CN204516369U - radionuclide generator device - Google Patents
radionuclide generator device Download PDFInfo
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- CN204516369U CN204516369U CN201520212161.7U CN201520212161U CN204516369U CN 204516369 U CN204516369 U CN 204516369U CN 201520212161 U CN201520212161 U CN 201520212161U CN 204516369 U CN204516369 U CN 204516369U
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- ion exchange
- exchange column
- generator device
- chromatographic column
- radionuclide generator
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Abstract
Be suitable for the radionuclide generator device being produced carrier-free rhenium-188 Re-188 by tungsten-188W-188, described device comprise be arranged to be mounted with inorganic adsorbent chromatographic column, for comprising the inlet tube of alkali-metal eluent and the outlet for eluate, described chromatographic column is made up of stainless steel, and has at least 40cm
3volume and between 5 to the height of 15cm.
Description
Technical field
A kind of radionuclide generator device for being produced rhenium-188 (Re-188) by tungsten-188 (W-188).
Background technology
Penetrating property labeling process enables Re-188 be used in treatment use, and condition provides Re-188 with suitable concentration in predetermined volumetric injection.
The decay of W-188 enables its daughter isotope produce Re-188.Known Re-188 has the half life period of 19.9 hours, and this described isotopic preparation giving to apply for foreign treatment is with difficulty.For this reason, the user itself being used for the treatment of the Re-188 of purposes to hope generation provides radionuclide generator device to be favourable.
US 5,186,913 discloses a kind of for providing generator system and the method for generation thereof of the carrier-free Re-188 of perrhenic acid form.
Patent US 5,186, generator system disclosed in 913 comprises the W-188/Re-188 generator post with Stationary liquid, accommodates W-188 and Re-188 in W-188/Re-188 generator post.Made it possible at salt perrhenic acid sodium (NaReO by chromatographic column wash-out sodium chloride (NaCl)
4) optionally wash-out Re-188 under form.
Generator system also comprises can produce perrhenic acid (HReO
4) ion exchange column, ion exchange column is in the end by by being combined the neutral substance of ion exchange column and analogous protein and analog and being used to therapeutical uses.
In addition, produce in post and perform by this radioisotopic reactor can be generated as raw-material W-188.Dissimilar reactor can produce W-188, but the intrinsic specific activity of W-188 will depend on used reactor.
The isotopic quantity held in the quality of radioisotopic intrinsic specific activity and product (that is, W-188) is relevant.So if intrinsic specific activity is very high, the isotopic quantity in the quality of product is also high, this is conducive to producing concentrated carrier-free Re-188.
The size that US 5,186,913 teaches post can be generally 1x3.5 centimetre, this means that in post, produce W-188 is realized by high intrinsic specific activity (3.5mCi/mg (millicurie/milligram)).
This means that in post, produce starting material needs specific reactor, specific reactor can for very expensive the consumer itself that hope produces Re-188.Described document shows, the size of post is inversely proportional to the intrinsic specific activity of the W-188 depending on used reactor.
But, be, as the intrinsic specific activity being arranged on the W-188 in post lower (such as, lower than 3mCi/mg), how to produce Re-188 for treatment use disclosed in described document does not have.The reactor that therefore user is limited to use expensive is provided as raw-material W-188 in systems in which.
In addition, US 5,186,913 does not consider that daughter isotope Re-188 may be polluted by parent isotope Re-188 during wash-out.For this reason, do not get rid of elution efficiency low, this produces other kind be not allowed to for treatment use by causing in generation Re-188 and the solution obtained.
Summary of the invention
Therefore, need to provide a kind of radionuclide generator device, described radionuclide generator device can effectively and simultaneously by reducing to produce Re-188 with daughter isotope contaminated relevant risk between processing period.
For this reason, the invention provides a kind of radionuclide generator device of preamble according to claim 1, it is characterized in that, chromatographic column is made up of stainless steel, and described chromatographic column has at least 40cm
3volume (volume) and between 5 to the height of 15cm.
Unexpectedly observe, the chromatographic column be made up of stainless steel makes it possible to produce Re-188 by reducing Re-188 at wash-out (elution) period contaminated risk cause W-188.In addition, the post be made up of stainless steel has suitable length and radiation hardness.Height and the volume of chromatographic column of the present invention contribute to the above-mentioned effect relevant with the pollution reducing daughter isotope.
The height of chromatographic column and the advantage of volume are, relative to the post of prior art, can produce the W-188 of greater number in post.
As mentioned above, height and its volume of post make it possible to use to generate compared with the W-188 generated by other specific reactor to have compared with the reactor as raw-material W-188 of low-activity than degree.
Therefore, by using height between the chromatographic column of 5 to 15cm and the risk of pollution simultaneously by reducing daughter isotope is come effectively and reliably generation carrier-free Re-188.
More preferably, inlet tube and outlet are also made up of stainless steel.
Advantageously, radionuclide generator device comprises concentrator apparatus, described concentrator apparatus has the first ion exchange column and the second ion exchange column successively, described first ion exchange column has the first port and the second port, described first port is connected to the outlet of chromatographic column, described second port is connected to the upstream open of described second ion exchange column, and described second ion exchange column has downstream opening.
Work as NaReO
4when being produced by chromatographic column of the present invention, the amount of eluent (eluent) makes a large amount of NaReO
4be received, this is not easy to therapeutical uses, because the injection of product needs to be accommodated in suitable volumetric injection.
For this reason and according to for generation of NaReO
4method, advantageously Re-188 is concentrated in and is convenient in the less volume of therapeutical uses.
