CO2022013648A2 - Generating columns for elution systems loaded with preloaded matrix - Google Patents

Generating columns for elution systems loaded with preloaded matrix

Info

Publication number
CO2022013648A2
CO2022013648A2 CONC2022/0013648A CO2022013648A CO2022013648A2 CO 2022013648 A2 CO2022013648 A2 CO 2022013648A2 CO 2022013648 A CO2022013648 A CO 2022013648A CO 2022013648 A2 CO2022013648 A2 CO 2022013648A2
Authority
CO
Colombia
Prior art keywords
column
matrix
present
generator
elution systems
Prior art date
Application number
CONC2022/0013648A
Other languages
Spanish (es)
Inventor
Robert Riddoch
Original Assignee
Jubilant Draximage Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Draximage Inc filed Critical Jubilant Draximage Inc
Publication of CO2022013648A2 publication Critical patent/CO2022013648A2/en

Links

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A61L2/06—Hot gas
    • A61L2/07—Steam
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0031—Rubidium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

La presente invención se refiere en general a la medicina nuclear y a los generadores para la producción de radiofármacos para uso médico. En particular, la presente invención se refiere a una columna generadora que resiste el calor elevado, como la despirogenación y la esterilización. Esto permite que algunos pasos de la preparación de la columna se realicen en un entorno no estéril. Esto también permite que la columna generadora sea reutilizable. La presente invención describe además métodos para la preparación de un generador en el que un radioisótopo parental se carga en la matriz de la columna antes o después de que la matriz se cargue en la columna.The present invention generally relates to nuclear medicine and to generators for the production of radiopharmaceuticals for medical use. In particular, the present invention relates to a generator column that withstands high heat, such as depyrogenation and sterilization. This allows some steps of the column preparation to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present invention further describes methods for preparing a generator in which a parent radioisotope is loaded onto the column matrix before or after the matrix is loaded onto the column.

CONC2022/0013648A 2020-02-24 2022-09-22 Generating columns for elution systems loaded with preloaded matrix CO2022013648A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16/799,154 US11443866B2 (en) 2020-02-24 2020-02-24 Generator columns for elution systems loaded with pre-charged matrix
PCT/CA2021/050214 WO2021168557A1 (en) 2020-02-24 2021-02-24 Generator columns for elution systems loaded with pre-charged matrix

Publications (1)

Publication Number Publication Date
CO2022013648A2 true CO2022013648A2 (en) 2022-10-21

Family

ID=77366266

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0013648A CO2022013648A2 (en) 2020-02-24 2022-09-22 Generating columns for elution systems loaded with preloaded matrix

Country Status (7)

Country Link
US (2) US11443866B2 (en)
EP (1) EP4110494A4 (en)
AU (1) AU2021228383A1 (en)
BR (1) BR112022016792A2 (en)
CA (1) CA3169156A1 (en)
CO (1) CO2022013648A2 (en)
WO (1) WO2021168557A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11443866B2 (en) * 2020-02-24 2022-09-13 Jubilant Draximage Inc. Generator columns for elution systems loaded with pre-charged matrix
US20210265069A1 (en) * 2020-02-24 2021-08-26 Jubilant Draximage Inc. Heat resistant generator columns for elution systems

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7476377B2 (en) * 2001-08-02 2009-01-13 Lynntech, Inc. Rubidium-82 generator based on sodium nonatitanate support, and improved separation methods for the recovery of strontium-82 from irradiated targets
US8071959B2 (en) * 2005-12-21 2011-12-06 Ottawa Heart Institute Research Corp. Rubidium generator for cardiac perfusion imaging and method of making and maintaining same
PL2157583T3 (en) * 2008-08-18 2011-11-30 Rubigen B V Strontium-82/rubidium-82 generator, method for producing a rubidium-82 comprising diagnostic agent, said diagnostic agent and its use in medicine
RU2503074C2 (en) * 2009-05-13 2013-12-27 Лантеус Медикал Имажинг, Инк. Isotope generator and method of sterilisation
CN204516369U (en) * 2015-04-09 2015-07-29 Ire环境与生命科学技术公司 radionuclide generator device
US11443866B2 (en) * 2020-02-24 2022-09-13 Jubilant Draximage Inc. Generator columns for elution systems loaded with pre-charged matrix
US20210265069A1 (en) * 2020-02-24 2021-08-26 Jubilant Draximage Inc. Heat resistant generator columns for elution systems

Also Published As

Publication number Publication date
WO2021168557A1 (en) 2021-09-02
US20230005637A1 (en) 2023-01-05
US11443866B2 (en) 2022-09-13
US20210265070A1 (en) 2021-08-26
BR112022016792A2 (en) 2022-10-11
CA3169156A1 (en) 2021-09-02
EP4110494A4 (en) 2024-03-20
US11694818B2 (en) 2023-07-04
AU2021228383A1 (en) 2022-09-15
EP4110494A1 (en) 2023-01-04

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