CO2022011987A2 - Uses and compositions based on polyphenols to improve the oral bioavailability of hydroxytyrol - Google Patents

Uses and compositions based on polyphenols to improve the oral bioavailability of hydroxytyrol

Info

Publication number
CO2022011987A2
CO2022011987A2 CONC2022/0011987A CO2022011987A CO2022011987A2 CO 2022011987 A2 CO2022011987 A2 CO 2022011987A2 CO 2022011987 A CO2022011987 A CO 2022011987A CO 2022011987 A2 CO2022011987 A2 CO 2022011987A2
Authority
CO
Colombia
Prior art keywords
hydroxytyrosol
polyphenols
compositions
hydroxytyrol
improve
Prior art date
Application number
CONC2022/0011987A
Other languages
Spanish (es)
Inventor
Hortigüela Óscar Bañuelos
Rojo Ruth Blanco
Lobón José Antonio Maldonado
Martínez Luis Pérez
Larramendi José Luis López
Martín Mónica María Olivares
Original Assignee
Biosearch S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosearch S A filed Critical Biosearch S A
Publication of CO2022011987A2 publication Critical patent/CO2022011987A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/55—Linaceae (Flax family), e.g. Linum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a composiciones de origen natural, que comprenden hidroxitirosol y polifenoles que no son hidroxitirosol y que no se encuentran de forma natural en el olivo (O. europaea), caracterizadas por permitir una biodisponibilidad particularmente alta de hidroxitirosol y una actividad antiaterosclerótica particularmente alta de hidroxitirosol, una vez administrado por vía oral. Dichas composiciones pueden consistir en mezclas de extractos vegetales. La invención también se refiere al uso de dichas composiciones para el tratamiento de enfermedades cardiovasculares, en particular la aterosclerosis.The invention relates to compositions of natural origin, comprising hydroxytyrosol and polyphenols that are not hydroxytyrosol and that are not found naturally in the olive tree (O. europaea), characterized by allowing a particularly high bioavailability of hydroxytyrosol and an antiatherosclerotic activity particularly high hydroxytyrosol, once administered orally. Said compositions may consist of mixtures of plant extracts. The invention also relates to the use of said compositions for the treatment of cardiovascular diseases, in particular atherosclerosis.

CONC2022/0011987A 2020-02-28 2022-08-23 Uses and compositions based on polyphenols to improve the oral bioavailability of hydroxytyrol CO2022011987A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES2020070147 2020-02-28
PCT/EP2021/054840 WO2021170806A1 (en) 2020-02-28 2021-02-26 Uses and compositions based on polyphenols for improving the oral bioavailability of hydroxytyrosol

Publications (1)

Publication Number Publication Date
CO2022011987A2 true CO2022011987A2 (en) 2022-09-09

Family

ID=70471066

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0011987A CO2022011987A2 (en) 2020-02-28 2022-08-23 Uses and compositions based on polyphenols to improve the oral bioavailability of hydroxytyrol

Country Status (10)

Country Link
EP (1) EP4110309A1 (en)
JP (1) JP2023514680A (en)
KR (1) KR20220123074A (en)
CN (1) CN115003291A (en)
AU (1) AU2021228197A1 (en)
BR (1) BR112022015705A2 (en)
CO (1) CO2022011987A2 (en)
MX (1) MX2022010216A (en)
TW (1) TWI795736B (en)
WO (1) WO2021170806A1 (en)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540884A (en) 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US5397894A (en) 1993-05-28 1995-03-14 Varian Associates, Inc. Method of high mass resolution scanning of an ion trap mass spectrometer
US6258846B1 (en) 1999-06-01 2001-07-10 Drugtech Corporation Nutritional supplements
US7112609B2 (en) 1999-06-01 2006-09-26 Drugtech Corporation Nutritional supplements
ES2288123B1 (en) * 2006-06-05 2008-10-01 Furfural Español, S.A. FUNCTIONAL FOOD COMPOSITION RICH IN PHENOLIC COMPOUNDS AND USE OF SUCH COMPOSITION.
WO2008006581A2 (en) * 2006-07-14 2008-01-17 Dsm Ip Assets B.V. Compositions and use thereof for the treatment, co-treatment or prevention of imflammatory disorders
PT2170090E (en) * 2007-07-23 2011-07-01 Probelte Pharma S A Hydroxytyrosol fortified oils and their uses
FR2942224B1 (en) * 2009-02-18 2012-11-30 Centre De Cooperation Internationale En Rech Agronomique Pour Le Developpement Cirad PROCESS FOR EXTRACTING PHENOLIC COMPOUNDS FROM WATER OF VEGETATION OF OLIVE AND PREPARATION OF TITLE EXTRACT OF OLIVE AND GRAPE POLYPHENOLS
ES2592210T3 (en) * 2009-04-17 2016-11-28 Dsm Ip Assets B.V. Hydroxytyrosol combinations to improve mitochondrial function and energy production
EP2338500A1 (en) * 2009-12-23 2011-06-29 Phenofarm S.r.l. Process for producing concentrated and refined actives from tissues and byproducts of Olea europaea with membrane technologies
EP3003338A1 (en) * 2013-05-29 2016-04-13 Nestec S.A. Compositions for use in cartilage breakdown
WO2015006651A1 (en) * 2013-07-11 2015-01-15 Specialty Nutrition Group, Inc. Compositions comprising hydroxytyrosol, resveratrol, lycopene, flavanols, and/or flavonoids and use thereof
SG11201600901VA (en) * 2013-08-09 2016-03-30 Suntory Holdings Ltd Agent for promoting in vivo absorption of hydroxytyrosol and derivatives thereof and use of same

Also Published As

Publication number Publication date
JP2023514680A (en) 2023-04-07
CN115003291A (en) 2022-09-02
TW202131912A (en) 2021-09-01
EP4110309A1 (en) 2023-01-04
WO2021170806A1 (en) 2021-09-02
AU2021228197A1 (en) 2022-07-07
KR20220123074A (en) 2022-09-05
MX2022010216A (en) 2022-09-19
TWI795736B (en) 2023-03-11
BR112022015705A2 (en) 2022-09-27

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