First ion exchange column and the second ion exchange column comprise Stationary liquid with optionally isolating ions.So the first ion exchange column makes it possible to discharge high rhenium ion (ReO
-), and the second ion exchange column makes it possible to high rhenium ion is fixed on Stationary liquid to be concentrated in volume little compared with the volume of chromatographic column by high rhenium ion.This causes producing Re-188 in the suitable volumetric injection that can be used in treatment use.
In a particular embodiment, concentrator apparatus is disposable concentrator apparatus.
Preferably, the connection between the first ion exchange column and chromatographic column and the connection between the first ion exchange column and the second ion exchange column are obtained by disposable insert and disposable valve.
Accompanying drawing explanation
Other embodiment according to device of the present invention is refer in claims.
Fig. 1 shows according to radionuclide generator device of the present invention;
Fig. 2 shows according to chromatographic column of the present invention;
Fig. 3 shows according to concentrator apparatus of the present invention.
Embodiment
Radionuclide generator device 1 (Fig. 1) according to the present invention is suitable for utilizing chromatographic column to produce carrier-free Re-188 by W-188 for treatment use, and chromatographic column is made up of stainless steel and is had at least 40cm
3, preferably 56cm
3volume and between 5 to the height (Fig. 2) of 15cm.
Radionuclide generator device 1 comprises chromatographic column 2, and chromatographic column 2 is arranged to be mounted with inorganic adsorbent, and has for the inlet tube 4 of eluent (preferably, the alkaline metal of such as NaCl and so on) and the outlet for eluate.The structure of radionuclide generator device 1 can mixed structure (Fig. 1) be surrounded chromatographic column 2 and environment to be isolated in the finite space.
More specifically, when chromatographic column 2 is mounted with Stationary liquid, W-188 is arranged on Stationary liquid and Re-188 is produced continuously by parent isotope.
The NaReO collecting scheduled volume (apredetermined volume) at the outlet place of post 2 is made it possible to by chromatographic column 2 wash-out NaCl
4.
Chromatographic column 2 can be connected to the concentrator apparatus (Fig. 3) with the first ion exchange column 6 and the second ion exchange column 7.
First ion exchange column 6 has the first port 8, second port 9 and Stationary liquid.Second ion exchange column 7 have upstream open 10 and for eluate downstream opening 11 and there is Stationary liquid.
Advantageously, the connection between chromatographic column 2 and concentrator apparatus can be connected with the first port 8 of the first ion exchange column 6 by the outlet of the eluate by being used for chromatographic column and to realize.In addition, the first ion exchange column can also be connected to the upstream open 10 of the second ion exchange column 7 by its second port 9.Those acquisition by the existence of insert and valve are connected and ensure that the fluid between each post is communicated with.
Like that, when concentrator apparatus is attached to radionuclide generator device 1 by insert and pipe, eluent can be introduced into by the inlet tube 4 of chromatographic column 2 and advance on the second ion exchange column 7.Then, carrier-free Re-188 can be collected from downstream opening 11.
More accurately, when chromatographic column 2 connects with concentrator apparatus, NaReO
4arrive the first ion exchange column 6 and high rhenium ion (ReO
4-) be released.So, ReO
4-arrive the second ion exchange column 7, wherein, ReO
4-be fixed in the fixing matrix of such as anion-exchange column and so on.
The advantage of concentrator apparatus of the present invention is: the concentration achieving high rhenium ion with the less volume in the second ion exchange column 7.Described less volume is less than the volume in chromatographic column.Like that, in suitable volumetric injection, produce Re-188 with suitable concentration, therefore Re-188 can be directly used in treatment use.
Although disclose the preferred embodiments of the present invention for illustrative purposes, it will be understood by those skilled in the art that, when not exceeding scope and spirit of the present invention disclosed in claims, multiple amendment, interpolation and replacement are possible.
Claims (4)
1. be suitable for the radionuclide generator device being produced carrier-free rhenium-188 by tungsten-188, this radionuclide generator device comprise be arranged to be mounted with inorganic adsorbent chromatographic column, for comprising the inlet tube of alkali-metal eluent and the outlet for eluate, it is characterized in that, described chromatographic column is made up of stainless steel, and has at least 40cm
3volume and between 5 to the height of 15cm.
2. radionuclide generator device according to claim 1, this radionuclide generator device comprises concentrator apparatus, described concentrator apparatus has the first ion exchange column and the second ion exchange column successively, described first ion exchange column has the first port and the second port, described first port is connected to the outlet of described chromatographic column, described second port is connected to the upstream open of described second ion exchange column, and described second ion exchange column has downstream opening.
3. radionuclide generator device according to claim 2, wherein, described concentrator apparatus is disposable concentrator apparatus.
4. radionuclide generator device according to claim 2, wherein, the connection between described first ion exchange column and described chromatographic column and the connection between described first ion exchange column and described second ion exchange column are obtained by disposable insert and disposable valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520212161.7U CN204516369U (en) | 2015-04-09 | 2015-04-09 | radionuclide generator device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520212161.7U CN204516369U (en) | 2015-04-09 | 2015-04-09 | radionuclide generator device |
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| Publication Number | Publication Date |
|---|---|
| CN204516369U true CN204516369U (en) | 2015-07-29 |
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|---|---|---|---|
| CN201520212161.7U Active CN204516369U (en) | 2015-04-09 | 2015-04-09 | radionuclide generator device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021168557A1 (en) * | 2020-02-24 | 2021-09-02 | Jubilant Draximage Inc. | Generator columns for elution systems loaded with pre-charged matrix |
-
2015
- 2015-04-09 CN CN201520212161.7U patent/CN204516369U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021168557A1 (en) * | 2020-02-24 | 2021-09-02 | Jubilant Draximage Inc. | Generator columns for elution systems loaded with pre-charged matrix |
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