pending
- 2021-03-31 CN CN202180037930.2A patent/CN115666654A/zh active Pending
- 2021-03-31 MX MX2022012318A patent/MX2022012318A/es unknown
- 2021-03-31 KR KR1020227038080A patent/KR20220163413A/ko unknown
- 2021-03-31 PE PE2022002182A patent/PE20231070A1/es unknown
- 2021-03-31 IL IL297014A patent/IL297014A/en unknown
- 2021-03-31 BR BR112022017588A patent/BR112022017588A2/pt not_active Application Discontinuation
- 2021-03-31 WO PCT/EP2021/058428 patent/WO2021198328A1/en active Application Filing
- 2021-03-31 US US17/905,747 patent/US20230364245A1/en active Pending
-
2022
- 2022-09-27 CL CL2022002639A patent/CL2022002639A1/es unknown
- 2022-09-28 DO DO2022000212A patent/DOP2022000212A/es unknown
- 2022-10-03 CO CONC2022/0014154A patent/CO2022014154A2/es unknown
- 2022-10-03 EC ECSENADI202277374A patent/ECSP22077374A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP22077374A (es) | 2022-11-30 |
CR20220500A (es) | 2022-11-18 |
WO2021198328A1 (en) | 2021-10-07 |
KR20220163413A (ko) | 2022-12-09 |
PE20231070A1 (es) | 2023-07-17 |
MX2022012318A (es) | 2022-10-27 |
DOP2022000212A (es) | 2022-10-31 |
US20230364245A1 (en) | 2023-11-16 |
CL2022002639A1 (es) | 2023-04-10 |
EP4126061A1 (en) | 2023-02-08 |
CA3177217A1 (en) | 2021-10-07 |
BR112022017588A2 (pt) | 2022-10-18 |
IL297014A (en) | 2022-12-01 |
AU2021247501A1 (en) | 2022-10-27 |
CN115666654A (zh) | 2023-01-31 |
JP2023520543A (ja) | 2023-05-17 |
JOP20220251A1 (ar) | 2023-01-30 |
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