CO2021003713A2 - Methods and compositions for treating deteriorations associated with aging using ccr3 inhibitors - Google Patents
Methods and compositions for treating deteriorations associated with aging using ccr3 inhibitorsInfo
- Publication number
- CO2021003713A2 CO2021003713A2 CONC2021/0003713A CO2021003713A CO2021003713A2 CO 2021003713 A2 CO2021003713 A2 CO 2021003713A2 CO 2021003713 A CO2021003713 A CO 2021003713A CO 2021003713 A2 CO2021003713 A2 CO 2021003713A2
- Authority
- CO
- Colombia
- Prior art keywords
- methods
- disease
- aging
- compositions
- treating
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
La presente invención se refiere a método para mejorar enfermedades neurodegenerativas con agentes moduladores de CCR3. Los métodos incluyen administrar una cantidad terapéuticamente efectiva del agente modulador de CCR3 al sujeto, con una mejora concomitante en la función cognitiva, motora u otra función afectada de manera neurodegenerativa. Las enfermedades cognitivas y motoras en las que los métodos de la invención pueden mejorar la cognición incluyen la enfermedad de Alzheimer, enfermedad de Parkinson, demencia frontotemporal, enfermedad de Huntington, esclerosis lateral amiotrófica, esclerosis múltiple, glaucoma, distrofia miotónica, demencia vascular, parálisis supranuclear progresiva.The present invention relates to a method for ameliorating neurodegenerative diseases with CCR3 modulating agents. The methods include administering a therapeutically effective amount of the CCR3 modulating agent to the subject, with a concomitant improvement in cognitive, motor, or other neurodegeneratively impaired function. Cognitive and motor diseases in which the methods of the invention can improve cognition include Alzheimer's disease, Parkinson's disease, frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, glaucoma, myotonic dystrophy, vascular dementia, paralysis. progressive supranuclear.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862737017P | 2018-09-26 | 2018-09-26 | |
PCT/US2019/052995 WO2020069008A1 (en) | 2018-09-26 | 2019-09-25 | Methods and compositions for treating aging-associated impairments using ccr3-inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021003713A2 true CO2021003713A2 (en) | 2021-04-08 |
Family
ID=69953286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0003713A CO2021003713A2 (en) | 2018-09-26 | 2021-03-24 | Methods and compositions for treating deteriorations associated with aging using ccr3 inhibitors |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP3856195A4 (en) |
JP (1) | JP2022502441A (en) |
KR (1) | KR20210065950A (en) |
CN (1) | CN112789044A (en) |
AU (1) | AU2019346456A1 (en) |
BR (1) | BR112021004938A2 (en) |
CA (1) | CA3111433A1 (en) |
CL (1) | CL2021000724A1 (en) |
CO (1) | CO2021003713A2 (en) |
EA (1) | EA202190463A1 (en) |
IL (1) | IL281578A (en) |
MA (1) | MA53743A (en) |
MX (1) | MX2021002967A (en) |
SG (1) | SG11202102105VA (en) |
TW (1) | TW202027752A (en) |
WO (1) | WO2020069008A1 (en) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200538098A (en) * | 2004-03-22 | 2005-12-01 | Astrazeneca Ab | Therapeutic agents |
EP1996551A2 (en) * | 2006-03-07 | 2008-12-03 | AstraZeneca AB | Piperidine derivatives, their process for preparation, their use as therapeutic agents and pharmaceutical compositions containing them. |
US8278302B2 (en) * | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
US20160208011A1 (en) * | 2010-01-28 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
UA109290C2 (en) * | 2010-10-07 | 2015-08-10 | Common Crystals and Salts of CCR3 Inhibitors | |
US20130261153A1 (en) * | 2012-04-03 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Use of ccr3-inhibitors |
US10213421B2 (en) * | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
IL269743B (en) * | 2017-04-05 | 2022-09-01 | Alkahest Inc | Methods and compositions for treating retina-associated disease using ccr3-inhibitors |
WO2018187503A1 (en) * | 2017-04-05 | 2018-10-11 | Alkahest, Inc. | Methods and compositions for treating aging-associated impairments using ccr3-inhibitors |
-
2019
- 2019-09-25 SG SG11202102105VA patent/SG11202102105VA/en unknown
- 2019-09-25 EA EA202190463A patent/EA202190463A1/en unknown
- 2019-09-25 MX MX2021002967A patent/MX2021002967A/en unknown
- 2019-09-25 WO PCT/US2019/052995 patent/WO2020069008A1/en active Application Filing
- 2019-09-25 CA CA3111433A patent/CA3111433A1/en active Pending
- 2019-09-25 MA MA053743A patent/MA53743A/en unknown
- 2019-09-25 EP EP19867321.2A patent/EP3856195A4/en active Pending
- 2019-09-25 AU AU2019346456A patent/AU2019346456A1/en not_active Abandoned
- 2019-09-25 KR KR1020217008493A patent/KR20210065950A/en unknown
- 2019-09-25 BR BR112021004938-0A patent/BR112021004938A2/en not_active Application Discontinuation
- 2019-09-25 CN CN201980063258.7A patent/CN112789044A/en active Pending
- 2019-09-25 JP JP2021517342A patent/JP2022502441A/en active Pending
- 2019-09-26 TW TW108134938A patent/TW202027752A/en unknown
-
2021
- 2021-03-17 IL IL281578A patent/IL281578A/en unknown
- 2021-03-23 CL CL2021000724A patent/CL2021000724A1/en unknown
- 2021-03-24 CO CONC2021/0003713A patent/CO2021003713A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2022502441A (en) | 2022-01-11 |
CA3111433A1 (en) | 2020-04-02 |
CN112789044A (en) | 2021-05-11 |
EA202190463A1 (en) | 2021-06-29 |
KR20210065950A (en) | 2021-06-04 |
MX2021002967A (en) | 2021-08-11 |
BR112021004938A2 (en) | 2021-06-01 |
SG11202102105VA (en) | 2021-04-29 |
TW202027752A (en) | 2020-08-01 |
IL281578A (en) | 2021-05-31 |
MA53743A (en) | 2022-01-05 |
EP3856195A1 (en) | 2021-08-04 |
AU2019346456A1 (en) | 2021-04-15 |
EP3856195A4 (en) | 2022-06-22 |
WO2020069008A1 (en) | 2020-04-02 |
CL2021000724A1 (en) | 2021-10-15 |
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